CELL, ESPECIALLY YEAST, RESISTANT TO PHLOROGLUCINOL

摘要

The present invention relates to a living cell, preferably a host cell, resistant to phloroglucinol, said host cell being characterized in that it overexpresses a polypeptide selected from (i) transmembrane transporters of the ABC family, in particular transmembrane transporters of the PDR subfamily, (ii) transcription factors controlling the expression of transmembrane transporters of the PDR subfamily, and (iii) transmembrane transporters of the MFS family; preferably a polypeptide chosen from SNQ2, STE6, PDR3, AQR1, DTR1, FLR1, QDR1, YHK8 and ATR1; and more preferably the SNQ2 transporter. The present invention also relates to a method of producing a recombinant host cell resistant to phloroglucinol. The present invention further relates to a method of producing phloroglucinol.