一种合成Headful包装型噬菌体的方法

摘要

本发明提供用于合成headful包装型噬菌体的多核苷酸。本发明还提供包含所述多核苷酸的载体和细胞，以及使用本发明的多核苷酸或载体合成Headful包装型噬菌体的方法。

说明书

技术领域

本发明涉及生物工程领域。具体而言，本发明涉及一种合成Headful包装型噬菌体的方法。

背景技术

噬菌体是指能够感染细菌并在其宿主体内复制和增殖的病毒。噬菌体对宿主具有极强的专一性，因此被广泛用于抗菌治疗。尤其是随着抗生素的滥用导致耐药病原菌的出现，应用噬菌体治疗耐药病原菌引起越来越多的关注。但是，病原菌会对天然噬菌体产生抗性，并且天然噬菌体可能编码毒力因子或毒素。因此，对天然噬菌体进行修饰有助于获得具备理想性能的合成噬菌体。

噬菌体合成包括两个步骤，分别是噬菌体基因组的组装和合成基因组的重启。在目前报道的噬菌体合成工作中基因组的组装技术主要包括Gibson Assembly和酵母转化相关的重组(TAR)克隆。

Gibson Assembly可以在体外将几个(如3-6个)DNA片段组装成环状的噬菌体基因组。但用Gibson Assembly组装噬菌体DNA，当噬菌体基因组较大(如超过20kb)时，则需要使用细菌宿主进行噬菌体DNA片段的克隆。而很多含有噬菌体遗传元件的DNA 片段编码对细菌宿主有毒的产物，不能用大肠杆菌(E.coli)等克隆宿主进行稳定克隆和增殖，限制了Gibson Assembly在噬菌体合成中的应用。

噬菌体的毒力基因在酵母中不表达，因此以酵母为宿主对噬菌体DNA片段进行克隆，可以克服噬菌体DNA对细菌宿主毒性的问题。酵母转化相关的重组(TAR)克隆是利用酵母细胞强大的同源重组能力将多个具有同源末端的噬菌体基因组片段高效地组装到酵母人工染色体(YAC)上，得到含有噬菌体基因组的重组质粒。

噬菌体基因组的重启是指从噬菌体的基因组产生有活性的子代噬菌体的过程。目前报道的噬菌体基因组的重启策略包括转化细菌宿主重启和基于无细胞体系的重启。

绝大多数噬菌体颗粒中包裹的是线性的基因组DNA，所述线性基因组DNA的末端主要有三种结构，粘性末端、末端重复(DTR)和末端冗余。具体而言，具备上述三种基因组结构特征的噬菌体基因组在复制过程先发生环化，然后复制形成基因组首尾相连的线性串联体DNA，再将线性串联体DNA进行切割并包装到噬菌体颗粒中，形成子代噬菌体。

基因组具有粘性末端或DTR的噬菌体(如lambda、T3和T7等)在包装过程中，对所述线性串联体DNA进行切割的位置是确定的，因此其子代噬菌体颗粒中包裹的基因组具有确定的基因组序列(包括基因组末端结构的序列和长度)，且每个噬菌体颗粒包裹的基因组DNA是同质的DNA分子(一个单位长度基因组)，即基因组数据库(如Genbank) 中列出的基因组序列与其噬菌体颗粒包裹的DNA分子序列一致。目前报道的通过酵母 TAR克隆合成的噬菌体均为这种具有确定基因组序列的噬菌体。

基因组具有末端冗余的噬菌体在包装(headful包装)过程中，对所述线性串联体DNA 进行切割的位置是不确定的，因此其子代噬菌体颗粒中包裹的基因组DNA是异质DNA分子(一个单位长度基因组DNA+不确定的冗余序列)。因此，基因组数据库(如Genbank) 中列出的Headful包装型噬菌体的基因组序列仅为其一个单位长度的基因组DNA序列，而不包含其末端冗余序列。由于Headful包装类型噬菌体颗粒中的DNA分子的异质性，难以确定基因组的末端结构和长度，导致难以实现该类型噬菌体基因组的合成与克隆。例如，目前报道的基于酵母TAR克隆合成DTR噬菌体的合成策略并不能解决Headful 包装型噬菌体的合成问题。

因此，有需要开发一种合成Headful包装型噬菌体的方法，例如，开发一种包含headful包装型噬菌体的基因组的构建体，使其能够在细菌中成功完成基因组重启。

发明内容

本发明多核苷酸，包含第一片段和与所述第一片段的3’端连接第二片段，其中所述第一片段的核苷酸序列是环状重排的Headful包装型噬菌体的单位长度的基因组序列，且其中所述第二片段的核苷酸序列是所述第一片段核苷酸序列的核苷酸1到n，n为至少40。在一些实施方案中，n为至少60。

在一些实施方案中，所述基因组是野生型基因组。在一些实施方案中，所述第一片段的核苷酸序列由SEQ ID NO:13-16之一的核苷酸序列组成。

在一些实施方案中，所述单位长度的基因组是经修饰的基因组。在一些实施方案中，与野生型基因组相比，所述经修饰的基因组包含一或多个核苷酸的插入、缺失、取代或添加。在一些实施方案中，所述第一片段的核苷酸序列是SEQ ID NO:13-16之一的核苷酸序列的经修饰的变体。

本发明还提供一种载体，包含本发明的多核苷酸。

本发明还提供一种细胞，如酵母细胞，包含本发明的多核苷酸或载体。

本发明还提供一种合成Headful包装型噬菌体的方法，包括用本发明的多核苷酸或载体转化所述细菌的步骤。

在一些实施方案中，所述细菌是所述噬菌体的天然宿主。

在一些实施方案中，所述方法还包括在酵母中基于转化相关的重组(TAR)组装所述核酸构建体的步骤。在一些实施方案中，所述酵母是酿酒酵母(Saccharomycescerevisiae)。在一些实施方案中，所述核酸构建体是酵母-细菌穿梭载体。

附图说明

图1显示基于酵母TAR克隆合成Headful包装型噬菌体的方法示意图。

图2A和2B显示构建pYEP-Ⅱ的PCR验证结果。图2A：接口1的菌落PCR电泳结果；图2B：接口2的菌落PCR电泳结果。泳道M：DL 2,000DNA标记；泳道1-8：转化子1-8；泳道N：阴性对照。

图3显示质粒pYEP-Ⅱ及其XhoI和NcoI消化产物电泳结果。泳道M：DL 15,000 DNA标记；泳道1和3：转化子1和3的质粒电泳结果；泳道2和4：转化子1和3的质粒酶切产物电泳结果。

图4显示pYEP-Ⅱ-S4-60-T酵母转化子的PCR接口验证结果。泳道M：DL 1,000DNA标记；泳道1-7：酵母转化子的PCR产物；泳道N：酵母MYA 3666的PCR产物(阴性对照)。

图5显示pRSII313-S4-60-T酵母转化子的PCR接口验证结果。泳道M：DL 2,000 DNA标记；泳道1-8：酵母转化子的PCR产物。

图6显示pYEP-Ⅱ-S4-60-H酵母转化子的PCR接口验证结果。泳道M：DL 2,000 DNA标记；泳道1-8：酵母转化子的PCR产物。

图7显示pRSII313-S4-60-H酵母转化子的PCR接口验证结果。泳道M：DL 2,000 DNA标记；泳道1-8：酵母转化子的PCR产物。

图8显示pYEP-Ⅱ-S4-60-I酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-8：酵母转化子的PCR产物。

图9显示pRSII313-S4-60-I酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-8：酵母转化子的PCR产物。

图10A显示pYEP-Ⅱ-S4-60-T在大肠杆菌中重启后的噬斑检测结果；图10B显示pRSII313-S4-60-T在大肠杆菌中重启后的噬斑检测结果。

图11A显示pYEP-Ⅱ-S4-60-H在大肠杆菌中重启后的噬斑检测结果；图11B显示pRSII313-S4-60-H在大肠杆菌中重启后的噬斑检测结果。

图12A显示pYEP-Ⅱ-S4-60-I在大肠杆菌中重启后的噬斑检测结果；图12B显示pRSII313-S4-60-I在大肠杆菌中重启后的噬斑检测结果。

图13显示pYEP-Ⅱ-S4-60-T在铜绿假单胞菌(Pseudomonas aeruginosa)ATCC9027 中重启后的噬斑检测结果。

图14显示RFP编码序列插入噬菌体合成基因组的示意图。

图15显示pYEP-Ⅱ-S4-60-RFP-T-1酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-16：酵母转化子的PCR产物。

图16显示pYEP-Ⅱ-S4-60-RFP-T-2酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-16：酵母转化子的PCR产物。

图17显示pRSII313-S4-60-RFP-T酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-8：酵母转化子的PCR产物。

图18显示pYEP-Ⅱ-S4-60-RFP-H酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-8：酵母转化子的PCR产物。

图19显示pRSII313-S4-60-RFP-H酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-8：酵母转化子的PCR产物。

图20显示pYEP-Ⅱ-S4-60-RFP-I酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-8：酵母转化子的PCR产物。

图21显示pRSII313-S4-60-RFP-I酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-8：酵母转化子的PCR产物。

图22A显示pYEP-Ⅱ-S4-60-RFP-T-1在大肠杆菌中重启后的噬斑检测结果；图22B显示pYEP-Ⅱ-S4-60-RFP-T-2在大肠杆菌中重启后的噬斑检测结果；图22C显示 pRSII313-S4-60-RFP-T在大肠杆菌中重启后的噬斑检测结果。

图23A显示pYEP-Ⅱ-S4-60-RFP-H在大肠杆菌中重启后的噬斑检测结果；图23B 显示pRSII313-S4-60-RFP-H在大肠杆菌中重启后的噬斑检测结果。

图24A显示pYEP-Ⅱ-S4-60-RFP-I在大肠杆菌中重启后的噬斑检测结果；图24B显示pRSII313-S4-60-RFP-I在大肠杆菌中重启后的噬斑检测结果。

图25A显示RFP序列插入合成噬菌体ORF11下游的验证结果；图25B显示RFP 序列插入合成噬菌体ORF42下游的验证结果。泳道M：DL 2,000DNA标记；泳道1： PCR模板来自野生型噬菌体S4；泳道2：PCR模板来自合成噬菌体S4-RFP-1；泳道3： PCR模板来自合成噬菌体S4-RFP-2；泳道4：PCR模板来自合成噬菌体S4-RFP-3。

图26显示基因组酶切验证结果。泳道M：l kb Extend DNA ladder；泳道1-5：分别为经EcoRI酶切的野生型噬菌体S4以及合成噬菌体S4-Syn、S4-RFP-1、S4-RFP-2和 S4-RFP-3的基因组；泳道6-10：分别为经Eco105I酶切的野生型噬菌体S4以及合成噬菌体S4-Syn、S4-RFP-1、S4-RFP-2和S4-RFP-3的基因组。

图27显示合成噬菌体和野生型噬菌体S4分别与宿主共培养后，培养物的相对光单位(RLU)与时间的关系。

图28显示合成噬菌体与野生型噬菌体S4分别与宿主共培养后，培养物的OD600 与时间的关系。

图29显示pYEP-Ⅱ-S4-0-T酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-16：酵母转化子的PCR产物；泳道N：酵母MYA 3666的菌落PCR产物(阴性对照)。

图30显示pRSII313-S4-0-T的酵母转化子的PCR接口验证结果。泳道M：DL 2,000DNA标记；泳道1-16：酵母转化子的PCR产物。

发明详述

尽管将结合以下所列举的实施方案描述本发明，但是应当理解，它们并不旨在将本发明限制于那些实施方案。相反，本发明旨在覆盖可包括在如权利要求所限定的本发明的范围内的所有替代、修改和等同形式。本领域技术人员将认识到许多与本文描述的方法或材料相似或等同的方法和材料可用于实施本发明。本发明不限于所描述的方法和材料。如果所引用的文献、专利和类似材料中的一个或多个与本申请不同或相矛盾，包括但不限于所定义的术语、术语用法、所描述的技术等，则以本申请为准。除非另有定义，否则本文使用的所有技术和科学术语具有与本发明所属领域的普通技术人员通常理解的相同含义。尽管与本文描述的那些类似或等同的方法和材料可以用于本发明的实践或测试中，但是下面描述了合适的方法和材料。本文提及的所有出版物、专利申请、专利和其他参考文献通过引用整体并入本文。

一、定义

如本文所用，术语“噬菌体”通常是指感染细菌的病毒，具有严格的宿主特异性，并且能够引起宿主菌的裂解。

如本文所用，术语“Headful包装型噬菌体”是指在噬菌体颗粒中的核酸不仅包含单位长度的噬菌体基因组，还包含冗余序列的噬菌体，例如T4、P22和P1噬菌体。

如本文所用，术语“多核苷酸”或者“核酸分子”包括DNA分子(例如cDNA或基因组DNA)和RNA分子(例如mRNA)及使用核苷酸类似物产生的DNA或RNA的类似物。所述核酸分子可以是单链或双链的，优选双链DNA。所述核酸的合成可以使用核苷酸类似物或衍生物(例如肌苷或硫代磷酸核苷酸)。这种核苷酸可以用于，例如，制备具有改变的碱基配对能力或者增加的核酸酶抗性的核酸。

如本文所用，术语“编码”是指多核苷酸直接指定其蛋白质产物的氨基酸序列。编码序列的边界一般由“开放读框(ORF)”确定，所述开放读框通常以ATG起始密码子或另外的起始密码子如GTG和TTG开始，以终止密码子如TAA、TAG和TGA结束。所述编码序列可以是DNA、cDNA或重组核苷酸序列。

如本文所用，术语“杂交”是在给定的严格杂交和洗涤条件下，彼此至少大约90％、优选至少大约95％、更优选至少大约96％、更优选至少98％同源的核苷酸序列通常保持彼此杂交。

本领域技术人员知道各种用于杂交的条件，如严格杂交条件和高度严格杂交条件。参见，例如，Sambrook et al.,1989,Molecular Cloning,A Laboratory Manual,ColdSpring Harbor Press,N.Y.；和Ausubel et al.(eds.),1995,Current Protocols inMolecular Biology, John Wiley&Sons,N.Y.。

如本文所用，“核苷酸相同性百分比”或者“核苷酸序列相同性百分比”是指比较两个核酸的核苷酸，当最佳比对时，所述两个多肽具有大约指定的相同核苷酸百分比。例如，“95％的核苷酸相同性”是指比较两个核酸的核苷酸，当最佳比对时，所述两个核酸有95％的核苷酸相同。

对于本发明，为确定两个核酸序列的相同性百分比，以最佳比较为目的比对序列(例如在第一个核酸序列中可导入缺口，以与第二个氨基酸或核酸序列进行最佳比对)。然后比较在相应核苷酸位置的核苷酸。当第一个序列中的位置在第二个序列中相应位置由相同核苷酸占据时，则这些分子在这个位置是相同的。两个序列之间的相同性百分比是所述序列共有的相同位置的数量的函数(即相同性百分比＝相同位置的数量/位置(即重叠位置)的总数量×100)。优选地，这两个序列是相同长度的。本领域技术人员知晓，可以使用不同的计算机程序确定两个序列之间的相同性。

如本文所用，术语噬菌体基因组的“变体”是指与参考噬菌体基因组不同但保留必要特性的多核苷酸。通常，差异是有限的，使得参考基因组和变体的序列总体上非常相似，并且在许多区域是相同的。变体和参考基因组的核苷酸序列可以通过一个或多个修饰(例如，取代，添加和/或缺失)而不同。

如本文所用，术语“环状重排”涉及对初始核酸进行如下设计：将初始核酸的5’端与3’端连接形成环状分子，并在环状分子中的某一位置打开环状分子形成线性分子。

如本文所用，术语“打开位点”是指环状重排的过程中，所生成的线性分子的5’端与3’端的位置。

打开位点可以与连接位点相同或不同。如果在不同于连接位点的位置打开(切割或断裂)所述环状分子，形成新的线性核酸，其具有与初始核酸不同的5’端与3’端；如果在连接位点打开环状分子，则产生与初始核酸相同的核酸。环状重排还包括产生本文所述的环状重排的线性分子的任何过程。通常，环状重排的分子可以是直接构建的线性分子，而不真正经历环化和打开的步骤。当在不同于连接位点的位置打开所述环状分子时，打开位点由位于初始核酸的5’端与3’端之间的一对核苷酸的位置指定，这些核苷酸成为新的线性分子的5’端与3’端。

如本文所用，“野生型”噬菌体是指天然存在的噬菌体，或与天然存在的噬菌体具有相同性质的合成噬菌体。野生型Headful包装型噬菌体的单位长度的基因组可以从网络数据库(如NCBI)获得。

如本文所用，术语“修饰”是指对多核苷酸序列的修饰，包括但不限于，取代、删除、插入和/或添加一或多个核苷酸或氨基酸。修饰也包括不改变多核苷酸或多肽的序列的化学修饰，如多核苷酸的甲基化等。在本文中，经修饰的变体也包括如上所述的环状重排的变体。

二、多核苷酸

本发明提供一种用于合成Headful包装型噬菌体的多核苷酸。

现有技术已知(亦如本申请实施例所证明的)，使用酵母TAR克隆制备的仅包含Headful包装型噬菌体单位长度的基因组的载体不能在宿主菌中成功实现基因组重启。发明人出人意料地发现，在环状重排的Headful包装型噬菌体的单位长度的基因组3’端连接额外的冗余序列，可以在细菌中成功实现基因组重启。

因此，在一些实施方案中，本发明的多核苷酸包含第一片段和与所述第一片段的3’端连接第二片段，其中所述第一片段的核苷酸序列是环状重排的Headful包装型噬菌体的单位长度的基因组序列，且其中所述第二片段的核苷酸序列是所述第一片段核苷酸序列的核苷酸1到n，n为至少40。在一些实施方案中，n为至少60。

在一些实施方案中，所述第二片段的长度小于所述噬菌体的野生型噬菌体颗粒中包装的基因组的冗余序列的长度。本领域技术人员知晓，冗余序列的长度随噬菌体的不同而改变，并且对于给定的噬菌体，冗余序列的长度通常是已知的。例如，在T4、P22和 P1噬菌体中，冗余序列的长度分别是其单位长度的基因组的2％、4％和12％，约900、 1,800和5,400bp。在一些实施方案中，所述第二片段的长度比野生型噬菌体的冗余序列的长度少100bp、200bp、300bp、400bp、500bp、600bp、700bp、800bp、900bp、 1,000bp、1,500bp、2,000bp、3,000bp、4,000bp、5,000bp或更多。

在一些实施方案中，n为40-5000、40-4000、40-3000、40-2000、40-1500、40-1000、40-800、40-600、40-400、40-200、40-100、40-80、60-5000、60-4000、60-3000、60-2000、 60-1500、60-1000、60-800、60-600、60-400、60-200、60-100或60-80。在一些实施方案中，n为40、50、60、70、80、90、100或更多。例如，n为60。

在一些实施方案中，在设计环状重排的单位长度的基因组时，单位长度的基因组的 5’端与3’端直接连接以形成环状分子。

在一些实施方案中，在设计环状重排的单位长度的基因组时，可以选择ORF中的位点作为打开位点。在一些实施方案中，在设计环状重排的单位长度的基因组时，可以选择ORF之间的位点作为打开位点。本领域技术人员会理解，缺失噬菌体基因组中的部分序列，例如非编码和/或非调控序列，可以不影响噬菌体的复制、包装或功能。因此，所述环状重排的单位长度的基因组的5’端与3’端可以是单位长度的基因组中相邻或不相邻的核苷酸。

在一些实施方案中，所述构建体用于合成野生型噬菌体，即所述基因组是野生型基因组。在一些实施方案中，所述噬菌体是vB_PaeS_SCUT-S4。在一些实施方案中，所述第一片段的核苷酸序列由SEQ ID NO:13的核苷酸序列组成。在一些实施方案中，在设计环状重排的单位长度的基因组时，所述打开位点在vB_PaeS_SCUT-S4的ORF45和 ORF46之间、ORF35和ORF36之间或ORF17和ORF18之间。在一些实施方案中，所述打开位点在SEQ ID NO:13的核苷酸37,952和37,953之间、32,385和32,386之间或 11,857和11,858之间。在一些实施方案中，所述第一片段的核苷酸序列由SEQ ID NO: 14-16之一的核苷酸序列组成。

在一些实施方案中，所述第二核苷酸序列包含SEQ ID NO:13-16之一的核苷酸1-n，其中n为至少40或至少60。在一些实施方案中，n为40-5000、40-4000、40-3000、40-2000、40-1500、40-1000、40-800、40-600、40-400、40-200、40-100、40-80、60-5000、60-4000、 60-3000、60-2000、60-1500、60-1000、60-800、60-600、60-400、60-200、60-100或60-80。在一些实施方案中，n为40、50、60、70、80、90、100或更多，例如，n为60。

为了克服细菌宿主对噬菌体的抗性，和/或消除或弱化噬菌体的毒性，可以对噬菌体基因组进行修饰。因此，在一些实施方案中，所述单位长度的基因组是经修饰的基因组。在一些实施方案中，野生型基因组相比，所述经修饰的基因组包含插入、缺失、取代或添加一或多个核苷酸。所述修饰包括但不限于缺失毒力基因的全部或部分、引入取代以弱化毒力基因、插入T-DNA以沉默毒力基因和在抗性相关的基因中引入取代。还可以修饰基因组的非编码区。在一些实施方案中，可以修饰基因组的调控区以调节基因表达。

本领域技术人员会理解，在非编码非调控区进行修饰通常不会影响噬菌体的性质和 /或功能。因此，在一些实施方案中，在噬菌体基因组的非编码非调控区引入修饰。

在一些实施方案中，所述经修饰的基因组与野生型基因组至少70％、80％、90％、95％、96％、97％、98％或99％相同。

在一些实施方案中，所述第一片段的核苷酸序列是SEQ ID NO:13-16之一的核苷酸序列的经修饰的单位长度的基因组。在一些实施方案中，第一片段的核苷酸序列与SEQID NO:13-16之一至少70％、80％、90％、95％、96％、97％、98％或99％相同。

在一些实施方案中，所述第一片段的核苷酸序列是SEQ ID NO:14，且所述第二片段的核苷酸序列是SEQ ID NO:14的核苷酸1-60。在一些实施方案中，所述第一片段的核苷酸序列是SEQ ID NO:15，且所述第二片段的核苷酸序列是SEQ ID NO:15的核苷酸1-60。在一些实施方案中，所述第一片段的核苷酸序列是SEQ ID NO:16，且所述第二片段的核苷酸序列是SEQ ID NO:16的核苷酸1-60。

本领域技术人员会理解，本发明的多核苷酸涵盖单链多核苷酸、双链多核苷酸，例如，如上所定义的多核苷酸的正义链，其中所述第二片段的5’末端与第一片段的3’末端连接；或者与其互补(例如可以与所述正义链杂交，优选在严格条件下杂交)的反义链，其中所述第一片段的反义链的5’末端与所述第二片段的反义链的3’末端连接。

三、载体、细胞和合成Headful包装型噬菌体的方法

为了构建、保存、扩增本发明的多核苷酸，以及用本发明的多核苷酸合成噬菌体，通常需要载体和细胞，如中间宿主细胞。

因此，本发明还提供包含本发明的多核苷酸的载体以及包含所述多核苷酸或载体的细胞，如酵母细胞。

Headful包装型噬菌体的基因组通常超过40kb。因此，本发明的载体是大容量的载体，例如酵母人工染色体(YAC)或细菌人工染色体(BAC)，例如包含酵母复制筛选元件的BAC。

本发明还提供一种合成Headful包装型噬菌体的方法，包括用本发明的多核苷酸或载体转化细菌的步骤。转化细菌的方法是本领域熟知的，例如，热休克法和电转化法。在一些实施方案中，本发明的方法包括用本发明的载体电转化所述噬菌体的宿主细菌的步骤。

在一些实施方案中，所述方法还包括在酵母中基于转化相关的重组(TAR)组装所述多核苷酸的步骤。在一些实施方案中，用于组装所述多核苷酸的载体是YAC或含有酵母复制筛选元件的BAC，所述载体包含酵母的中心粒序列(CEN)、自主复制起始位点 (ARS)和筛选标记(如HIS3、URA3和LEU2)。在一些实施方案中，所述载体是酵母-细菌穿梭载体。

在一些实施方案中，本发明的方法包括

i)在酵母中基于转化相关的重组(TAR)组装多核苷酸，包含第一片段和与所述第一片段的3’端连接第二片段，其中所述第一片段的核苷酸序列是环状重排的Headful包装型噬菌体的单位长度的基因组序列，且其中所述第二片段的核苷酸序列是所述第一片段核苷酸序列的核苷酸1到n，n为至少40或60；

ii)从酵母分离包含所述多核苷酸的载体；和

iii)用所述载体转化细菌细胞进行噬菌体基因组重启。

vB_PaeS_SCUT-S4噬菌体可以感染来自埃希氏菌属(Escherichia，如大肠杆菌)和假单胞菌属(Pseudomonas，如铜绿假单胞菌)的细菌。因此，在一些实施方案中，本发明的方法包括用本发明的多核苷酸或载体转化来自埃希氏菌属或假单胞菌属的细菌，例如大肠杆菌或铜绿假单胞菌，以进行基因组重启，其中所述第一片段的核苷酸序列由SEQ ID NO:13-16之一的核苷酸序列组成，或者与SEQ ID NO:13-16之一至少70％、80％、90％、 95％、96％、97％、98％或99％相同。

在一些实施方案中，本发明的方法包括：

i)在酵母中基于转化相关的重组(TAR)组装多核苷酸，包含第一片段和与所述第一片段的3’端连接第二片段，所述第一片段的核苷酸序列是SEQ ID NO:14，且所述第二片段的核苷酸序列是SEQ ID NO:14的核苷酸1-60；

ii)从酵母分离包含所述多核苷酸的载体；和

iii)用所述载体转化细菌细胞进行噬菌体基因组重启。

在一些实施方案中，本发明的方法包括：

i)在酵母中基于转化相关的重组(TAR)组装多核苷酸，包含第一片段和与所述第一片段的3’端连接第二片段，所述第一片段的核苷酸序列是SEQ ID NO:15，且所述第二片段的核苷酸序列是SEQ ID NO:15的核苷酸1-60；

ii)从酵母分离包含所述多核苷酸的载体；和

iii)用所述载体转化细菌细胞进行噬菌体基因组重启。

在一些实施方案中，本发明的方法包括：

i)在酵母中基于转化相关的重组(TAR)组装多核苷酸，包含第一片段和与所述第一片段的3’端连接第二片段，所述第一片段的核苷酸序列是SEQ ID NO:16，且所述第二片段的核苷酸序列是SEQ ID NO:16的核苷酸1-60；

ii)从酵母分离包含所述多核苷酸的载体；和

iii)用所述载体转化细菌细胞进行噬菌体基因组重启。

可以使用可商购的载体骨架组装本发明的多核苷酸，本发明的载体包含所述载体骨架和本发明的多核苷酸。在一些实施方案中，所述载体骨架是pRSII313(Addgene， #35449)。

也可以根据以上列举的元件构建新的载体骨架来组装本发明的多核苷酸。例如，通过将酵母复制筛选元件CEN-ARS-HIS3引入BAC中以构建所述载体骨架。在一些实施方案中，所述载体骨架包含SEQ ID NO:22的核苷酸序列。

在一些实施方案中，所述酵母是酿酒酵母。在一些实施方案中，基于营养缺陷型标记筛选阳性克隆，其中营养缺陷型标记包括但不局限于HIS3、URA3和LEU2。在一些实施方案中，所述酵母是酿酒酵母ATCC MYA 3666(获自广东省微生物菌种保藏中心)，所述营养缺陷型标记是HIS3。

实施例

通过以下实施例，本领域技术人员会更清楚地理解本发明。应理解，实施例只是用于说明，而非限制本发明的范围。如无特别说明，本发明中使用的实验方法均为常规方法，基因克隆操作具体可参见Sambrook,J.,Russell,David W.,Molecular Cloning:ALaboratory Manual,3rd edition,2001,NY,Cold Spring Harbor。实施例中所使用的引物的合成和测序均由生工生物工程(上海)股份有限公司进行。

实施例1、穿梭质粒pYEP-Ⅱ的构建

以pRSII313(Addgene,#35449)为模板，用引物HL19023(SEQ ID NO:1)和HL19024(SEQ ID NO:2)扩增含有酵母复制筛选元件序列CEN-ARS-HIS3的片段1(SEQ ID NO: 9)。以发明人构建并保存的pBAC shuttle为模板，用引物HL19025(SEQ ID NO:3)和 HL19091(SEQID NO:8)扩增片段2(SEQ ID NO:10)，用引物HL19088(SEQ ID NO:6) 和HL19036(SEQ IDNO:5)扩增片段3(SEQ ID NO:11)，以及用引物HL19089(SEQ ID NO:7)和HL19030(SEQ IDNO:4)分别扩增片段4(SEQ ID NO:12)。PCR反应体系如表 1所示，并以如下步骤进行PCR反应：98℃，30s；98℃，10s，68℃，30s，72℃，1kb/min， 30个循环；72℃，2min。用1％琼脂糖凝胶电泳分离PCR产物，并用凝胶DNA回收试剂盒(Magen)回收PCR产物。使用Nanodrop 2000(Thermo Scientific)测定回收的PCR产物浓度。

表1

将片段1、2、3和4(每个片段的量为30fmol)与15μL Gibson Assembly缓冲液混合，并加入ddH

用10μL经温育的混合物转化大肠杆菌EPI 300，通过在含有抗生素(氯霉素25 μg/mL，庆大霉素10μg/mL)的LB平板上，37℃温育12-16h筛选阳性克隆并进行PCR 验证(如图2所示)。挑选菌落PCR验证为阳性的转化子进行培养，使用质粒小提试剂盒 (TIANprep MiniPlasmid Kit，天根生化科技(北京)有限公司，DP103-03)提取质粒pYEP- Ⅱ并将从对应于图2中泳道1和3的克隆提取的质粒用XhoI和NcoI消化并进行凝胶电泳(如图3所示)。对所述质粒进行测序得到目标载体(pYF-II，SEQ ID NO:22)。

实施例2、噬菌体vB_PaeS_SCUT-S4基因组的组装和重启

2.1、制备合成噬菌体所需的DNA片段

选定两个ORF之间的位点作为打开位点，设计噬菌体vB_PaeS_SCUT-S4的(GenBank序列号为MK165658.1，简称S4)的环状重排的单位长度的基因组，并将其拆分为长度为4.8-6.0kb的八个片段(F1-F8)，相邻的两个DNA片段之间的同源臂为60bp，基因组片段F8在3’端连接有片段F1的核苷酸1-60。

以噬菌体vB_PaeS_SCUT-S4的基因组DNA为模板扩增所述片段。

使用pYEP-Ⅱ为载体进行酵母TAR组装时，可以通过两种方法线性化所述载体，包括：i)使用限制性核酸内切酶SphI和HindⅢ对载体线性化；和ii)通过PCR扩增得到线性载体产物，并在扩增产物两端各引入30bp来自片段F1的5’端和片段F8的3’端的序列作为同源臂，并且在片段F1的5’端和片段F8的3’端各引入30bp来自载体的序列作为同源臂。

使用pRSII313为载体进行酵母TAR组装时，采用如上所述的方法ii)。

使用KOD FX DNA聚合酶进行PCR扩增，PCR体系如表2所示，并以如下步骤进行PCR反应：94℃，2min；98℃，10s，60℃，30s，68℃，1kb/min，30个循环。用 1％琼脂糖凝胶电泳分离PCR产物，并用凝胶DNA回收试剂盒(Magen)回收PCR产物。使用Nanodrop 2000(ThermoScientific)测定回收的PCR产物浓度。

表2

2.2、酵母TAR克隆组装

根据制造商的说明书，使用酵母转化试剂盒Frozen-EZ Yeast TransformationII Kit (Zymo research，T2001)制备酵母感受态细胞，步骤如下：

a)挑选经YPD平板活化的酿酒酵母MYA 3666单克隆到约10mL的YPD液体培养基中，于30℃，200rpm振荡培养到中对数生长期(OD600为0.8-1.0)；

b)在500g，室温下离心4分钟收集菌体，弃上清；

c)加入10mL的EZ 1溶液重悬菌体，在500g室温离心4min，弃上清；

d)加入1mL的EZ 2溶液重悬菌体；

e)以100μL每管分装重悬后的菌体，于-80℃保存。

按照以下步骤进行酵母TAR克隆转化：

a)将-80℃保存的酿酒酵母MYA3666的感受态细胞在冰上融化；

b)将组装所需要的噬菌体基因组DNA片段(每个片段200ng)和载体(100ng)加入到100μL酵母感受态细胞中，同时加入500μL EZ 3溶液，充分混匀；

c)于30℃孵育2h，每间隔半小时用手或涡旋仪轻轻振荡；

d)在500g室温离心4min，弃部分上清后重悬菌体，均匀地涂布在SD-HIS平板上，于30℃倒置培养2-4天。

经酵母TAR克隆组装后得到的含有噬菌体S4合成基因组序列(环状重排的单位长度的基因组+60bp的冗余序列)的酵母质粒信息如表3所示。

表3

2.3、酵母转化子接口验证

挑取转化后平板上的单克隆到20μL 25mM的NaOH溶液中，在95℃孵育30min 以裂解细胞，然后短暂离心后取1μL上清作为PCR模板，通过PCR进行接口验证PCR 体系如表4所示，PCR步骤如实施例2.1所示，采用凝胶电泳验证PCR产物。

表4

组装pYEP-Ⅱ-S4-60-T的酵母转化子的部分验证结果如附图4所示，所有接口的阳性率为5/16；组装pRSII313-S4-60-T的酵母转化子的验证结果如附图5所示，所有接口的阳性率分别为4/8；pYEP-Ⅱ-S4-60-H的酵母转化子的验证结果如附图6所示，所有接口的阳性率为8/8；组装pRSII313-S4-60-H的酵母转化子的验证结果如附图7所示，所有接口的阳性率分别为5/8；pYEP-Ⅱ-S4-60-I的酵母转化子的验证结果如附图8所示，所有接口的阳性率为2/8；组装pRSII313-S4-60-I的酵母转化子的验证结果如附图9所示，所有接口的阳性率分别为3/8。

