COMBINAISON DE PEPTIDES TOLÉROGÉNIQUES ET DE TFG-B POUR UNE UTILISATION DANS L'INDUCTION ET L'ENTRETIEN DE LA TOLÉRANCE ORALE CHEZ LES JEUNES MAMMIFÈRES

摘要

This invention relates to the administration of a combination of TGF-β and one or more peptides comprising specific sequences of β-lacto-globulin. The peptides are hypoallergenic but retain the capability to induce tolerance to the native protein. The combination of TGF-β and one or more of these peptides has the therapeutic effect of inducing and maintaining oral tolerance towards newly introduced proteins, in particular, at the weaning period. The combination can modulate the infant and toddler immune response to allergens.