Self-assembled polymeric micelles of phosphonium glycol chitosan derivatives specifically targeting mitochondria, preparation method and uses thereof

摘要

The present invention relates to a self-assembled polymer micelle of a mitochondrial targeted phosphonium glycol chitosan derivative, a method for manufacturing the same, and uses thereof, wherein the phosphonium glycol chitosan derivative (GC-TPP and GME-TPP) has little cytotoxicity, It is excellent in moving into cells, and after moving into cells, it not only has the characteristic of specifically moving to the mitochondria, but also can easily mount hydrophobic drugs such as anticancer agents into the micelles of the present invention, thereby providing excellent effects as a drug delivery system. Is there.