2.4、酵母质粒提取

对验证为阳性酵母转化子进行培养，并按照以下步骤提取酵母质粒：

(1)将阳性单克隆在10mL的SD-HIS液体培养基中培养36-48h；

(2)在室温4,000rpm离心5min，弃上清，并用500μL P1溶液(Tiangen)重悬菌体，加入2μL的β-巯基乙醇和20μL 10mg/mL的zymolyase-20T，于37℃、220rpm振荡 2-3h；

(3)加入60μL 2％的SDS溶液，于70℃孵育15min，加入60μL预冷(冰上)的5M 乙酸钾，混匀并轻轻振荡，冰浴5min后于12,000g离心10min，转移上清到新的离心管中；

(4)加入600μL的异丙醇并混匀，冰浴5min后12,000g离心15min，弃上清；

(5)用600μL预冷(冰上)的70％乙醇洗涤沉淀三次，室温干燥DNA沉淀后用30μL 预热(37℃)的去离子水溶解DNA沉淀。

2.5、酵母质粒电转化大肠杆菌及噬斑检测

按照以下步骤将实施例2.4中提取的酵母质粒转化大肠杆菌并进行噬斑检测：

(1)将10μL酵母质粒溶液与100μL的大肠杆菌NEB 10-beta(博迈德生物)电转感受态细胞混匀，冰浴约5min；

(2)缓慢地将上述混合液转移到预冷(冰)的2mm电击杯中，避免产生气泡，将电击杯插在冰中；

(3)在电压2.5kV、电容25μF、电阻200Ω进行电转，电转后立即加入800μL预热(37℃)的SOC培养液，充分混匀后将电击杯中的液体转移到1.5mL离心管中，放入 37℃，220rpm振荡培养2h；

(4)加入10μL的氯仿，轻轻震荡并静置10min，然后在12,000g、室温下离心2min。转移上清到新的离心管中，并加入300μL过夜培养的宿主铜绿假单胞菌ATCC 9027菌液混匀，静置15min。然后将混合液与5mL预热(55℃)的琼脂浓度为0.6％的上层LB 培养基充分混匀，倒在琼脂浓度为1.5％的LB平板上，待冷却凝固后于37℃培养箱倒置培养过夜。

图10显示用pYEP-Ⅱ-S4-60-T(图10A)或pRSII313-S4-60-T(图10B)转化的大肠杆菌NEB 10-beta中的重启后噬斑检测的结果；图11显示用pYEP-Ⅱ-S4-60-H(图11A)或pRSII313-S4-60-H(图11B)转化的大肠杆菌NEB 10-beta中的重启后噬斑检测的结果；图12显示用pYEP-Ⅱ-S4-60-I(图12A)或pRSII313-S4-60-I(图12B)转化的大肠杆菌NEB 10-beta中的重启后噬斑检测的结果。

结果显示，对于6种含有噬菌体S4合成基因组序列(SEQ ID NO:14-16)的酵母质粒，经转化的大肠杆菌裂解物的上清与噬菌体宿主在双层琼脂平板上共培养后均产生了噬菌斑，表明了6种质粒转化到大肠杆菌后均成功重启。

2.6、酵母质粒电转化铜绿假单胞菌及噬斑检测

按照以下步骤将实施例2.4中提取的酵母质粒pYEP-Ⅱ-S4-60-T转化铜绿假单胞菌ATCC 9027，并进行噬斑检测：

(1)将10μL酵母质粒溶液与100μL铜绿假单胞菌ATCC 9027的电转感受态细胞混匀，冰浴约5min；

(2)缓慢地将上述混合液转移到预冷(冰)的2mm电击杯中，避免产生气泡，将电击杯插在冰中；

(3)在电压3.0kV、电容25μF、电阻400Ω进行电转，电转后立即加入800μL预热的SOC培养液，充分混匀后将电击杯中的液体转移到1.5mL离心管中，在37℃，220 rpm振荡培养2h；

(4)在生物安全柜中将培养液与5mL预热的琼脂浓度为0.6％的上层LB培养基充分混匀，倒在琼脂浓度为1.5％的LB平板上，待冷却凝固后于37℃恒温培养箱倒置培养过夜。

噬斑检测结果如附图13所示，在双层琼脂平板上观察到了噬斑，表明pYEP-Ⅱ -S4-60-T质粒转化到噬菌体的宿主铜绿假单胞菌ATCC 9027中后噬菌体成功重启。

实施例3、经修饰的噬菌体vB_PaeS_SCUT-S4合成基因组的组装和重启

3.1、噬菌体vB_PaeS_SCUT-S4经修饰的合成基因组的组装

扩增含有红色荧光蛋白(RFP)编码序列(SEQ ID NO:17)的核苷酸序列，并将其插入噬菌体基因组ORF11(编码主要衣壳蛋白)或ORF42(编码假定的蛋白)的终止密码子下游(如图14所示)。在扩增该序列时利用引物在其5’和3’末端分别引入插入位点上下游各30bp的序列作为同源臂。其他片段的设计和扩增，以及包含RFP编码序列的经修饰的合成基因组的组装以类似于实施例2.1和2.2的方法进行，质粒信息如表5所示。

表5

3.2、噬菌体vB_PaeS_SCUT-S4重组基因组的验证与重启

按照实施例2.3中的接口验证方案验证上述酵母TAR克隆转化后的转化子，pYEP-Ⅱ-S4-60-RFP-T-1的验证结果如图15所示，阳性率为12/16；pYEP-Ⅱ-S4-60-RFP-T-2 的验证结果如图16所示，阳性率分别为15/16；pRSII313-S4-60-RFP-T的验证结果如图 17所示，阳性率分别为5/8；pYEP-Ⅱ-S4-60-RFP-H的验证结果如图18所示，阳性率分别为7/8；pRSII313-S4-60-RFP-H的验证结果如图19所示，阳性率分别为5/8；pYEP- Ⅱ-S4-60-RFP-I的验证结果如图20所示，阳性率分别为5/8；和pRSII313-S4-60-RFP-I 的酵母转化子的验证结果如图21所示，阳性率分别为5/8。

按照实施例2.4中描述的方法提取酵母质粒，并按照实施例2.5中描述的方法电转化大肠杆菌并进行噬斑检测。图22显示用pYEP-Ⅱ-S4-60-RFP-T-1(图22A)、pYEP-Ⅱ -S4-60-RFP-T-2(图22B)和pRSII313-S4-60-RFP-T(图22C)转化的大肠杆菌NEB 10-beta 中重启后噬斑检测的结果；图23显示用pYEP-Ⅱ-S4-60-RFP-H(图23A)和 pRSII313-S4-60-RFP-H(图23B)转化的大肠杆菌NEB 10-beta中重启后噬斑检测的结果；图24显示用pYEP-Ⅱ-S4-60-RFP-I(图24A)和pRSII313-S4-60-RFP-I(图24B)转化的大肠杆菌NEB 10-beta中重启后噬斑检测的结果。

结果显示，七种质粒转化的大肠杆菌裂解物的上清与噬菌体宿主在双层琼脂平板上共培养后均产生了噬斑，表明七种包含经修饰的合成基因组的酵母质粒转化到大肠杆菌后均成功重启。

实施例4、合成噬菌体的验证及表征

对实施例2和实施例3中得到的部分合成噬菌体(如表6所示)进行验证和表征，验证合成噬菌体的引物如表7所示。

表6

表7

4.1、合成噬菌体的验证

将单个噬斑重悬于1mL的SM缓冲液中，10,000g离心后将上清加到10mL生长到对数生长期的铜绿假单胞菌ATCC 9027的培养液中，37℃，220rpm培养过夜。然后加入100μL的氯仿，37℃培养15min后于4,000rpm，4℃离心15min去除菌体碎片，将上清用0.2μm的滤膜过滤后转移到新的离心管中，加入50μL的氯仿于4℃保存。

使用SM缓冲液将扩增后的合成噬菌体以10倍梯度稀释，直至10

提取合成噬菌体的基因组，并作为模板进行PCR检测，分别采用引物对HL20108 和HL20109、引物对HL20137和HL20138验证合成噬菌体S4-RFP-1、S4-RFP-2和 S4-RFP-3的基因组上的RFP序列，对PCR产物采用DNA凝胶电泳分析。

PCR产物验证的电泳结果如附图25所示，当用引物对HL20108和HL20109检测时，从RFP编码序列位于合成噬菌体基因组的ORF11下游的合成噬菌体S4-RFP-1和合成噬菌体S4-RFP-2扩增到的条带是1372bp，而从野生型噬菌体S4和合成噬菌体 S4-RFP-3扩增到的条带是589bp(图25A)；当用引物对HL20137和HL20138RFP检测时，从RFP编码序列位于序列位于合成噬菌体基因组的ORF42下游的合成噬菌体 S4-RFP-3扩增到的条带是1239bp，而从野生型噬菌体S4、合成噬菌体S4-RFP-1和合成噬菌体S4-RFP-2扩增到的条带是456bp(图25B)。

对合成噬菌体S4-syn、S4-RFP-1、S4-RFP-2和S4-RFP-3的基因组采用限制性内切酶EcoRI和Eco105I进行酶切验证，并以野生型噬菌体的基因组酶切产物为对照，对酶切产物进行凝胶电泳分析。

结果如图26所示，合成噬菌体S4-Syn和野生型噬菌体S4的基因组被两种不同的内切酶消化后的条带一致。合成噬菌体S4-RFP-1、S4-RFP-2和S4-RFP-3的基因组酶切后的结果显示插入RFP序列导致的差异条带(图26中箭头所述)，其它条带与野生型一致。

4.2、合成噬菌体的表征

将过夜培养的铜绿假单胞菌ATCC 9027用新鲜的LB液体培养基稀释到10

以感染时间为横坐标，分别以RLU和OD600为纵坐标，检测合成噬菌体感染宿主后RFP的表达量和OD600的变化趋势。

感染时间与RLU的变化关系如附图27所示，插入RFP序列的合成噬菌体S4-RFP-1、S4-RFP-2和S4-RFP-3在与宿主共培养24小时后RLU的数值显著高于不含RFP序列的合成噬菌体S4-Syn以及野生型噬菌体S4。合成噬菌体S4-Syn与野生型噬菌体S4的RLU 数值几乎一致。RFP序列位于ORF11后的合成噬菌体S4-RFP-1和S4-RFP-2的RLU数值几乎一致，RFP序列位于ORF42后的合成噬菌体S4-RFP-3的RLU数值显著低于RFP 序列位于ORF11后的合成噬菌体S4-RFP-1和S4-RFP-2。

感染时间与OD600的变化关系如附图28所示。四株合成噬菌体与宿主共培养后OD600随时间的变化趋势和野生型噬菌体S4与宿主共培养后OD600随时间的变化趋势几乎一致，说明合成噬菌体对宿主的杀伤能力与野生型噬菌体S4无明显差别。

实施例5、噬菌体vB_PaeS_SCUT-S4基因组的组装和重启

根据与实施例2类似的方法设计噬菌体S4的合成基因组，其中所述合成基因组仅包含环状重排的单位长度的基因组SEQ ID NO:14，而不包含所述冗余序列，并分别组装入pYEP-II和pRSII313载体，得到质粒pYEP-Ⅱ-S4-0-T和pRSII313-S4-0-T。

按照实施例2中的接口验证方案验证上述酵母TAR克隆的转化子，pYEP-Ⅱ-S4-0-T的酵母转化子的验证结果如图29所示，阳性率为6/16；pRSII313-S4-0-T的酵母转化子的验证结果如图30所示，阳性率分别为14/16。

按照实施例2的方法从阳性克隆提取酵母质粒，并用酵母质粒电转化大肠杆菌及进行噬斑检测。结果显示pYEP-Ⅱ-S4-0-T和pRSII313-S4-0-T转化的大肠杆菌NEB 10-beta中进行基因组重启，在噬斑检测中均未观察到噬斑形成，表明没有冗余序列的合成基因组不能在细菌中成功重启。

实施例6、包含噬菌体S4合成基因组的质粒在大肠杆菌中的稳定性

根据实施例2的方法，用酵母质粒pYEP-Ⅱ-S4-60-T电转化大肠杆菌NEB 10-beta，在孵育两个小时后10,000g离心并弃部分上清，重悬菌体沉淀后将菌液均匀的涂布在含有抗生素(氯霉素25μg/mL，庆大霉素10μg/mL)的LB固体培养基的平板上，于37℃倒置培养过夜。

结果显示，在含有抗生素的LB固体培养基的平板上未观察到转化子。结果表明，酵母质粒pYEP-Ⅱ-S4-60-T在大肠杆菌中不能稳定存在。

发明人认为，可能是噬菌体S4的基因组表达产物(如holin和endolysin等蛋白)对大肠杆菌有毒害。

序列表

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aatggctctc agtccccgtg gatggaggag caaattcggg atgcctgggg aagcatggtt 1200

ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag gtcagatccg gatgagaact 1260

gtttttgaac aggccattga tcaacgctct tcaactggtg cctggagaaa tgctctttct 1320

atttgggaac ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg ctgggagatt 1380

agataatgaa gcgtgcgcct gttattccaa aacatacgct caatactcaa ccggttgaag 1440

atacttcgtt atcgacacca gctgccccga tggtggattc gttaattgcg cgcgtaggag 1500

taatggctcg cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg aagtttactc 1560

ttgaagtgct ccggggtgat agtgttgaga agacctctcg ggtatggtca ggtaatgaac 1620

gtgaccagga gctgcttact gaggacgcac tggatgatct catcccttct tttctactga 1680

ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa attgccgatg 1740

ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt ctggttggcg 1800

agctggatga tgagcagatg gctgcattat ccagattggg taacgattat cgcccaacaa 1860

gtgcttatga acgtggtcag cgttatgcaa gccgattgca gaatgaattt gctggaaata 1920

tttctgcgct ggctgatgcg gaaaatattt cacgtaagat tattacccgc tgtatcaaca 1980

ccgccaaatt gcctaaatca gttgttgctc ttttttctca ccccggtgaa ctatctgccc 2040

ggtcaggtga tgcacttcaa aaagccttta cagataaaga ggaattactt aagcagcagg 2100

catctaacct tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa gaagttatca 2160

ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag aactagttta agctcacgac 2220

