PROCÉDÉS ET COMPOSITIONS DE NANOPARTICULES LIPIDIQUES DESTINÉS À LA PRODUCTION DE CELLULES ÉRYTHROÏDES MODIFIÉES

摘要

Carriers such as lipid nanoparticles are useful for delivering payloads (such as RNA, DNA, proteins, or small molecules) to cells such as erythroid cells. This disclosure provides improved carriers that comprise a targeting agent that binds a cell surface receptor. In some embodiments, the cell surface receptor is one that undergoes a high rate of endocytosis.