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EXTRACELLULAR DELIVERY OF BIOLOGICAL MOLECULES FOR INDUCING TOLERANCE
EXTRACELLULAR DELIVERY OF BIOLOGICAL MOLECULES FOR INDUCING TOLERANCE
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机译:胞外递送诱导耐受性的生物分子
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摘要
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.
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