atcagtttgc tcctggagcg acagtattgt ataagggcga taaaatggtg cttaacctgg 2280

acagatctcg tgttccaact gagtgtatag agaaaattga ggccattctt aaggaacttg 2340

aaaagccagc accctgatgc gaccacgttt tagtctacgt ttatctgtct ttacttaatg 2400

tcctttgtta caggccagaa agcataactg gcctgaatat tctctctggg cccactgttc 2460

cacttgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt atcgtcggtc 2520

tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat tagtctggga 2580

ccacggtccc actcgtatcg tcggtctgat aatcagactg ggaccacggt cccactcgta 2640

tcgtcggtct gattattagt ctgggaccat ggtcccactc gtatcgtcgg tctgattatt 2700

agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg aaccacggtc 2760

ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg tatcgtcggt 2820

ctgattatta gtctgggacc acgatcccac tcgtgttgtc ggtctgatta tcggtctggg 2880

accacggtcc cacttgtatt gtcgatcaga ctatcagcgt gagactacga ttccatcaat 2940

gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt aacctcggtg 3000

tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa cattttgcgc 3060

acggttatgt ggacaaaata cctggttacc caggccgtgc cggcacgtta acttggtaac 3120

g 3121

<210> 11

<211> 2670

<212> DNA

<213> Artificial Sequence

<220>

<223> 载体片段

<400> 11

gcggccgcaa ggggttcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 60

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 120

gcgtaaggag aaaataccgc atcaggcgcc attcgccatt caggctgcgc aactgttggg 180

aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 240

caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 300

ccagtgaatt gtaatacgac tcactatagg gcgaattcga gctcggtacc cggggatcct 360

ctagagtcga cctgcaggca tgcaagcttg agtattctat agtgtcacct aaatagcttg 420

gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 480

aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc 540

acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg 600

cattaatgaa tcggccaacg cgaacccctt gcggccgccc gggccgtcga ccaattctca 660

tgtttgacag cttatcatcg aatttctgcc attcatccgc ttattatcac ttattcaggc 720

gtagcaacca ggcgtttaag ggcaccaata actgccttaa aaaaattacg ccccgccctg 780

ccactcatcg cagtactgtt gtaattcatt aagcattctg ccgacatgga agccatcaca 840

aacggcatga tgaacctgaa tcgccagcgg catcagcacc ttgtcgcctt gcgtataata 900

tttgcccatg gtgaaaacgg gggcgaagaa gttgtccata ttggccacgt ttaaatcaaa 960

actggtgaaa ctcacccagg gattggctga gacgaaaaac atattctcaa taaacccttt 1020

agggaaatag gccaggtttt caccgtaaca cgccacatct tgcgaatata tgtgtagaaa 1080

ctgccggaaa tcgtcgtggt attcactcca gagcgatgaa aacgtttcag tttgctcatg 1140

gaaaacggtg taacaagggt gaacactatc ccatatcacc agctcaccgt ctttcattgc 1200

catacggaat tccggatgag cattcatcag gcgggcaaga atgtgaataa aggccggata 1260

aaacttgtgc ttatttttct ttacggtctt taaaaaggcc gtaatatcca gctgaacggt 1320

ctggttatag gtacattgag caactgactg aaatgcctca aaatgttctt tacgatgcca 1380

ttgggatata tcaacggtgg tatatccagt gatttttttc tccattttag cttccttagc 1440

tcctgaaaat ctcgataact caaaaaatac gcccggtagt gatcttattt cattatggtg 1500

aaagttggaa cctcttacgt gccgatcaac gtctcatttt cgccaaaagt tggcccaggg 1560

cttcccggta tcaacaggga caccaggatt tatttattct gcgaagtgat cttccgtcac 1620

aggtatttat tcgcgataag ctcatggagc ggcgtaaccg tcgcacagga aggacagaga 1680

aagcgcggat ctgggaagtg acggacagaa cggtcaggac ctggattggg gaggcggttg 1740

ccgccgctgc tgctgacggt gtgacgttct ctgttccggt cacaccacat acgttccgcc 1800

attcctatgc gatgcacatg ctgtatgccg gtataccgct gaaagttctg caaagcctga 1860

tgggacataa gtccatcagt tcaacggaag tctacacgaa ggtttttgcg ctggatgtgg 1920

ctgcccggca ccgggtgcag tttgcgatgc cggagtctga tgcggttgcg atgctgaaac 1980

aattatcctg agaataaatg ccttggcctt tatatggaaa tgtggaactg agtggatatg 2040

ctgtttttgt ctgttaaaca gagaagctgg ctgttatcca ctgagaagcg aacgaaacag 2100

tcgggaaaat ctcccattat cgtagagatc cgcattatta atctcaggag cctgtgtagc 2160

gtttatagga agtagtgttc tgtcatgatg cctgcaagcg gtaacgaaaa cgatttgaat 2220

atgccttcag gaacaataga aatcttcgtg cggtgttacg ttgaagtgga gcggattatg 2280

tcagcaatgg acagaacaac ctaatgaaca cagaaccatg atgtggtctg tccttttaca 2340

gccagtagtg ctcgccgcag tcgagcgaca gggcgaagcc aagagtttgt agaaacgcaa 2400

aaaggccatc cgtcaggatg gccttctgct taatttgatg cctggcagtt tatggcgggc 2460

gtcctgcccg ccaccctccg ggccgttgct tcgcaacgtt caaatccgct cccggcggat 2520

ttgtcctact caggagagcg ttcaccgaca aacaacagat aaaacgaaag gcccagtctt 2580

tcgactgagc ctttcgtttt atttgatgcc tggttaggtg gcggtacttg ggtcgatatc 2640

aaagtgcatc acttcttccc gtatgcccaa 2670

<210> 12

<211> 3676

<212> DNA

<213> Artificial Sequence

<220>

<223> 载体片段

<400> 12

gcatcacttc ttcccgtatg cccaactttg tatagagagc cactgcggga tcgtcaccgt 60

aatctgcttg cacgtagatc acataagcac caagcgcgtt ggcctcatgc ttgaggagat 120

tgatgagcgc ggtggcaatg ccctgcctcc ggtgctcgcc ggagactgcg agatcataga 180

tatagatctc actacgcggc tgctcaaacc tgggcagaac gtaagccgcg agagcgccaa 240

caaccgcttc ttggtcgaag gcagcaagcg cgatgaatgt cttactacgg agcaagttcc 300

cgaggtaatc ggagtccggc tgatgttggg agtaggtggc tacgtctccg aactcacgac 360

cgaaaagatc aagagcagcc cgcatggatt tgacttggtc agggccgagc ctacatgtgc 420

gaatgatgcc catacttgag ccacctaact ttgttttagg gcgactgccc tgctgcgtaa 480

catcgttgct gctgcgtaac atcgttgctg ctccataaca tcaaacatcg acccacggcg 540

taacgcgctt gctgcttgga tgcccgaggc atagactgta caaaaaaaca gtcataacaa 600

gccatgaaaa ccgccactgc gccgttacca ccgctgcgtt cggtcaaggt tctggaccag 660

ttgcgtgagc gcatacgcta cttgcattac agtttacgaa ccgaacaggc ttatgtcaat 720

tcgctagagt cgatcttcgc cagcagggcg aggatcgtgg catcaccgaa ccgcgccgtg 780

cgcgggtcgt cggtgagcca gagtttcagc aggccgccca ggcggcccag gtcgccattg 840

atgcgggcca gctcgcggac gtgctcatag tccacgacgc ccgtgatttt gtagccctgg 900

ccgacggcca gcaggtaggc cgacaggctc atgccggctg ccgccgcctt ttcctcaatc 960

gctcttcgtt cgtctggaag gcagtacacc ttgataggtg ggctgccctt cctggttggc 1020

ttggtttcat cagccatccg cttgccctca tctgttacgc cggcggtagc cggccagcct 1080

cgcagagcag gattcccgtt gagcaccgcc aggtgcgaat aagggacagt gaagaaggaa 1140

cacccgctcg cgggtgggcc tacttcacct atcctgcccg gctgacgccg ttggatacac 1200

caaggaaagt ctacacgaac cctttggcaa aatcctgtat atcgtgcgaa aaaggatgga 1260

tataccgaaa aaatcgctat aatgaccccg aagcagggtt atgcagcgga aaagcgctgc 1320

ttccctgctg ttttgtggaa tatctaccga ctggaaacag gcaaatgcag gaaattactg 1380

aactgagggg acaggcgaga gacgatgcca aagagctaca ccgacgagct ggccgagtgg 1440

gttgaatccc gcgcggccaa gaagcgccgg cgtgatgagg ctgcggttgc gttcctggcg 1500

gtgagggcgg atgtcgaccg ggagggttcg agaagggggg gcacccccct tcggcgtgcg 1560

cggtcacgcg cacagggcgc agccctggtt aaaaacaagg tttataaata ttggtttaaa 1620

agcaggttaa aagacaggtt agcggtggcc gaaaaacggg cggaaaccct tgcaaatgct 1680

ggattttctg cctgtggaca gcccctcaaa tgtcaatagg tgcgcccctc atctgtcagc 1740

actctgcccc tcaagtgtca aggatcgcgc ccctcatctg tcagtagtcg cgcccctcaa 1800

gtgtcaatac cgcagggcac ttatccccag gcttgtccac atcatctgtg ggaaactcgc 1860

gtaaaatcag gcgttttcgc cgatttgcga ggctggccag ctccacgtcg ccggccgaaa 1920

tcgagcctgc ccctcatctg tcaacgccgc gccgggtgag tcggcccctc aagtgtcaac 1980

gtccgcccct catctgtcag tgagggccaa gttttccgcg aggtatccac aacgccggcg 2040

gccggccgcg gtgtctcgca cacggcttcg acggcgtttc tggcgcgttt gcagggccat 2100

agacggccgc cagcccagcg gcgagggcaa ccagcccggc tcgagtgagc gaggaagcac 2160

cagggaacag cacttatata ttctgcttac acacgatgcc tgaaaaaact tcccttgggg 2220

ttatccactt atccacgggg atatttttat aattattttt tttatagttt ttagatcttc 2280

ttttttagag cgccttgtag gcctttatcc atgctggttc tagagaaggt gttgtgacaa 2340

attgcccttt cagtgtgaca aatcaccctc aaatgacagt cctgtctgtg acaaattgcc 2400

cttaaccctg tgacaaattg ccctcagaag aagctgtttt ttcacaaagt tatccctgct 2460

tattgactct tttttattta gtgtgacaat ctaaaaactt gtcacacttc acatggatct 2520

gtcatggcgg aaacagcggt tatcaatcac aagaaacgta aaaatagccc gcgaatcgtc 2580

cagtcaaacg acctcactga ggcggcatat agtctctccc gggatcaaaa acgtatgctg 2640

tatctgttcg ttgaccagat cagaaaatct gatggcaccc tacaggaaca tgacggtatc 2700

tgcgagatcc atgttgctaa atatgctgaa atattcggat tgacctctgc ggaagccagt 2760

aaggatatac ggcaggcatt gaagagtttc gcggggaagg aagtggtttt ttatcgccct 2820

gaagaggatg ccggcgatga aaaaggctat gaatcttttc cttggtttat caaacgtgcg 2880

cacagtccat ccagagggct ttacagtgta catatcaacc catatctcat tcccttcttt 2940

atcgggttac agaaccggtt tacgcagttt cggcttagtg aaacaaaaga aatcaccaat 3000

ccgtatgcca tgcgtttata cgaatccctg tgtcagtatc gtaagccgga tggctcaggc 3060

atcgtctctc tgaaaatcga ctggatcata gagcgttacc agctgcctca aagttaccag 3120

cgtatgcctg acttccgccg ccgcttcctg caggtctgtg ttaatgagat caacagcaga 3180

actccaatgc gcctctcata cattgagaaa aagaaaggcc gccagacgac tcatatcgta 3240

ttttccttcc gcgatatcac ttccatgacg acaggatagt ctgagggtta tctgtcacag 3300

atttgagggt ggttcgtcac atttgttctg acctactgag ggtaatttgt cacagttttg 3360

ctgtttcctt cagcctgcat ggattttctc atactttttg aactgtaatt tttaaggaag 3420

ccaaatttga gggcagtttg tcacagttga tttccttctc tttcccttcg tcatgtgacc 3480

tgatatcggg ggttagttcg tcatcattga tgagggttga ttatcacagt ttattactct 3540

gaattggcta tccgcgtgtg tacctctacc tggagttttt cccacggtgg atatttcttc 3600

ttgcgctgag cgtaagagct atctgacaga acagttcttc tttgcttcct cgccagttcg 3660

ctatcacgtg ctataa 3676

<210> 13

<211> 42932

<212> DNA

<213> s4 phage

<400> 13

atgaacgaac aacaattttt taacgtagcc gtcgcaatta tcggcgcgtt gggcggttgg 60

tggatgcgcg ttatgtggca gtcacttaaa gaacttcaag cgcaagattc gaagttggcc 120

gataaagtcg gcaatatcga agttcttgta gccgggcagt atgtcaagcg cgacgatatg 180

aaccgcgaca taatggcgat tttcgccaaa cttgaccgca tcgaagacaa gatagacaaa 240

aaggccgaca aatgaagaag cccgaactta tcgaagattg gcgcgaatgc tggcgctttt 300

ggtcggttcg actggccgca gtcggcaccg caattactgg ccttcttgtt gcgtttcccg 360

acgcagcgtt ggccgcttgg gcaatccttc cgcacgaatt gaagtcgtcg attccgccgc 420

agtatatgcc gcttatcggc gttgttgttt tcgcgctttc catcgttgcc cgccttgtca 480

agcaaaagaa cttgaacaag gggccgaagg atgaataacg aacttccttg ggtagccgaa 540

gcccgaaagt atatcggcct tcgcgaagac acttcgaaga cttcgcataa cccgaagctt 600

cttgccatgc ttgaccgcat gggcgaattt tccaacgaat cccgcgcttg gtggcatgac 660

gacgaaacgc cttggtgcgg tctgttcgtc ggctattgct tgggcgtagc cgggcgctac 720

gtcgtccgcg aatggtacag ggcgcgggca tgggaagccc cgcagcttac caagcttgac 780

cggcccgcat acggcgcgct tgtgaccttc acgcgaagcg gcggcggcca cgtcggtttt 840

attgtgggca aggatgcgcg cggtaatctt atggttcttg gcggtaatca gtcgaacgcc 900

gtaagtatcg caccgttcgc agtatcccgc gtaaccggct atttctggcc gtcgttctgg 960

cgaaacaaga ccgcagttaa aagcgttccg ttcgaagaac gttattcgct gccgctgttg 1020

aagtcgaacg gcgaactttc gacgaatgaa gcttaaaggg gcatcgcatg ttttccgtaa 1080

tttgggccaa gtttggcaaa tggcttgccg caatcggcgc gggtcttgtc atgctggcaa 1140

gtatttttta tgccggtcgc aagtccggcg caaccaaggc cgaagccaac gcagcaaacg 1200

aacgggcaaa cgaccgcgaa gcaatcgcag ttcgccaagt taacgaagcc cgcgaagctt 1260

ccgaacaaca ggtaaaggcg gtacaaaatg cgaaagacgt tgcttccgat aattctactt 1320

ttgacgacga cgaagttact aagcggctgc gcgacgaatg gtcgcgcgac tgaaccgcaa 1380

agcatcgccg acgcagtgca aacgaagccc gttgtaatcg acacggcttg caaatgggtt 1440

gcgcctattt ggatttcgaa ggccgacggc ttgaccgctg gcacggcccg gcaaattctg 1500

aaccataacg aagccgtcga acgcaattgc gggccgcagt cgccgcctaa atctgcggac 1560

aagccttaac agaacgcggg gcttgcggta tagtgaagcc aacgacgtat aaactaggcc 1620

gacactatgt ccgacgaact gaaagaaagc gaagaaaagg ccgcatacgc ggcccttctt 1680

ttgaaagaac gcgacccgtt caaggctgcg ctttcgctgt ttccgaacaa cacgaatcgc 1740

gcgctatggg ttgcgaacca ttggccgaac gacgccgaag ttaaggccga acaaaagcgc 1800

cttaccgacg aaggcggcga tatggcattt cttccgggca aaggcgacct tgcccgcgac 1860

atttggcagc gtatgcaagg tacgacgctt ccgaacggcg taaccattcc gccgacgccc 1920

gaagaatacg cgaagcttgc caagctttac gccgacgttc gcgggttcat cgaaaaaccg 1980

caaacgaacg ttaacgtaac gacgaacgta aaccgcgtcg tcgaaatgcc cgtattcgct 2040

aacgaaagcg aatgggaagc ggaagccgca cggcaacagc gcgaattgtt agaaaatgca 2100

cgcactcgcc attgatacga acggggcgaa acctgttccg tatgaagtcg tatttaagcc 2160

ccttccgggg tcgcagacta tcgccctttg ttcgatggca gcgcatacgc tgtacgaagg 2220

cgcacgcggc cccggtaaga cgcttacgca gcttatgcgc ttttatcgta acgtcggcaa 2280

aggctacggc aagttctggc gcggcgttat cttcgatttg gaatttgacc atttgggcgg 2340

ccttgttgcc gaatcgaaaa aatggttcgg cgataacgga aagctaaaag acggcggcaa 2400

gttttacgaa tcaacgtcgg cttataaatg ggtttggccg acaggcgaag aactgttgtt 2460

tcggcacgtt aagaagctgt cggattacga aggcttccac ggtcacgaat acccgtttat 2520

cggttggaac gaacttacga agcatccaag cggcgacctt tacgacaaat ttatgtcggt 2580

caaccgctgt acgttcgacc cgataaaaga cacgccgaaa gacccgaaaa ccgggcgcta 2640

tttgacgccg aacggcgaac cgctgccgcc tgtaaagtgc gaagtattca gcacaacgaa 2700

cccaagcggc cccggtcaca attgggtaaa acgtcgcttt attacgattg ccccgcgcgg 2760

caccgtagtt cgtcgcgaaa ttcagattta caacccggcg accgaaaaag aagaaacgca 2820

cgtaattagc caaatcgcta tcttcggttc gtataaggaa aacccgtacc ttccggcttc 2880

gtatatcgcc gaactggaaa gtatcaaaga accgaacttg cggaaggctt ggctttacgg 2940

cgattgggac gttaccgcag gcggcgcaat cgacgacctt tggcaatcgc atatacacgt 3000

tgtaccgcgc ttcgtcattc cgccaagctg gcgaatcgac agaacatacg acgacgggtc 3060

ttcgcatccg tttagtgtgg gctggtgggc ggaagcggac ggcaccgaag cgaccatagt 3120

tctttcggat ggcaccgaat ttacgttttg cccgcaaccg ggttcgcttg ttcagttgtt 3180

cgaatggtac ggatgcgcga aagacgaaaa aggcgaatac ataccgaata aaggtttgaa 3240

gctttcggcg tcgaatatcg cacaaggtat aatcgaccgc gaaatttcgc taatggcgaa 3300

cggttggatt tattcgcagc cttggcccgg ccctgccgac aaccgcattc gccaagtaat 3360

cgacagcgaa ctagacacga ccgaaaagct tatgtcgaag aagggcgttc gttggacgga 3420

atcggacaaa tcgccgggtt cgcgcgtaat cgggttgcag cttttccgcg accggctaga 3480

agcgtctgtt aatcgcgaag ggccgggtat atactttatg tcgaattgcg ttgcaagtat 3540

tgatttgctg cccacactgc cgcgcgacga aaagaagatt gacgacgtag acacgaccgc 3600

cgaagaccat tgttacgata tggtgcgtta tcgcgtattg aaaggcgcga acaaagcggc 3660

agcgaaattc aaacttgtta tgccaactta aaggaaccca aatcatgccg aacgtttcat 3720

ttattcgccc cgaacttggt aagctgctgc cgctgtatta cctgattcgc gacgcaatcg 3780

cgggcgaacc aacggtaaaa ggcgcgcgga cgacttatct tccgatgccg aacgccgaag 3840

accaatcgaa agaaaataag gcgcgatacg aagcgtactt gaagcgggcc gttttctata 3900

acgtagcccg tcgaaccttg ttcggcttgg tcggtcaagt gttcatgcgc gacccggttg 3960

taaaggttcc cgcgctgttg aacccgcttg tcgcaaacgc gacgggttcg ggtatcaacc 4020

ttacgcagct tgcgaaaaag gccgtatcgc tgaaccttgc gtattcccgc gccgggctgt 4080

tggtcgatta cccgacgacc gaagccgaag gcggcgcgtc gattgccgac cttgaagccg 4140

ggcgcattcg tccgaccctg tacgtatatt cgccgaccga aattatcaat tggcgaacga 4200

ccgaccgggg cgcggaagaa gttttatcgt tggtcgtact gttcgaaact tggtgcgctg 4260

ccgatgatgg ttttgaaatg aaaacgtcgg ggcaattccg cgttttgcgt ttggacgaag 4320

aaggttatta cgtccacgaa atttggcgcg aaccgcagcc gaccaaagcc gacggtacga 4380

agattccgaa aggcaattac caacaataca cggtttacaa gccgacggac gcaaacggca 4440

atcgtcttac cgaaattccg tttatgttca tcggttcgga aaacaacgat tcgaacccgg 4500

acaacccgaa cttttacgac cttgcgtcgc tgaatatggc gcattatcgc aattcggcgg 4560

attacgaaga aagttgttat atcgtcggac agccgacgcc ggttcttatc ggacttaccg 4620

aagaatgggt tacgaacgtt cttaaaggtt ccgttaactt cggttcgcgc ggcggtattc 4680

cgcttcctgc cggggccgac gcgaagttgc ttcaagcatc cgaaaacacc atgcttaaag 4740

aagcaatgga taccaaagaa cgccaaatgg tcgcacttgg cgcaaagctt gtcgaacaaa 4800

aggaagtgca acgcacggca accgaagccg aattggaagc cgcttcggaa ggttcgacgc 4860

tttccagtgc aaccaagaac gtttcggcgg cctttgaatg ggcgttgaaa tgggcggccc 4920

gttgggtcgg tcaagccgac agcggcgtta agttcgaact gaatacagat ttcgacattg 4980

cccgcatgac gccggaagaa cgccgttcgc ttgttgaaga atggcagaaa ggcgcaatta 5040

ccttcgaaga aatgcgaacc ggcttgcgta aagctggcgt cgcaaccgaa gacgacgcca 5100

aggctaaaga aaaaatcgcc aaggataccg ccgaagcaat ggcccttgct gccccggcta 5160

acgtgccggg cgatggcagc ggcggcgata atgtgggcaa caacggataa ggggcgcaat 5220

catggcacta tcggacaata agcgactgta cgatattgcg acgcgccttg ctgtttacgt 5280

cgaagacgtg aaagtttggc agtcccgaca attcgggttc gtacttcgcg aagtaaactt 5340

ggaattaacg cgccttcttg gtcgtgttcg ttataagacc cttgacggtc tttcgaaggc 5400

gcagttaaac aagcttgttt cggaattacg ggaatcgcaa tcgaagattt acagcgcata 5460

cacgcaaacg ctgcttgaac agttaaagga attcatgcgg gccgacttgg aagtaaaccg 5520

gcgcgcttgg gttacgggtt atatcgaact tgacggcgaa gaaagcgacg acattatttc 5580

ggacgaagaa gcgatacagt ttcttttaga agtaccaaac gccgattcga accctttgtt 5640

cggtttggcc gctgttacag gaagcgacga acgcatttgg tcgcaagtta cgaatacgcc 5700

aattccggca aatggtttgt acttgctgcc gtttatcaag acgtttacga attcggcaca 5760

agctggcgtc gaaagcatga ttcgcaaagc ttgggcgaac cgttggacgg ttgaagaaac 5820

cttaacggcg cttgtcggcg atggaaccgc agcgcagggc acgccgtcgc agttgcaccg 5880

ggtcaacgcg caagccgcgt cggtaatcca tacggcaacc gcgcacgttg cggcggtcgt 5940

tgcggctggc gttatgtctg cggttttcgg tcgttacgtt tggtattcgg taatcgacgg 6000

aagaacgacg gacatttgca taagtcgaaa tcgccgaatc tatcgcttcg gcgaagggcc 6060

gttgccgccc gcgcatatcc gttgccggtc gcacgttgcc ccggcaaata ccgctagtga 6120

cttggccgaa gaaacgtttt atacttgggt tgcccgtcaa cctgcccaag tgcaagacga 6180

catattaggc gacgaaggcg gcgaagcttt gcgcgatggt cgcttaaagg cgaaggatat 6240

tccgaagtat gatgcggaca ggccgctaac ttacgaagaa ttccgacgca agattaaaga 6300

aattctttcc cgctgattcg gtgaatcggc ataaccgcaa ggagtccttg aaatggcact 6360

gaaaaagaaa cttaccaaag aagaacacgc gaagctttcg gatgcactga aagccgaata 6420

tatcgaagac ggcgacggct tccgccttga cgttgacggc gacgaagata cgggcgcttt 6480

gaagcgcgcc aaagaccgcg aagcgcagtt gcgcaaagac gccgaaaagg aagcgaagga 6540

acttcgcgaa cggctggaat ccatcgaagg cgacgacgcg cgcaagaaag gcgacattgc 6600

gacgcttgaa aagtcttggc aatcgaagct tgaaaaacag cgcgaagaat acgaagccaa 6660

ggtttccaag cttaccgcgc atacgacgaa aacgcttgtc gataacgtcg cgtcgcagct 6720

tgcccacaag atttcgaacg ccccggcaat catcatgccg catatcaagt cgcggcttat 6780

cgcagacttc gaaggcgaca cgccggttac gcgcgttctg gacaaggacg gcaagccgtc 6840

ggcccttact atcgacgaac tggcaaacga attcgttgca aacaaggatt tttctgctat 6900

tatcacagct agtaaggcgt ccggcggtgc cggtaagcct tcgcagaacg gcggcggtgc 6960

cccgaaattt aacggtcaat ccgacaaacc cgccgacctt tcgaagatga atcccgcaga 7020

acttgcggcg catcttaaag aagcgaaggc aaacgaaact aaggacgctt aatcatggca 7080

ctttccgacc ttgctgttta ctccgaatac gcttattcgg ctttctccga aaccctgcgc 7140

caacaggttg atttgttcaa cgctgcgacg ggcggggcta tcatgctgca atccgcagcg 7200

caccaaggcg acttttccga cgttgccttt ttcgccaagg taacgggcgg ccttgttcgc 7260

cgtcgtaacg cctacggttc cggcaccgtc gccgaaaagg tcttgaaaca ccttgtcgat 7320

acgtcggtta aggtcgcagc cggtacgccg cctgttcgcc ttgaccccgg ccaattccgt 7380

tggattcagc agaacccgga agtcgcaggc gcggcaatgg ggcagcaact cgccgtcgat 7440

acgatggcgg atatgctgaa cgttggtctt ggttcggtct attcggcact ttcgcaggtt 7500

gcggcggttg tttacgacgc gaccggcaat actgcgcccg acgacggccc gacttggaac 7560

aaccttaaca acggccaagc caagttcggc gaccaatccg cgcagattgc ggcatggatt 7620

atgcacagta cgcccatgca caagctgtac ggtaacaacc tgaacaactc cgaacgcctg 7680

tttacttacg gcaccgtgaa cgttgttcgc gacccgttcg gcaagcttct tgttatgacc 7740

gattcgccaa acctgttcga agccggtacg ccgaacgttt atcgcatcct tggccttgtg 7800

ccgggcgcgg ttatgattgg tcaaaacaac gacttcgacg cgaacgaaga aaccaagaac 7860

ggcgacgaaa acattattcg gacttaccaa gccgaatggt cgtacaacgt cggcgttaag 7920

ggcttcgctt gggacaaggc gaacggcggc aagtcgccga ccgacgcggc gttgttcact 7980

tcgaccaatt gggacaagta cgcaacttcc gaaaaggatt tggcgggcgt tgtcgtcgaa 8040

gttcactaac ggacggcaga cggacggggc ttcggccccg ttcttctagt ccttcacaaa 8100

ttcaaaggag tttcgaagat gaaaccggca aaaatcctgt atttcgtcga tggcaacgca 8160

ccgaccccgg aagacttcgc agccgccgcc gaactgaacg cgcaagttat gttcaggaac 8220

gcccgcgctg ttccgtccga accgcattcg ctggaaatct gcgacggcgt agcgggcaag 8280

gttccgaagc tgtacgccga cgcttacccg gaagcgggcg aagcaatcaa gaagaaggcc 8340

gccgaactga aagcccttgc ttcgaaggtc ggcgacgccc cggcaccgaa ggccagcggc 8400

aaggccgccg acaagcccgc agccgctacg cagggccaga aagccccggc agcggccccg 8460

cagggcggca gcgccccggc ttggaaccct aacccggcgc agtaaccaac ggacggcctg 8520

tcgcttattg tgggcaggcc gtttcaacaa cgaactaagg agtcttcgca atggcaacga 8580

aaaaggttgt ttattttacg gcaggcatta ccgcaaccgc tggcgaactt gccgcaattg 8640

cgaagcttaa cgcagccgcc gaaccgcaat atgaagtttt ggtagccaat ggcgcggcaa 8700

atgccgaata cggcgaaacc gaccgaatca ttccgtcgga ttatgtcgcc ggtactgttc 8760

cttcggaata ttcggcggtt gacgtaatcg accccgacgc aatcccgaat caggcgctta 8820

cgccaacgca agcaatcgtt aacgacgccg aagccttgac cgttccggtt actggcactt 8880

acacgacgac cgcaaccgtt agcgttgcga acggcgttgt aaccggcatc gttctttcgt 8940

aaggacgttg acgcatggca attacaatcg ttgttgaaga cggaagcggc gtaacaaacg 9000

cgaacagtta cgtaagcgtc gcagacgcgc gcatttacgc ttcgaatcgc ggcgtcgaac 9060

ttccgttgga cgacgacgaa ttggcggcca tgctgattcg ttcgacggat tacctagaag 9120

cgcaggcttg ccggttccaa ggcaagccaa cttcgacgac gcaggctttg caatggccgc 9180

gaactggcgt ctttcttaac gaagacgaag taccgtcgaa cgttattccg aagtcgctta 9240

ttgccgcgca agttcagctt gcaatggcga ttaacgcagg cttcgacctt caaccgaacg 9300

tttcgccgca agactacgtt acgcgcgaaa aggtcgggcc gattgaaacg gaatacgccg 9360

acccgctgtc ggttggcatc atgcccacat ttaccgcagc gaacgcactt cttgcgccgc 9420

tgtttggcga atgcgcttcg aacaagtttg cgcttcgtac aataagggtt tgacgaatgg 9480

cacgtttcga cgcagcaatt aaaacggcgc aacgccttat cgcaaagaac ggcgaaaagg 9540

tgaaatggcg cgttatcgaa gacgcgacgc cgacagaccc gaacaagcct tgggaacccg 9600

gcccggcatt gccggacgac aaagacgtta ccatttgctt tttgccggtt gaccggcaga 9660

cgcaagaaac tttcaacttc attaaaggca ccgaagttcc gaaaggttcg gtaatggggc 9720

ttatgggcaa tgttccgttt gaaccgaatt tgaaagacgt tgtaattcgt aacggggtcg 9780

aacttcgctt ggcttatatc gacgtacttt cgccgaacgg gcaaaaggta ctttatacga 9840

tggtatttca agcatgattg aattcgacca agttaacgac gaagtaaacg cgctttttct 9900

tgcaacttgg aacgcaggaa gcgcggcaat tgcgggttat gttcccgaaa ttcgttggca 9960

gggcgtgcaa tatcgcgact tgccggacgg ttcgaagttt tgggttcggc tgtcgaagca 10020

aaccgttttt gaagaacaag cgaccctttc aacctgcgaa ggagtaccgg ggcaaagaaa 10080

atatacggcg tcgggtcttg tcttcgtaca aatcttttgc ccgaaatcga atacgcaagc 10140

gttcgaactt gggcagaaat tggcgaaact ttcccgtaat gcttttcgcg ggaaatcgac 10200

gccgggtaag gtttggtttc gcaatacgcg aattaacgaa cttccgcccg aagaacttta 10260

cgaacggttt aacgtcgtta ccgaatttga atacgacgaa ataggttaag gagttcttaa 10320

catggtatgc gaaattgcca aaatcgacag caacattacc ggacttgcct tcgccgaaga 10380

agaatgcttg aagcaacttc cgacgacgcc cgtttggtac ggactggaac ccaacagcta 10440

ttcggacttc ggcggcgaac tttcgaccgt tgcccgcgcg cctatcgacc cgtcgcgcca 10500

gaacaagaaa ggcacgatta ccgaccttga cgcatcgggc ggcttcaacg ccgactttac 10560

gaagaccaac cttacgcgaa ttctgcaagg cttcttcttc gcagacgcgc gcgaacttcc 10620

ttcgacgcag ccgcttaacg gcgcatcggt cgcacttacc ggcgttaccg cagttgacag 10680

cacttacgcc gcagcttccg ggcttggcgt gttcggtgcc gatatgctgg tatatgcgac 10740

cggctttacc aacgcggcga acaacggcct taaaaccgtc gtttcggcta ccgctgcggg 10800

cgtcgttgtt gctgaaacct tgattgacga aaccccgccc gcaggcgcga agctggaatg 10860

cgtcggtcgc cagcttgccg ccgcagacgc gaacattgcc gtaactggca acgtcgtttc 10920

gcttatcgtt accgctggcg actttacgac catgcccgaa ctgttccccg gtcgttgggt 10980

cttcgtcggc ggcgatgcga cggcaaaccg cttcgctaat aatgtgggct atgcccgcat 11040

taagtcggtt gcagcgaagg cgcttgtttt cgacgacgtg acttggcagg cggccaacga 11100

aaccggaacc ggcaagtcga ttcgtctttt cgtcggaact gttatcaaga acgaaaagac 11160

cccggcactt atcaagcgtc gttcgtatca aatcgaacgc accttgggcg aaggtttgaa 11220

cggtacgcag tgcgaatatc tggaaggcgc agtaccgaac gaatttacgt tgaacgttcc 11280

gcaggccgac aagctgaacg ccgacctttc gtttgttgcg tgcgacaaca cttaccgcag 11340

cggcgacccc ggcgacgaac agaaaaccgg aacccgcgtg cctgcgcccg gcgaagacgc 11400

ttacaacact tcttcggacg tttaccgaat caagatggcc gttcacgacg ccgcgtcgtc 11460

gaaccccgcc gccctgttcg gctacgtttc cgaagcgaac gtttcgatta acaacaacgt 11520

tacgccgaac aaggcggtcg gcgtgttggg cgcgttcgat acttcggcgg gtaacttcga 11580

agtcggcggt tcgattaccg cttactttac gaccgtcgca gcggttaagg ctgttcgcgc 11640

gaacgccgac gttggtttgt cggtaatcag tgcggccaag aacgccggtt tcgtgttcga 11700

tattccgttg cttggtttgg gcggcggtcg tctgaacgtc gaaaaagacg cgccgattac 11760

cgttccgctg gaacccgcag gcgcagaaaa cgcgaacggc tatacgatgc tgtacgaagt 11820

gttttcttat ctgccgaatc tggcaatgcc ggactaattg cggtaaactc aaagggccgg 11880

gtaataccgg ccctttcttc attcaatcgg agtaaatcaa atgtctggac tgtttaagca 11940

attcaaaacg aattcgacca aggaagtcga aggcgtcgaa atcgaatttc ccgaagcgca 12000

gaacgacgac ggcagcgttc cgactttcgt tatttcccgc atgggcaaat cgaacaaggc 12060

gtattcaaag gcgcttgacg cggcgacccg tccttatcgc cgtcaagtcg aacttggcac 12120

gctgaaaaac gaagtcgccg aatcgctgtt tatgggcgtg ttcgtcgata ccgtgttgcg 12180

cggctggaaa aacgttcagg gcgaagacgg caaggaaatt gcgtattcga aagacgccgc 12240

aatttcgctt ctttccgaac tgccggacgt ttacgaacgt ttgcaggaag aagccaagtt 12300

ggcttcgaac ttccgcgata acgctttgga agccgaagca aaaaactaac cgaagttttg 12360

