首页> 外国专利> METHOD FOR INITIATION OF DEATH OF TUMOUR CELLS OF HYDROXYALUMINIUM TRISULFOPHTHALOCYANINE AND ASCORBIC ACID AND HF- AND MICROWAVE RADIATION WAVE ENERGY

METHOD FOR INITIATION OF DEATH OF TUMOUR CELLS OF HYDROXYALUMINIUM TRISULFOPHTHALOCYANINE AND ASCORBIC ACID AND HF- AND MICROWAVE RADIATION WAVE ENERGY

机译:羟丙基三硫酞菁和抗坏血酸及HF和微波辐射波能量启动的肿瘤细胞死亡方法

摘要

FIELD: medicine.;SUBSTANCE: invention relates to method of initiating tumour cell death, intended for local treatment of oncological patients having tumour tissues with multiple metastases, for their hyperthermia in all organs of human body HF- and UHF energy, characterized by that before treatment, person for 3 days is transferred to a non-carbohydrate diet for subsequent maximum saturation of tumour cells with electron-ion solutions of Photosens hydroxyaluminium trisulfophthalocyanine preparation intravenously in megadose 0.81 mg/kg of body weight and ascorbic acid orally in megadose to 500 mg, for maximum accumulation in tumour tissues respectively 1.5–1.8 times more than in healthy tissues, after administration of Photosens hydroxyaluminium trisulfophthalocyanine solution and ascorbic acid after 8 hours and after 4 hours, selective hyperthermia of tumour tissues HF energy is performed in accordance with depth of their location and penetration depth of electromagnetic wave into human body of 1100 cm at the allowed frequency f = 13.56 MHz with total heating rate of tumour tissues of 0.073 °C/s for 162 s to temperature of tumour tissues heating of 48.5 °C, with heating of healthy tissues not higher than 40 °C.;EFFECT: disclosed is a method for initiation of death of tumour cells of hydroxyaluminium with trisulfophthalocyanine and ascorbic acid and Hg- and microwave radiation of microwave radiation.;1 cl, 1 ex, 2 tbl
机译:发明领域本发明涉及引发肿瘤细胞死亡的方法,其旨在局部治疗具有多种转移的肿瘤组织的肿瘤患者在人体所有器官中的HF-和UHF能量的高热,其特征在于治疗,将3天的患者转移到非碳水化合物饮食中,随后用光敏羟基三铝酞菁光敏剂的电子离子溶液静脉内以大剂量0.81 mg / kg体重静脉注射抗坏血酸,以500 mg大剂量口服抗坏血酸使肿瘤细胞达到最大饱和度,为了使肿瘤组织中的最大积累分别比健康组织多1.5-1.8倍,在分别于8小时和4小时后施用光敏羟基三铝酞菁铝溶液和抗坏血酸后,根据肿瘤组织的深度进行选择性的HF热疗它们的位置和电磁波进入呼玛的穿透深度在允许的频率f = 13.56 MHz下,1100 cm的n体,肿瘤组织的总加热速率为0.073°C / s,持续162 s,肿瘤组织的温度达到48.5°C,健康组织的加热速率不高于40° C .;效果:公开了一种用三磺酞菁和抗坏血酸以及微波辐射的Hg-和微波辐射引发羟基铝肿瘤细胞死亡的方法。1cl,1 ex,2 tbl

著录项

  • 公开/公告号RU2723490C2

    专利类型

  • 公开/公告日2020-06-11

    原文格式PDF

  • 申请/专利权人 TSUGLENOK NIKOLAJ VASILEVICH;

    申请/专利号RU20180126432

  • 发明设计人 TSUGLENOK NIKOLAJ VASILEVICH (RU);

    申请日2018-07-17

  • 分类号A61B18/18;A61N5;A61P35;A61K41;A61K31/375;A61K31/409;C07D487/22;

  • 国家 RU

  • 入库时间 2022-08-21 11:02:26

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