Self-assembled polymeric micelles of phosphonium glycol chitosan derivatives specifically targeting mitochondria preparation method and uses thereof

摘要

The present invention relates to a self-assembled polymer micelle of a mitochondrial-targeted phosphonium glycol chitosan derivative, a preparation method thereof, and a use thereof, wherein the phosphonium glycol chitosan derivatives (GC-TPP and GME-TPP) have little cytotoxicity, It is excellent in migration into the cell, and after it is moved into the cell, it specifically moves to the mitochondria, as well as hydrophobic drugs such as anticancer agents can be easily mounted inside the micelles of the present invention, which has an excellent effect as a drug delivery system. There is.