Cyclic AC253 a novel amylin receptor antagonist improves cognitive deficits in a mouse model of Alzheimers disease

摘要

IntroductionAmylin receptor serves as a portal for the expression of deleterious effects of amyloid β-protein (Aβ), a key pathologic hallmark of Alzheimer's disease. Previously, we showed that AC253, an amylin receptor antagonist, is neuroprotective against Aβ toxicity in vitro and abrogates Aβ-induced impairment of hippocampal long-term potentiation.