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Echo30单克隆抗体的制备及其用途

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摘要

本发明涉及Echo30单克隆抗体的制备及其用途。本发明的抗体的CDR序列如SEQ ID NO：1‑3和SEQ ID NO：5‑7所示，抗体重链可变区的序列如SEQ ID NO：4所示，抗体轻链可变区的序列如SEQ ID NO：8所示。本发明的抗体可使用本领域常规方法制备，利用体外实验证明纯化的抗体具有Echo30结合特异性和中和Echo30的中和活性，故本发明的抗体可用于临床诊断或治疗。

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公开/公告号CN111153989B

专利类型发明专利
公开/公告日2020-09-15

原文格式PDF
申请/专利权人江苏省疾病预防控制中心(江苏省公共卫生研究院);
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申请/专利号CN202010043727.3
发明设计人张黎;王康;郑滨洋;朱玲;苏璇;张倩;陶焱炀;崔仑标;潘红星;葛以跃;吴涛;王祥喜;朱凤才;
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申请日2020-01-15
分类号C07K16/10(20060101);C12N15/13(20060101);C12N15/85(20060101);G01N33/577(20060101);G01N33/569(20060101);A61K39/42(20060101);A61P31/14(20060101);
代理机构11736 北京预立生科知识产权代理有限公司;
代理人孟祥斌;朱萍
地址 210009 江苏省南京市江苏路172号
入库时间 2022-08-23 11:14:00

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1. Echo30单克隆抗体的制备及其用途 [P] . 中国专利： CN111153989B . 2020.09.15
2. 针对Echo30的单克隆抗体、制备方法及其应用 [P] . 中国专利： CN111153990B . 2020.10.27
3. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A2 . 2018-01-23

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
4. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A8 . 2018-06-26

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
5. Purified Human Macrophage Migration Inhibition Factor (Human MIF) and Its Single Proteins, Methods of Preparation thereof, Monoclonal Antibodies to Human MIF and Method of Preparation, Hybridoma Cell Lines Producing Monoclonal Antibodies to Human MIF, Their Use and Procedure for their Preparation pharmaceutical preparations containing purified human MIF or [P] . DK171646B1 . 1997-03-03

机译：纯化的人巨噬细胞迁移抑制因子（人MIF）及其单一蛋白，其制备方法，人MIF单克隆抗体及其制备方法，产生人MIF单克隆抗体的杂交瘤细胞系，其用途和制备方法纯化的人MIF或