gcgcacctgt tggaacttgg cccacacgaa caggcgatag caaaacaagc gatgcgcgcg 12420

gggcagccgt tacccgaacg catcgcgaac gcgccagaac ttgaagtagg cttgcagttg 12480

tatttgcaag ccttcttcga cctagatagc gaacggtcgc acggcaacgg tttaacgccg 12540

ataccttgga caagtatggc ggcttacgca agggctttcg agtttgacga agaacaaacc 12600

gaagacttgt tttactttat gcgaaagctt gattcggaac acttgaagaa actagcggat 12660

aaacagaaag cggcggcatc gaatggcaaa aagcctgcta gacctagccg ataggctgga 12720

aaagaaagcg aaggcaatag acgaagcggc gtcacaaaac gccgtcgata ccgctttggc 12780

tattgtgggc gacttggcgt acaaaacgcc cgtagatact tcgcaagctt tgtcgaactg 12840

gattgtaacg ctagaaagtc cgtcgggtca acaaatcaag ccgcattttc cgggttcgca 12900

gggttcaacg caacgcgctt cggcggctga aacgttgaat tctgcgaagc ttgttttacg 12960

aaacaagaag cccggccaag cgatatttat tacgaacaac cttccgtata tccgcaggct 13020

gaacgacggt tattcggcac aagccccggc ggggttcgtc gaacgcgccg ttttgattgg 13080

tcgcaaaatg cgtaagaagt tcaagattaa ggattaaaag aaatggccga cgaaaacata 13140

gaaattaagg ttcaagacaa agtttcgccg tccatttcga cgaagcttcg cacaattgca 13200

agcgaagccc gcaacgccga cgccgcagtt aagaaccttc aaacgcagct ttcggcaatt 13260

aacgtcggcg gcttgtcgca gcttatcaac gcatcggcca gcgcaacgcg ccagcttcaa 13320

caaggcgcgc ttgccgcgca acggctggca accgaacagc agcgcaccgc aacagccgca 13380

gcgcaggccg ccgcagccca acagcgcgtc gcgacggctg cgacccaagg ggcaaccgcg 13440

caagccaacc ttgccagcgc cacgcagcgc acgcagacgg cccaacagca gacggcgaca 13500

gccgcgcagc gcctagcgac agaacagcag cggacagccg ttcagacggc caacgcggcg 13560

gcagcgaacg accgggccgc ccttgccgcc ctgcggctgc aacaggcgca agaccgggcc 13620

gccaattcga cccgcaatgc gacttcggcc cttggcggat acattcgaac cgctgccgga 13680

attcttggcg taacgatttc ggcgaacgca attcttgcaa gcgccgacgc atacgttacg 13740

cttcaaaaca agttgcagaa cgtaacgaag tcgcaagaac aagttaacac gcttacgaac 13800

gaacttttcg aactgtcgaa ccgcacgcgc gcgggtattg aagaaacggc gacagcgttt 13860

acacgcttcg accgtgcctt ggcgtttatg ggtaagtcgc aagaagattc gttgcgaatg 13920

accgaaacca ttaacaaggc tttgattgtt tccggtgcaa cagcgcaaga agcgtcgtcg 13980

gctttgttgc agctttcgca gggcttcaac gccggtaagc tgcaaggcga cgaattccgc 14040

gccgtttcgg aaaatatgcc aatcgttttg gacgcagtag cgaaggcgct taacgttccg 14100

attaaccgcg ttaaagaact ttcgaccgaa ggtaagatta cttccgaagt tctgtttgaa 14160

gctttcaagc ttatacaaga ccaagtagac gcaacgttta acaagacgac gcccacaatc 14220

ggccaaagct tgacggttct tcgcaacaat gcaattcagt tcttcggcga attgaacaaa 14280

gcgaccggct ttactgccgg gctttcgcgc gcgattattt ggcttggcga aaacttgaag 14340

acggttgccg taattgtcgc cgggcttggc gtcgcattgc ttgtcgcctt cggtgccccg 14400

ttggttggtg cgctggccgg tgcgacggct gcggtaaaag cctttacgct ggcgcttgct 14460

tcgaacccga ttggccttat cgtcgtcgcg ctttcgaccg cgattgcgta tctaacgctt 14520

ttccgcgacg aaattaactt gggaatcgac gacgttacga cgttgggcga tttcttccgc 14580

gcgacctttg aaggcatcgg ccaagcaatc gacgacgtta aaaccatcgc gtcgcaattg 14640

tgggcagaac ttagcgactt cgcaagcgca gcccttggcg aaattacttc gaacgttgac 14700

gattcgactt cttcttggtc ggacagttac gccgaatttt tccaaaccaa ccgtacaggt 14760

tgggccggtg cgttggaaaa cgccgcaaaa gttcttgacg caatcgccgg gcttttgacc 14820

ggggccgcaa cgttcgcagg ccgtgcaatg gccgaagttg ttatttcggt tcaaaacgga 14880

atcgcaaacg cttacaacgt tgtcgcgggt tggattgaaa acgtaacgaa taaagccatt 14940

gaagccgcga acaggcttcg cgcgatggtt ggtaagtcgg cttacgaact tgtccaattc 15000

gaacgcatgg gcagcgcagg ccaaaccgaa ttcgaatctt ggggcaagct ttgggcgcaa 15060

tcgctggaag acggatttaa cagccaaggc ggcgcaatgc aaaacctgtt gaacggcctt 15120

ttcgaccgtt cgcagcaaat cggcgcgcag cgcagggccg caggaagcgc gcagcttcgc 15180

ggggccggta cgtcgcagct tgccggggct accgacgcaa acgcggcgaa ggctgcggaa 15240

cgtcgcgcgc tggcgttgga aaaaatcaat acgcagcttg ataacgaatt ggcgcgcatg 15300

ttccagcttc aaccgcagcg cgaagcgcaa gcgaagttcg accaaatcga agaaagcttg 15360

attcagaaaa agattaagct tacgtcggaa gaagccgaag caatcaaggc gaagattaag 15420

gccgttcaag acgcgaccga agttcaacgc cagttcgacg caatttacgc cgaagctgtt 15480

aaccctttga aggagtacaa cgcggcgcag gaagcggcga acaagcttct tcaaatgggc 15540

gcgattacgc aggaacagca cgcccgcgca gtaacgaagg cgtcggaagc ttacgcgaat 15600

tcgcaagacc cgttgcggca gtataaccgc gaccttgaac agcaattgca gcttttgcaa 15660

atgctgccga agcaacgcga aatcgaacag caggttatgc aagttcagaa cgatttgctt 15720

gcaaagggca tcgttctaaa cgaaaccgaa ttggcgcagc ttcgcgaaaa gctgttgctt 15780

attcagcaag taaacgccgt ttcgcagcaa gaagcgtcgt tgttggacgc cagcgtaaac 15840

aagcgccaac agtttatcga ccaacttaaa gcaattcaga acttgcgcaa caacagcgga 15900

agcggtttca acgcaggcga ccaagccgaa gcaactaaca gcatgttgca aggcatgggc 15960

attgatacga cgaactttca aacgcagctt aacgcgcaat tggcgcaata tcaaacttac 16020

gtcgaacagc ttaaaatgct gaacgaacag cgtttgatta gcgaccaaga atacgccgcc 16080

gcaagtatgc aacttgaatt gcagcggcaa aacctgtact tgaattcggc aagtagtttc 16140

ttcggaaact tggccgcgct tcaacagtcg ggaaataaga aaatggcggc ggtcgggaag 16200

gccgcagcaa tcgcgcaagc gatgattaat acgtatcaat cggcaacgtc ggcttatgct 16260

gcgatggcgt cgattcctta cgtcggcccg gcgttgggcg cggctgcggc tgcggctgca 16320

attgccgcag gcttggcgaa cgttcagcaa atccggtcgc agaataccgg gtttaagtcg 16380

ggcggtttta ccgggtcaat gggcgtaaac gaagtcgcgg gcgtcgtaca cggccaagaa 16440

ttcgttatga acgcagcggc gaccaaccgt attggcgttg cagaccttca agccctgcaa 16500

acgggcgcgg ccagtgttca gcgcaacgac gaacaggcaa tggcggctag tgtgggcagg 16560

ggcggcaatt ccgaacccgc gcccgcgccg gttgtcaatg taccttttag cgccgttgtc 16620

gtacaatcga aagaagcggc cttggccggg cttaaatctg cggaaggtcg ggctttcatt 16680

ctggaaacta tcgaacaaaa cggcggcacc gtcgcaaaaa tcgtcggagt taaataaatg 16740

ggttacgcaa ttggaacagt tacaaaaggc ggcggcgacg attgccatta tcaagttttg 16800

gcaattatca aaacgctggc cgaagcgaac ggatggacga cgcttcgtta cgtatcaacc 16860

ggacttgacc gcgaattgat tttgaaaggc gttggtttgt ccggtcttga agaaatcttt 16920

gtagggttta agtgttatca aagcgtcggc ggcgattatt acaatattaa ttgcggaact 16980

ttcgtcggtt acgtaagcgg aaacactttc gaaacgcaac ccggcgcgca gtttagcgca 17040

acgcctgccc acaataacgc gattacgtat ttcataacgg ccaacgccca acgaatcgtc 17100

ggatgcttca aagtcggtac gccggtttac gaacattttt acgtcggcaa gttctttccg 17160

tatgcgcggc ccggtgaata tccgtcgccg cttgtttgcg gtgcgatgct ttccaacgcg 17220

caggcaatgc gattcgacaa caacgcgcag tcgttcccgt atccgggcta ttattacgac 17280

acgacgaaca accgccttta tattcgcgac caagcgggca actggattcg cccttggtgt 17340

tggccattta ccaatggaaa cggcgcaaac accgcgcttg cagggccgca aggaacttcg 17400

acgcttgttc ctgccgacgt gtattaccaa cttgaaccaa ttattttggc gcagcaaagc 17460

aacaataaca acccttcgaa cgtatggggc gaattcgacg gcgtttattt ctgttccggc 17520

tttaacaacg gcgtcgaaaa cgtagttcag gaaggcggaa gttctgtcgt tgaccaaacc 17580

gggcttaccg tacttcaagc cgtagacgct attaaggcgg tcggcgggcg ggcgtttgta 17640

atgttgcaaa acgtctatcg tacttcttgg cgcgatttta tcgctttgga aatgaaataa 17700

tggcatacat tacaggaacc gccgcaaact ttgcggattt gaaaacagcc attgaaaacg 17760

cctgtacttc taacggttgg gcgcttgccg acggcatatt gtcgaagaac ggttgtttct 17820

ttcaactaat cgccgatagt ttgggcggtt atccgcaact tcgcttgcat ggcggaacag 17880

gcaaaagcgg ttcgacgctt acaggccagc cgcctagcaa ttacggggca aaggtcgcaa 17940

gccctgtcgg aaatcaaatc gtattcccga ttaattacga aatacatttg tttaccgacc 18000

ccgacgaagt ttattgtatc attaattaca attcggactt ttaccaacaa ctttcgttcg 18060

gcaagtctga tattccgggc attggtggaa ctggcgcatg gtttaccggg gcatatcggc 18120

acgactacgg attgaccgac gcaacttacg cccatagggt ttttacggcg atttcttggc 18180

ccgaaataac tggcgtcgca acttatgccg gaatgtgcgt cggtttgttt tttgaaggca 18240

acgcttcgca aactggcgga agttatttcg caagcttcgt acataccggg cttgattcga 18300

cgccttggcg aagcggccac ggcggcgaca cgctgttaag cggctatcgc ggggccggtc 18360

tttccgtcgg ttcgctttta atgtcactgc cgaatatttc gaaccaagca acgattttgc 18420

ttcctattaa gccggttgcg cgtcgttcaa gcggcggcgc aactattatc gcaaacccga 18480

aaaacgcgcg ttatttgcga atcgacaacg ttgtaccggg cgaaattatt acattcggtg 18540

ccgaccaatg gaaggtttac ccgttttacc gcaaagacgc aaccgttcga aacggcgtcg 18600

gttggtcaag cggcgcgacg catagcggaa cgttcggata cgccattaaa tacactggaa 18660

cttaaaaaga atggccggaa gaattggaac atttttagcg gcggaaagtt ttatttacgg 18720

cgattataac ccgaaccttt ccgccgaact taacgaactt accgccgcag aatacgcgcc 18780

gacgatttac gacccgcgcg atatgttctt gcgcggcgga tattcggcgt acaaaatcgc 18840

gccttcgaat cgctggccta ttgtgggcaa agaacaaggc aacttcgggc gcgactatta 18900

ttatcgcgtt cacgtttcgc cattggtctt ggacttgcaa acggtcgcgt cgtcgcaaac 18960

gcgcgaattc aacgtttgga acgcatggcc cgaccgtgcg gctaatcttg acgacatttt 19020

ggtaagtaat ccggtcggta ttgaaattac aggccaagcg acgccgtatg caatgccgcc 19080

gcttcaagaa cttacttacg aaataaccgt aggcgtttcg gggccgccga atattaacgt 19140

tgaagttcaa tttgactttt ccaacgttcc cgacccgctg ccgattctga ttacaggaac 19200

gcgcgcggtt aagttcgaca ttgtgcccga agttccattg aacgaaactt gggaatggtt 19260

aagcgacaac attgtagcgg ttgacggaac agaacagcgc atagcacttc gcggcgaaat 19320

gccgcgtatt gaagaacgct tgaaagtaat ttttgattct gtcgaagccg tgcgccgttt 19380

ttacggcgac gttatgtcgg cagttggtcg gctttggatt cccgaatttc agtacgcgac 19440

ccgaattact gccgcaagca atagcggcgc gcttcaaatt tattttgacc gaacgaagac 19500

cgacgttcgc gataccgaat acgtcttgat tcaaacgccg cttgttgcgg cacttgtcga 19560

aatcgacgta ttgacagccg acggggctac gcttggttcg ccgctgttgt tcgacattcc 19620

ggcagggtcg ttaatcatgc cgggttcgcc cgcgcttatt gacgacaata cagcacttgc 19680

gcggtattcc gtcgataccg tcggcgaagt agaaattaac gcgaagatga ttcgccagcg 19740

ttcgcaactt acccgacccg gcgcaaccgt cgtacttgaa cagttcggcg gcgtgccgat 19800

tttgacgaag cgtccgcttg cgaacgacct tgtacgcgac gaagtttcaa ccggccaaat 19860

ttcaatcgac aatcaaaccg gacttgccga cattattagc cgttgggact atagccgcat 19920

cggcgggccg cgaagcttca aagtaaaccg tatttcgaat cccgaagaat tggattattg 19980

gaaagcgatt cttgcgtatg cacgcggaca ggcgcgcaag ttttggatgc ccacatatcg 20040

aaccgatttg gctttggccg tgcaaccgtc cgacgcgact tcaagctata ccgtcgaagg 20100

gtcggagtat gccgaaaaga tttggccgat tatcacgcat cgttatatcg aaatcgaaac 20160

agcgtccggc attcatcgaa ccgaaatatt gggcgcaact ttgcttgaaa ctggcaatac 20220

aattcttctt cttggtacgc cgcttccgac cggggccgga tggatggaag ttaagcgaat 20280

ttcgtacttg ttgcctgtac gccttggcga cgataaagta gaatggaagc attacggcct 20340

tgaatcaatc ttgaatcttt caattcgaac ggcggaaccc taatgtctga ttacgacgac 20400

aaagaagaaa gcgtaggcga tagcgcgcca tttgaacttt acgaattcgt cggttcatat 20460

cgcaattatt acatgacttc cgacgttctg gcgcacgtct tcaacagtgc gacatataac 20520

cccgttccgg gtttgaagcg cagtacgtta aaagtcggaa cgcacgaaga cgacaacgta 20580

gatatgacgg ttacgcttcc gattacggaa caaatcgtta aagactatgc gtttcaaact 20640

acgccgccgt ctttggtttt gacgatttac cgtcgccagc gcgacgccgc aacttgggtt 20700

gcatactgga aagggccgat tgcttcaatt tcggttgacg acgaatttgt aacgtttaga 20760

acgccaagca agttcggttc gatgctgtcg ggcaatatac cgaacgttta cgtacagccg 20820

ccttgcaata acgttttgtt cgacgaacgt tgtaaggtaa gtcgcgtaag caattcgcta 20880

gatacgcagg tttcggcggt cgaaggtcgt aacatttcga ttccgtcgct tggcggtttt 20940

cccgacggtt ggtttatcgg cggcgaaatc gcaatacctg cgcgcaacga acgtcgaatg 21000

attgtcgcgc aagccggggc aattctaacg gtaaattacg aattcgcgcg tatttctgtc 21060

ggcacttcgg ttcaggttac ggcaggttgc gaccattctt acaacggggc caacggttgc 21120

cccaagttca acaatcaacc gaacttcggc ggttgcccgt ttgttccggg cgaatcgaat 21180

aacgtatttc aaagcggggt tcattaacaa atgtggattg caattgtctt cgtcgtcgcc 21240

ttcttactta tggcggcgct tatgccgaaa ccgaacgtcg aaaacgcacg cgcggcgaaa 21300

cttggcgact tccaatttcc gcgttctaag tacggcgacc caatgccgct agtgtgggga 21360

acagtgcgcc agaaatcgcc gataacggct tggtttggcg acttccgccc ggtgccaatt 21420

cgtaagaaaa tgaagaccgg gctttttagt tcgaagaaag ttacggtcgg ttataaaaat 21480

tatcttggca ttgattgcat tttgtgcctt ggccccggcg ttcggcttcg taagttttgg 21540

gccggtactt accttgtttg ggaaggcaac ttaacttcgt ccggcgatat ttacattaac 21600

aagccgaact tgtttggcgg cgaagatgaa cgcggcggcc tgcaaggtac aatttcgttt 21660

tacgacggtc gttttgaccc gccgcaagat tcttacttgg tttcgaagat tggcccgaat 21720

gttccggctt acaacggctt tgcgcgtgcg ttgttcaaag ccttttatat cggaacaggt 21780

acgacgccgg aaccgttcag cttcgaaatt cagcgcatta cgtccggctt gcacgcgact 21840

tattcaatca tgccaaacgg gttggacgtt aacccgatgg aaattgttta cgacgcaatg 21900

acgcaaaaat ggggccgatt cggcaacctt gaaagcgaaa ttgatatgcc ttcgttcacg 21960

gcctgcgcgc aaacgctgta taacgaaggc ttgggtatgt cgcttattgt tcaatctgcg 22020

attaccggaa aagacttgtt ggaagaagta atgcgcgtcg ccgacggcgt gttgtatcaa 22080

gacccggcaa cggcgaagat tgttgcgaaa cttgttcgcc aagattacac aatttccgaa 22140

cttcttgttc ttgacgaatc ttccgttaag gaacttcgca atttccagaa aacaacatgg 22200

gaaaacacct ttaaccaatg ccgggttacg ttcaaaaacc gcgccagtag ttacgacgac 22260

agcgtagcaa ttacccaaga cttcgcaaat atcaactttc aaaaccgcgt taagtctacg 22320

gaagtttcga cgcccggcgt taccgacgca acggtagcaa gcaagattgc ggcgcgtcaa 22380

ctttcaattt tgaacgttcc gctttacaag tgcgacttga ccgttaaccg caaggcgcag 22440

aacttgcggc ccggaagcgt gttcgttctg aattggtcgc cgttcggcat ttcgaatatg 22500

gttatgcgtg ttacgaaaat tgatttcggc gaacttacgt ctaaccaaat caagctttct 22560

tgcgttcaag accgcttttc gtcttcaacg cttacgttcg caccgcccga aggttcagga 22620

tggacgccaa ttagtacgga accgacgccg gttacaacgc ggcttctttt tacgccgcct 22680

gcgttcctta cgtcaaacag cgaaaacgaa acactttcca attttgataa ctacggtcgg 22740

ttgtatcttg ccgcagttgc gccgggttct acgtctattt cttacgacgc aatgacggcc 22800

ccggacaatt tcagttcgtc gcctattctg tcgcttgaaa gtgccccgta caacggcggc 22860

ggcgtgttgc tgaacgccta cgcttcgaca gtcgccagcg aaacccgtaa cgatacaagc 22920

ggaagccttg tcgtaaccgg cgtgtcgcaa gcaagcattg aaggtttgca gcaatacacg 22980

acgctagacc aagcgcgcga cggttcggcc ttcctgctga ttaataacga actgttcgtt 23040

tatgtgggct tcgttgacaa tggcggcggt caagttactt tcccgaacgt gtatcgcggc 23100

gttctggata ccgtgccggg caatcatgcg gcgaacgacc gcgtttggtt cattagcgga 23160

accgacggac tgttgccgga acttgtttcg gtcggaacga cgcgatacgt taagcttttg 23220

gatacgactt cgggcggcaa gcttgatatt tcgttggccc cgtcgtttag cgggtcgctt 23280

accaaccggg ccgggttgcc gctgccgccg cagtacctaa cgcttgcagg aagccgcacg 23340

ccaagcccac aagtaggcgc aacgtcgatt gttgcggaat ggcgcaaccg cagccgggcc 23400

gataccttgt tgcgcgtgta tcacgacacg gcgaacacgc gggaagctgg caccgaaacc 23460

cgcgttcgct ggcgtgtagg cggcggcgct tacacgaccg ttacgactgc cggaagttca 23520

acaacccttg acgtaacggg caagtacggc acgctagaag ttattgtaga ttcgttcatt 23580

acgtcgaatt cgaaatattc gacgtacagc gattcgctta caatgaccct aacggcaccg 23640

ccgccgccgt aatcaaaaga acgacagcgc ggcggttttg gccttcttca accgcccgca 23700

gtcgtacaac atttcgaccg cttcgttaat gtaccaatcg taatttatat cgtcgggaaa 23760

ttccgtcggc aagtccatta cagggcgcgc gccgtcggtt ttcccgactt tgtttccgct 23820

ggatacgtaa gcaatatatc cggcttcgtt cttcgggtaa taccaacgaa cgaccttgcc 23880

aagataacga ccgttctttt cgccgccgcc gcgcacgttc tttactgcaa cgaagcgccg 23940

gaagtcgcgg cattccttaa ttgtcttttc gaccggcgtt ccgtcaacaa ggaaccgaac 24000

aacggcgtcg gaacaaatca gggtttcggg gttcttcgaa agaatcgaat tcaaagccga 24060

cccgcgttcg caataagcgc ccttcgtttt tgcgcccaac tgttcgtcaa taaagcgcgc 24120

ttcggggtcg ccgccgtctt ccttgattgc gacataacta ttaacgtcgc ggctgaatac 24180

ggctttatat cgcgtttctt cggtcttgta tcctgtccat tcttcccaag acgcaataag 24240

cgcccttact tcgtcgtgtc gcgatttgtg atacttggaa ataatgccgt cggtattgcc 24300

ggaaataact tcgatgccga tttgttccaa agcttcgata agcataagca acacaagttg 24360

cccggtaatc gttacttgca acataagttg cggcgcgtaa agcgtcgaat acttgttgcc 24420

aagcttgccg aagcttccgt taatggtaat tttcaaactg tcggcaattg tcttccattt 24480

cttcgcggct gcgcggtcgc ccgccttctt tgcctttgcc gcttcggctt tggcgtgaat 24540

tcgcgtattt acgatttttt cgtaaacggt caagaaagct tcgcccaagt gcggcgggca 24600

aagtctttga ttaaggattg ttcgcgggta aaacgattct acgtcgttgt ctgccaaaat 24660

tatttcgtcg gtcgcatagt gcgccgtttt cttttcggta gaatgcaaac cgcccatgcc 24720

tagtttgtac gtcgaaccgc caatggttac tttcagcttt tccagttcgg gcggcatgat 24780

tggcgacccc aagccgtcaa gatagaagcg ggcatttcgc acgacttcca gcatttcgcg 24840

aagctgcgtc gtttgatagc aaacgaagtc gggcacgtcg taaaccaaga ccgtatcggc 24900

ggatagtgtg ggcttcttcg gataatagcc aaggactttt tgaagttcgg agttaataac 24960

cgcttcggct acttgtgcgt ctgatttcga ccgaaggtct acgccgtatt cttccgacat 25020

ttcggcccgc aacttcaatt cgggcgcaag ttcgttaaaa agaagttcgg tattcgaaag 25080

gtcgttgcag caataaggcc gcactatttc ggcgtcttcc tgcgttaata catggtcttc 25140

gggaaacggc aagtcttgca tacgttcgca atgcaagcgc cccgcgtaca gcttcaacga 25200

accttgaagc ggcgcaactt ctataaggtc gatatgattg tatcggccaa tttgtacgcc 25260

gtacttcttt tcgaacgcga acggcgttac cttttcggtt ccatagttcg gcccgctttt 25320

aatgatgaaa tcggacgctt ctttaagctt cgcgcagctt gccccgcgtg cggctagttc 25380

aatcatcggc aagtcataat tacgcgaatt gaagccgacg atacagaacc gccaaagcat 25440

ccaaagaagc ttcgtcgggt taaaatcatg gtcggggctg cgttcgaacg cgacgaactt 25500

tccgttatca agcgacttaa acgctacgta aaagaaattt acgtaagttt caacgtcgaa 25560

gacgaagaca cttccggcag gcattgccgt tagttcttcg tccgacataa attcgacagg 25620

ccgcaaagcc tgtcgaatgc ttgcggccag cttatcgacg acgcggcttt tctttgcgac 25680

gataaagcct tgttcgttaa tcatgcgaaa gccccttaaa acggtatgtc gtcttcgtaa 25740

ttgtccgacg gattatgcgt cgcttcgctg ccaaggtcaa gacccataag aacgccgcgc 25800

aaattgtcgc cgaaaaatac gaccttgttt gcttccggtg cgaaatgcgc tttcttaaac 25860

gcatgttcga cggaaagaag caacttcgca gaaaagccca ttcgttccgg caagccttcg 25920

attttgtacg tcgaagcttc ttctttgtgc atcttcgaca aaaccgcgcc gtcgtcgaag 25980

aatacgtttc cgttcgggct gaatgactga atcgcgcgaa cgccgttgta aaaatcgtcg 26040

ggaaccggcc aagggttcaa accgtcaact tcgaaaacga cttggtaatt cgggtaacgt 26100

tcgccgtaaa gctgcgtttt gataaacgcc ccgttttcga aatagaacgt tgccgacgac 26160

gccgaaaagc cgaagccggt aagggccggg ccagccttgg cgacagcgac cgccgcgcac 26220

ttcggaagca tcatgccggg cggaaggtcg ataccgtgcc acgcttccag caaggccgcc 26280

ccgttggtcg cgacggcgct tccggcttgc agcaagacgg cggcataggt cgcattcggt 26340

gcgccgtctg tcgcaagccc tgcgaccgca gcgaaggccg ttttaatccg gtcgtcgatt 26400

gtggcgcatt gcgggtcggg cgcggtaatc ggcacgtcgt cgaagcccac acaaggcacc 26460

aacgcccgga acgcgccaga cgatacggca agggcgttcg cggtaagctg cgtaatcgac 26520

agttcttcgc cgaccttcga cagcgcgtcg ataaactgca acgtatgcgg gcacgctacc 26580

aagtcttctt cgataggatg cgcgacggtc aaaaccccgt cggaagccgc cgcccaattg 26640

tgggcaatat gcccgaactg aacgttcgtc ggcccggctt ttttctgcgc gatggcaacg 26700

aacttcaacg ccgccaaaag cgacgccgca gggcttggcc ccttcgcctt tttctttccg 26760

gctgcggctt gcctgcgcgc ccttggcttt ttcttcggct gttcggcggc tggcgcttcg 26820

tcttcgggcg gaagcggaat attactgtcg attttcattt tcggcccctt cttcgtcaag 26880

tttcgaaatt gccgcttgaa gatagttcgc taagtctagc gtttcttcta gcgcgtgttg 26940

caaccaatcg cgaagcgata acgggttatt atccgtcgtt acgccgtact ttgcaagtcc 27000

aacgattgaa cgttgcaaca gtaattcgcg gttcttttct acgtttttat cgggcgatgt 27060

ttcggccatt tgttcaccat tcagcggaaa gaacttcggg atactttttg ttcacccata 27120

cgcgaacacg gcgcggcgtg cgaagttctg aaacacgctg caaagcttga taagtcgtcg 27180

gcggcggttc ttcggcgtgc cgctgccgcc accaatcgcg cgaacgtttc gcagcaagcc 27240

ccggatgttc aagcattata aattcgttga acatttggaa gccgcaaaag taactaacct 27300

taatcatcgg cggtttcgtt agatttccgt ttgcgtcgcg cttttcgtgc aaattgtaaa 27360

gtaccttttg aacgtcgaaa tattcgacta tcggcgcgtc gcttcgcagc ggttccagcg 27420

ttccggcagt tgcaaacaac ttcgtttcaa aagtaaattc ggtgccgcag ttgatacact 27480

gccgggccgc agcgtgatta tatacgccgc atacgtcgca aatacgaacg ggcgcgtcgc 27540

cgccgccttt gcccggtctg ttcggaattc gcgggtcgtt gattgggcca agccttcgaa 27600

cgtttccggc aaagtccgcg tacaggcaat tttgtttgcc agtatccggc gacggtcggg 27660

ttccgcgtcc caacttttga acgtgtttgc ccggcgatag cgtcgggttc aaatcgccga 27720

taaagtcgat tggcggatgg tcgaaacccg ttgtaagttt ctgccctgat accaagccgc 27780

gaagttcgcc agctttgaaa gcgcgcaagc gttcggtatt ggtcttcgaa ggcaacttgg 27840

aatgaaccgg caaaacttcc aagccgtaag actgaattac gttcgcgacg tgttcggtat 27900

tatcaatgcc agttgcgaag ataagccaag tcgaacggtc gtaagctatt tcggtcattt 27960

cccgaacagc gttaaaaaca acttcgtcgg tatctacggc ggcttctagt tgcttgctgt 28020

tgaattcgcc agccgttacg cctactttcg acaagtcgat ttcggttcgc gtcggccttg 28080

cgataagcgg cgacaagtag ccttcggcga taagtcggtt aaacgattcg acgccggtta 28140

tatcgtaaca aatgtcggta aaaattccgt tgtcggtaat aagccccatt ttcattcgat 28200

agggcgttgc cgtaaatcca ataactttaa gatgcgggtt aatcttgcga agttcggcga 28260

taatgtattg gtaatgcgaa tcttccttgt cgcttaacaa atggcattcg tcgattaaca 28320

gcaagtcgcg ccaaccgaaa tggcgaagat gcgccgggcg tccgtcgtct tcttcaagcc 28380

cgcgtttaat cgcaggcgct acggactgaa cgccgccgaa tacgattggc ataatcatat 28440

cgcgggaatt caagcccgcc gaataaatgc ccattggcgc ggtcggccaa atcgacataa 28500

gcttttcggc gttctgttcg attagttctt taacgtgcgt aagcatcatt attcgttgat 28560

tcggccagta accgaaaatt cgacgaataa agtttgcaat tacgaccgac tttccggttc 28620

ctgtcggcat ggcgacgacg gggtttccga ccccgccgcg ctggaaataa tcgaatattg 28680

aatattccgc ttcgtcttga taccaacgcg gaacataaat attagacatt ctttgcaacc 28740

gctgtaattg gcgaataaga atcgcaaccc gtagcgatga aatcgcccgg aattacgccg 28800

ttgtgaactt cgcaaaacca ttcgccgttt tcgacaggat ttgcggcctt gcagcttcgg 28860

cagttctttt caggaatcgc gcccttgtgg caaatatcct tcgccgcgca atatccgcac 28920

ttgtgaaacg tcggattatc cgacaagcgc ggcggcgctt cctgcgacag aatgatttgt 28980

tcggccttct ccttcatttg ctggcctagc cgatggtcta gctttacaac ttcgcaatgc 29040

aagtcgtcgt cgttcttgtt aatgttcagg taaagaacat aacgaaaacg atattcgttg 29100

ccatacgtcg aagtttgggc gaaatgctgc ggcttgctta ctgccattcc ttgcgacatt 29160

aagtccgaaa agcctttgcc ggttccgttg gtcttgaatt ccagcaaaac gggttcgtcg 29220

ataccgtagc gttcgggaag ccgggcgatg ccgtcaagcg acccgccgaa gtgccccata 29280

acgccggaaa tgcggtattg tgggaattcc aagccgtcgg ctttcgcgcg tgcgacgtgt 29340

tgggcgtaat acggattttc gttcgtaata aggtcgcagc ccaacggcag ttcttcgcct 29400

tccttcaata tgccgtaact gtcgctttcg gcttggtaaa agaaaccgtc gcggttttcg 29460

taccaacatt gaacgccgat gccttccagc cattcgataa agcgggcttc ttcacggtgc 29520

ccacgattaa acaagcgttg cttgcgcccg tcggtttgtt cgcggaaaca ccaacggaag 29580

atataccaaa gcttccgctt gcattcgtcg ccaatcaaag acgcgccaag gtgccgacgg 29640

tgcccgccgt catacgtgcg aacgcaatat tcgtctatat cttctttaat gcgcttcgca 29700

agggcggttg caacgccggg cgcgtcaagg tctacgcttt gttttcctgc gtcggatttc 29760

gtcggctgcg cgtcgttcag cgttaattgt gcgttcttcg cgtctttgct gttttgcatc 29820

gttcttcacc ttgcgccgca taagggcttc gtaattgttc gctagataat ccgccgaaag 29880

tgtcgcaacg tctttaagtt ggtctttcga cagccaagat atatggcatt ccgacgggtc 29940

gattcctaat tggttcgcaa gccaattgta cgccttcgcg cgcgacatta agccggtttg 30000

ccaaaggcgg tcgaattcgt tatgggcttt cgttcgaagc tggcgcgttg ttctgtcggc 30060

catacgaccc aacggaataa acgtgcccgg atggcaacca acggcggcgc gacaatcatt 30120

gcaataataa atgtgcggcc aattgccata agttcgcccg taaatcttgt cgttcgttgt 30180

tagttcaatg ttgaacgaac aacaagtatc gcattgttcg ggcgtcggca atgcgtcttt 30240

tattttcgac ataagttcgc atactcctta aaaagaaacg ccggggccgg ttaagacccc 30300

ggcgaatcta cgccgcgacg gcgttacgcc ttaacgctgg ccccaaggtg ccgcgcctgc 30360

cggtgcgccg ccctgcgcgg gctggccgcc gccctgttgc cagccgccgc cctgcggttg 30420

ctgctgcgcg ggctgttggg caggctggcc gccccatgcc ggttggccgc cctgcggggc 30480

cgggttctgc gccggttggc cgccccaagc tgcgccgccc tgcggctgtt gggccggttg 30540

ctgcgcgggc tgctgctgtc cgccccaagc ggcaccgcct gcgggctgct gcggctggcc 30600

ctgcggggca ccgccccaag cgccgttcgg ctggccctgc ggctgctgtt gctgcggctg 30660

cgctgccgct gcgcctgcgc cagccttgcc cggttcgttc ccgttcatat cgaagacctt 30720

tttaacttcg gtatactgcg ggtcgttttt ctgcgggccg acttcgataa gaaacggcag 30780

gttgtgaagc tgcgacgaat cggtaacttg gaacacgccg attacgtggc agattgccga 30840

aagctggcga tgcgcgattt cgacggtctg ttggttggaa tggtacaggt tcaggcgata 30900

agcgccggtc gtgccctgct gcgggccgtc gataatccgc aagttcagtt gcagataacc 30960

gccgtcgttc gccttgttgg ccttgacttc ggaagattcg acgataaccg gatgcttgcc 31020

aatcggcagg cttccgacgc cttgggtcgg gtcgtactgt tgggcgttga acgcttggat 31080

aagttgcatg atgtttcacc ttttcgaaaa gtcttcgcca ttggttacgg cggcgaagta 31140

aaccgtttta ttgcatcgct ttcgcgaaca atgcggtaag gtcgggctgt tcaagttcgt 31200

taagattgcc caaacggtcg cgcgcgaaaa cttcgggaat ttccttcgtt cgcagcgccc 31260

gaaccggctt cggcattccg ggtacgcttg cttcgcccaa gtgcataacg ttatcgaaca 31320

aatgcggaac tttaacgtta aggtctttgc ccggaaagaa cgggcgtttt tgcataatcg 31380

gttcgtaagt aacttcgccg ttctgcaaaa tcgtttgccg tccgttttcg acaagggctt 31440

gctttgcaat cattacgata tgcttttgcg gcatgtaata caagtcgttc gcgattttca 31500

ttacacgttc ggacatattg ccgtaagcct tcataccgtg tttaaccttg cccaattcgt 31560

cggccaagat aatttcggcg atgttcgaaa tactgtcaat acccaacgta tcgaaattcg 31620

cagcttcgcg cgatttcata aaccattcga agaattcgac gataagcgcg ggcgaatacg 31680

cttcccatgc gggaacgttc gaaccgcgca tggacagcat accgggttcg gtcacaagca 31740

aaaccggacg cggcgcagta ttgataagcg gcgttttgcc ggaaccgggc gcaccgaata 31800

cgacggactt tacgccgtag cggcgggcca gttgcgacgc cggttttaat tgcgacattt 31860

gcataacttg caccttcggg aatggccccg gcgcttgtgg gcaaccgggg cggggttgtt 31920

