Screening method for specific inhibition of caveolae formation in cancer cell, screening kit, vector and transformant used in the kit, and adaptive patient selection method of molecular target drug

摘要

Provided is a method for screening a compound that can specifically suppress the formation of caveolae in cancer cells and can inhibit various RTK activities with a single compound. A method for screening a compound that specifically inhibits the formation of caveolae in cancer cells, wherein the screening method comprises contacting a test compound with a system capable of detecting inhibition of binding between Cavin-1 and CAV1, A step of selecting a compound having an activity of suppressing the binding of CAV1.