首页> 外国专利> Method for increasing platycodin E content in Platycodon grandiflorum using Aspergillus shirousamii

Method for increasing platycodin E content in Platycodon grandiflorum using Aspergillus shirousamii

机译：利用亚米曲霉增加桔梗中桔梗E含量的方法

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摘要

The present invention is a platicoside of bellflower comprising the step of inoculating and fermenting the Aspergillus shirousamii 6957 strain deposited with the accession number KCTC6957 or the Aspergillus shirousamii 6958 strain deposited with the accession number KCTC6958 into the bellflower Regarding a method of enhancing the E content, it was confirmed that bellflower fermented with Aspergillus Shirosami 6957 strain or Aspergillus Shirosami 6958 strain had higher platicoside E content than bellflower fermented with other Aspergillus strains. I did. As the content of platicoside E in bellflowers can be improved through the method of the present invention, bellflowers produced by the method of the present invention have excellent industrial utility.

机译：本发明是风铃草的白菊糖苷，其包括接种并发酵保藏号为KCTC6957的 Shirousamii 6957菌株或保藏号为 Shirousamii 6958的菌株的步骤。关于提高E含量的方法，已证实，用白曲霉6957菌株或白曲霉6958菌株发酵的桔梗比其他用曲霉菌株发酵的桔梗具有更高的铂苷E含量。是的由于通过本发明的方法可以提高风铃草中铂菊苷E的含量，因此通过本发明的方法生产的风铃草具有优异的工业实用性。 ~~展开▼~~

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公开/公告号KR102169156B1

专利类型

公开/公告日2020-10-22

原文格式PDF

申请/专利权人
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申请/专利号KR1020180162498

发明设计人 임푸름;김상범;최애진;황인국;김찬우;최정숙;
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申请日2018-12-14

分类号A23L19/10;A23L29;C12N1/20;

国家 KR

入库时间 2022-08-21 11:03:32

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5. PLATYCODON GRANDIFLORUM TEA COMPOSITION WITH INCREASED THE CONTENT OF PLATYCODIN D OR PLATYCODIN D3, AND MANUFACTURING METHOD THEREOF [P] . KR102227386B1 . 2021-03-12

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1. A new triterpenoid saponin from the roots of Platycodon grandiflorum [J] . Wei Li, Lan Xiang, Jing Zhang, 中国化学快报（英文版） . 2007,第003期

2. Effect of processing method on platycodin D content in Platycodon grandiflorum roots [J] . Jaeyoung Kwon, Hyaemin Lee, Nahyun Kim, Archives of pharmacal research . 2017,第9期

3. Effects of different phosphorus applications on growth and platycodin content of Balloon Flower (Platycodon grandiflorum) [J] . Zhu Li-xiang, Liu Dan Scientia horticulturae . 2014,第Null期

4. Effect of Drying Methods on the Saponin and Mineral Contents of Platycodon grandiflorum Radix [J] . Byung-Jin Lee, Seung-Ho Jeon, Shin-Woo Lee, Korean Journal of Food Science and Technology . 2014,第5期

5. Research on Platycodon Grandiflorum Eriobotrya Japonica Honey Tablet Technology and Determination of Content of Platycodin D, Ursolic and Oleanolic Acid [C] . Xiuying Wang, Wei Zhang, Chunlin Zhao, International Conference on Mechatronics, Materials, Chemistry and Computer Engineering . 2017

6. Evaluation of methods to increase free procyanidin content in the cider fermentation process of Jonathan Apples. [D] . Tan, Mavis. 2005

7. Platycodin D a bioactive component of Platycodon grandiflorum induces cancer cell death associated with extreme vacuolation [O] . Daun Jeon, Seung-Woo Kim, Hong Seok Kim 2019

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1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

2. Enhancement of Power Generation in Microbial Fuel Cells through Supplementation of iPlatycodon grandiflorum/iin Doraji Roots [J] . Jung-In Park ,Hyunjin Kim ,Dae Kyung Go . 可持续生物质能源系统（英文） . 2019,第4期

3. 桔梗(Platycodon grandiflorum (Jacq.)A.DC.)的组织培养和植株再生 [J] . 曾宣姣 ,张书娟 ,胡晓 . 北京农学院学报 . 2015,第003期

4. Platycodon grandiflorum （ Jacq. ） A. mey extracts inhibits hepatic fibrosis DC. and Panax Ginseng C. A. in activated hepatic stellate cells [J] . . 中国药理学通报 . 2015,第B11期

5. 不同干燥方法对桔梗中桔梗皂苷D含量的影响 [C] . 金传山 ,黄力 ,吴德玲 . 中华中医药学会中药炮制分会2009年学术研讨会 . 2009

6. 桔梗//大葱间作对桔梗根系及根际的调控研究 [A] . 孙文帅 . 2019