1,3-DIHYDROIMIDAZOLE-2-THIONE DERIVATIVES FOR USE IN TREATING PULMONARY ARTERIAL HYPERTENSION AND LUNG INJURY

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: invention relates to use of (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione or a pharmaceutically acceptable salt thereof, optionally in combination with at least one other active pharmaceutical ingredient selected from endothelin antagonists and prostacyclin analogues for treating pulmonary arterial hypertension. Invention also relates to a method of treating pulmonary arterial hypertension based on the use of (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazol-2(3H)-thione or its pharmaceutically acceptable salt.;EFFECT: technical result is the development of a new therapeutic approach in the treatment of pulmonary arterial hypertension.;5 cl, 7 dwg, 1 tbl, 2 ex