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COMPOSITION PHARMACEUTIQUE DESTINÉE À PRÉVENIR OU À TRAITER UNE LÉSION D'ISCHÉMIE-REPERFUSION, CONTENANT DE L'ACIDE BILIAIRE
COMPOSITION PHARMACEUTIQUE DESTINÉE À PRÉVENIR OU À TRAITER UNE LÉSION D'ISCHÉMIE-REPERFUSION, CONTENANT DE L'ACIDE BILIAIRE
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摘要
The present invention relates to a composition for preventing, treating, or alleviating ischemia-reperfusion injury, containing bile acid. According to the present invention, bile acid increases intranuclear beta-catenin levels, interferes with the opening of a mitochondria permeable transition pore (mPTP), and has excellent effects, in ischemia-reperfusion injury animal models, of alleviating tissue injury and reducing the size of infarcts, thereby being usable in the prevention, treatment, or alleviation of ischemia-reperfusion injury.
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