COMPOSITIONS ET PROCÉDÉS POUR AMÉLIORER LA MATURATION DE CARDIOMYOCYTES SAINS ET MALADES

摘要

The methods and compositions as disclosed herein describe the making of mature stem cell- derived cardiomyocytes for applications such as disease modeling, cardiotoxicity screening, drug screening and identification, among other uses. The methods involve physical and biochemical cues that promote a transition of stem cell-derived cardiomyocytes from a fetal phenotype to a more mature phenotype that more closely resembles that of adult cardiomyocytes.