acttcgactt cggcgcgaca agttcaagcg cgggcgttgc ttccttcgac gttacaactt 31980

cgtcgataag cttacggaac ttgtcgggaa ggttcttgta ttcggtaacg gaaagttcgg 32040

gcttccattt taccaaacgt tcggcgataa attcgccttc ggggccggtc ttttcgattt 32100

tctgcaaagc cttttcgacg gcttcttggc cgcctgcgaa gctgcggtta atcttaaaaa 32160

cggctttcag cttgtaacct gcgccaagtt cgacgttttc ggttccttcg cgcaaagctt 32220

cggggtcgaa agcgaaagcg tttttcagaa cttcggcgcg caatgcggat tcggcttctt 32280

tcgctgcggc aagcgccttc gttgcttcct gccattgcag aatcaaagcg tcgcggttag 32340

cgttttcgtt gaaagacatt gttgttactc cttcggttgg gccgccgcac aattgcgccg 32400

gtatgtacga actatacgac ggcccttcgt tactgtcaag cccctttttc aagaattttt 32460

cgttcttcga acaagtcgcg attgttggcg tcgaattcgg taaaggcgtt cgggaagcga 32520

cgacgaagct tcgcgatgtt gaccgactgc gcttcgccga agttcgaacc aatggcgcgc 32580

agcaaaagcg catcgtacca aaagccgtcg ccgacttctt caagcgcgtt aacagcgtcg 32640

aaagcttcgc cttcggctgc ggcgcttagg gcttccaaca gttcgcccgc ttcggtcgcc 32700

ttgccgataa ttgcatgaat gacgttcacg gctgcggcgt cgtcttcggg gcggtcggaa 32760

atccattcgg gaagcttcgc cagcgttgcc gcgttggctt ccggggccgg aacgccagcg 32820

tcgcgaccgt agaacatggt tttctcgatt gcgtcaagct tgttaagggc ttcgacggct 32880

tcggcgatgg tttcgcggaa gtaggccagc gacacgcggt cgccgtaata cttatccgac 32940

gcggttacgt gcgcttcttc gatatagtcg aaggtctttg cgggttcgtt catacgttca 33000

ccttttagaa gggccgggca ccatgcgcca gcgttccagc actgtaaccg accgcgcctt 33060

tcctgtcaac aacaattgac agcaagcaag aagccgggta agctgcccac aattgctaga 33120

aggtggcgtt atggacattg aagaacttac gaagcgggta aagaaagcaa gcgtcgggcg 33180

gtcgctgcgg gcgctggccg cgcaatgcaa cgtttcgcac gaacttataa gaaagctttt 33240

gcttgccaat tctgcgccga acataacggc gacgacttat aacaagattg ataaaggatt 33300

ggcgaagaat ggactttaac aatattccgc acgaaatgcg gatttacccg caatgggtcg 33360

tttggcgata cgaagacacg gattcaaaga aaccgacgaa ggttccgtat tcagcaaaaa 33420

ccgggcacct tgccagcgta accgacccga acacttgggc cgggttcgac gaatgcgtta 33480

acgctatgtc gtccggttgg tatgccggaa tcggtttcgt attgactgaa aacgacccgt 33540

attcgtttat cgaccttgac gacacaaaag gcgaccaaac ggcgcttgac cgccaaataa 33600

agatttttaa cgaattcaac agctacgccg aacggtcgcc ttccggttcg gggttgcata 33660

tcatcgttaa gggcgcgatt ccgtcgggcc gccgtcgttc gtttatcgaa gtttattctt 33720

cgcttcgtta tatgacaatg accggcgacg tttaccgcaa cgcaccgatt aacgattgta 33780

acgaactgtt aaacgttctt tggggccaaa tggggcaagg ttcggtcgcc gtcgcgcatt 33840

atgccggact tgccgaagcc aaggaaaccg acgaacaggt ttataaccgc gcagtcgccg 33900

cagccaatgg cgacaagttc gccgaactgt acgcgggcaa atgggaaggc atgtacgctt 33960

cgcagtccga agccgacttt gccttggtcg atattatcgc gttttatacg cagaaccggg 34020

cgcagatttc gcgaatgttt cgcgcgtcgg gcttggggca gcgtgacaaa gcaaaacgcg 34080

acgattacgt ttcgtacatg ctgaacaagt gtttcgaccg catgttgccg cccgttgacg 34140

ttgacggatt gcgcaacaag ctagacgaag ccatagcgaa gaaagaagcc gccgacaggg 34200

ccgccgcgtt gtcgcagaac agcgaagcga cgccgcatcc gaaagccccg gccccgaacc 34260

ttagcgaagt ttcgaaggta tacagcgtgc cgcccggatt agtcggagaa attgcgcaat 34320

acatttacgc acaagcgccg cgcccggtgc ccgaaatcgc gttggccggt gcccttggct 34380

tggtcgccgg tattgtgggc agggcgtaca acatttccgg cactggcctt aatcaatacg 34440

ttctgttgtt ggcaccgacc ggaacaggta aagaagccat cgcaagcggc attgataagc 34500

taatggcgca ggttatccga accgttcccg ctgcgtcgga ctttatcggc cccggtgaaa 34560

ttgcgtcggc ccaagcgatt attaagtata tgtcgcgcgg cccaacgtcg ttcgtttcgt 34620

tggtcggcga attcggcatt taccttcaac aaatggcaag cgtaaacgca ccgccgcacc 34680

ttaccgggct tcgtcgcttc ctgttggatg cttacaacaa gtcgggcgaa ggcaaggtac 34740

ttcggccttc gatttattca gacaaggaca agaacacgac cgccgttctt tcgccgtcct 34800

ttaccttgct tggcgaatcg acgcccgaaa agttttacga aggtttgcac gaaggtttga 34860

tttccgaagg tctgttgccg cgttttacga tgattgaata tcacggcgaa cgcccggcgt 34920

tgaatccggg gcacctgtcg gcccaacctt cgttcgaact tatcgacagg ctttcgacct 34980

tgtgcgccca tgcgctaatg ctgaacagcc agcataaggc gattcacgtt caaaccgacg 35040

caaccgcccg cgaactgttc cagcaattcg acgcgcattg cgacgcgaac attaacacaa 35100

gcgaccgcga agttcggcgg cacctttgga accgggcgca cgtaaaggcg ttgaagctgg 35160

ccggaattat cgccgtcggc tgcaaccctt acgacccgac cattaccgcc gacgttgcgt 35220

cttgggcgat taaccttgtc gtcgccgacg ttcgaaactt gcttgcccgg ttcgatgctg 35280

gcgaaattgg catagacaac gacgaaacga aacagcttgc gaaggttatt gcaaccgtta 35340

aagatttcgt cgtttcacct tggccggacg ttgcgaagta cgcaggcgaa ggaatgtcca 35400

accttcattc gaaccgaatt gttccgtaca gctacgttca acgcaggctt gccgctgttg 35460

ccgtctttcg taaagaccgc atcggcgcaa gcggggcaat caagcgcgcc ttgaagaccc 35520

tttgcgaacg cggcgatttg caggaagtaa gccgggccac actggcgaag gattacggaa 35580

caagcgccgt tgcatacatg gtcgcgcatc cgggcgtttt cggcctgtaa cgcgcgcccg 35640

ccagtgtggg cagaacgggc cgccttcggg cggctttttc gtgcctgtaa aaaaaagttc 35700

gtcgtacctg ttgacgtagc ttcgaactgt acgtagaata caaaccatcg aagcaacgaa 35760

acaaaccaag gaaccgaagc catgaacgta accaacctta aaaccgccgt cgaaatcaaa 35820

attgaaattg aattggccgc ttgggccaac ggcgaaaaga aagttaacgt ttccaaccaa 35880

ttcgacgaaa gcgttttgga atcggccaaa gaagcaatta gcgtcgaagc aatcgccgca 35940

atcgttgcca agtatccggg cgcgaacttc gaaggctttt cggttatgac ttgggcgcac 36000

gaactttcgg cgttcaaagc cccggaaatc gaccgggctt ggttcgacta agcaagcgcc 36060

cttcggggcg ttttttttgt tcgtacctat tgacgaagct tcgaagttgc cgtatattta 36120

aaccatcgaa gcaaacaacg aaggactaac gaacatgaac gcacttaaca acattcaacg 36180

ggtcgtaagc tggaacagca agaagaacgc cgacggcacc tttaccgcta ccgcgtacag 36240

cttcgaccat aacgcgccga ccgtcgtaca tgccagctac acgcgcgcca gccgcgccca 36300

agccgtcgca gacgccaaga aggccgttcg ttacctgaaa gcccaacagc gcaccgcgta 36360

aggagtcgcc gccatgtttg cccattactt cgccagcaag aaaacgaagt tcgttgtaat 36420

cagcgaaacg aaccgcccgg aaggccagcg aatcgccgta agcggcaaag ccgaagcccg 36480

cagggtcgcc aaggaacgca acgcgcagcc ttggaacttc taaccccggc cacggccctt 36540

ggcacgcgct aggggccgcg cagcctgccc acattaagcg aaggacgacc gaccatgcgt 36600

acaacccttg cagccgtaaa caaagccctt gccgccgctg gaatcgacgc ggaattggtc 36660

aagggtcgcg ggtactttta cttcgttggt tccgccgtag attgcgccaa agaacaaggc 36720

gtttacggcg tgtatcggct ttccgaattg accgtttccc aatgggtcga agaagcccgc 36780

caacgtatcg aaaaggagta agaacaaatg accgcatatt ttatcgcatt tggcgtcgcg 36840

cttgggttgg cccttgcgcg cttggccgct tcccaattcg aagccgcttg ttacctgttc 36900

tgcaacggcg aatttcgaaa ggcattccgg gcaacgatgc acgcccttac ctgcgttgcg 36960

ttgcttgcgt tggttgtttc gcccgttgct tcgttcttcg atagcttcga agttataagc 37020

attgaacaac cttcgcccaa tccttcgaag ggtcttcgcg tataatagcc gacgggtcgt 37080

ataatgggca cgtataagcc ttaaaccctt gatacataag gctttcagcg gattcataac 37140

aagtataacg tataacgccc ttgaccctga aaccccggcc caatgttata aattaagctt 37200

tctttatata gattgatttt tagttattat acttattaaa tttattatat ttccttattt 37260

atcaaggact tagcagctat acagcccctt caattcgtat aacgggcttt ttgtgttata 37320

acgttgttga catacaaact ttataaggct atgattccgg cacgcactaa cgaaaggggc 37380

ttgcaatgtc ttacgaaata atcgaatgtt cgccgaaggc gcgaagcaaa attaagtcgt 37440

tcgaagatgc gctaggcgtt gacgccgaat tgacgcacca acgttcgaag tatccttggc 37500

cgctgttgaa aatcggccag tcgttcgccg tgccgttggc cgaaggtaac gaagcatcgt 37560

tgcgaaacgg cgcgtcgcag ttcagcaaga agaccggcaa gaagtttgcg gttattcggc 37620

attctgaata cggctgtttc gaatgcgcgc gcatcgctta gcgccgggcc aatgtgggca 37680

acaaccgaag gggcaaccaa tgtacgaaat cgaaaccggc cataaagtgc cgaagcaacg 37740

tcgcaaggct ggaagcgtgc cgaaggccgt tcaacaggcg ttcaacgact acgccgaagc 37800

gtataaggcc gtttacggcg ttcgcccgct gtcgttcacg tatgaccgcg aaagcggctt 37860

tattcgtgtc gaaagtagcg gcggcgtaag cgtcgcaagg ctgcgcgaaa tgacgaaaca 37920

gcttcgttac cgaaaaggat aaaaaaattc gttcgaaggg ttgacgtact gtcgaagccg 37980

tcgtactata tacccatacc aacgaacaca aggaaccgcc gaaatgcaaa acgtccaaat 38040

caaacgcccc gcagcgatta ccgaaggcca agcaatgaac gcagttttcg acgccttccg 38100

ccaagtgtgg cgcaacgtcg aagcccgcgc cgaaatgctt aaaggcgttt cgcagtcggt 38160

caaggtcggc ggcttcgaag tgtcggtttt cgcatggcgc gacggtcgca ttcaagccaa 38220

cgtttacgca ggcggcttta accccgtcgc aaccgccgaa gttgacgaat tcgacgccta 38280

atcaaccaag cgcgccgggc gcaacccggc atttttgaag gagttataac aatgtgcatc 38340

gtatgcgata ttaaacaggc cgtcgaagct tccggcccga acaaagaaga ccgcgccaaa 38400

atccttggct tggtcgaaaa gctggccgaa gccttgggcg atgttctgga agtcgcgcag 38460

gaagtacacg aagccaagcc cgaagcgttc cagccggaac acgtcgaacg cttgcagaac 38520

gccgccgact tgctgaacga ccggggcgaa ctgcccgacg ccctgttggc cctgctgttg 38580

gccgcccttg ggcgcggcgt caaggtcgaa acaatccgcg tcgaactgcg cgaaggcgaa 38640

acgccagaac aggccgtagc gcgtgtaatg gccgaacgcg aaggcggggc cgcgacgaaa 38700

cactaaccaa agcgccccgg ctgttgtata gtcggggctt ctttctatca tggggaacga 38760

aagaacatgg cggacgaagt agaccaaaca gccgaccgaa tagaaaacga agtaagcttt 38820

acggtcggcg aactttgccg aaaggccgca gcgatacccg caggccgtcc gggcgaatgt 38880

gatttttgcg gcgaacactt cgcgcgcgtt gtcgaagtga ccgacccgcg aacgggcgaa 38940

gtcgtcgaaa gctgcggtcg ctgtcgtgac cgaaggggca tcgcatgacg cccgcaaccc 39000

ttgccaagtc tggcaccgaa cacgcgcacc aaacggcgct ttttgcctat gctgccgtcg 39060

catacttaca cggcttcgac gttgccgacg aatggtcaaa gaccggcaag ctaccgaagc 39120

gcgacccgga cgcaccgccg aaggtgcccg cccttgaatg gttccacgcc ataccgaacg 39180

gcggcagtcg cggcgacgac gacaagtcgc gaaagatacg cggcgcgcag ttgaaggccg 39240

aaggcgtgcg gcagggcgta gccgatacgt tcttgccttg gcctgtttac gaaccgtgcc 39300

caagcgaccc gcaaataatg atgatgaaat gggccggtct ttatatcgaa atgaagaagc 39360

cgaccgaacg tccgaagtcg gaaaccgcaa agggcggcgt atcggacgaa caacgcagct 39420

tcggcgaata cgcaaagcgc gtcggctatg gttgggccgt ctgctatgat tgggaacaag 39480

cggcgtcgta ccttcgttcc tatatcgaat ggggttcgta atggggcttt cgtgccttgc 39540

ctgcgaactt acccgcgccc ggttgaaagc ggcggcgctg gcccttgtgg gctggcccct 39600

tgaccgcatc gccgggcatt tgtcgtcatg ctatggcgaa cggtattacg tcgaaggcgg 39660

caagctgtat cgcgcgtcga agttgccgcc gtatcaaccg cacttgataa ggggcgaaga 39720

atgaaaaaga ccgacgaaga attgatagac gaagcccgca gcattgcgcg ttcgaaacgc 39780

tgtttcgtcg taacgaagcc gggttattgg ctgttatacc gcgaatgcac gccgcgtaac 39840

gtatgcgtcg gcaaacggtc gtcggctgcg gcgttgcttc aacttgcgaa aaaggcttga 39900

cgtagcttcg aagctgtcgt acacttcttc gtaagttgaa cgaacaaagg agtaacgacc 39960

atgcccgcat ataacgtaac aaccgaattc gaaatgaccg acggtcgcgt tctgtcgtgc 40020

gaatacgtct tgtcggttac gcccggtcgc tattccggcc cttgggaaga ttgttacccg 40080

gacgaatccg acgcaggcga accgacgtat tttatcgacg gcgaagaagt cgattacaaa 40140

gaacttccaa aaggattgga cgcaatcgcc gacaagcttt acgaagctgg cgacggcgaa 40200

tacaattaca aggaagaacg cgacgaaccg gattacgaac cggattacga ttacgattat 40260

taacgaagga gtaacgaaaa tgtcttggct tattggttgg gccgtacttt ccgtcggcgt 40320

tgttgtcggc ttcttgcttg cggccttgct gcgggccaac gggcgcgacg tgccggttcc 40380

ttcggctacc gttaccgccc tgtcgccgca ggaacgcgcc cgcatgggct acgcgctggc 40440

aagggctggc gacttgctgg acagcggcga ccttgaatac gtgtcgggcg gctttatggt 40500

gcaagacgta ggacacggcg tcgtaattat caaaggcgat ttgtcgttgc gggttgccga 40560

agatgaataa ggacgaagcg cgcgaaatgt tcgaagccgt caaggccaac cgggcgaaga 40620

ttgacggttg cgcccgccat cgcttcgaaa tcggcgaccc gccgtacacg ttcgggcaaa 40680

agttcacttg ttcgaactgc ggcggaacaa tggacgccgt acaggcgttc cgatactgtc 40740

aaggcttcaa ggccgcaggc ggcgacccga acgaagttat accgggttac gaataacgct 40800

tgacaagcgg cgaaggttcg gcgaaactta gacgtaacga agaaaccccg ttaaggagtt 40860

gccgaaatga ccgttctaat tttgcttctt tgcaccgttg ccgctttgtt cattcatcgc 40920

atgtttgttc gtccgattct ggattggttc gaacaacgcg aatacgccga acgtatgcgc 40980

gaagctgaac agcgcgcggc gttggaagaa gcaaggcggg ccaagtgtcg ataatctacg 41040

caccgcgcga cgccctgtcg aaatgggacg cgcgatttat tgaactggcc gaacacgtcg 41100

ccggatggtc gaaagggccg cgtaagcgca tcggcgcggc tatcgtgcgc ccgaatcggt 41160

cgattgcgtc gcttgggtac aacggcccgc cgcgcggctt cgacgacgcc gtttttctga 41220

acatgacgcg cgacgaacaa cacgcggtcg taattcatgc cgaagacaac gcaattcgac 41280

aggctgcgcc gggcgaagac ttgtccgcgt gtacgctgta cgtttcgccg ctgtttccgt 41340

gcgccatttg tgccgaccgc attgttcggg ccggtatccg tcgcgttgtc gcttattgtg 41400

ggcatatatc gccagactgg cgcgcgtctg ccgacgaagc cgaacgcatc tttaaccaag 41460

cgggcgtcga atgcctgttt acaatggatt aacgaacatg aaaccgctag accattcgca 41520

aatcgaaggc ttgttgttct atcaagaccc gacaacgcaa aactatatcg gcgcaccgaa 41580

ggccgacccg ttcaaccaag ccggaagctt cgtcgcattc gggccgcgtg ttaccgttga 41640

cccggcgttg tataacttgc ttgccgcagc gccgacaatg taccaagccc tttcgatgca 41700

atacgcttac cttcaagcgc aaatcgaagt tatcgaacgc ttgccaaagg cgggcgaact 41760

tgataagctg ttgtcgtcgc taatcgaagc gcagaacgct tgcctaatgg cccaacgtat 41820

cgcgcaagtc ggttacgaaa atgtcgcaaa ttcacttgac aaaggttcga agcggtcgta 41880

agcttgaacc atcgaaacga acaaaggtgc ccacaatgaa ccgtaagctt cttgttatcg 41940

ctggaatcgt cgccttcgtc gcgttgcttg gcatggtcgg gcaaatggac ttcgaagacg 42000

aagcccgcgc gcacctgttg tattgtgaca acgtagcgaa cggcgtttgg ccggattacg 42060

acaaaattta cgattctgaa tgcacgcccg aacgcatcgc agaaatcgaa gaaattttgc 42120

gttgaccgct tgacacgaag aacggtcggc gtaaaatcaa cccgtcgcaa caacgcgaca 42180

taaccttaac gttaaggagt tacacaaaat ggctaccaag aaatcgaccg cgaagaagaa 42240

caccgccgcc ccggttatcg gccttgccga aattgttgca gccgggccga atggtctgta 42300

tacttcgcct gccgtacatg gcccgcttgt cgaagccggt atggtggaaa tcaacccggc 42360

aatgaccaac gaagcgggcg aaatcgcaac ccgcgcaacc caaaaaggaa tcgacgaaat 42420

gaaccagaac accgaaaccg gcaccgccgc agcttccgcc ccggtcgcta cttccttcgc 42480

catcgaagac aacgtaccca tgccgaccgg cagcggtcgc ggtcgcggcg gcaacgtcta 42540

cccgttcgac gcgctggaag tcggccaaag cttcttcgtt ccgaacagcg aagaaaagcc 42600

gaacgccgcg aagtcgcttg cttcgaccgt ttccagcgca accgcccgtt tcgccgtgcc 42660

ttccgaagac ggcgcgacca agaccaacaa gaagggcgaa accgtgcccg tcatggtcga 42720

aacccgcaag ttcgttgttc gttcggtcga aggcggcgcg cgcgtctggc gcaccaagta 42780

agcgacggcg cgggctacgg cccgccctac gcctacgctt caacggaaac cccggccatt 42840

gcgccggggt tttcttttgc ttttcttgtc aatttgtgct aatccgtgct aatcttcggc 42900

caaatacatt tcggggccgg ggcttgtgat ga 42932

<210> 14

<211> 42932

<212> DNA

<213> Artificial Sequence

<220>

<223> s4 phage变体

<400> 14

tcgaagggtt gacgtactgt cgaagccgtc gtactatata cccataccaa cgaacacaag 60

gaaccgccga aatgcaaaac gtccaaatca aacgccccgc agcgattacc gaaggccaag 120

caatgaacgc agttttcgac gccttccgcc aagtgtggcg caacgtcgaa gcccgcgccg 180

aaatgcttaa aggcgtttcg cagtcggtca aggtcggcgg cttcgaagtg tcggttttcg 240

catggcgcga cggtcgcatt caagccaacg tttacgcagg cggctttaac cccgtcgcaa 300

ccgccgaagt tgacgaattc gacgcctaat caaccaagcg cgccgggcgc aacccggcat 360

ttttgaagga gttataacaa tgtgcatcgt atgcgatatt aaacaggccg tcgaagcttc 420

cggcccgaac aaagaagacc gcgccaaaat ccttggcttg gtcgaaaagc tggccgaagc 480

cttgggcgat gttctggaag tcgcgcagga agtacacgaa gccaagcccg aagcgttcca 540

gccggaacac gtcgaacgct tgcagaacgc cgccgacttg ctgaacgacc ggggcgaact 600

gcccgacgcc ctgttggccc tgctgttggc cgcccttggg cgcggcgtca aggtcgaaac 660

aatccgcgtc gaactgcgcg aaggcgaaac gccagaacag gccgtagcgc gtgtaatggc 720

cgaacgcgaa ggcggggccg cgacgaaaca ctaaccaaag cgccccggct gttgtatagt 780

cggggcttct ttctatcatg gggaacgaaa gaacatggcg gacgaagtag accaaacagc 840

cgaccgaata gaaaacgaag taagctttac ggtcggcgaa ctttgccgaa aggccgcagc 900

gatacccgca ggccgtccgg gcgaatgtga tttttgcggc gaacacttcg cgcgcgttgt 960

cgaagtgacc gacccgcgaa cgggcgaagt cgtcgaaagc tgcggtcgct gtcgtgaccg 1020

aaggggcatc gcatgacgcc cgcaaccctt gccaagtctg gcaccgaaca cgcgcaccaa 1080

acggcgcttt ttgcctatgc tgccgtcgca tacttacacg gcttcgacgt tgccgacgaa 1140

tggtcaaaga ccggcaagct accgaagcgc gacccggacg caccgccgaa ggtgcccgcc 1200

cttgaatggt tccacgccat accgaacggc ggcagtcgcg gcgacgacga caagtcgcga 1260

aagatacgcg gcgcgcagtt gaaggccgaa ggcgtgcggc agggcgtagc cgatacgttc 1320

ttgccttggc ctgtttacga accgtgccca agcgacccgc aaataatgat gatgaaatgg 1380

gccggtcttt atatcgaaat gaagaagccg accgaacgtc cgaagtcgga aaccgcaaag 1440

ggcggcgtat cggacgaaca acgcagcttc ggcgaatacg caaagcgcgt cggctatggt 1500

tgggccgtct gctatgattg ggaacaagcg gcgtcgtacc ttcgttccta tatcgaatgg 1560

ggttcgtaat ggggctttcg tgccttgcct gcgaacttac ccgcgcccgg ttgaaagcgg 1620

cggcgctggc ccttgtgggc tggccccttg accgcatcgc cgggcatttg tcgtcatgct 1680

atggcgaacg gtattacgtc gaaggcggca agctgtatcg cgcgtcgaag ttgccgccgt 1740

atcaaccgca cttgataagg ggcgaagaat gaaaaagacc gacgaagaat tgatagacga 1800

agcccgcagc attgcgcgtt cgaaacgctg tttcgtcgta acgaagccgg gttattggct 1860

gttataccgc gaatgcacgc cgcgtaacgt atgcgtcggc aaacggtcgt cggctgcggc 1920

gttgcttcaa cttgcgaaaa aggcttgacg tagcttcgaa gctgtcgtac acttcttcgt 1980

aagttgaacg aacaaaggag taacgaccat gcccgcatat aacgtaacaa ccgaattcga 2040

aatgaccgac ggtcgcgttc tgtcgtgcga atacgtcttg tcggttacgc ccggtcgcta 2100

ttccggccct tgggaagatt gttacccgga cgaatccgac gcaggcgaac cgacgtattt 2160

tatcgacggc gaagaagtcg attacaaaga acttccaaaa ggattggacg caatcgccga 2220

caagctttac gaagctggcg acggcgaata caattacaag gaagaacgcg acgaaccgga 2280

ttacgaaccg gattacgatt acgattatta acgaaggagt aacgaaaatg tcttggctta 2340

ttggttgggc cgtactttcc gtcggcgttg ttgtcggctt cttgcttgcg gccttgctgc 2400

gggccaacgg gcgcgacgtg ccggttcctt cggctaccgt taccgccctg tcgccgcagg 2460

aacgcgcccg catgggctac gcgctggcaa gggctggcga cttgctggac agcggcgacc 2520

ttgaatacgt gtcgggcggc tttatggtgc aagacgtagg acacggcgtc gtaattatca 2580

aaggcgattt gtcgttgcgg gttgccgaag atgaataagg acgaagcgcg cgaaatgttc 2640

gaagccgtca aggccaaccg ggcgaagatt gacggttgcg cccgccatcg cttcgaaatc 2700

ggcgacccgc cgtacacgtt cgggcaaaag ttcacttgtt cgaactgcgg cggaacaatg 2760

gacgccgtac aggcgttccg atactgtcaa ggcttcaagg ccgcaggcgg cgacccgaac 2820

gaagttatac cgggttacga ataacgcttg acaagcggcg aaggttcggc gaaacttaga 2880

cgtaacgaag aaaccccgtt aaggagttgc cgaaatgacc gttctaattt tgcttctttg 2940

caccgttgcc gctttgttca ttcatcgcat gtttgttcgt ccgattctgg attggttcga 3000

acaacgcgaa tacgccgaac gtatgcgcga agctgaacag cgcgcggcgt tggaagaagc 3060

aaggcgggcc aagtgtcgat aatctacgca ccgcgcgacg ccctgtcgaa atgggacgcg 3120

cgatttattg aactggccga acacgtcgcc ggatggtcga aagggccgcg taagcgcatc 3180

ggcgcggcta tcgtgcgccc gaatcggtcg attgcgtcgc ttgggtacaa cggcccgccg 3240

cgcggcttcg acgacgccgt ttttctgaac atgacgcgcg acgaacaaca cgcggtcgta 3300

attcatgccg aagacaacgc aattcgacag gctgcgccgg gcgaagactt gtccgcgtgt 3360

acgctgtacg tttcgccgct gtttccgtgc gccatttgtg ccgaccgcat tgttcgggcc 3420

ggtatccgtc gcgttgtcgc ttattgtggg catatatcgc cagactggcg cgcgtctgcc 3480

gacgaagccg aacgcatctt taaccaagcg ggcgtcgaat gcctgtttac aatggattaa 3540

cgaacatgaa accgctagac cattcgcaaa tcgaaggctt gttgttctat caagacccga 3600

caacgcaaaa ctatatcggc gcaccgaagg ccgacccgtt caaccaagcc ggaagcttcg 3660

tcgcattcgg gccgcgtgtt accgttgacc cggcgttgta taacttgctt gccgcagcgc 3720

cgacaatgta ccaagccctt tcgatgcaat acgcttacct tcaagcgcaa atcgaagtta 3780

tcgaacgctt gccaaaggcg ggcgaacttg ataagctgtt gtcgtcgcta atcgaagcgc 3840

agaacgcttg cctaatggcc caacgtatcg cgcaagtcgg ttacgaaaat gtcgcaaatt 3900

cacttgacaa aggttcgaag cggtcgtaag cttgaaccat cgaaacgaac aaaggtgccc 3960

acaatgaacc gtaagcttct tgttatcgct ggaatcgtcg ccttcgtcgc gttgcttggc 4020

atggtcgggc aaatggactt cgaagacgaa gcccgcgcgc acctgttgta ttgtgacaac 4080

gtagcgaacg gcgtttggcc ggattacgac aaaatttacg attctgaatg cacgcccgaa 4140

cgcatcgcag aaatcgaaga aattttgcgt tgaccgcttg acacgaagaa cggtcggcgt 4200

aaaatcaacc cgtcgcaaca acgcgacata accttaacgt taaggagtta cacaaaatgg 4260

ctaccaagaa atcgaccgcg aagaagaaca ccgccgcccc ggttatcggc cttgccgaaa 4320

ttgttgcagc cgggccgaat ggtctgtata cttcgcctgc cgtacatggc ccgcttgtcg 4380

aagccggtat ggtggaaatc aacccggcaa tgaccaacga agcgggcgaa atcgcaaccc 4440

gcgcaaccca aaaaggaatc gacgaaatga accagaacac cgaaaccggc accgccgcag 4500

cttccgcccc ggtcgctact tccttcgcca tcgaagacaa cgtacccatg ccgaccggca 4560

gcggtcgcgg tcgcggcggc aacgtctacc cgttcgacgc gctggaagtc ggccaaagct 4620

tcttcgttcc gaacagcgaa gaaaagccga acgccgcgaa gtcgcttgct tcgaccgttt 4680

ccagcgcaac cgcccgtttc gccgtgcctt ccgaagacgg cgcgaccaag accaacaaga 4740

agggcgaaac cgtgcccgtc atggtcgaaa cccgcaagtt cgttgttcgt tcggtcgaag 4800

gcggcgcgcg cgtctggcgc accaagtaag cgacggcgcg ggctacggcc cgccctacgc 4860

ctacgcttca acggaaaccc cggccattgc gccggggttt tcttttgctt ttcttgtcaa 4920

tttgtgctaa tccgtgctaa tcttcggcca aatacatttc ggggccgggg cttgtgatga 4980

atgaacgaac aacaattttt taacgtagcc gtcgcaatta tcggcgcgtt gggcggttgg 5040

tggatgcgcg ttatgtggca gtcacttaaa gaacttcaag cgcaagattc gaagttggcc 5100

gataaagtcg gcaatatcga agttcttgta gccgggcagt atgtcaagcg cgacgatatg 5160

aaccgcgaca taatggcgat tttcgccaaa cttgaccgca tcgaagacaa gatagacaaa 5220

aaggccgaca aatgaagaag cccgaactta tcgaagattg gcgcgaatgc tggcgctttt 5280

ggtcggttcg actggccgca gtcggcaccg caattactgg ccttcttgtt gcgtttcccg 5340

acgcagcgtt ggccgcttgg gcaatccttc cgcacgaatt gaagtcgtcg attccgccgc 5400

agtatatgcc gcttatcggc gttgttgttt tcgcgctttc catcgttgcc cgccttgtca 5460

agcaaaagaa cttgaacaag gggccgaagg atgaataacg aacttccttg ggtagccgaa 5520

gcccgaaagt atatcggcct tcgcgaagac acttcgaaga cttcgcataa cccgaagctt 5580

cttgccatgc ttgaccgcat gggcgaattt tccaacgaat cccgcgcttg gtggcatgac 5640

gacgaaacgc cttggtgcgg tctgttcgtc ggctattgct tgggcgtagc cgggcgctac 5700

gtcgtccgcg aatggtacag ggcgcgggca tgggaagccc cgcagcttac caagcttgac 5760

cggcccgcat acggcgcgct tgtgaccttc acgcgaagcg gcggcggcca cgtcggtttt 5820

attgtgggca aggatgcgcg cggtaatctt atggttcttg gcggtaatca gtcgaacgcc 5880

gtaagtatcg caccgttcgc agtatcccgc gtaaccggct atttctggcc gtcgttctgg 5940

cgaaacaaga ccgcagttaa aagcgttccg ttcgaagaac gttattcgct gccgctgttg 6000

aagtcgaacg gcgaactttc gacgaatgaa gcttaaaggg gcatcgcatg ttttccgtaa 6060

tttgggccaa gtttggcaaa tggcttgccg caatcggcgc gggtcttgtc atgctggcaa 6120

gtatttttta tgccggtcgc aagtccggcg caaccaaggc cgaagccaac gcagcaaacg 6180

aacgggcaaa cgaccgcgaa gcaatcgcag ttcgccaagt taacgaagcc cgcgaagctt 6240

ccgaacaaca ggtaaaggcg gtacaaaatg cgaaagacgt tgcttccgat aattctactt 6300

ttgacgacga cgaagttact aagcggctgc gcgacgaatg gtcgcgcgac tgaaccgcaa 6360

agcatcgccg acgcagtgca aacgaagccc gttgtaatcg acacggcttg caaatgggtt 6420

gcgcctattt ggatttcgaa ggccgacggc ttgaccgctg gcacggcccg gcaaattctg 6480

aaccataacg aagccgtcga acgcaattgc gggccgcagt cgccgcctaa atctgcggac 6540

aagccttaac agaacgcggg gcttgcggta tagtgaagcc aacgacgtat aaactaggcc 6600

gacactatgt ccgacgaact gaaagaaagc gaagaaaagg ccgcatacgc ggcccttctt 6660

ttgaaagaac gcgacccgtt caaggctgcg ctttcgctgt ttccgaacaa cacgaatcgc 6720

gcgctatggg ttgcgaacca ttggccgaac gacgccgaag ttaaggccga acaaaagcgc 6780

cttaccgacg aaggcggcga tatggcattt cttccgggca aaggcgacct tgcccgcgac 6840

atttggcagc gtatgcaagg tacgacgctt ccgaacggcg taaccattcc gccgacgccc 6900

gaagaatacg cgaagcttgc caagctttac gccgacgttc gcgggttcat cgaaaaaccg 6960

caaacgaacg ttaacgtaac gacgaacgta aaccgcgtcg tcgaaatgcc cgtattcgct 7020

aacgaaagcg aatgggaagc ggaagccgca cggcaacagc gcgaattgtt agaaaatgca 7080

cgcactcgcc attgatacga acggggcgaa acctgttccg tatgaagtcg tatttaagcc 7140

ccttccgggg tcgcagacta tcgccctttg ttcgatggca gcgcatacgc tgtacgaagg 7200

cgcacgcggc cccggtaaga cgcttacgca gcttatgcgc ttttatcgta acgtcggcaa 7260

aggctacggc aagttctggc gcggcgttat cttcgatttg gaatttgacc atttgggcgg 7320

ccttgttgcc gaatcgaaaa aatggttcgg cgataacgga aagctaaaag acggcggcaa 7380

gttttacgaa tcaacgtcgg cttataaatg ggtttggccg acaggcgaag aactgttgtt 7440

tcggcacgtt aagaagctgt cggattacga aggcttccac ggtcacgaat acccgtttat 7500

cggttggaac gaacttacga agcatccaag cggcgacctt tacgacaaat ttatgtcggt 7560

caaccgctgt acgttcgacc cgataaaaga cacgccgaaa gacccgaaaa ccgggcgcta 7620

tttgacgccg aacggcgaac cgctgccgcc tgtaaagtgc gaagtattca gcacaacgaa 7680

cccaagcggc cccggtcaca attgggtaaa acgtcgcttt attacgattg ccccgcgcgg 7740

caccgtagtt cgtcgcgaaa ttcagattta caacccggcg accgaaaaag aagaaacgca 7800

cgtaattagc caaatcgcta tcttcggttc gtataaggaa aacccgtacc ttccggcttc 7860

gtatatcgcc gaactggaaa gtatcaaaga accgaacttg cggaaggctt ggctttacgg 7920

cgattgggac gttaccgcag gcggcgcaat cgacgacctt tggcaatcgc atatacacgt 7980

tgtaccgcgc ttcgtcattc cgccaagctg gcgaatcgac agaacatacg acgacgggtc 8040

ttcgcatccg tttagtgtgg gctggtgggc ggaagcggac ggcaccgaag cgaccatagt 8100

tctttcggat ggcaccgaat ttacgttttg cccgcaaccg ggttcgcttg ttcagttgtt 8160

cgaatggtac ggatgcgcga aagacgaaaa aggcgaatac ataccgaata aaggtttgaa 8220

gctttcggcg tcgaatatcg cacaaggtat aatcgaccgc gaaatttcgc taatggcgaa 8280

cggttggatt tattcgcagc cttggcccgg ccctgccgac aaccgcattc gccaagtaat 8340

cgacagcgaa ctagacacga ccgaaaagct tatgtcgaag aagggcgttc gttggacgga 8400

atcggacaaa tcgccgggtt cgcgcgtaat cgggttgcag cttttccgcg accggctaga 8460

agcgtctgtt aatcgcgaag ggccgggtat atactttatg tcgaattgcg ttgcaagtat 8520

tgatttgctg cccacactgc cgcgcgacga aaagaagatt gacgacgtag acacgaccgc 8580

