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甘草苷在制备治疗或预防肠道病毒71型感染药物中的应用

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摘要

本申请公开了中药制药技术领域中甘草苷在制备治疗或预防肠道病毒71型感染药物中的应用以及制备抑制肠道病毒71型复制药物中的应用，研究发现，本申请采用甘草苷，灌胃给药后，可通过降低脑组织中EV71VP1表达量，降低炎症因子IL‑6，抑制病毒复制，进而改善EV71引起手足口病的神经症状。

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公开/公告号CN113633652A

专利类型发明专利
公开/公告日2021-11-12

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申请/专利权人遵义医科大学;
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申请/专利号CN202111057305.2
发明设计人李晋;徐尚福;杜文琪;
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申请日2021-09-09
分类号A61K31/7048(20060101);A61P31/14(20060101);
代理机构50217 重庆强大凯创专利代理事务所(普通合伙);
代理人张显琴
地址 563000 贵州省遵义市汇川区大连路201号
入库时间 2023-06-19 13:15:27

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1. 甘草苷在制备治疗或预防肠道病毒71型感染药物中的应用 [P] . 中国专利： CN113633652A . 2021-11-12
2. 灵芝酸Y在制备治疗或预防肠道病毒71型感染药物中的应用 [P] . 中国专利： CN102274234B . 2012.10.17
3. "use of polyols, appropriate device for the treatment or prophylaxis of mucosal infection caused by yeast in mammals, process for therapeutic or prophylactic treatment of mammals suffering from or being subjected to an increased risk of infection of the mucosa caused by yeast, composition for use in this treatment, and, pharmaceutical preparation for use in the prophylactic or therapeutic systemic or topical treatment of mucosal infections caused by yeast. " [P] . BR9814721A . 2000-10-03

机译： “多元醇的用途，用于治疗或预防哺乳动物中酵母引起的粘膜感染的适当装置，用于治疗或预防由酵母引起的粘膜感染或增加感染风险的哺乳动物的方法，使用的组合物在这种治疗中，以及用于预防性或治疗性全身或局部治疗由酵母引起的粘膜感染的药物制剂。”
4. Pharmaceutical composition for epithelial wound prevention and treatment, immunoregulatory pharmaceutical composition, pharmaceutical composition, insecticide, insecticide composition, use of insecticide of lectin KM + in the treatment of scarring, use of lectin KM + in preparation of immunoregulatory drug , Use of lectin KM + in formulating antibacterial drugs, use of lectin KM + in formulating antiviral drugs, use of lectin KM + in formulating antifungal drugs, use of lectin KM + in formulating antiparasitic drugs, expression methods, DNA vectors, recombinant organisms , Nucleotide sequences, antibodies, proteins and extranuclear genes [P] . 日本专利： JP2007528869A . 2007-10-18

机译：用于上皮伤口预防和治疗的药物组合物，免疫调节药物组合物，药物组合物，杀虫剂，杀虫剂组合物，凝集素KM +杀虫剂在瘢痕形成中的用途，凝集素KM +在制备免疫调节药物中的用途，凝集素KM +的用途在制备抗菌药物中，凝集素KM +在抗病毒药中的应用，凝集素KM +在抗真菌药中的应用，凝集素KM +在抗寄生虫药中的应用，表达方法，DNA载体，重组生物，核苷酸序列，抗体，蛋白质和核外基因
5. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法