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COMPOSITIONS PHARMACEUTIQUES, PROCÉDÉS DE PRÉPARATION UTILISANT DES PARTICULES DE VÉSICULES LIPIDIQUES DE TAILLE DÉFINIE, ET LEURS UTILISATIONS
COMPOSITIONS PHARMACEUTIQUES, PROCÉDÉS DE PRÉPARATION UTILISANT DES PARTICULES DE VÉSICULES LIPIDIQUES DE TAILLE DÉFINIE, ET LEURS UTILISATIONS
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摘要
The present disclosure relates to methods for preparing a dried preparation comprising lipids and a therapeutic agent by using lipid vesicle particles having a mean particle size of ≤ 120 nm and a polydispersity index (PDI) of ≤ 0.1. The present application also provides stable, water-free pharmaceutical compositions comprising one or more lipid-based structures having a single layer lipid assembly, at least one therapeutic agent, and a hydrophobic carrier, as well as methods of treatment, uses and kits relating thereto, such as for example for inducing an antibody and/or CTL immune response.
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