TRAITEMENT DE CARDIOPATHIES PAR INHIBITION DE L'ACTION DES PROTÉINES D'ANCRAGE AUX PROTÉINES KINASES A (MAKAP) DU MUSCLE

摘要

The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ, or the expression or activity of one or both of those molecules. This composition is preferably in the form of an siRNA construct, more preferably an shRNA construct, which inhibits the expression of mAKAPβ.