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凝血酶抗体、其抗原结合片段及医药用途

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摘要

本发明涉及凝血酶抗体、其抗原结合片段及医药用途。进一步地，本发明涉及包含所述凝血酶抗体CDR区的嵌合抗体、人源化抗体，以及包含凝血酶抗体及其抗原结合片段的药物组合物，以及其作为抗凝药物的用途。特别地，本发明涉及一种人源化的凝血酶抗体在制备用于治疗凝血酶介导的疾病或病症的药物中的用途。

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公开/公告号CN107043423B

专利类型发明专利
公开/公告日2021-02-26

原文格式PDF
申请/专利权人江苏恒瑞医药股份有限公司;上海恒瑞医药有限公司;
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申请/专利号CN201710060629.9
发明设计人应华;刘佳建;付雅媛;张玲;张昊颖;孙嘉康;张连山;陶维康;孙飘扬;胡齐悦;
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申请日2017-01-25
分类号C07K16/40(20060101);A61K39/395(20060101);A61P7/02(20060101);A61P9/10(20060101);G01N33/573(20060101);
代理机构11314 北京戈程知识产权代理有限公司;
代理人程伟
地址 222047 江苏省连云港市经济技术开发区昆仑山路7号
入库时间 2022-08-23 11:33:30

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1. 凝血酶抗体、其抗原结合片段及医药用途 [P] . 中国专利： CN107043423B . 2021.02.26
2. 凝血酶抗体、其抗原结合片段及医药用途 [P] . 中国专利： CN111094354A . 2020-05-01
3. anti-human sirpa antibody or antigen-binding fragment thereof or antigen-binding antibody mimetic, pharmaceutical composition, combination product, isolated nucleic acid molecule, vector, isolated host cell, polypeptide, methods for making an antibody, in in vitro or ex vivo to determine sirp positive, diagnostic and predictive response cells of a subject, and use of an anti-sirp antibody or antigen-binding fragment thereof or an antibody-binding mimetic in vitro or ex vivo of at least one anti-human sirpa antibody or antigen binding fragment thereof or antigen binding antibody mimetic. [P] . BR112018070823A2 . 2019-02-05

机译：抗人Sirpa抗体或其抗原结合片段或抗原结合抗体模拟物，药物组合物，联合产品，分离的核酸分子，载体，分离的宿主细胞，多肽，在体外或离体制备抗体的方法确定受试者的sirp阳性，诊断和预测反应细胞，以及至少一种抗人sirpa抗体或抗原结合的体外或离体的抗sirp抗体或其抗原结合片段或抗体结合模拟物的用途其片段或抗原结合抗体模拟物。
4. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A2 . 2018-01-23

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
5. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A8 . 2018-06-26

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