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一种具有治疗神经退行性疾病作用的药物组合物

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摘要

本发明公开了一种具有治疗神经退行性疾病作用的药物组合物，包括如下重量份的：天麻提取物10‑90份、三七提取物10‑90份、石菖蒲提取物10‑90份、毛喉鞘蕊花提取物10‑90份、花生壳提取物10‑90份。本发明所述药物组合物对神经退行性疾病具有较强的预防或拮抗作用，同等剂量下药物组合物相比单一提取物具有更好的药理活性。

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公开/公告号CN111569008B

专利类型发明专利
公开/公告日2021-10-08

原文格式PDF
申请/专利权人昆明医科大学;昭通市天麻研究院;
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申请/专利号CN202010385274.2
发明设计人杨为民;陈晨;田孟华;翁稚颖;李鲜;何海艳;刘毅;王玉川;余显伦;施蕊;王红艳;郑昌博;宋流东;
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申请日2020-05-09
分类号A61K36/8988(20060101);A61P25/28(20060101);A23L33/10(20160101);A23L33/105(20160101);
代理机构32297 南京艾普利德知识产权代理事务所(特殊普通合伙);
代理人张铂
地址 650500 云南省昆明市呈贡区雨花街道春融西路1168号
入库时间 2022-08-23 12:35:17

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1. 一种具有治疗神经元损伤及/或神经炎症相关的神经退行性疾病作用的药物组合物 [P] . 中国专利： CN112641784A . 2021-04-13
2. 一种具有治疗神经退行性疾病作用的药物组合物 [P] . 中国专利： CN111569008A . 2020-08-25
3. compound, pharmaceutical composition, method of selective activation/stimulation of nicotinic receptors from to-7 in a patient in which such activation/stimulation has a therapeutic effect, method of treating a patient suffering from a psychotic disease, a neurodegenerative disease involving a dysfunction of the cholinergic system, and/or a condition of impaired memory and/or cognition, method of treatment of a patient suffering from dementia and/or another condition with memory loss, method of treatment of a patient suffering from memory impairment due to mild cognitive impairment due to aging, alzheimer's malady,schizophrenia, parkinson malady, huntington malady, pick malady, creutzfeldt-jakob malady, depression, aging, head trauma, stroke, snc hypoxia, cerebral senility, multiinfarction dementia, HIV and/or cardiovascular disease, method of treatment and/or prevention of dementia in a patient with alzheimer's disease, method of treating a patient to cut off the alcohol vein or treat [P] . BRPI0517494A . 2008-10-14

机译：化合物，药物组合物，在其中这种激活/刺激具有治疗作用的患者中选择性激活/刺激烟碱受体从to-7的方法，治疗患有精神病，涉及神经功能障碍的神经退行性疾病的患者的方法胆碱能系统和/或记忆力和/或认知障碍的状况，患有痴呆症的患者的治疗方法和/或患有记忆力丧失的另一种状况，由于轻度认知障碍而遭受记忆力障碍的患者的治疗方法由于衰老，阿尔茨海默氏病，精神分裂症，帕金森氏病，亨廷顿氏病，匹克病，creutzfeldt-jakob病，抑郁症，衰老，头部外伤，中风，snc缺氧，脑衰老，多发性梗塞性痴呆，HIV和/或心血管疾病，治疗方法治疗和/或预防老年痴呆症患者的痴呆症，治疗患者的方法以切断酒精静脉或治疗
4. An extract composition, a method for producing it, a method for stimulating wound healing, a method for stimulating neuronal proliferation, treating brain diseases, and treating neurodegenerative diseases, a method for treating breast cancer, a method for reducing side effects of drugs affecting DNA and / or RNA replication, and enhancing the pharmacological effects of drugs affecting the replication of DNA and / or RNA [P] . 俄罗斯专利： RU2016122238A . 2017-12-11

机译：提取物组合物，其制备方法，刺激伤口愈合的方法，刺激神经元增殖，治疗脑部疾病和治疗神经退行性疾病的方法，治疗乳腺癌的方法，减少影响DNA的药物副作用的方法和/或RNA复制，并增强影响DNA和/或RNA复制的药物的药理作用
5. compound of formula i; pharmaceutical composition; method of treating disorders that are related to or affected by inhibition of norepinephrine reuptake, the 5-ht6 receptor or the 5-ht2a receptor; a method of treating a learning disorder, a cognitive disorder, a memory disorder, a personality disorder, a behavioral disorder, a movement disorder, a neurodegenerative disorder, drug withdrawal disorder, sleep, an eating disorder, acute drug toxicity, a cardiovascular disorder, a sexual dysfunction, a gastrointestinal disorder, a genitourinary disorder, a pain disorder, a nervous disorder or a symptom disorder vasomotor; method of treating alzheimer's disease, attention deficit disorder, schizophrenia, parkinson's disease, tardive dyskinesia, ataxia, bradykinesia, paroxysmal dyskinesias, restless leg syndrome, tremor, essential tremor epilepsy, stroke or head trauma; method of treating coronary artery disease, myocardial infarction, transient ischemic attack, angina, atrial fibrillation, p [P] . BRPI0706523A2 . 2011-01-04

机译：式I化合物;药物组合物;治疗与去甲肾上腺素再摄取，5-ht6受体或5-ht2a受体相关或受其抑制的疾病的方法;一种治疗学习障碍，认知障碍，记忆障碍，人格障碍，行为障碍，运动障碍，神经退行性疾病，戒断药物，睡眠，进食障碍，急性药物毒性，心血管疾病的方法，性功能障碍，胃肠道疾病，泌尿生殖系统疾病，疼痛疾病，神经疾病或症状-血管舒缩;治疗阿尔茨海默氏病，注意力缺陷障碍，精神分裂症，帕金森氏病，迟发性运动障碍，共济失调，运动迟缓，阵发性运动障碍，不安腿综合征，震颤，原发性震颤癫痫，中风或头部外伤的方法;治疗冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，心房颤动，p的方法