cgaagaccat tgttacgata tggtgcgtta tcgcgtattg aaaggcgcga acaaagcggc 8640

agcgaaattc aaacttgtta tgccaactta aaggaaccca aatcatgccg aacgtttcat 8700

ttattcgccc cgaacttggt aagctgctgc cgctgtatta cctgattcgc gacgcaatcg 8760

cgggcgaacc aacggtaaaa ggcgcgcgga cgacttatct tccgatgccg aacgccgaag 8820

accaatcgaa agaaaataag gcgcgatacg aagcgtactt gaagcgggcc gttttctata 8880

acgtagcccg tcgaaccttg ttcggcttgg tcggtcaagt gttcatgcgc gacccggttg 8940

taaaggttcc cgcgctgttg aacccgcttg tcgcaaacgc gacgggttcg ggtatcaacc 9000

ttacgcagct tgcgaaaaag gccgtatcgc tgaaccttgc gtattcccgc gccgggctgt 9060

tggtcgatta cccgacgacc gaagccgaag gcggcgcgtc gattgccgac cttgaagccg 9120

ggcgcattcg tccgaccctg tacgtatatt cgccgaccga aattatcaat tggcgaacga 9180

ccgaccgggg cgcggaagaa gttttatcgt tggtcgtact gttcgaaact tggtgcgctg 9240

ccgatgatgg ttttgaaatg aaaacgtcgg ggcaattccg cgttttgcgt ttggacgaag 9300

aaggttatta cgtccacgaa atttggcgcg aaccgcagcc gaccaaagcc gacggtacga 9360

agattccgaa aggcaattac caacaataca cggtttacaa gccgacggac gcaaacggca 9420

atcgtcttac cgaaattccg tttatgttca tcggttcgga aaacaacgat tcgaacccgg 9480

acaacccgaa cttttacgac cttgcgtcgc tgaatatggc gcattatcgc aattcggcgg 9540

attacgaaga aagttgttat atcgtcggac agccgacgcc ggttcttatc ggacttaccg 9600

aagaatgggt tacgaacgtt cttaaaggtt ccgttaactt cggttcgcgc ggcggtattc 9660

cgcttcctgc cggggccgac gcgaagttgc ttcaagcatc cgaaaacacc atgcttaaag 9720

aagcaatgga taccaaagaa cgccaaatgg tcgcacttgg cgcaaagctt gtcgaacaaa 9780

aggaagtgca acgcacggca accgaagccg aattggaagc cgcttcggaa ggttcgacgc 9840

tttccagtgc aaccaagaac gtttcggcgg cctttgaatg ggcgttgaaa tgggcggccc 9900

gttgggtcgg tcaagccgac agcggcgtta agttcgaact gaatacagat ttcgacattg 9960

cccgcatgac gccggaagaa cgccgttcgc ttgttgaaga atggcagaaa ggcgcaatta 10020

ccttcgaaga aatgcgaacc ggcttgcgta aagctggcgt cgcaaccgaa gacgacgcca 10080

aggctaaaga aaaaatcgcc aaggataccg ccgaagcaat ggcccttgct gccccggcta 10140

acgtgccggg cgatggcagc ggcggcgata atgtgggcaa caacggataa ggggcgcaat 10200

catggcacta tcggacaata agcgactgta cgatattgcg acgcgccttg ctgtttacgt 10260

cgaagacgtg aaagtttggc agtcccgaca attcgggttc gtacttcgcg aagtaaactt 10320

ggaattaacg cgccttcttg gtcgtgttcg ttataagacc cttgacggtc tttcgaaggc 10380

gcagttaaac aagcttgttt cggaattacg ggaatcgcaa tcgaagattt acagcgcata 10440

cacgcaaacg ctgcttgaac agttaaagga attcatgcgg gccgacttgg aagtaaaccg 10500

gcgcgcttgg gttacgggtt atatcgaact tgacggcgaa gaaagcgacg acattatttc 10560

ggacgaagaa gcgatacagt ttcttttaga agtaccaaac gccgattcga accctttgtt 10620

cggtttggcc gctgttacag gaagcgacga acgcatttgg tcgcaagtta cgaatacgcc 10680

aattccggca aatggtttgt acttgctgcc gtttatcaag acgtttacga attcggcaca 10740

agctggcgtc gaaagcatga ttcgcaaagc ttgggcgaac cgttggacgg ttgaagaaac 10800

cttaacggcg cttgtcggcg atggaaccgc agcgcagggc acgccgtcgc agttgcaccg 10860

ggtcaacgcg caagccgcgt cggtaatcca tacggcaacc gcgcacgttg cggcggtcgt 10920

tgcggctggc gttatgtctg cggttttcgg tcgttacgtt tggtattcgg taatcgacgg 10980

aagaacgacg gacatttgca taagtcgaaa tcgccgaatc tatcgcttcg gcgaagggcc 11040

gttgccgccc gcgcatatcc gttgccggtc gcacgttgcc ccggcaaata ccgctagtga 11100

cttggccgaa gaaacgtttt atacttgggt tgcccgtcaa cctgcccaag tgcaagacga 11160

catattaggc gacgaaggcg gcgaagcttt gcgcgatggt cgcttaaagg cgaaggatat 11220

tccgaagtat gatgcggaca ggccgctaac ttacgaagaa ttccgacgca agattaaaga 11280

aattctttcc cgctgattcg gtgaatcggc ataaccgcaa ggagtccttg aaatggcact 11340

gaaaaagaaa cttaccaaag aagaacacgc gaagctttcg gatgcactga aagccgaata 11400

tatcgaagac ggcgacggct tccgccttga cgttgacggc gacgaagata cgggcgcttt 11460

gaagcgcgcc aaagaccgcg aagcgcagtt gcgcaaagac gccgaaaagg aagcgaagga 11520

acttcgcgaa cggctggaat ccatcgaagg cgacgacgcg cgcaagaaag gcgacattgc 11580

gacgcttgaa aagtcttggc aatcgaagct tgaaaaacag cgcgaagaat acgaagccaa 11640

ggtttccaag cttaccgcgc atacgacgaa aacgcttgtc gataacgtcg cgtcgcagct 11700

tgcccacaag atttcgaacg ccccggcaat catcatgccg catatcaagt cgcggcttat 11760

cgcagacttc gaaggcgaca cgccggttac gcgcgttctg gacaaggacg gcaagccgtc 11820

ggcccttact atcgacgaac tggcaaacga attcgttgca aacaaggatt tttctgctat 11880

tatcacagct agtaaggcgt ccggcggtgc cggtaagcct tcgcagaacg gcggcggtgc 11940

cccgaaattt aacggtcaat ccgacaaacc cgccgacctt tcgaagatga atcccgcaga 12000

acttgcggcg catcttaaag aagcgaaggc aaacgaaact aaggacgctt aatcatggca 12060

ctttccgacc ttgctgttta ctccgaatac gcttattcgg ctttctccga aaccctgcgc 12120

caacaggttg atttgttcaa cgctgcgacg ggcggggcta tcatgctgca atccgcagcg 12180

caccaaggcg acttttccga cgttgccttt ttcgccaagg taacgggcgg ccttgttcgc 12240

cgtcgtaacg cctacggttc cggcaccgtc gccgaaaagg tcttgaaaca ccttgtcgat 12300

acgtcggtta aggtcgcagc cggtacgccg cctgttcgcc ttgaccccgg ccaattccgt 12360

tggattcagc agaacccgga agtcgcaggc gcggcaatgg ggcagcaact cgccgtcgat 12420

acgatggcgg atatgctgaa cgttggtctt ggttcggtct attcggcact ttcgcaggtt 12480

gcggcggttg tttacgacgc gaccggcaat actgcgcccg acgacggccc gacttggaac 12540

aaccttaaca acggccaagc caagttcggc gaccaatccg cgcagattgc ggcatggatt 12600

atgcacagta cgcccatgca caagctgtac ggtaacaacc tgaacaactc cgaacgcctg 12660

tttacttacg gcaccgtgaa cgttgttcgc gacccgttcg gcaagcttct tgttatgacc 12720

gattcgccaa acctgttcga agccggtacg ccgaacgttt atcgcatcct tggccttgtg 12780

ccgggcgcgg ttatgattgg tcaaaacaac gacttcgacg cgaacgaaga aaccaagaac 12840

ggcgacgaaa acattattcg gacttaccaa gccgaatggt cgtacaacgt cggcgttaag 12900

ggcttcgctt gggacaaggc gaacggcggc aagtcgccga ccgacgcggc gttgttcact 12960

tcgaccaatt gggacaagta cgcaacttcc gaaaaggatt tggcgggcgt tgtcgtcgaa 13020

gttcactaac ggacggcaga cggacggggc ttcggccccg ttcttctagt ccttcacaaa 13080

ttcaaaggag tttcgaagat gaaaccggca aaaatcctgt atttcgtcga tggcaacgca 13140

ccgaccccgg aagacttcgc agccgccgcc gaactgaacg cgcaagttat gttcaggaac 13200

gcccgcgctg ttccgtccga accgcattcg ctggaaatct gcgacggcgt agcgggcaag 13260

gttccgaagc tgtacgccga cgcttacccg gaagcgggcg aagcaatcaa gaagaaggcc 13320

gccgaactga aagcccttgc ttcgaaggtc ggcgacgccc cggcaccgaa ggccagcggc 13380

aaggccgccg acaagcccgc agccgctacg cagggccaga aagccccggc agcggccccg 13440

cagggcggca gcgccccggc ttggaaccct aacccggcgc agtaaccaac ggacggcctg 13500

tcgcttattg tgggcaggcc gtttcaacaa cgaactaagg agtcttcgca atggcaacga 13560

aaaaggttgt ttattttacg gcaggcatta ccgcaaccgc tggcgaactt gccgcaattg 13620

cgaagcttaa cgcagccgcc gaaccgcaat atgaagtttt ggtagccaat ggcgcggcaa 13680

atgccgaata cggcgaaacc gaccgaatca ttccgtcgga ttatgtcgcc ggtactgttc 13740

cttcggaata ttcggcggtt gacgtaatcg accccgacgc aatcccgaat caggcgctta 13800

cgccaacgca agcaatcgtt aacgacgccg aagccttgac cgttccggtt actggcactt 13860

acacgacgac cgcaaccgtt agcgttgcga acggcgttgt aaccggcatc gttctttcgt 13920

aaggacgttg acgcatggca attacaatcg ttgttgaaga cggaagcggc gtaacaaacg 13980

cgaacagtta cgtaagcgtc gcagacgcgc gcatttacgc ttcgaatcgc ggcgtcgaac 14040

ttccgttgga cgacgacgaa ttggcggcca tgctgattcg ttcgacggat tacctagaag 14100

cgcaggcttg ccggttccaa ggcaagccaa cttcgacgac gcaggctttg caatggccgc 14160

gaactggcgt ctttcttaac gaagacgaag taccgtcgaa cgttattccg aagtcgctta 14220

ttgccgcgca agttcagctt gcaatggcga ttaacgcagg cttcgacctt caaccgaacg 14280

tttcgccgca agactacgtt acgcgcgaaa aggtcgggcc gattgaaacg gaatacgccg 14340

acccgctgtc ggttggcatc atgcccacat ttaccgcagc gaacgcactt cttgcgccgc 14400

tgtttggcga atgcgcttcg aacaagtttg cgcttcgtac aataagggtt tgacgaatgg 14460

cacgtttcga cgcagcaatt aaaacggcgc aacgccttat cgcaaagaac ggcgaaaagg 14520

tgaaatggcg cgttatcgaa gacgcgacgc cgacagaccc gaacaagcct tgggaacccg 14580

gcccggcatt gccggacgac aaagacgtta ccatttgctt tttgccggtt gaccggcaga 14640

cgcaagaaac tttcaacttc attaaaggca ccgaagttcc gaaaggttcg gtaatggggc 14700

ttatgggcaa tgttccgttt gaaccgaatt tgaaagacgt tgtaattcgt aacggggtcg 14760

aacttcgctt ggcttatatc gacgtacttt cgccgaacgg gcaaaaggta ctttatacga 14820

tggtatttca agcatgattg aattcgacca agttaacgac gaagtaaacg cgctttttct 14880

tgcaacttgg aacgcaggaa gcgcggcaat tgcgggttat gttcccgaaa ttcgttggca 14940

gggcgtgcaa tatcgcgact tgccggacgg ttcgaagttt tgggttcggc tgtcgaagca 15000

aaccgttttt gaagaacaag cgaccctttc aacctgcgaa ggagtaccgg ggcaaagaaa 15060

atatacggcg tcgggtcttg tcttcgtaca aatcttttgc ccgaaatcga atacgcaagc 15120

gttcgaactt gggcagaaat tggcgaaact ttcccgtaat gcttttcgcg ggaaatcgac 15180

gccgggtaag gtttggtttc gcaatacgcg aattaacgaa cttccgcccg aagaacttta 15240

cgaacggttt aacgtcgtta ccgaatttga atacgacgaa ataggttaag gagttcttaa 15300

catggtatgc gaaattgcca aaatcgacag caacattacc ggacttgcct tcgccgaaga 15360

agaatgcttg aagcaacttc cgacgacgcc cgtttggtac ggactggaac ccaacagcta 15420

ttcggacttc ggcggcgaac tttcgaccgt tgcccgcgcg cctatcgacc cgtcgcgcca 15480

gaacaagaaa ggcacgatta ccgaccttga cgcatcgggc ggcttcaacg ccgactttac 15540

gaagaccaac cttacgcgaa ttctgcaagg cttcttcttc gcagacgcgc gcgaacttcc 15600

ttcgacgcag ccgcttaacg gcgcatcggt cgcacttacc ggcgttaccg cagttgacag 15660

cacttacgcc gcagcttccg ggcttggcgt gttcggtgcc gatatgctgg tatatgcgac 15720

cggctttacc aacgcggcga acaacggcct taaaaccgtc gtttcggcta ccgctgcggg 15780

cgtcgttgtt gctgaaacct tgattgacga aaccccgccc gcaggcgcga agctggaatg 15840

cgtcggtcgc cagcttgccg ccgcagacgc gaacattgcc gtaactggca acgtcgtttc 15900

gcttatcgtt accgctggcg actttacgac catgcccgaa ctgttccccg gtcgttgggt 15960

cttcgtcggc ggcgatgcga cggcaaaccg cttcgctaat aatgtgggct atgcccgcat 16020

taagtcggtt gcagcgaagg cgcttgtttt cgacgacgtg acttggcagg cggccaacga 16080

aaccggaacc ggcaagtcga ttcgtctttt cgtcggaact gttatcaaga acgaaaagac 16140

cccggcactt atcaagcgtc gttcgtatca aatcgaacgc accttgggcg aaggtttgaa 16200

cggtacgcag tgcgaatatc tggaaggcgc agtaccgaac gaatttacgt tgaacgttcc 16260

gcaggccgac aagctgaacg ccgacctttc gtttgttgcg tgcgacaaca cttaccgcag 16320

cggcgacccc ggcgacgaac agaaaaccgg aacccgcgtg cctgcgcccg gcgaagacgc 16380

ttacaacact tcttcggacg tttaccgaat caagatggcc gttcacgacg ccgcgtcgtc 16440

gaaccccgcc gccctgttcg gctacgtttc cgaagcgaac gtttcgatta acaacaacgt 16500

tacgccgaac aaggcggtcg gcgtgttggg cgcgttcgat acttcggcgg gtaacttcga 16560

agtcggcggt tcgattaccg cttactttac gaccgtcgca gcggttaagg ctgttcgcgc 16620

gaacgccgac gttggtttgt cggtaatcag tgcggccaag aacgccggtt tcgtgttcga 16680

tattccgttg cttggtttgg gcggcggtcg tctgaacgtc gaaaaagacg cgccgattac 16740

cgttccgctg gaacccgcag gcgcagaaaa cgcgaacggc tatacgatgc tgtacgaagt 16800

gttttcttat ctgccgaatc tggcaatgcc ggactaattg cggtaaactc aaagggccgg 16860

gtaataccgg ccctttcttc attcaatcgg agtaaatcaa atgtctggac tgtttaagca 16920

attcaaaacg aattcgacca aggaagtcga aggcgtcgaa atcgaatttc ccgaagcgca 16980

gaacgacgac ggcagcgttc cgactttcgt tatttcccgc atgggcaaat cgaacaaggc 17040

gtattcaaag gcgcttgacg cggcgacccg tccttatcgc cgtcaagtcg aacttggcac 17100

gctgaaaaac gaagtcgccg aatcgctgtt tatgggcgtg ttcgtcgata ccgtgttgcg 17160

cggctggaaa aacgttcagg gcgaagacgg caaggaaatt gcgtattcga aagacgccgc 17220

aatttcgctt ctttccgaac tgccggacgt ttacgaacgt ttgcaggaag aagccaagtt 17280

ggcttcgaac ttccgcgata acgctttgga agccgaagca aaaaactaac cgaagttttg 17340

gcgcacctgt tggaacttgg cccacacgaa caggcgatag caaaacaagc gatgcgcgcg 17400

gggcagccgt tacccgaacg catcgcgaac gcgccagaac ttgaagtagg cttgcagttg 17460

tatttgcaag ccttcttcga cctagatagc gaacggtcgc acggcaacgg tttaacgccg 17520

ataccttgga caagtatggc ggcttacgca agggctttcg agtttgacga agaacaaacc 17580

gaagacttgt tttactttat gcgaaagctt gattcggaac acttgaagaa actagcggat 17640

aaacagaaag cggcggcatc gaatggcaaa aagcctgcta gacctagccg ataggctgga 17700

aaagaaagcg aaggcaatag acgaagcggc gtcacaaaac gccgtcgata ccgctttggc 17760

tattgtgggc gacttggcgt acaaaacgcc cgtagatact tcgcaagctt tgtcgaactg 17820

gattgtaacg ctagaaagtc cgtcgggtca acaaatcaag ccgcattttc cgggttcgca 17880

gggttcaacg caacgcgctt cggcggctga aacgttgaat tctgcgaagc ttgttttacg 17940

aaacaagaag cccggccaag cgatatttat tacgaacaac cttccgtata tccgcaggct 18000

gaacgacggt tattcggcac aagccccggc ggggttcgtc gaacgcgccg ttttgattgg 18060

tcgcaaaatg cgtaagaagt tcaagattaa ggattaaaag aaatggccga cgaaaacata 18120

gaaattaagg ttcaagacaa agtttcgccg tccatttcga cgaagcttcg cacaattgca 18180

agcgaagccc gcaacgccga cgccgcagtt aagaaccttc aaacgcagct ttcggcaatt 18240

aacgtcggcg gcttgtcgca gcttatcaac gcatcggcca gcgcaacgcg ccagcttcaa 18300

caaggcgcgc ttgccgcgca acggctggca accgaacagc agcgcaccgc aacagccgca 18360

gcgcaggccg ccgcagccca acagcgcgtc gcgacggctg cgacccaagg ggcaaccgcg 18420

caagccaacc ttgccagcgc cacgcagcgc acgcagacgg cccaacagca gacggcgaca 18480

gccgcgcagc gcctagcgac agaacagcag cggacagccg ttcagacggc caacgcggcg 18540

gcagcgaacg accgggccgc ccttgccgcc ctgcggctgc aacaggcgca agaccgggcc 18600

gccaattcga cccgcaatgc gacttcggcc cttggcggat acattcgaac cgctgccgga 18660

attcttggcg taacgatttc ggcgaacgca attcttgcaa gcgccgacgc atacgttacg 18720

cttcaaaaca agttgcagaa cgtaacgaag tcgcaagaac aagttaacac gcttacgaac 18780

gaacttttcg aactgtcgaa ccgcacgcgc gcgggtattg aagaaacggc gacagcgttt 18840

acacgcttcg accgtgcctt ggcgtttatg ggtaagtcgc aagaagattc gttgcgaatg 18900

accgaaacca ttaacaaggc tttgattgtt tccggtgcaa cagcgcaaga agcgtcgtcg 18960

gctttgttgc agctttcgca gggcttcaac gccggtaagc tgcaaggcga cgaattccgc 19020

gccgtttcgg aaaatatgcc aatcgttttg gacgcagtag cgaaggcgct taacgttccg 19080

attaaccgcg ttaaagaact ttcgaccgaa ggtaagatta cttccgaagt tctgtttgaa 19140

gctttcaagc ttatacaaga ccaagtagac gcaacgttta acaagacgac gcccacaatc 19200

ggccaaagct tgacggttct tcgcaacaat gcaattcagt tcttcggcga attgaacaaa 19260

gcgaccggct ttactgccgg gctttcgcgc gcgattattt ggcttggcga aaacttgaag 19320

acggttgccg taattgtcgc cgggcttggc gtcgcattgc ttgtcgcctt cggtgccccg 19380

ttggttggtg cgctggccgg tgcgacggct gcggtaaaag cctttacgct ggcgcttgct 19440

tcgaacccga ttggccttat cgtcgtcgcg ctttcgaccg cgattgcgta tctaacgctt 19500

ttccgcgacg aaattaactt gggaatcgac gacgttacga cgttgggcga tttcttccgc 19560

gcgacctttg aaggcatcgg ccaagcaatc gacgacgtta aaaccatcgc gtcgcaattg 19620

tgggcagaac ttagcgactt cgcaagcgca gcccttggcg aaattacttc gaacgttgac 19680

gattcgactt cttcttggtc ggacagttac gccgaatttt tccaaaccaa ccgtacaggt 19740

tgggccggtg cgttggaaaa cgccgcaaaa gttcttgacg caatcgccgg gcttttgacc 19800

ggggccgcaa cgttcgcagg ccgtgcaatg gccgaagttg ttatttcggt tcaaaacgga 19860

atcgcaaacg cttacaacgt tgtcgcgggt tggattgaaa acgtaacgaa taaagccatt 19920

gaagccgcga acaggcttcg cgcgatggtt ggtaagtcgg cttacgaact tgtccaattc 19980

gaacgcatgg gcagcgcagg ccaaaccgaa ttcgaatctt ggggcaagct ttgggcgcaa 20040

tcgctggaag acggatttaa cagccaaggc ggcgcaatgc aaaacctgtt gaacggcctt 20100

ttcgaccgtt cgcagcaaat cggcgcgcag cgcagggccg caggaagcgc gcagcttcgc 20160

ggggccggta cgtcgcagct tgccggggct accgacgcaa acgcggcgaa ggctgcggaa 20220

cgtcgcgcgc tggcgttgga aaaaatcaat acgcagcttg ataacgaatt ggcgcgcatg 20280

ttccagcttc aaccgcagcg cgaagcgcaa gcgaagttcg accaaatcga agaaagcttg 20340

attcagaaaa agattaagct tacgtcggaa gaagccgaag caatcaaggc gaagattaag 20400

gccgttcaag acgcgaccga agttcaacgc cagttcgacg caatttacgc cgaagctgtt 20460

aaccctttga aggagtacaa cgcggcgcag gaagcggcga acaagcttct tcaaatgggc 20520

gcgattacgc aggaacagca cgcccgcgca gtaacgaagg cgtcggaagc ttacgcgaat 20580

tcgcaagacc cgttgcggca gtataaccgc gaccttgaac agcaattgca gcttttgcaa 20640

atgctgccga agcaacgcga aatcgaacag caggttatgc aagttcagaa cgatttgctt 20700

gcaaagggca tcgttctaaa cgaaaccgaa ttggcgcagc ttcgcgaaaa gctgttgctt 20760

attcagcaag taaacgccgt ttcgcagcaa gaagcgtcgt tgttggacgc cagcgtaaac 20820

aagcgccaac agtttatcga ccaacttaaa gcaattcaga acttgcgcaa caacagcgga 20880

agcggtttca acgcaggcga ccaagccgaa gcaactaaca gcatgttgca aggcatgggc 20940

attgatacga cgaactttca aacgcagctt aacgcgcaat tggcgcaata tcaaacttac 21000

gtcgaacagc ttaaaatgct gaacgaacag cgtttgatta gcgaccaaga atacgccgcc 21060

gcaagtatgc aacttgaatt gcagcggcaa aacctgtact tgaattcggc aagtagtttc 21120

ttcggaaact tggccgcgct tcaacagtcg ggaaataaga aaatggcggc ggtcgggaag 21180

gccgcagcaa tcgcgcaagc gatgattaat acgtatcaat cggcaacgtc ggcttatgct 21240

gcgatggcgt cgattcctta cgtcggcccg gcgttgggcg cggctgcggc tgcggctgca 21300

attgccgcag gcttggcgaa cgttcagcaa atccggtcgc agaataccgg gtttaagtcg 21360

ggcggtttta ccgggtcaat gggcgtaaac gaagtcgcgg gcgtcgtaca cggccaagaa 21420

ttcgttatga acgcagcggc gaccaaccgt attggcgttg cagaccttca agccctgcaa 21480

acgggcgcgg ccagtgttca gcgcaacgac gaacaggcaa tggcggctag tgtgggcagg 21540

ggcggcaatt ccgaacccgc gcccgcgccg gttgtcaatg taccttttag cgccgttgtc 21600

gtacaatcga aagaagcggc cttggccggg cttaaatctg cggaaggtcg ggctttcatt 21660

ctggaaacta tcgaacaaaa cggcggcacc gtcgcaaaaa tcgtcggagt taaataaatg 21720

ggttacgcaa ttggaacagt tacaaaaggc ggcggcgacg attgccatta tcaagttttg 21780

gcaattatca aaacgctggc cgaagcgaac ggatggacga cgcttcgtta cgtatcaacc 21840

ggacttgacc gcgaattgat tttgaaaggc gttggtttgt ccggtcttga agaaatcttt 21900

gtagggttta agtgttatca aagcgtcggc ggcgattatt acaatattaa ttgcggaact 21960

ttcgtcggtt acgtaagcgg aaacactttc gaaacgcaac ccggcgcgca gtttagcgca 22020

acgcctgccc acaataacgc gattacgtat ttcataacgg ccaacgccca acgaatcgtc 22080

ggatgcttca aagtcggtac gccggtttac gaacattttt acgtcggcaa gttctttccg 22140

tatgcgcggc ccggtgaata tccgtcgccg cttgtttgcg gtgcgatgct ttccaacgcg 22200

caggcaatgc gattcgacaa caacgcgcag tcgttcccgt atccgggcta ttattacgac 22260

acgacgaaca accgccttta tattcgcgac caagcgggca actggattcg cccttggtgt 22320

tggccattta ccaatggaaa cggcgcaaac accgcgcttg cagggccgca aggaacttcg 22380

acgcttgttc ctgccgacgt gtattaccaa cttgaaccaa ttattttggc gcagcaaagc 22440

aacaataaca acccttcgaa cgtatggggc gaattcgacg gcgtttattt ctgttccggc 22500

tttaacaacg gcgtcgaaaa cgtagttcag gaaggcggaa gttctgtcgt tgaccaaacc 22560

gggcttaccg tacttcaagc cgtagacgct attaaggcgg tcggcgggcg ggcgtttgta 22620

atgttgcaaa acgtctatcg tacttcttgg cgcgatttta tcgctttgga aatgaaataa 22680

tggcatacat tacaggaacc gccgcaaact ttgcggattt gaaaacagcc attgaaaacg 22740

cctgtacttc taacggttgg gcgcttgccg acggcatatt gtcgaagaac ggttgtttct 22800

ttcaactaat cgccgatagt ttgggcggtt atccgcaact tcgcttgcat ggcggaacag 22860

gcaaaagcgg ttcgacgctt acaggccagc cgcctagcaa ttacggggca aaggtcgcaa 22920

gccctgtcgg aaatcaaatc gtattcccga ttaattacga aatacatttg tttaccgacc 22980

ccgacgaagt ttattgtatc attaattaca attcggactt ttaccaacaa ctttcgttcg 23040

gcaagtctga tattccgggc attggtggaa ctggcgcatg gtttaccggg gcatatcggc 23100

acgactacgg attgaccgac gcaacttacg cccatagggt ttttacggcg atttcttggc 23160

ccgaaataac tggcgtcgca acttatgccg gaatgtgcgt cggtttgttt tttgaaggca 23220

acgcttcgca aactggcgga agttatttcg caagcttcgt acataccggg cttgattcga 23280

cgccttggcg aagcggccac ggcggcgaca cgctgttaag cggctatcgc ggggccggtc 23340

tttccgtcgg ttcgctttta atgtcactgc cgaatatttc gaaccaagca acgattttgc 23400

ttcctattaa gccggttgcg cgtcgttcaa gcggcggcgc aactattatc gcaaacccga 23460

aaaacgcgcg ttatttgcga atcgacaacg ttgtaccggg cgaaattatt acattcggtg 23520

ccgaccaatg gaaggtttac ccgttttacc gcaaagacgc aaccgttcga aacggcgtcg 23580

gttggtcaag cggcgcgacg catagcggaa cgttcggata cgccattaaa tacactggaa 23640

cttaaaaaga atggccggaa gaattggaac atttttagcg gcggaaagtt ttatttacgg 23700

cgattataac ccgaaccttt ccgccgaact taacgaactt accgccgcag aatacgcgcc 23760

gacgatttac gacccgcgcg atatgttctt gcgcggcgga tattcggcgt acaaaatcgc 23820

gccttcgaat cgctggccta ttgtgggcaa agaacaaggc aacttcgggc gcgactatta 23880

ttatcgcgtt cacgtttcgc cattggtctt ggacttgcaa acggtcgcgt cgtcgcaaac 23940

gcgcgaattc aacgtttgga acgcatggcc cgaccgtgcg gctaatcttg acgacatttt 24000

ggtaagtaat ccggtcggta ttgaaattac aggccaagcg acgccgtatg caatgccgcc 24060

gcttcaagaa cttacttacg aaataaccgt aggcgtttcg gggccgccga atattaacgt 24120

tgaagttcaa tttgactttt ccaacgttcc cgacccgctg ccgattctga ttacaggaac 24180

gcgcgcggtt aagttcgaca ttgtgcccga agttccattg aacgaaactt gggaatggtt 24240

aagcgacaac attgtagcgg ttgacggaac agaacagcgc atagcacttc gcggcgaaat 24300

gccgcgtatt gaagaacgct tgaaagtaat ttttgattct gtcgaagccg tgcgccgttt 24360

ttacggcgac gttatgtcgg cagttggtcg gctttggatt cccgaatttc agtacgcgac 24420

ccgaattact gccgcaagca atagcggcgc gcttcaaatt tattttgacc gaacgaagac 24480

cgacgttcgc gataccgaat acgtcttgat tcaaacgccg cttgttgcgg cacttgtcga 24540

aatcgacgta ttgacagccg acggggctac gcttggttcg ccgctgttgt tcgacattcc 24600

ggcagggtcg ttaatcatgc cgggttcgcc cgcgcttatt gacgacaata cagcacttgc 24660

gcggtattcc gtcgataccg tcggcgaagt agaaattaac gcgaagatga ttcgccagcg 24720

ttcgcaactt acccgacccg gcgcaaccgt cgtacttgaa cagttcggcg gcgtgccgat 24780

tttgacgaag cgtccgcttg cgaacgacct tgtacgcgac gaagtttcaa ccggccaaat 24840

ttcaatcgac aatcaaaccg gacttgccga cattattagc cgttgggact atagccgcat 24900

cggcgggccg cgaagcttca aagtaaaccg tatttcgaat cccgaagaat tggattattg 24960

gaaagcgatt cttgcgtatg cacgcggaca ggcgcgcaag ttttggatgc ccacatatcg 25020

aaccgatttg gctttggccg tgcaaccgtc cgacgcgact tcaagctata ccgtcgaagg 25080

gtcggagtat gccgaaaaga tttggccgat tatcacgcat cgttatatcg aaatcgaaac 25140

agcgtccggc attcatcgaa ccgaaatatt gggcgcaact ttgcttgaaa ctggcaatac 25200

aattcttctt cttggtacgc cgcttccgac cggggccgga tggatggaag ttaagcgaat 25260

ttcgtacttg ttgcctgtac gccttggcga cgataaagta gaatggaagc attacggcct 25320

tgaatcaatc ttgaatcttt caattcgaac ggcggaaccc taatgtctga ttacgacgac 25380

aaagaagaaa gcgtaggcga tagcgcgcca tttgaacttt acgaattcgt cggttcatat 25440

cgcaattatt acatgacttc cgacgttctg gcgcacgtct tcaacagtgc gacatataac 25500

cccgttccgg gtttgaagcg cagtacgtta aaagtcggaa cgcacgaaga cgacaacgta 25560

gatatgacgg ttacgcttcc gattacggaa caaatcgtta aagactatgc gtttcaaact 25620

acgccgccgt ctttggtttt gacgatttac cgtcgccagc gcgacgccgc aacttgggtt 25680

gcatactgga aagggccgat tgcttcaatt tcggttgacg acgaatttgt aacgtttaga 25740

acgccaagca agttcggttc gatgctgtcg ggcaatatac cgaacgttta cgtacagccg 25800

ccttgcaata acgttttgtt cgacgaacgt tgtaaggtaa gtcgcgtaag caattcgcta 25860

gatacgcagg tttcggcggt cgaaggtcgt aacatttcga ttccgtcgct tggcggtttt 25920

cccgacggtt ggtttatcgg cggcgaaatc gcaatacctg cgcgcaacga acgtcgaatg 25980

attgtcgcgc aagccggggc aattctaacg gtaaattacg aattcgcgcg tatttctgtc 26040

ggcacttcgg ttcaggttac ggcaggttgc gaccattctt acaacggggc caacggttgc 26100

cccaagttca acaatcaacc gaacttcggc ggttgcccgt ttgttccggg cgaatcgaat 26160

aacgtatttc aaagcggggt tcattaacaa atgtggattg caattgtctt cgtcgtcgcc 26220

ttcttactta tggcggcgct tatgccgaaa ccgaacgtcg aaaacgcacg cgcggcgaaa 26280

cttggcgact tccaatttcc gcgttctaag tacggcgacc caatgccgct agtgtgggga 26340

acagtgcgcc agaaatcgcc gataacggct tggtttggcg acttccgccc ggtgccaatt 26400

cgtaagaaaa tgaagaccgg gctttttagt tcgaagaaag ttacggtcgg ttataaaaat 26460

tatcttggca ttgattgcat tttgtgcctt ggccccggcg ttcggcttcg taagttttgg 26520

gccggtactt accttgtttg ggaaggcaac ttaacttcgt ccggcgatat ttacattaac 26580

aagccgaact tgtttggcgg cgaagatgaa cgcggcggcc tgcaaggtac aatttcgttt 26640

tacgacggtc gttttgaccc gccgcaagat tcttacttgg tttcgaagat tggcccgaat 26700

gttccggctt acaacggctt tgcgcgtgcg ttgttcaaag ccttttatat cggaacaggt 26760

acgacgccgg aaccgttcag cttcgaaatt cagcgcatta cgtccggctt gcacgcgact 26820

tattcaatca tgccaaacgg gttggacgtt aacccgatgg aaattgttta cgacgcaatg 26880

acgcaaaaat ggggccgatt cggcaacctt gaaagcgaaa ttgatatgcc ttcgttcacg 26940

gcctgcgcgc aaacgctgta taacgaaggc ttgggtatgt cgcttattgt tcaatctgcg 27000

attaccggaa aagacttgtt ggaagaagta atgcgcgtcg ccgacggcgt gttgtatcaa 27060

gacccggcaa cggcgaagat tgttgcgaaa cttgttcgcc aagattacac aatttccgaa 27120

cttcttgttc ttgacgaatc ttccgttaag gaacttcgca atttccagaa aacaacatgg 27180

gaaaacacct ttaaccaatg ccgggttacg ttcaaaaacc gcgccagtag ttacgacgac 27240

agcgtagcaa ttacccaaga cttcgcaaat atcaactttc aaaaccgcgt taagtctacg 27300

gaagtttcga cgcccggcgt taccgacgca acggtagcaa gcaagattgc ggcgcgtcaa 27360

ctttcaattt tgaacgttcc gctttacaag tgcgacttga ccgttaaccg caaggcgcag 27420

aacttgcggc ccggaagcgt gttcgttctg aattggtcgc cgttcggcat ttcgaatatg 27480

gttatgcgtg ttacgaaaat tgatttcggc gaacttacgt ctaaccaaat caagctttct 27540

tgcgttcaag accgcttttc gtcttcaacg cttacgttcg caccgcccga aggttcagga 27600

tggacgccaa ttagtacgga accgacgccg gttacaacgc ggcttctttt tacgccgcct 27660

gcgttcctta cgtcaaacag cgaaaacgaa acactttcca attttgataa ctacggtcgg 27720

ttgtatcttg ccgcagttgc gccgggttct acgtctattt cttacgacgc aatgacggcc 27780

ccggacaatt tcagttcgtc gcctattctg tcgcttgaaa gtgccccgta caacggcggc 27840

ggcgtgttgc tgaacgccta cgcttcgaca gtcgccagcg aaacccgtaa cgatacaagc 27900

ggaagccttg tcgtaaccgg cgtgtcgcaa gcaagcattg aaggtttgca gcaatacacg 27960

acgctagacc aagcgcgcga cggttcggcc ttcctgctga ttaataacga actgttcgtt 28020

tatgtgggct tcgttgacaa tggcggcggt caagttactt tcccgaacgt gtatcgcggc 28080

