FIELD: biotechnology.;SUBSTANCE: invention represents a pharmaceutical composition for targeting the released phosphatidylserine (PtdS), comprising an effective amount of the polypeptide and a pharmaceutically acceptable carrier, and use of a pharmaceutical composition for treating cancer. Also, use of a pharmaceutical composition for treating viral diseases. Invention relates to recombinant proteins of Gla domain and use thereof for targeting residues of phosphatidylserine (PtdS) on cell surface, in particular those expressing high levels of PtdS, such as cells that have undergone apoptosis.;EFFECT: these proteins can be associated with both diagnostic and therapeutic loads, thus allowing to identify and treat cells that express elevated levels of PtdS.;14 cl, 8 dwg, 1 ex
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机译：技术领域本发明表示一种靶向有效释放的磷脂酰丝氨酸（PtdS）的药物组合物，其包含有效量的多肽和药学上可接受的载体，以及该药物组合物在治疗癌症中的用途。另外，药物组合物在治疗病毒性疾病中的用途。本发明涉及Gla结构域的重组蛋白及其在细胞表面上靶向磷脂酰丝氨酸（PtdS）残基的用途，特别是那些表达高水平PtdS的残基，例如已经凋亡的细胞。诊断和治疗负荷，因此可以鉴定和治疗表达高水平PtdS的细胞; 14 cl，8 dwg，1 ex
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