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一种用于抗白色念珠菌的环状多肽及其制备方法

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摘要

本发明属于抗菌剂技术领域，具体涉及一种用于抗白色念珠菌的环状多肽及其制备方法。所述环状多肽的氨基酸序列如SEQ ID NO.1所示，为分子内环状多肽，通过其氨基酸序列中的两个半胱氨酸残基之间形成分子内二硫键，形成具有分子内环状结构，其中，C端末尾由8个精氨酸组成，序列中含有两个非天然氨基酸，多肽位于β转角处的脯氨酸替换成DPRO‑LPRO来增加β‑转弯的稳定性。本发明环状多肽其氨基酸序列结构简单、合成方便、用于白色念珠菌引起的疾病的预防与治疗，其抗菌活性高。

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公开/公告号CN109796523B

专利类型发明专利
公开/公告日2022-02-11

原文格式PDF
申请/专利权人常州大学;
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申请/专利号CN201910246760.3
发明设计人王建浩;王建鹏;邱琳;滕一万;柳丽;王苏南;马剑鹤;徐以洋;杨菲;马秀娟;罗海燕;
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申请日2019-03-29
分类号C07K14/00(20060101);A61K38/16(20060101);A61P31/10(20060101);
代理机构32258 常州市英诺创信专利代理事务所(普通合伙);
代理人谢新萍
地址 213164 江苏省常州市武进区滆湖路1号
入库时间 2022-08-23 13:06:22

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