gttctggata ccgtgccggg caatcatgcg gcgaacgacc gcgtttggtt cattagcgga 28140

accgacggac tgttgccgga acttgtttcg gtcggaacga cgcgatacgt taagcttttg 28200

gatacgactt cgggcggcaa gcttgatatt tcgttggccc cgtcgtttag cgggtcgctt 28260

accaaccggg ccgggttgcc gctgccgccg cagtacctaa cgcttgcagg aagccgcacg 28320

ccaagcccac aagtaggcgc aacgtcgatt gttgcggaat ggcgcaaccg cagccgggcc 28380

gataccttgt tgcgcgtgta tcacgacacg gcgaacacgc gggaagctgg caccgaaacc 28440

cgcgttcgct ggcgtgtagg cggcggcgct tacacgaccg ttacgactgc cggaagttca 28500

acaacccttg acgtaacggg caagtacggc acgctagaag ttattgtaga ttcgttcatt 28560

acgtcgaatt cgaaatattc gacgtacagc gattcgctta caatgaccct aacggcaccg 28620

ccgccgccgt aatcaaaaga acgacagcgc ggcggttttg gccttcttca accgcccgca 28680

gtcgtacaac atttcgaccg cttcgttaat gtaccaatcg taatttatat cgtcgggaaa 28740

ttccgtcggc aagtccatta cagggcgcgc gccgtcggtt ttcccgactt tgtttccgct 28800

ggatacgtaa gcaatatatc cggcttcgtt cttcgggtaa taccaacgaa cgaccttgcc 28860

aagataacga ccgttctttt cgccgccgcc gcgcacgttc tttactgcaa cgaagcgccg 28920

gaagtcgcgg cattccttaa ttgtcttttc gaccggcgtt ccgtcaacaa ggaaccgaac 28980

aacggcgtcg gaacaaatca gggtttcggg gttcttcgaa agaatcgaat tcaaagccga 29040

cccgcgttcg caataagcgc ccttcgtttt tgcgcccaac tgttcgtcaa taaagcgcgc 29100

ttcggggtcg ccgccgtctt ccttgattgc gacataacta ttaacgtcgc ggctgaatac 29160

ggctttatat cgcgtttctt cggtcttgta tcctgtccat tcttcccaag acgcaataag 29220

cgcccttact tcgtcgtgtc gcgatttgtg atacttggaa ataatgccgt cggtattgcc 29280

ggaaataact tcgatgccga tttgttccaa agcttcgata agcataagca acacaagttg 29340

cccggtaatc gttacttgca acataagttg cggcgcgtaa agcgtcgaat acttgttgcc 29400

aagcttgccg aagcttccgt taatggtaat tttcaaactg tcggcaattg tcttccattt 29460

cttcgcggct gcgcggtcgc ccgccttctt tgcctttgcc gcttcggctt tggcgtgaat 29520

tcgcgtattt acgatttttt cgtaaacggt caagaaagct tcgcccaagt gcggcgggca 29580

aagtctttga ttaaggattg ttcgcgggta aaacgattct acgtcgttgt ctgccaaaat 29640

tatttcgtcg gtcgcatagt gcgccgtttt cttttcggta gaatgcaaac cgcccatgcc 29700

tagtttgtac gtcgaaccgc caatggttac tttcagcttt tccagttcgg gcggcatgat 29760

tggcgacccc aagccgtcaa gatagaagcg ggcatttcgc acgacttcca gcatttcgcg 29820

aagctgcgtc gtttgatagc aaacgaagtc gggcacgtcg taaaccaaga ccgtatcggc 29880

ggatagtgtg ggcttcttcg gataatagcc aaggactttt tgaagttcgg agttaataac 29940

cgcttcggct acttgtgcgt ctgatttcga ccgaaggtct acgccgtatt cttccgacat 30000

ttcggcccgc aacttcaatt cgggcgcaag ttcgttaaaa agaagttcgg tattcgaaag 30060

gtcgttgcag caataaggcc gcactatttc ggcgtcttcc tgcgttaata catggtcttc 30120

gggaaacggc aagtcttgca tacgttcgca atgcaagcgc cccgcgtaca gcttcaacga 30180

accttgaagc ggcgcaactt ctataaggtc gatatgattg tatcggccaa tttgtacgcc 30240

gtacttcttt tcgaacgcga acggcgttac cttttcggtt ccatagttcg gcccgctttt 30300

aatgatgaaa tcggacgctt ctttaagctt cgcgcagctt gccccgcgtg cggctagttc 30360

aatcatcggc aagtcataat tacgcgaatt gaagccgacg atacagaacc gccaaagcat 30420

ccaaagaagc ttcgtcgggt taaaatcatg gtcggggctg cgttcgaacg cgacgaactt 30480

tccgttatca agcgacttaa acgctacgta aaagaaattt acgtaagttt caacgtcgaa 30540

gacgaagaca cttccggcag gcattgccgt tagttcttcg tccgacataa attcgacagg 30600

ccgcaaagcc tgtcgaatgc ttgcggccag cttatcgacg acgcggcttt tctttgcgac 30660

gataaagcct tgttcgttaa tcatgcgaaa gccccttaaa acggtatgtc gtcttcgtaa 30720

ttgtccgacg gattatgcgt cgcttcgctg ccaaggtcaa gacccataag aacgccgcgc 30780

aaattgtcgc cgaaaaatac gaccttgttt gcttccggtg cgaaatgcgc tttcttaaac 30840

gcatgttcga cggaaagaag caacttcgca gaaaagccca ttcgttccgg caagccttcg 30900

attttgtacg tcgaagcttc ttctttgtgc atcttcgaca aaaccgcgcc gtcgtcgaag 30960

aatacgtttc cgttcgggct gaatgactga atcgcgcgaa cgccgttgta aaaatcgtcg 31020

ggaaccggcc aagggttcaa accgtcaact tcgaaaacga cttggtaatt cgggtaacgt 31080

tcgccgtaaa gctgcgtttt gataaacgcc ccgttttcga aatagaacgt tgccgacgac 31140

gccgaaaagc cgaagccggt aagggccggg ccagccttgg cgacagcgac cgccgcgcac 31200

ttcggaagca tcatgccggg cggaaggtcg ataccgtgcc acgcttccag caaggccgcc 31260

ccgttggtcg cgacggcgct tccggcttgc agcaagacgg cggcataggt cgcattcggt 31320

gcgccgtctg tcgcaagccc tgcgaccgca gcgaaggccg ttttaatccg gtcgtcgatt 31380

gtggcgcatt gcgggtcggg cgcggtaatc ggcacgtcgt cgaagcccac acaaggcacc 31440

aacgcccgga acgcgccaga cgatacggca agggcgttcg cggtaagctg cgtaatcgac 31500

agttcttcgc cgaccttcga cagcgcgtcg ataaactgca acgtatgcgg gcacgctacc 31560

aagtcttctt cgataggatg cgcgacggtc aaaaccccgt cggaagccgc cgcccaattg 31620

tgggcaatat gcccgaactg aacgttcgtc ggcccggctt ttttctgcgc gatggcaacg 31680

aacttcaacg ccgccaaaag cgacgccgca gggcttggcc ccttcgcctt tttctttccg 31740

gctgcggctt gcctgcgcgc ccttggcttt ttcttcggct gttcggcggc tggcgcttcg 31800

tcttcgggcg gaagcggaat attactgtcg attttcattt tcggcccctt cttcgtcaag 31860

tttcgaaatt gccgcttgaa gatagttcgc taagtctagc gtttcttcta gcgcgtgttg 31920

caaccaatcg cgaagcgata acgggttatt atccgtcgtt acgccgtact ttgcaagtcc 31980

aacgattgaa cgttgcaaca gtaattcgcg gttcttttct acgtttttat cgggcgatgt 32040

ttcggccatt tgttcaccat tcagcggaaa gaacttcggg atactttttg ttcacccata 32100

cgcgaacacg gcgcggcgtg cgaagttctg aaacacgctg caaagcttga taagtcgtcg 32160

gcggcggttc ttcggcgtgc cgctgccgcc accaatcgcg cgaacgtttc gcagcaagcc 32220

ccggatgttc aagcattata aattcgttga acatttggaa gccgcaaaag taactaacct 32280

taatcatcgg cggtttcgtt agatttccgt ttgcgtcgcg cttttcgtgc aaattgtaaa 32340

gtaccttttg aacgtcgaaa tattcgacta tcggcgcgtc gcttcgcagc ggttccagcg 32400

ttccggcagt tgcaaacaac ttcgtttcaa aagtaaattc ggtgccgcag ttgatacact 32460

gccgggccgc agcgtgatta tatacgccgc atacgtcgca aatacgaacg ggcgcgtcgc 32520

cgccgccttt gcccggtctg ttcggaattc gcgggtcgtt gattgggcca agccttcgaa 32580

cgtttccggc aaagtccgcg tacaggcaat tttgtttgcc agtatccggc gacggtcggg 32640

ttccgcgtcc caacttttga acgtgtttgc ccggcgatag cgtcgggttc aaatcgccga 32700

taaagtcgat tggcggatgg tcgaaacccg ttgtaagttt ctgccctgat accaagccgc 32760

gaagttcgcc agctttgaaa gcgcgcaagc gttcggtatt ggtcttcgaa ggcaacttgg 32820

aatgaaccgg caaaacttcc aagccgtaag actgaattac gttcgcgacg tgttcggtat 32880

tatcaatgcc agttgcgaag ataagccaag tcgaacggtc gtaagctatt tcggtcattt 32940

cccgaacagc gttaaaaaca acttcgtcgg tatctacggc ggcttctagt tgcttgctgt 33000

tgaattcgcc agccgttacg cctactttcg acaagtcgat ttcggttcgc gtcggccttg 33060

cgataagcgg cgacaagtag ccttcggcga taagtcggtt aaacgattcg acgccggtta 33120

tatcgtaaca aatgtcggta aaaattccgt tgtcggtaat aagccccatt ttcattcgat 33180

agggcgttgc cgtaaatcca ataactttaa gatgcgggtt aatcttgcga agttcggcga 33240

taatgtattg gtaatgcgaa tcttccttgt cgcttaacaa atggcattcg tcgattaaca 33300

gcaagtcgcg ccaaccgaaa tggcgaagat gcgccgggcg tccgtcgtct tcttcaagcc 33360

cgcgtttaat cgcaggcgct acggactgaa cgccgccgaa tacgattggc ataatcatat 33420

cgcgggaatt caagcccgcc gaataaatgc ccattggcgc ggtcggccaa atcgacataa 33480

gcttttcggc gttctgttcg attagttctt taacgtgcgt aagcatcatt attcgttgat 33540

tcggccagta accgaaaatt cgacgaataa agtttgcaat tacgaccgac tttccggttc 33600

ctgtcggcat ggcgacgacg gggtttccga ccccgccgcg ctggaaataa tcgaatattg 33660

aatattccgc ttcgtcttga taccaacgcg gaacataaat attagacatt ctttgcaacc 33720

gctgtaattg gcgaataaga atcgcaaccc gtagcgatga aatcgcccgg aattacgccg 33780

ttgtgaactt cgcaaaacca ttcgccgttt tcgacaggat ttgcggcctt gcagcttcgg 33840

cagttctttt caggaatcgc gcccttgtgg caaatatcct tcgccgcgca atatccgcac 33900

ttgtgaaacg tcggattatc cgacaagcgc ggcggcgctt cctgcgacag aatgatttgt 33960

tcggccttct ccttcatttg ctggcctagc cgatggtcta gctttacaac ttcgcaatgc 34020

aagtcgtcgt cgttcttgtt aatgttcagg taaagaacat aacgaaaacg atattcgttg 34080

ccatacgtcg aagtttgggc gaaatgctgc ggcttgctta ctgccattcc ttgcgacatt 34140

aagtccgaaa agcctttgcc ggttccgttg gtcttgaatt ccagcaaaac gggttcgtcg 34200

ataccgtagc gttcgggaag ccgggcgatg ccgtcaagcg acccgccgaa gtgccccata 34260

acgccggaaa tgcggtattg tgggaattcc aagccgtcgg ctttcgcgcg tgcgacgtgt 34320

tgggcgtaat acggattttc gttcgtaata aggtcgcagc ccaacggcag ttcttcgcct 34380

tccttcaata tgccgtaact gtcgctttcg gcttggtaaa agaaaccgtc gcggttttcg 34440

taccaacatt gaacgccgat gccttccagc cattcgataa agcgggcttc ttcacggtgc 34500

ccacgattaa acaagcgttg cttgcgcccg tcggtttgtt cgcggaaaca ccaacggaag 34560

atataccaaa gcttccgctt gcattcgtcg ccaatcaaag acgcgccaag gtgccgacgg 34620

tgcccgccgt catacgtgcg aacgcaatat tcgtctatat cttctttaat gcgcttcgca 34680

agggcggttg caacgccggg cgcgtcaagg tctacgcttt gttttcctgc gtcggatttc 34740

gtcggctgcg cgtcgttcag cgttaattgt gcgttcttcg cgtctttgct gttttgcatc 34800

gttcttcacc ttgcgccgca taagggcttc gtaattgttc gctagataat ccgccgaaag 34860

tgtcgcaacg tctttaagtt ggtctttcga cagccaagat atatggcatt ccgacgggtc 34920

gattcctaat tggttcgcaa gccaattgta cgccttcgcg cgcgacatta agccggtttg 34980

ccaaaggcgg tcgaattcgt tatgggcttt cgttcgaagc tggcgcgttg ttctgtcggc 35040

catacgaccc aacggaataa acgtgcccgg atggcaacca acggcggcgc gacaatcatt 35100

gcaataataa atgtgcggcc aattgccata agttcgcccg taaatcttgt cgttcgttgt 35160

tagttcaatg ttgaacgaac aacaagtatc gcattgttcg ggcgtcggca atgcgtcttt 35220

tattttcgac ataagttcgc atactcctta aaaagaaacg ccggggccgg ttaagacccc 35280

ggcgaatcta cgccgcgacg gcgttacgcc ttaacgctgg ccccaaggtg ccgcgcctgc 35340

cggtgcgccg ccctgcgcgg gctggccgcc gccctgttgc cagccgccgc cctgcggttg 35400

ctgctgcgcg ggctgttggg caggctggcc gccccatgcc ggttggccgc cctgcggggc 35460

cgggttctgc gccggttggc cgccccaagc tgcgccgccc tgcggctgtt gggccggttg 35520

ctgcgcgggc tgctgctgtc cgccccaagc ggcaccgcct gcgggctgct gcggctggcc 35580

ctgcggggca ccgccccaag cgccgttcgg ctggccctgc ggctgctgtt gctgcggctg 35640

cgctgccgct gcgcctgcgc cagccttgcc cggttcgttc ccgttcatat cgaagacctt 35700

tttaacttcg gtatactgcg ggtcgttttt ctgcgggccg acttcgataa gaaacggcag 35760

gttgtgaagc tgcgacgaat cggtaacttg gaacacgccg attacgtggc agattgccga 35820

aagctggcga tgcgcgattt cgacggtctg ttggttggaa tggtacaggt tcaggcgata 35880

agcgccggtc gtgccctgct gcgggccgtc gataatccgc aagttcagtt gcagataacc 35940

gccgtcgttc gccttgttgg ccttgacttc ggaagattcg acgataaccg gatgcttgcc 36000

aatcggcagg cttccgacgc cttgggtcgg gtcgtactgt tgggcgttga acgcttggat 36060

aagttgcatg atgtttcacc ttttcgaaaa gtcttcgcca ttggttacgg cggcgaagta 36120

aaccgtttta ttgcatcgct ttcgcgaaca atgcggtaag gtcgggctgt tcaagttcgt 36180

taagattgcc caaacggtcg cgcgcgaaaa cttcgggaat ttccttcgtt cgcagcgccc 36240

gaaccggctt cggcattccg ggtacgcttg cttcgcccaa gtgcataacg ttatcgaaca 36300

aatgcggaac tttaacgtta aggtctttgc ccggaaagaa cgggcgtttt tgcataatcg 36360

gttcgtaagt aacttcgccg ttctgcaaaa tcgtttgccg tccgttttcg acaagggctt 36420

gctttgcaat cattacgata tgcttttgcg gcatgtaata caagtcgttc gcgattttca 36480

ttacacgttc ggacatattg ccgtaagcct tcataccgtg tttaaccttg cccaattcgt 36540

cggccaagat aatttcggcg atgttcgaaa tactgtcaat acccaacgta tcgaaattcg 36600

cagcttcgcg cgatttcata aaccattcga agaattcgac gataagcgcg ggcgaatacg 36660

cttcccatgc gggaacgttc gaaccgcgca tggacagcat accgggttcg gtcacaagca 36720

aaaccggacg cggcgcagta ttgataagcg gcgttttgcc ggaaccgggc gcaccgaata 36780

cgacggactt tacgccgtag cggcgggcca gttgcgacgc cggttttaat tgcgacattt 36840

gcataacttg caccttcggg aatggccccg gcgcttgtgg gcaaccgggg cggggttgtt 36900

acttcgactt cggcgcgaca agttcaagcg cgggcgttgc ttccttcgac gttacaactt 36960

cgtcgataag cttacggaac ttgtcgggaa ggttcttgta ttcggtaacg gaaagttcgg 37020

gcttccattt taccaaacgt tcggcgataa attcgccttc ggggccggtc ttttcgattt 37080

tctgcaaagc cttttcgacg gcttcttggc cgcctgcgaa gctgcggtta atcttaaaaa 37140

cggctttcag cttgtaacct gcgccaagtt cgacgttttc ggttccttcg cgcaaagctt 37200

cggggtcgaa agcgaaagcg tttttcagaa cttcggcgcg caatgcggat tcggcttctt 37260

tcgctgcggc aagcgccttc gttgcttcct gccattgcag aatcaaagcg tcgcggttag 37320

cgttttcgtt gaaagacatt gttgttactc cttcggttgg gccgccgcac aattgcgccg 37380

gtatgtacga actatacgac ggcccttcgt tactgtcaag cccctttttc aagaattttt 37440

cgttcttcga acaagtcgcg attgttggcg tcgaattcgg taaaggcgtt cgggaagcga 37500

cgacgaagct tcgcgatgtt gaccgactgc gcttcgccga agttcgaacc aatggcgcgc 37560

agcaaaagcg catcgtacca aaagccgtcg ccgacttctt caagcgcgtt aacagcgtcg 37620

aaagcttcgc cttcggctgc ggcgcttagg gcttccaaca gttcgcccgc ttcggtcgcc 37680

ttgccgataa ttgcatgaat gacgttcacg gctgcggcgt cgtcttcggg gcggtcggaa 37740

atccattcgg gaagcttcgc cagcgttgcc gcgttggctt ccggggccgg aacgccagcg 37800

tcgcgaccgt agaacatggt tttctcgatt gcgtcaagct tgttaagggc ttcgacggct 37860

tcggcgatgg tttcgcggaa gtaggccagc gacacgcggt cgccgtaata cttatccgac 37920

gcggttacgt gcgcttcttc gatatagtcg aaggtctttg cgggttcgtt catacgttca 37980

ccttttagaa gggccgggca ccatgcgcca gcgttccagc actgtaaccg accgcgcctt 38040

tcctgtcaac aacaattgac agcaagcaag aagccgggta agctgcccac aattgctaga 38100

aggtggcgtt atggacattg aagaacttac gaagcgggta aagaaagcaa gcgtcgggcg 38160

gtcgctgcgg gcgctggccg cgcaatgcaa cgtttcgcac gaacttataa gaaagctttt 38220

gcttgccaat tctgcgccga acataacggc gacgacttat aacaagattg ataaaggatt 38280

ggcgaagaat ggactttaac aatattccgc acgaaatgcg gatttacccg caatgggtcg 38340

tttggcgata cgaagacacg gattcaaaga aaccgacgaa ggttccgtat tcagcaaaaa 38400

ccgggcacct tgccagcgta accgacccga acacttgggc cgggttcgac gaatgcgtta 38460

acgctatgtc gtccggttgg tatgccggaa tcggtttcgt attgactgaa aacgacccgt 38520

attcgtttat cgaccttgac gacacaaaag gcgaccaaac ggcgcttgac cgccaaataa 38580

agatttttaa cgaattcaac agctacgccg aacggtcgcc ttccggttcg gggttgcata 38640

tcatcgttaa gggcgcgatt ccgtcgggcc gccgtcgttc gtttatcgaa gtttattctt 38700

cgcttcgtta tatgacaatg accggcgacg tttaccgcaa cgcaccgatt aacgattgta 38760

acgaactgtt aaacgttctt tggggccaaa tggggcaagg ttcggtcgcc gtcgcgcatt 38820

atgccggact tgccgaagcc aaggaaaccg acgaacaggt ttataaccgc gcagtcgccg 38880

cagccaatgg cgacaagttc gccgaactgt acgcgggcaa atgggaaggc atgtacgctt 38940

cgcagtccga agccgacttt gccttggtcg atattatcgc gttttatacg cagaaccggg 39000

cgcagatttc gcgaatgttt cgcgcgtcgg gcttggggca gcgtgacaaa gcaaaacgcg 39060

acgattacgt ttcgtacatg ctgaacaagt gtttcgaccg catgttgccg cccgttgacg 39120

ttgacggatt gcgcaacaag ctagacgaag ccatagcgaa gaaagaagcc gccgacaggg 39180

ccgccgcgtt gtcgcagaac agcgaagcga cgccgcatcc gaaagccccg gccccgaacc 39240

ttagcgaagt ttcgaaggta tacagcgtgc cgcccggatt agtcggagaa attgcgcaat 39300

acatttacgc acaagcgccg cgcccggtgc ccgaaatcgc gttggccggt gcccttggct 39360

tggtcgccgg tattgtgggc agggcgtaca acatttccgg cactggcctt aatcaatacg 39420

ttctgttgtt ggcaccgacc ggaacaggta aagaagccat cgcaagcggc attgataagc 39480

taatggcgca ggttatccga accgttcccg ctgcgtcgga ctttatcggc cccggtgaaa 39540

ttgcgtcggc ccaagcgatt attaagtata tgtcgcgcgg cccaacgtcg ttcgtttcgt 39600

tggtcggcga attcggcatt taccttcaac aaatggcaag cgtaaacgca ccgccgcacc 39660

ttaccgggct tcgtcgcttc ctgttggatg cttacaacaa gtcgggcgaa ggcaaggtac 39720

ttcggccttc gatttattca gacaaggaca agaacacgac cgccgttctt tcgccgtcct 39780

ttaccttgct tggcgaatcg acgcccgaaa agttttacga aggtttgcac gaaggtttga 39840

tttccgaagg tctgttgccg cgttttacga tgattgaata tcacggcgaa cgcccggcgt 39900

tgaatccggg gcacctgtcg gcccaacctt cgttcgaact tatcgacagg ctttcgacct 39960

tgtgcgccca tgcgctaatg ctgaacagcc agcataaggc gattcacgtt caaaccgacg 40020

caaccgcccg cgaactgttc cagcaattcg acgcgcattg cgacgcgaac attaacacaa 40080

gcgaccgcga agttcggcgg cacctttgga accgggcgca cgtaaaggcg ttgaagctgg 40140

ccggaattat cgccgtcggc tgcaaccctt acgacccgac cattaccgcc gacgttgcgt 40200

cttgggcgat taaccttgtc gtcgccgacg ttcgaaactt gcttgcccgg ttcgatgctg 40260

gcgaaattgg catagacaac gacgaaacga aacagcttgc gaaggttatt gcaaccgtta 40320

aagatttcgt cgtttcacct tggccggacg ttgcgaagta cgcaggcgaa ggaatgtcca 40380

accttcattc gaaccgaatt gttccgtaca gctacgttca acgcaggctt gccgctgttg 40440

ccgtctttcg taaagaccgc atcggcgcaa gcggggcaat caagcgcgcc ttgaagaccc 40500

tttgcgaacg cggcgatttg caggaagtaa gccgggccac actggcgaag gattacggaa 40560

caagcgccgt tgcatacatg gtcgcgcatc cgggcgtttt cggcctgtaa cgcgcgcccg 40620

ccagtgtggg cagaacgggc cgccttcggg cggctttttc gtgcctgtaa aaaaaagttc 40680

gtcgtacctg ttgacgtagc ttcgaactgt acgtagaata caaaccatcg aagcaacgaa 40740

acaaaccaag gaaccgaagc catgaacgta accaacctta aaaccgccgt cgaaatcaaa 40800

attgaaattg aattggccgc ttgggccaac ggcgaaaaga aagttaacgt ttccaaccaa 40860

ttcgacgaaa gcgttttgga atcggccaaa gaagcaatta gcgtcgaagc aatcgccgca 40920

atcgttgcca agtatccggg cgcgaacttc gaaggctttt cggttatgac ttgggcgcac 40980

gaactttcgg cgttcaaagc cccggaaatc gaccgggctt ggttcgacta agcaagcgcc 41040

cttcggggcg ttttttttgt tcgtacctat tgacgaagct tcgaagttgc cgtatattta 41100

aaccatcgaa gcaaacaacg aaggactaac gaacatgaac gcacttaaca acattcaacg 41160

ggtcgtaagc tggaacagca agaagaacgc cgacggcacc tttaccgcta ccgcgtacag 41220

cttcgaccat aacgcgccga ccgtcgtaca tgccagctac acgcgcgcca gccgcgccca 41280

agccgtcgca gacgccaaga aggccgttcg ttacctgaaa gcccaacagc gcaccgcgta 41340

aggagtcgcc gccatgtttg cccattactt cgccagcaag aaaacgaagt tcgttgtaat 41400

cagcgaaacg aaccgcccgg aaggccagcg aatcgccgta agcggcaaag ccgaagcccg 41460

cagggtcgcc aaggaacgca acgcgcagcc ttggaacttc taaccccggc cacggccctt 41520

ggcacgcgct aggggccgcg cagcctgccc acattaagcg aaggacgacc gaccatgcgt 41580

acaacccttg cagccgtaaa caaagccctt gccgccgctg gaatcgacgc ggaattggtc 41640

aagggtcgcg ggtactttta cttcgttggt tccgccgtag attgcgccaa agaacaaggc 41700

gtttacggcg tgtatcggct ttccgaattg accgtttccc aatgggtcga agaagcccgc 41760

caacgtatcg aaaaggagta agaacaaatg accgcatatt ttatcgcatt tggcgtcgcg 41820

cttgggttgg cccttgcgcg cttggccgct tcccaattcg aagccgcttg ttacctgttc 41880

tgcaacggcg aatttcgaaa ggcattccgg gcaacgatgc acgcccttac ctgcgttgcg 41940

ttgcttgcgt tggttgtttc gcccgttgct tcgttcttcg atagcttcga agttataagc 42000

attgaacaac cttcgcccaa tccttcgaag ggtcttcgcg tataatagcc gacgggtcgt 42060

ataatgggca cgtataagcc ttaaaccctt gatacataag gctttcagcg gattcataac 42120

aagtataacg tataacgccc ttgaccctga aaccccggcc caatgttata aattaagctt 42180

tctttatata gattgatttt tagttattat acttattaaa tttattatat ttccttattt 42240

atcaaggact tagcagctat acagcccctt caattcgtat aacgggcttt ttgtgttata 42300

acgttgttga catacaaact ttataaggct atgattccgg cacgcactaa cgaaaggggc 42360

ttgcaatgtc ttacgaaata atcgaatgtt cgccgaaggc gcgaagcaaa attaagtcgt 42420

tcgaagatgc gctaggcgtt gacgccgaat tgacgcacca acgttcgaag tatccttggc 42480

cgctgttgaa aatcggccag tcgttcgccg tgccgttggc cgaaggtaac gaagcatcgt 42540

tgcgaaacgg cgcgtcgcag ttcagcaaga agaccggcaa gaagtttgcg gttattcggc 42600

attctgaata cggctgtttc gaatgcgcgc gcatcgctta gcgccgggcc aatgtgggca 42660

acaaccgaag gggcaaccaa tgtacgaaat cgaaaccggc cataaagtgc cgaagcaacg 42720

tcgcaaggct ggaagcgtgc cgaaggccgt tcaacaggcg ttcaacgact acgccgaagc 42780

gtataaggcc gtttacggcg ttcgcccgct gtcgttcacg tatgaccgcg aaagcggctt 42840

tattcgtgtc gaaagtagcg gcggcgtaag cgtcgcaagg ctgcgcgaaa tgacgaaaca 42900

gcttcgttac cgaaaaggat aaaaaaattc gt 42932

<210> 15

<211> 42932

<212> DNA

<213> Artificial Sequence

<220>

<223> s4 phage变体

<400> 15

cgcacaattg cgccggtatg tacgaactat acgacggccc ttcgttactg tcaagcccct 60

ttttcaagaa tttttcgttc ttcgaacaag tcgcgattgt tggcgtcgaa ttcggtaaag 120

gcgttcggga agcgacgacg aagcttcgcg atgttgaccg actgcgcttc gccgaagttc 180

gaaccaatgg cgcgcagcaa aagcgcatcg taccaaaagc cgtcgccgac ttcttcaagc 240

gcgttaacag cgtcgaaagc ttcgccttcg gctgcggcgc ttagggcttc caacagttcg 300

cccgcttcgg tcgccttgcc gataattgca tgaatgacgt tcacggctgc ggcgtcgtct 360

tcggggcggt cggaaatcca ttcgggaagc ttcgccagcg ttgccgcgtt ggcttccggg 420

gccggaacgc cagcgtcgcg accgtagaac atggttttct cgattgcgtc aagcttgtta 480

agggcttcga cggcttcggc gatggtttcg cggaagtagg ccagcgacac gcggtcgccg 540

taatacttat ccgacgcggt tacgtgcgct tcttcgatat agtcgaaggt ctttgcgggt 600

tcgttcatac gttcaccttt tagaagggcc gggcaccatg cgccagcgtt ccagcactgt 660

aaccgaccgc gcctttcctg tcaacaacaa ttgacagcaa gcaagaagcc gggtaagctg 720

cccacaattg ctagaaggtg gcgttatgga cattgaagaa cttacgaagc gggtaaagaa 780

agcaagcgtc gggcggtcgc tgcgggcgct ggccgcgcaa tgcaacgttt cgcacgaact 840

tataagaaag cttttgcttg ccaattctgc gccgaacata acggcgacga cttataacaa 900

gattgataaa ggattggcga agaatggact ttaacaatat tccgcacgaa atgcggattt 960

acccgcaatg ggtcgtttgg cgatacgaag acacggattc aaagaaaccg acgaaggttc 1020

cgtattcagc aaaaaccggg caccttgcca gcgtaaccga cccgaacact tgggccgggt 1080

tcgacgaatg cgttaacgct atgtcgtccg gttggtatgc cggaatcggt ttcgtattga 1140

ctgaaaacga cccgtattcg tttatcgacc ttgacgacac aaaaggcgac caaacggcgc 1200

ttgaccgcca aataaagatt tttaacgaat tcaacagcta cgccgaacgg tcgccttccg 1260

gttcggggtt gcatatcatc gttaagggcg cgattccgtc gggccgccgt cgttcgttta 1320

tcgaagttta ttcttcgctt cgttatatga caatgaccgg cgacgtttac cgcaacgcac 1380

cgattaacga ttgtaacgaa ctgttaaacg ttctttgggg ccaaatgggg caaggttcgg 1440

tcgccgtcgc gcattatgcc ggacttgccg aagccaagga aaccgacgaa caggtttata 1500

accgcgcagt cgccgcagcc aatggcgaca agttcgccga actgtacgcg ggcaaatggg 1560

aaggcatgta cgcttcgcag tccgaagccg actttgcctt ggtcgatatt atcgcgtttt 1620

atacgcagaa ccgggcgcag atttcgcgaa tgtttcgcgc gtcgggcttg gggcagcgtg 1680

acaaagcaaa acgcgacgat tacgtttcgt acatgctgaa caagtgtttc gaccgcatgt 1740

tgccgcccgt tgacgttgac ggattgcgca acaagctaga cgaagccata gcgaagaaag 1800

aagccgccga cagggccgcc gcgttgtcgc agaacagcga agcgacgccg catccgaaag 1860

ccccggcccc gaaccttagc gaagtttcga aggtatacag cgtgccgccc ggattagtcg 1920

gagaaattgc gcaatacatt tacgcacaag cgccgcgccc ggtgcccgaa atcgcgttgg 1980

ccggtgccct tggcttggtc gccggtattg tgggcagggc gtacaacatt tccggcactg 2040

gccttaatca atacgttctg ttgttggcac cgaccggaac aggtaaagaa gccatcgcaa 2100

gcggcattga taagctaatg gcgcaggtta tccgaaccgt tcccgctgcg tcggacttta 2160

tcggccccgg tgaaattgcg tcggcccaag cgattattaa gtatatgtcg cgcggcccaa 2220

cgtcgttcgt ttcgttggtc ggcgaattcg gcatttacct tcaacaaatg gcaagcgtaa 2280

acgcaccgcc gcaccttacc gggcttcgtc gcttcctgtt ggatgcttac aacaagtcgg 2340

gcgaaggcaa ggtacttcgg ccttcgattt attcagacaa ggacaagaac acgaccgccg 2400

ttctttcgcc gtcctttacc ttgcttggcg aatcgacgcc cgaaaagttt tacgaaggtt 2460

tgcacgaagg tttgatttcc gaaggtctgt tgccgcgttt tacgatgatt gaatatcacg 2520

gcgaacgccc ggcgttgaat ccggggcacc tgtcggccca accttcgttc gaacttatcg 2580

acaggctttc gaccttgtgc gcccatgcgc taatgctgaa cagccagcat aaggcgattc 2640

acgttcaaac cgacgcaacc gcccgcgaac tgttccagca attcgacgcg cattgcgacg 2700

cgaacattaa cacaagcgac cgcgaagttc ggcggcacct ttggaaccgg gcgcacgtaa 2760

aggcgttgaa gctggccgga attatcgccg tcggctgcaa cccttacgac ccgaccatta 2820

ccgccgacgt tgcgtcttgg gcgattaacc ttgtcgtcgc cgacgttcga aacttgcttg 2880

cccggttcga tgctggcgaa attggcatag acaacgacga aacgaaacag cttgcgaagg 2940

ttattgcaac cgttaaagat ttcgtcgttt caccttggcc ggacgttgcg aagtacgcag 3000

gcgaaggaat gtccaacctt cattcgaacc gaattgttcc gtacagctac gttcaacgca 3060

ggcttgccgc tgttgccgtc tttcgtaaag accgcatcgg cgcaagcggg gcaatcaagc 3120

gcgccttgaa gaccctttgc gaacgcggcg atttgcagga agtaagccgg gccacactgg 3180

cgaaggatta cggaacaagc gccgttgcat acatggtcgc gcatccgggc gttttcggcc 3240

tgtaacgcgc gcccgccagt gtgggcagaa cgggccgcct tcgggcggct ttttcgtgcc 3300

tgtaaaaaaa agttcgtcgt acctgttgac gtagcttcga actgtacgta gaatacaaac 3360

catcgaagca acgaaacaaa ccaaggaacc gaagccatga acgtaaccaa ccttaaaacc 3420

gccgtcgaaa tcaaaattga aattgaattg gccgcttggg ccaacggcga aaagaaagtt 3480

aacgtttcca accaattcga cgaaagcgtt ttggaatcgg ccaaagaagc aattagcgtc 3540

gaagcaatcg ccgcaatcgt tgccaagtat ccgggcgcga acttcgaagg cttttcggtt 3600

atgacttggg cgcacgaact ttcggcgttc aaagccccgg aaatcgaccg ggcttggttc 3660

gactaagcaa gcgcccttcg gggcgttttt tttgttcgta cctattgacg aagcttcgaa 3720

gttgccgtat atttaaacca tcgaagcaaa caacgaagga ctaacgaaca tgaacgcact 3780

taacaacatt caacgggtcg taagctggaa cagcaagaag aacgccgacg gcacctttac 3840

cgctaccgcg tacagcttcg accataacgc gccgaccgtc gtacatgcca gctacacgcg 3900

cgccagccgc gcccaagccg tcgcagacgc caagaaggcc gttcgttacc tgaaagccca 3960

acagcgcacc gcgtaaggag tcgccgccat gtttgcccat tacttcgcca gcaagaaaac 4020

gaagttcgtt gtaatcagcg aaacgaaccg cccggaaggc cagcgaatcg ccgtaagcgg 4080

caaagccgaa gcccgcaggg tcgccaagga acgcaacgcg cagccttgga acttctaacc 4140

ccggccacgg cccttggcac gcgctagggg ccgcgcagcc tgcccacatt aagcgaagga 4200

cgaccgacca tgcgtacaac ccttgcagcc gtaaacaaag cccttgccgc cgctggaatc 4260

gacgcggaat tggtcaaggg tcgcgggtac ttttacttcg ttggttccgc cgtagattgc 4320

gccaaagaac aaggcgttta cggcgtgtat cggctttccg aattgaccgt ttcccaatgg 4380

gtcgaagaag cccgccaacg tatcgaaaag gagtaagaac aaatgaccgc atattttatc 4440

gcatttggcg tcgcgcttgg gttggccctt gcgcgcttgg ccgcttccca attcgaagcc 4500

gcttgttacc tgttctgcaa cggcgaattt cgaaaggcat tccgggcaac gatgcacgcc 4560

cttacctgcg ttgcgttgct tgcgttggtt gtttcgcccg ttgcttcgtt cttcgatagc 4620

ttcgaagtta taagcattga acaaccttcg cccaatcctt cgaagggtct tcgcgtataa 4680

