PRINCE REACTION AND INTERMEDIATE PRODUCTS USED IN THE SYNTHESIS OF GALICHONDRIN SERIES MACROLIDES AND THEIR ANALOGUES

摘要

The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.