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三氟拉嗪在制备治疗卒中后脑水肿药物组合物中的应用

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摘要

本发明公开了三氟拉嗪在制备治疗卒中后脑水肿药物组合物中的应用，具体是钙调蛋白抑制剂三氟拉嗪通过调节水通道蛋白AQP4极性分布抑制卒中后脑水肿药物组合物中的应用。本发明实验研究证实，三氟拉嗪能够用于治疗脑卒中导致的脑水肿，三氟拉嗪能够抑制脑出血后AQP4的极性分布，抑制脑水肿，改善神经功能。

著录项

公开/公告号CN113181187B

专利类型发明专利
公开/公告日2022.09.13

原文格式PDF
申请/专利权人台州恩泽医疗中心(集团);
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申请/专利号CN202110619240.X
发明设计人吴刚;刘玺昌;洪卫军;刘翠敏;
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申请日2021.06.03
分类号A61K31/5415;A61K9/08;A61K9/19;A61P7/10;A61P25/00;A61P7/04;A61P9/10;
代理机构广西中知华誉知识产权代理有限公司;
代理人陆丽婷
地址 317000 浙江省台州市临海市西门街150号
入库时间 2022-09-26 23:20:12

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法律状态公告日

法律状态信息

法律状态
2022-09-13

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1. 三氟拉嗪在制备治疗卒中后脑水肿药物组合物中的应用 [P] . 中国专利： CN113181187A . 2021-07-30
2. 丹参素甲酯在制备治疗缺血性脑卒中药物中的应用、药物组合物、丹参素甲酯的制备方法 [P] . 中国专利： CN113952324A . 2022-01-21
3. spirocyclic heterocyclic compound, pharmaceutical composition, method to bind opioid receptors, methods to prevent or treat pain, gastrointestinal dysfunction, a urogenital tract disorder, an immunomodulatory disorder, an inflammatory disorder, a respiratory function disorder, anxiety, mood disorder, a stress-related disorder, sympathetic nervous system disorder, cough, and a motor disorder, method for treating traumatic injury to the central nervous system, methods for preventing or treating stroke, cardiac arrhythmia, glaucoma, and sexual dysfunction, methods for treating a condition selected from the group consisting of shock, cerebral edema, cerebral ischemia, cerebral deficit after cardiac surgery (bypass) and graft, systemic lupus erythematosus, hodgkin's disease, sjogren's disease, epilepsy, and rejection in organ transplants and skin grafts, and to treat substance dependence, method to improve organ and cell survival, and cardioprotection after myocardial infarction, methods to [P] . BRPI0415165A . 2007-01-09

机译：螺环杂环化合物，药物组合物，阿片受体的结合方法，预防或治疗疼痛，胃肠道功能障碍，泌尿生殖道疾病，免疫调节疾病，炎性疾病，呼吸功能疾病，焦虑症，情绪障碍，与压力有关的方法疾病，交感神经系统疾病，咳嗽和运动障碍，治疗中枢神经系统创伤的方法，预防或治疗中风，心律不齐，青光眼和性功能障碍的方法，治疗选自以下组的疾病的方法包括休克，脑水肿，脑缺血，心脏手术（旁路）和移植后脑缺损，系统性红斑狼疮，霍奇金病，干燥综合征，癫痫和器官移植和皮肤移植排斥反应，以及治疗药物依赖的方法改善器官和细胞存活率以及心肌梗死后的心脏保护作用，
4. Pharmaceutical composition for epithelial wound prevention and treatment, immunoregulatory pharmaceutical composition, pharmaceutical composition, insecticide, insecticide composition, use of insecticide of lectin KM + in the treatment of scarring, use of lectin KM + in preparation of immunoregulatory drug , Use of lectin KM + in formulating antibacterial drugs, use of lectin KM + in formulating antiviral drugs, use of lectin KM + in formulating antifungal drugs, use of lectin KM + in formulating antiparasitic drugs, expression methods, DNA vectors, recombinant organisms , Nucleotide sequences, antibodies, proteins and extranuclear genes [P] . 日本专利： JP2007528869A . 2007-10-18

机译：用于上皮伤口预防和治疗的药物组合物，免疫调节药物组合物，药物组合物，杀虫剂，杀虫剂组合物，凝集素KM +杀虫剂在瘢痕形成中的用途，凝集素KM +在制备免疫调节药物中的用途，凝集素KM +的用途在制备抗菌药物中，凝集素KM +在抗病毒药中的应用，凝集素KM +在抗真菌药中的应用，凝集素KM +在抗寄生虫药中的应用，表达方法，DNA载体，重组生物，核苷酸序列，抗体，蛋白质和核外基因
5. composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion [P] . BRPI0617987A2 . 2011-08-16

机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病