DYRK1A DYRK1A knock-out transgenic animal model and method for screening drugs related to neurodegenerative disorders using the same

摘要

The present invention relates to a transgenic animal model knocked out of the DYRK1A gene, and a method of screening for a drug for diseases related to neurological disorders using the same, as a result of producing the DYRK1A gene knockout zebrafish, the DYRK1A gene knockout zebra In fish, brain cell death increased rapidly, and the total brain size decreased, resulting in a microcephaly phenotype, and the expression of the c-fos gene, which is a marker for brain activity and the expression of crh, a stress marker, also decreased, thereby regulating the activity of brain neurons. By confirming that there is a problem, the DYRK1A gene knockout zebrafish of the present invention can be usefully used in a method for screening drugs related to neurological disorders including autism.