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含艰难梭菌类毒素A和B的药物组合物

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摘要

本发明涉及包括艰难梭菌毒素和/或类毒素的组合物及相应方法。本发明的组合物包括一种或多种增加所述毒素的稳定性和/或减少所述毒素聚集的赋形剂。

著录项

公开/公告号CN101855336B

专利类型发明专利
公开/公告日2019-07-30

原文格式PDF
申请/专利权人赛诺菲巴斯德生物制剂有限责任公司;
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申请/专利号CN200880116603.0
发明设计人 C·R·米道夫;R·法尔纳;P·恰拉梅塔罗;
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申请日2008-09-15
分类号
代理机构中国专利代理(香港)有限公司;
代理人梁谋
地址美国特拉华州
入库时间 2022-08-23 10:36:46

法律信息

法律状态公告日

法律状态信息

法律状态
2019-07-30

授权

授权
2016-06-01

著录事项变更 IPC(主分类):C12N1/20 变更前: 变更后: 申请日:20080915

著录事项变更
2016-06-01

著录事项变更 IPC(主分类):C12N 1/20 变更前: 变更后: 申请日:20080915

著录事项变更
2010-11-24

实质审查的生效 IPC(主分类):C12N1/20 申请日:20080915

实质审查的生效
2010-11-24

实质审查的生效 IPC(主分类):C12N 1/20 申请日:20080915

实质审查的生效
2010-10-06

公开

公开
2010-10-06

公开

公开

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1. 含艰难梭菌类毒素A和B的药物组合物 [P] . 中国专利： CN101855336B . 2019.07.30
2. 含艰难梭菌类毒素A和B的药物组合物 [P] . 中国专利： CN101855336A . 2010-10-06
3. uses of immunogenic composition and vaccine comprising clostridium difficile toxoids to treat and / or prevent disease caused by clostridium sp, immunogenic composition and vaccine comprising c toxoids. difficile and c. perfringens, process for preparing said vaccine, as well as vaccination kit that comprises said immunogenic composition [P] . BR112019024412A2 . 2020-07-14

机译：包含艰难梭菌类毒素的免疫原性组合物和疫苗在治疗和/或预防由梭状芽孢杆菌引起的疾病中的用途，包含c类毒素的免疫原性组合物和疫苗。艰难和c。香水，制备所述疫苗的方法以及包含所述免疫原性组合物的疫苗接种试剂盒
4. Use in the manufacture of a medicament of an antibody having specific activity against Clostridium difficile, and pharmaceutical compositions comprising Anti-Clostridium difficile bovine immunoglobulin concentrate; for treating diseases associated with Clostridium difficile [P] . NZ291659A . 2001-04-27

机译：用于制造对艰难梭菌具有特定活性的抗体的药物，以及包含抗艰难梭菌牛免疫球蛋白浓缩物的药物组合物;用于治疗艰难梭菌相关疾病
5. Fusion protein Fusion protein The soluble composition of the host cell material Process to generate a neutralizing anti-toxin directed against Clostridium botulinum toxin type A antibody to purify a recombinant fusion protein derived from a Clostridium botulinum toxin type A process to generate an antitoxin neutralizing directed against clostridium difficile toxin type b antibody treatment process process to generate a neutralizing antitoxin directed against clostridium difficile type a toxin composition process to vaccinate an individual to produce neutralizing antitoxin directed against clostridium difficile toxin processing the detection of clostridium antigens difficile in an ample process of purification of toxins from clostridium difficile from a culture and process of generation of a solid dosage form of a bird antitoxin directed against a protein of clostridial toxin [P] . BR9509903A . 1997-11-25

机译：融合蛋白融合蛋白宿主细胞材料的可溶性组成物产生针对A型肉毒梭菌毒素的中和抗毒素的过程纯化源自A型肉毒杆菌毒素的重组融合蛋白的抗体产生针对人肉毒杆菌的抗毒素的过程B型艰难梭菌毒素抗体处理工艺过程，产生针对A艰难梭菌毒素的中和抗毒素组合物，对个体进行疫苗接种，以生产针对艰难梭菌毒素的中和抗毒素，在充足的纯化纯化过程中检测艰难梭菌抗原来源于梭状芽胞杆菌毒素蛋白的鸟抗毒素固体剂型的培养物和固体剂型产生过程中的艰难梭菌毒素