tagccgacgg gtcgtataat gggcacgtat aagccttaaa cccttgatac ataaggcttt 4740

cagcggattc ataacaagta taacgtataa cgcccttgac cctgaaaccc cggcccaatg 4800

ttataaatta agctttcttt atatagattg atttttagtt attatactta ttaaatttat 4860

tatatttcct tatttatcaa ggacttagca gctatacagc cccttcaatt cgtataacgg 4920

gctttttgtg ttataacgtt gttgacatac aaactttata aggctatgat tccggcacgc 4980

actaacgaaa ggggcttgca atgtcttacg aaataatcga atgttcgccg aaggcgcgaa 5040

gcaaaattaa gtcgttcgaa gatgcgctag gcgttgacgc cgaattgacg caccaacgtt 5100

cgaagtatcc ttggccgctg ttgaaaatcg gccagtcgtt cgccgtgccg ttggccgaag 5160

gtaacgaagc atcgttgcga aacggcgcgt cgcagttcag caagaagacc ggcaagaagt 5220

ttgcggttat tcggcattct gaatacggct gtttcgaatg cgcgcgcatc gcttagcgcc 5280

gggccaatgt gggcaacaac cgaaggggca accaatgtac gaaatcgaaa ccggccataa 5340

agtgccgaag caacgtcgca aggctggaag cgtgccgaag gccgttcaac aggcgttcaa 5400

cgactacgcc gaagcgtata aggccgttta cggcgttcgc ccgctgtcgt tcacgtatga 5460

ccgcgaaagc ggctttattc gtgtcgaaag tagcggcggc gtaagcgtcg caaggctgcg 5520

cgaaatgacg aaacagcttc gttaccgaaa aggataaaaa aattcgttcg aagggttgac 5580

gtactgtcga agccgtcgta ctatataccc ataccaacga acacaaggaa ccgccgaaat 5640

gcaaaacgtc caaatcaaac gccccgcagc gattaccgaa ggccaagcaa tgaacgcagt 5700

tttcgacgcc ttccgccaag tgtggcgcaa cgtcgaagcc cgcgccgaaa tgcttaaagg 5760

cgtttcgcag tcggtcaagg tcggcggctt cgaagtgtcg gttttcgcat ggcgcgacgg 5820

tcgcattcaa gccaacgttt acgcaggcgg ctttaacccc gtcgcaaccg ccgaagttga 5880

cgaattcgac gcctaatcaa ccaagcgcgc cgggcgcaac ccggcatttt tgaaggagtt 5940

ataacaatgt gcatcgtatg cgatattaaa caggccgtcg aagcttccgg cccgaacaaa 6000

gaagaccgcg ccaaaatcct tggcttggtc gaaaagctgg ccgaagcctt gggcgatgtt 6060

ctggaagtcg cgcaggaagt acacgaagcc aagcccgaag cgttccagcc ggaacacgtc 6120

gaacgcttgc agaacgccgc cgacttgctg aacgaccggg gcgaactgcc cgacgccctg 6180

ttggccctgc tgttggccgc ccttgggcgc ggcgtcaagg tcgaaacaat ccgcgtcgaa 6240

ctgcgcgaag gcgaaacgcc agaacaggcc gtagcgcgtg taatggccga acgcgaaggc 6300

ggggccgcga cgaaacacta accaaagcgc cccggctgtt gtatagtcgg ggcttctttc 6360

tatcatgggg aacgaaagaa catggcggac gaagtagacc aaacagccga ccgaatagaa 6420

aacgaagtaa gctttacggt cggcgaactt tgccgaaagg ccgcagcgat acccgcaggc 6480

cgtccgggcg aatgtgattt ttgcggcgaa cacttcgcgc gcgttgtcga agtgaccgac 6540

ccgcgaacgg gcgaagtcgt cgaaagctgc ggtcgctgtc gtgaccgaag gggcatcgca 6600

tgacgcccgc aacccttgcc aagtctggca ccgaacacgc gcaccaaacg gcgctttttg 6660

cctatgctgc cgtcgcatac ttacacggct tcgacgttgc cgacgaatgg tcaaagaccg 6720

gcaagctacc gaagcgcgac ccggacgcac cgccgaaggt gcccgccctt gaatggttcc 6780

acgccatacc gaacggcggc agtcgcggcg acgacgacaa gtcgcgaaag atacgcggcg 6840

cgcagttgaa ggccgaaggc gtgcggcagg gcgtagccga tacgttcttg ccttggcctg 6900

tttacgaacc gtgcccaagc gacccgcaaa taatgatgat gaaatgggcc ggtctttata 6960

tcgaaatgaa gaagccgacc gaacgtccga agtcggaaac cgcaaagggc ggcgtatcgg 7020

acgaacaacg cagcttcggc gaatacgcaa agcgcgtcgg ctatggttgg gccgtctgct 7080

atgattggga acaagcggcg tcgtaccttc gttcctatat cgaatggggt tcgtaatggg 7140

gctttcgtgc cttgcctgcg aacttacccg cgcccggttg aaagcggcgg cgctggccct 7200

tgtgggctgg ccccttgacc gcatcgccgg gcatttgtcg tcatgctatg gcgaacggta 7260

ttacgtcgaa ggcggcaagc tgtatcgcgc gtcgaagttg ccgccgtatc aaccgcactt 7320

gataaggggc gaagaatgaa aaagaccgac gaagaattga tagacgaagc ccgcagcatt 7380

gcgcgttcga aacgctgttt cgtcgtaacg aagccgggtt attggctgtt ataccgcgaa 7440

tgcacgccgc gtaacgtatg cgtcggcaaa cggtcgtcgg ctgcggcgtt gcttcaactt 7500

gcgaaaaagg cttgacgtag cttcgaagct gtcgtacact tcttcgtaag ttgaacgaac 7560

aaaggagtaa cgaccatgcc cgcatataac gtaacaaccg aattcgaaat gaccgacggt 7620

cgcgttctgt cgtgcgaata cgtcttgtcg gttacgcccg gtcgctattc cggcccttgg 7680

gaagattgtt acccggacga atccgacgca ggcgaaccga cgtattttat cgacggcgaa 7740

gaagtcgatt acaaagaact tccaaaagga ttggacgcaa tcgccgacaa gctttacgaa 7800

gctggcgacg gcgaatacaa ttacaaggaa gaacgcgacg aaccggatta cgaaccggat 7860

tacgattacg attattaacg aaggagtaac gaaaatgtct tggcttattg gttgggccgt 7920

actttccgtc ggcgttgttg tcggcttctt gcttgcggcc ttgctgcggg ccaacgggcg 7980

cgacgtgccg gttccttcgg ctaccgttac cgccctgtcg ccgcaggaac gcgcccgcat 8040

gggctacgcg ctggcaaggg ctggcgactt gctggacagc ggcgaccttg aatacgtgtc 8100

gggcggcttt atggtgcaag acgtaggaca cggcgtcgta attatcaaag gcgatttgtc 8160

gttgcgggtt gccgaagatg aataaggacg aagcgcgcga aatgttcgaa gccgtcaagg 8220

ccaaccgggc gaagattgac ggttgcgccc gccatcgctt cgaaatcggc gacccgccgt 8280

acacgttcgg gcaaaagttc acttgttcga actgcggcgg aacaatggac gccgtacagg 8340

cgttccgata ctgtcaaggc ttcaaggccg caggcggcga cccgaacgaa gttataccgg 8400

gttacgaata acgcttgaca agcggcgaag gttcggcgaa acttagacgt aacgaagaaa 8460

ccccgttaag gagttgccga aatgaccgtt ctaattttgc ttctttgcac cgttgccgct 8520

ttgttcattc atcgcatgtt tgttcgtccg attctggatt ggttcgaaca acgcgaatac 8580

gccgaacgta tgcgcgaagc tgaacagcgc gcggcgttgg aagaagcaag gcgggccaag 8640

tgtcgataat ctacgcaccg cgcgacgccc tgtcgaaatg ggacgcgcga tttattgaac 8700

tggccgaaca cgtcgccgga tggtcgaaag ggccgcgtaa gcgcatcggc gcggctatcg 8760

tgcgcccgaa tcggtcgatt gcgtcgcttg ggtacaacgg cccgccgcgc ggcttcgacg 8820

acgccgtttt tctgaacatg acgcgcgacg aacaacacgc ggtcgtaatt catgccgaag 8880

acaacgcaat tcgacaggct gcgccgggcg aagacttgtc cgcgtgtacg ctgtacgttt 8940

cgccgctgtt tccgtgcgcc atttgtgccg accgcattgt tcgggccggt atccgtcgcg 9000

ttgtcgctta ttgtgggcat atatcgccag actggcgcgc gtctgccgac gaagccgaac 9060

gcatctttaa ccaagcgggc gtcgaatgcc tgtttacaat ggattaacga acatgaaacc 9120

gctagaccat tcgcaaatcg aaggcttgtt gttctatcaa gacccgacaa cgcaaaacta 9180

tatcggcgca ccgaaggccg acccgttcaa ccaagccgga agcttcgtcg cattcgggcc 9240

gcgtgttacc gttgacccgg cgttgtataa cttgcttgcc gcagcgccga caatgtacca 9300

agccctttcg atgcaatacg cttaccttca agcgcaaatc gaagttatcg aacgcttgcc 9360

aaaggcgggc gaacttgata agctgttgtc gtcgctaatc gaagcgcaga acgcttgcct 9420

aatggcccaa cgtatcgcgc aagtcggtta cgaaaatgtc gcaaattcac ttgacaaagg 9480

ttcgaagcgg tcgtaagctt gaaccatcga aacgaacaaa ggtgcccaca atgaaccgta 9540

agcttcttgt tatcgctgga atcgtcgcct tcgtcgcgtt gcttggcatg gtcgggcaaa 9600

tggacttcga agacgaagcc cgcgcgcacc tgttgtattg tgacaacgta gcgaacggcg 9660

tttggccgga ttacgacaaa atttacgatt ctgaatgcac gcccgaacgc atcgcagaaa 9720

tcgaagaaat tttgcgttga ccgcttgaca cgaagaacgg tcggcgtaaa atcaacccgt 9780

cgcaacaacg cgacataacc ttaacgttaa ggagttacac aaaatggcta ccaagaaatc 9840

gaccgcgaag aagaacaccg ccgccccggt tatcggcctt gccgaaattg ttgcagccgg 9900

gccgaatggt ctgtatactt cgcctgccgt acatggcccg cttgtcgaag ccggtatggt 9960

ggaaatcaac ccggcaatga ccaacgaagc gggcgaaatc gcaacccgcg caacccaaaa 10020

aggaatcgac gaaatgaacc agaacaccga aaccggcacc gccgcagctt ccgccccggt 10080

cgctacttcc ttcgccatcg aagacaacgt acccatgccg accggcagcg gtcgcggtcg 10140

cggcggcaac gtctacccgt tcgacgcgct ggaagtcggc caaagcttct tcgttccgaa 10200

cagcgaagaa aagccgaacg ccgcgaagtc gcttgcttcg accgtttcca gcgcaaccgc 10260

ccgtttcgcc gtgccttccg aagacggcgc gaccaagacc aacaagaagg gcgaaaccgt 10320

gcccgtcatg gtcgaaaccc gcaagttcgt tgttcgttcg gtcgaaggcg gcgcgcgcgt 10380

ctggcgcacc aagtaagcga cggcgcgggc tacggcccgc cctacgccta cgcttcaacg 10440

gaaaccccgg ccattgcgcc ggggttttct tttgcttttc ttgtcaattt gtgctaatcc 10500

gtgctaatct tcggccaaat acatttcggg gccggggctt gtgatgaatg aacgaacaac 10560

aattttttaa cgtagccgtc gcaattatcg gcgcgttggg cggttggtgg atgcgcgtta 10620

tgtggcagtc acttaaagaa cttcaagcgc aagattcgaa gttggccgat aaagtcggca 10680

atatcgaagt tcttgtagcc gggcagtatg tcaagcgcga cgatatgaac cgcgacataa 10740

tggcgatttt cgccaaactt gaccgcatcg aagacaagat agacaaaaag gccgacaaat 10800

gaagaagccc gaacttatcg aagattggcg cgaatgctgg cgcttttggt cggttcgact 10860

ggccgcagtc ggcaccgcaa ttactggcct tcttgttgcg tttcccgacg cagcgttggc 10920

cgcttgggca atccttccgc acgaattgaa gtcgtcgatt ccgccgcagt atatgccgct 10980

tatcggcgtt gttgttttcg cgctttccat cgttgcccgc cttgtcaagc aaaagaactt 11040

gaacaagggg ccgaaggatg aataacgaac ttccttgggt agccgaagcc cgaaagtata 11100

tcggccttcg cgaagacact tcgaagactt cgcataaccc gaagcttctt gccatgcttg 11160

accgcatggg cgaattttcc aacgaatccc gcgcttggtg gcatgacgac gaaacgcctt 11220

ggtgcggtct gttcgtcggc tattgcttgg gcgtagccgg gcgctacgtc gtccgcgaat 11280

ggtacagggc gcgggcatgg gaagccccgc agcttaccaa gcttgaccgg cccgcatacg 11340

gcgcgcttgt gaccttcacg cgaagcggcg gcggccacgt cggttttatt gtgggcaagg 11400

atgcgcgcgg taatcttatg gttcttggcg gtaatcagtc gaacgccgta agtatcgcac 11460

cgttcgcagt atcccgcgta accggctatt tctggccgtc gttctggcga aacaagaccg 11520

cagttaaaag cgttccgttc gaagaacgtt attcgctgcc gctgttgaag tcgaacggcg 11580

aactttcgac gaatgaagct taaaggggca tcgcatgttt tccgtaattt gggccaagtt 11640

tggcaaatgg cttgccgcaa tcggcgcggg tcttgtcatg ctggcaagta ttttttatgc 11700

cggtcgcaag tccggcgcaa ccaaggccga agccaacgca gcaaacgaac gggcaaacga 11760

ccgcgaagca atcgcagttc gccaagttaa cgaagcccgc gaagcttccg aacaacaggt 11820

aaaggcggta caaaatgcga aagacgttgc ttccgataat tctacttttg acgacgacga 11880

agttactaag cggctgcgcg acgaatggtc gcgcgactga accgcaaagc atcgccgacg 11940

cagtgcaaac gaagcccgtt gtaatcgaca cggcttgcaa atgggttgcg cctatttgga 12000

tttcgaaggc cgacggcttg accgctggca cggcccggca aattctgaac cataacgaag 12060

ccgtcgaacg caattgcggg ccgcagtcgc cgcctaaatc tgcggacaag ccttaacaga 12120

acgcggggct tgcggtatag tgaagccaac gacgtataaa ctaggccgac actatgtccg 12180

acgaactgaa agaaagcgaa gaaaaggccg catacgcggc ccttcttttg aaagaacgcg 12240

acccgttcaa ggctgcgctt tcgctgtttc cgaacaacac gaatcgcgcg ctatgggttg 12300

cgaaccattg gccgaacgac gccgaagtta aggccgaaca aaagcgcctt accgacgaag 12360

gcggcgatat ggcatttctt ccgggcaaag gcgaccttgc ccgcgacatt tggcagcgta 12420

tgcaaggtac gacgcttccg aacggcgtaa ccattccgcc gacgcccgaa gaatacgcga 12480

agcttgccaa gctttacgcc gacgttcgcg ggttcatcga aaaaccgcaa acgaacgtta 12540

acgtaacgac gaacgtaaac cgcgtcgtcg aaatgcccgt attcgctaac gaaagcgaat 12600

gggaagcgga agccgcacgg caacagcgcg aattgttaga aaatgcacgc actcgccatt 12660

gatacgaacg gggcgaaacc tgttccgtat gaagtcgtat ttaagcccct tccggggtcg 12720

cagactatcg ccctttgttc gatggcagcg catacgctgt acgaaggcgc acgcggcccc 12780

ggtaagacgc ttacgcagct tatgcgcttt tatcgtaacg tcggcaaagg ctacggcaag 12840

ttctggcgcg gcgttatctt cgatttggaa tttgaccatt tgggcggcct tgttgccgaa 12900

tcgaaaaaat ggttcggcga taacggaaag ctaaaagacg gcggcaagtt ttacgaatca 12960

acgtcggctt ataaatgggt ttggccgaca ggcgaagaac tgttgtttcg gcacgttaag 13020

aagctgtcgg attacgaagg cttccacggt cacgaatacc cgtttatcgg ttggaacgaa 13080

cttacgaagc atccaagcgg cgacctttac gacaaattta tgtcggtcaa ccgctgtacg 13140

ttcgacccga taaaagacac gccgaaagac ccgaaaaccg ggcgctattt gacgccgaac 13200

ggcgaaccgc tgccgcctgt aaagtgcgaa gtattcagca caacgaaccc aagcggcccc 13260

ggtcacaatt gggtaaaacg tcgctttatt acgattgccc cgcgcggcac cgtagttcgt 13320

cgcgaaattc agatttacaa cccggcgacc gaaaaagaag aaacgcacgt aattagccaa 13380

atcgctatct tcggttcgta taaggaaaac ccgtaccttc cggcttcgta tatcgccgaa 13440

ctggaaagta tcaaagaacc gaacttgcgg aaggcttggc tttacggcga ttgggacgtt 13500

accgcaggcg gcgcaatcga cgacctttgg caatcgcata tacacgttgt accgcgcttc 13560

gtcattccgc caagctggcg aatcgacaga acatacgacg acgggtcttc gcatccgttt 13620

agtgtgggct ggtgggcgga agcggacggc accgaagcga ccatagttct ttcggatggc 13680

accgaattta cgttttgccc gcaaccgggt tcgcttgttc agttgttcga atggtacgga 13740

tgcgcgaaag acgaaaaagg cgaatacata ccgaataaag gtttgaagct ttcggcgtcg 13800

aatatcgcac aaggtataat cgaccgcgaa atttcgctaa tggcgaacgg ttggatttat 13860

tcgcagcctt ggcccggccc tgccgacaac cgcattcgcc aagtaatcga cagcgaacta 13920

gacacgaccg aaaagcttat gtcgaagaag ggcgttcgtt ggacggaatc ggacaaatcg 13980

ccgggttcgc gcgtaatcgg gttgcagctt ttccgcgacc ggctagaagc gtctgttaat 14040

cgcgaagggc cgggtatata ctttatgtcg aattgcgttg caagtattga tttgctgccc 14100

acactgccgc gcgacgaaaa gaagattgac gacgtagaca cgaccgccga agaccattgt 14160

tacgatatgg tgcgttatcg cgtattgaaa ggcgcgaaca aagcggcagc gaaattcaaa 14220

cttgttatgc caacttaaag gaacccaaat catgccgaac gtttcattta ttcgccccga 14280

acttggtaag ctgctgccgc tgtattacct gattcgcgac gcaatcgcgg gcgaaccaac 14340

ggtaaaaggc gcgcggacga cttatcttcc gatgccgaac gccgaagacc aatcgaaaga 14400

aaataaggcg cgatacgaag cgtacttgaa gcgggccgtt ttctataacg tagcccgtcg 14460

aaccttgttc ggcttggtcg gtcaagtgtt catgcgcgac ccggttgtaa aggttcccgc 14520

gctgttgaac ccgcttgtcg caaacgcgac gggttcgggt atcaacctta cgcagcttgc 14580

gaaaaaggcc gtatcgctga accttgcgta ttcccgcgcc gggctgttgg tcgattaccc 14640

gacgaccgaa gccgaaggcg gcgcgtcgat tgccgacctt gaagccgggc gcattcgtcc 14700

gaccctgtac gtatattcgc cgaccgaaat tatcaattgg cgaacgaccg accggggcgc 14760

ggaagaagtt ttatcgttgg tcgtactgtt cgaaacttgg tgcgctgccg atgatggttt 14820

tgaaatgaaa acgtcggggc aattccgcgt tttgcgtttg gacgaagaag gttattacgt 14880

ccacgaaatt tggcgcgaac cgcagccgac caaagccgac ggtacgaaga ttccgaaagg 14940

caattaccaa caatacacgg tttacaagcc gacggacgca aacggcaatc gtcttaccga 15000

aattccgttt atgttcatcg gttcggaaaa caacgattcg aacccggaca acccgaactt 15060

ttacgacctt gcgtcgctga atatggcgca ttatcgcaat tcggcggatt acgaagaaag 15120

ttgttatatc gtcggacagc cgacgccggt tcttatcgga cttaccgaag aatgggttac 15180

gaacgttctt aaaggttccg ttaacttcgg ttcgcgcggc ggtattccgc ttcctgccgg 15240

ggccgacgcg aagttgcttc aagcatccga aaacaccatg cttaaagaag caatggatac 15300

caaagaacgc caaatggtcg cacttggcgc aaagcttgtc gaacaaaagg aagtgcaacg 15360

cacggcaacc gaagccgaat tggaagccgc ttcggaaggt tcgacgcttt ccagtgcaac 15420

caagaacgtt tcggcggcct ttgaatgggc gttgaaatgg gcggcccgtt gggtcggtca 15480

agccgacagc ggcgttaagt tcgaactgaa tacagatttc gacattgccc gcatgacgcc 15540

ggaagaacgc cgttcgcttg ttgaagaatg gcagaaaggc gcaattacct tcgaagaaat 15600

gcgaaccggc ttgcgtaaag ctggcgtcgc aaccgaagac gacgccaagg ctaaagaaaa 15660

aatcgccaag gataccgccg aagcaatggc ccttgctgcc ccggctaacg tgccgggcga 15720

tggcagcggc ggcgataatg tgggcaacaa cggataaggg gcgcaatcat ggcactatcg 15780

gacaataagc gactgtacga tattgcgacg cgccttgctg tttacgtcga agacgtgaaa 15840

gtttggcagt cccgacaatt cgggttcgta cttcgcgaag taaacttgga attaacgcgc 15900

cttcttggtc gtgttcgtta taagaccctt gacggtcttt cgaaggcgca gttaaacaag 15960

cttgtttcgg aattacggga atcgcaatcg aagatttaca gcgcatacac gcaaacgctg 16020

cttgaacagt taaaggaatt catgcgggcc gacttggaag taaaccggcg cgcttgggtt 16080

acgggttata tcgaacttga cggcgaagaa agcgacgaca ttatttcgga cgaagaagcg 16140

atacagtttc ttttagaagt accaaacgcc gattcgaacc ctttgttcgg tttggccgct 16200

gttacaggaa gcgacgaacg catttggtcg caagttacga atacgccaat tccggcaaat 16260

ggtttgtact tgctgccgtt tatcaagacg tttacgaatt cggcacaagc tggcgtcgaa 16320

agcatgattc gcaaagcttg ggcgaaccgt tggacggttg aagaaacctt aacggcgctt 16380

gtcggcgatg gaaccgcagc gcagggcacg ccgtcgcagt tgcaccgggt caacgcgcaa 16440

gccgcgtcgg taatccatac ggcaaccgcg cacgttgcgg cggtcgttgc ggctggcgtt 16500

atgtctgcgg ttttcggtcg ttacgtttgg tattcggtaa tcgacggaag aacgacggac 16560

atttgcataa gtcgaaatcg ccgaatctat cgcttcggcg aagggccgtt gccgcccgcg 16620

catatccgtt gccggtcgca cgttgccccg gcaaataccg ctagtgactt ggccgaagaa 16680

acgttttata cttgggttgc ccgtcaacct gcccaagtgc aagacgacat attaggcgac 16740

gaaggcggcg aagctttgcg cgatggtcgc ttaaaggcga aggatattcc gaagtatgat 16800

gcggacaggc cgctaactta cgaagaattc cgacgcaaga ttaaagaaat tctttcccgc 16860

tgattcggtg aatcggcata accgcaagga gtccttgaaa tggcactgaa aaagaaactt 16920

accaaagaag aacacgcgaa gctttcggat gcactgaaag ccgaatatat cgaagacggc 16980

gacggcttcc gccttgacgt tgacggcgac gaagatacgg gcgctttgaa gcgcgccaaa 17040

gaccgcgaag cgcagttgcg caaagacgcc gaaaaggaag cgaaggaact tcgcgaacgg 17100

ctggaatcca tcgaaggcga cgacgcgcgc aagaaaggcg acattgcgac gcttgaaaag 17160

tcttggcaat cgaagcttga aaaacagcgc gaagaatacg aagccaaggt ttccaagctt 17220

accgcgcata cgacgaaaac gcttgtcgat aacgtcgcgt cgcagcttgc ccacaagatt 17280

tcgaacgccc cggcaatcat catgccgcat atcaagtcgc ggcttatcgc agacttcgaa 17340

ggcgacacgc cggttacgcg cgttctggac aaggacggca agccgtcggc ccttactatc 17400

gacgaactgg caaacgaatt cgttgcaaac aaggattttt ctgctattat cacagctagt 17460

aaggcgtccg gcggtgccgg taagccttcg cagaacggcg gcggtgcccc gaaatttaac 17520

ggtcaatccg acaaacccgc cgacctttcg aagatgaatc ccgcagaact tgcggcgcat 17580

cttaaagaag cgaaggcaaa cgaaactaag gacgcttaat catggcactt tccgaccttg 17640

ctgtttactc cgaatacgct tattcggctt tctccgaaac cctgcgccaa caggttgatt 17700

tgttcaacgc tgcgacgggc ggggctatca tgctgcaatc cgcagcgcac caaggcgact 17760

tttccgacgt tgcctttttc gccaaggtaa cgggcggcct tgttcgccgt cgtaacgcct 17820

acggttccgg caccgtcgcc gaaaaggtct tgaaacacct tgtcgatacg tcggttaagg 17880

tcgcagccgg tacgccgcct gttcgccttg accccggcca attccgttgg attcagcaga 17940

acccggaagt cgcaggcgcg gcaatggggc agcaactcgc cgtcgatacg atggcggata 18000

tgctgaacgt tggtcttggt tcggtctatt cggcactttc gcaggttgcg gcggttgttt 18060

acgacgcgac cggcaatact gcgcccgacg acggcccgac ttggaacaac cttaacaacg 18120

gccaagccaa gttcggcgac caatccgcgc agattgcggc atggattatg cacagtacgc 18180

ccatgcacaa gctgtacggt aacaacctga acaactccga acgcctgttt acttacggca 18240

ccgtgaacgt tgttcgcgac ccgttcggca agcttcttgt tatgaccgat tcgccaaacc 18300

tgttcgaagc cggtacgccg aacgtttatc gcatccttgg ccttgtgccg ggcgcggtta 18360

tgattggtca aaacaacgac ttcgacgcga acgaagaaac caagaacggc gacgaaaaca 18420

ttattcggac ttaccaagcc gaatggtcgt acaacgtcgg cgttaagggc ttcgcttggg 18480

acaaggcgaa cggcggcaag tcgccgaccg acgcggcgtt gttcacttcg accaattggg 18540

acaagtacgc aacttccgaa aaggatttgg cgggcgttgt cgtcgaagtt cactaacgga 18600

cggcagacgg acggggcttc ggccccgttc ttctagtcct tcacaaattc aaaggagttt 18660

cgaagatgaa accggcaaaa atcctgtatt tcgtcgatgg caacgcaccg accccggaag 18720

acttcgcagc cgccgccgaa ctgaacgcgc aagttatgtt caggaacgcc cgcgctgttc 18780

cgtccgaacc gcattcgctg gaaatctgcg acggcgtagc gggcaaggtt ccgaagctgt 18840

acgccgacgc ttacccggaa gcgggcgaag caatcaagaa gaaggccgcc gaactgaaag 18900

cccttgcttc gaaggtcggc gacgccccgg caccgaaggc cagcggcaag gccgccgaca 18960

agcccgcagc cgctacgcag ggccagaaag ccccggcagc ggccccgcag ggcggcagcg 19020

ccccggcttg gaaccctaac ccggcgcagt aaccaacgga cggcctgtcg cttattgtgg 19080

gcaggccgtt tcaacaacga actaaggagt cttcgcaatg gcaacgaaaa aggttgttta 19140

ttttacggca ggcattaccg caaccgctgg cgaacttgcc gcaattgcga agcttaacgc 19200

agccgccgaa ccgcaatatg aagttttggt agccaatggc gcggcaaatg ccgaatacgg 19260

cgaaaccgac cgaatcattc cgtcggatta tgtcgccggt actgttcctt cggaatattc 19320

ggcggttgac gtaatcgacc ccgacgcaat cccgaatcag gcgcttacgc caacgcaagc 19380

aatcgttaac gacgccgaag ccttgaccgt tccggttact ggcacttaca cgacgaccgc 19440

aaccgttagc gttgcgaacg gcgttgtaac cggcatcgtt ctttcgtaag gacgttgacg 19500

catggcaatt acaatcgttg ttgaagacgg aagcggcgta acaaacgcga acagttacgt 19560

aagcgtcgca gacgcgcgca tttacgcttc gaatcgcggc gtcgaacttc cgttggacga 19620

cgacgaattg gcggccatgc tgattcgttc gacggattac ctagaagcgc aggcttgccg 19680

gttccaaggc aagccaactt cgacgacgca ggctttgcaa tggccgcgaa ctggcgtctt 19740

tcttaacgaa gacgaagtac cgtcgaacgt tattccgaag tcgcttattg ccgcgcaagt 19800

tcagcttgca atggcgatta acgcaggctt cgaccttcaa ccgaacgttt cgccgcaaga 19860

ctacgttacg cgcgaaaagg tcgggccgat tgaaacggaa tacgccgacc cgctgtcggt 19920

tggcatcatg cccacattta ccgcagcgaa cgcacttctt gcgccgctgt ttggcgaatg 19980

cgcttcgaac aagtttgcgc ttcgtacaat aagggtttga cgaatggcac gtttcgacgc 20040

agcaattaaa acggcgcaac gccttatcgc aaagaacggc gaaaaggtga aatggcgcgt 20100

tatcgaagac gcgacgccga cagacccgaa caagccttgg gaacccggcc cggcattgcc 20160

ggacgacaaa gacgttacca tttgcttttt gccggttgac cggcagacgc aagaaacttt 20220

caacttcatt aaaggcaccg aagttccgaa aggttcggta atggggctta tgggcaatgt 20280

tccgtttgaa ccgaatttga aagacgttgt aattcgtaac ggggtcgaac ttcgcttggc 20340

ttatatcgac gtactttcgc cgaacgggca aaaggtactt tatacgatgg tatttcaagc 20400

atgattgaat tcgaccaagt taacgacgaa gtaaacgcgc tttttcttgc aacttggaac 20460

gcaggaagcg cggcaattgc gggttatgtt cccgaaattc gttggcaggg cgtgcaatat 20520

cgcgacttgc cggacggttc gaagttttgg gttcggctgt cgaagcaaac cgtttttgaa 20580

gaacaagcga ccctttcaac ctgcgaagga gtaccggggc aaagaaaata tacggcgtcg 20640

ggtcttgtct tcgtacaaat cttttgcccg aaatcgaata cgcaagcgtt cgaacttggg 20700

cagaaattgg cgaaactttc ccgtaatgct tttcgcggga aatcgacgcc gggtaaggtt 20760

tggtttcgca atacgcgaat taacgaactt ccgcccgaag aactttacga acggtttaac 20820

gtcgttaccg aatttgaata cgacgaaata ggttaaggag ttcttaacat ggtatgcgaa 20880

attgccaaaa tcgacagcaa cattaccgga cttgccttcg ccgaagaaga atgcttgaag 20940

caacttccga cgacgcccgt ttggtacgga ctggaaccca acagctattc ggacttcggc 21000

ggcgaacttt cgaccgttgc ccgcgcgcct atcgacccgt cgcgccagaa caagaaaggc 21060

acgattaccg accttgacgc atcgggcggc ttcaacgccg actttacgaa gaccaacctt 21120

acgcgaattc tgcaaggctt cttcttcgca gacgcgcgcg aacttccttc gacgcagccg 21180

cttaacggcg catcggtcgc acttaccggc gttaccgcag ttgacagcac ttacgccgca 21240

gcttccgggc ttggcgtgtt cggtgccgat atgctggtat atgcgaccgg ctttaccaac 21300

gcggcgaaca acggccttaa aaccgtcgtt tcggctaccg ctgcgggcgt cgttgttgct 21360

gaaaccttga ttgacgaaac cccgcccgca ggcgcgaagc tggaatgcgt cggtcgccag 21420

cttgccgccg cagacgcgaa cattgccgta actggcaacg tcgtttcgct tatcgttacc 21480

gctggcgact ttacgaccat gcccgaactg ttccccggtc gttgggtctt cgtcggcggc 21540

gatgcgacgg caaaccgctt cgctaataat gtgggctatg cccgcattaa gtcggttgca 21600

gcgaaggcgc ttgttttcga cgacgtgact tggcaggcgg ccaacgaaac cggaaccggc 21660

aagtcgattc gtcttttcgt cggaactgtt atcaagaacg aaaagacccc ggcacttatc 21720

aagcgtcgtt cgtatcaaat cgaacgcacc ttgggcgaag gtttgaacgg tacgcagtgc 21780

gaatatctgg aaggcgcagt accgaacgaa tttacgttga acgttccgca ggccgacaag 21840

ctgaacgccg acctttcgtt tgttgcgtgc gacaacactt accgcagcgg cgaccccggc 21900

gacgaacaga aaaccggaac ccgcgtgcct gcgcccggcg aagacgctta caacacttct 21960

tcggacgttt accgaatcaa gatggccgtt cacgacgccg cgtcgtcgaa ccccgccgcc 22020

ctgttcggct acgtttccga agcgaacgtt tcgattaaca acaacgttac gccgaacaag 22080

gcggtcggcg tgttgggcgc gttcgatact tcggcgggta acttcgaagt cggcggttcg 22140

attaccgctt actttacgac cgtcgcagcg gttaaggctg ttcgcgcgaa cgccgacgtt 22200

ggtttgtcgg taatcagtgc ggccaagaac gccggtttcg tgttcgatat tccgttgctt 22260

ggtttgggcg gcggtcgtct gaacgtcgaa aaagacgcgc cgattaccgt tccgctggaa 22320

cccgcaggcg cagaaaacgc gaacggctat acgatgctgt acgaagtgtt ttcttatctg 22380

ccgaatctgg caatgccgga ctaattgcgg taaactcaaa gggccgggta ataccggccc 22440

tttcttcatt caatcggagt aaatcaaatg tctggactgt ttaagcaatt caaaacgaat 22500

tcgaccaagg aagtcgaagg cgtcgaaatc gaatttcccg aagcgcagaa cgacgacggc 22560

agcgttccga ctttcgttat ttcccgcatg ggcaaatcga acaaggcgta ttcaaaggcg 22620

cttgacgcgg cgacccgtcc ttatcgccgt caagtcgaac ttggcacgct gaaaaacgaa 22680

gtcgccgaat cgctgtttat gggcgtgttc gtcgataccg tgttgcgcgg ctggaaaaac 22740

gttcagggcg aagacggcaa ggaaattgcg tattcgaaag acgccgcaat ttcgcttctt 22800

tccgaactgc cggacgttta cgaacgtttg caggaagaag ccaagttggc ttcgaacttc 22860

cgcgataacg ctttggaagc cgaagcaaaa aactaaccga agttttggcg cacctgttgg 22920

aacttggccc acacgaacag gcgatagcaa aacaagcgat gcgcgcgggg cagccgttac 22980

ccgaacgcat cgcgaacgcg ccagaacttg aagtaggctt gcagttgtat ttgcaagcct 23040

tcttcgacct agatagcgaa cggtcgcacg gcaacggttt aacgccgata ccttggacaa 23100

gtatggcggc ttacgcaagg gctttcgagt ttgacgaaga acaaaccgaa gacttgtttt 23160

actttatgcg aaagcttgat tcggaacact tgaagaaact agcggataaa cagaaagcgg 23220

cggcatcgaa tggcaaaaag cctgctagac ctagccgata ggctggaaaa gaaagcgaag 23280

gcaatagacg aagcggcgtc acaaaacgcc gtcgataccg ctttggctat tgtgggcgac 23340

ttggcgtaca aaacgcccgt agatacttcg caagctttgt cgaactggat tgtaacgcta 23400

gaaagtccgt cgggtcaaca aatcaagccg cattttccgg gttcgcaggg ttcaacgcaa 23460

cgcgcttcgg cggctgaaac gttgaattct gcgaagcttg ttttacgaaa caagaagccc 23520

ggccaagcga tatttattac gaacaacctt ccgtatatcc gcaggctgaa cgacggttat 23580

tcggcacaag ccccggcggg gttcgtcgaa cgcgccgttt tgattggtcg caaaatgcgt 23640

aagaagttca agattaagga ttaaaagaaa tggccgacga aaacatagaa attaaggttc 23700

aagacaaagt ttcgccgtcc atttcgacga agcttcgcac aattgcaagc gaagcccgca 23760

acgccgacgc cgcagttaag aaccttcaaa cgcagctttc ggcaattaac gtcggcggct 23820

tgtcgcagct tatcaacgca tcggccagcg caacgcgcca gcttcaacaa ggcgcgcttg 23880

ccgcgcaacg gctggcaacc gaacagcagc gcaccgcaac agccgcagcg caggccgccg 23940

cagcccaaca gcgcgtcgcg acggctgcga cccaaggggc aaccgcgcaa gccaaccttg 24000

ccagcgccac gcagcgcacg cagacggccc aacagcagac ggcgacagcc gcgcagcgcc 24060

tagcgacaga acagcagcgg acagccgttc agacggccaa cgcggcggca gcgaacgacc 24120

gggccgccct tgccgccctg cggctgcaac aggcgcaaga ccgggccgcc aattcgaccc 24180

gcaatgcgac ttcggccctt ggcggataca ttcgaaccgc tgccggaatt cttggcgtaa 24240

cgatttcggc gaacgcaatt cttgcaagcg ccgacgcata cgttacgctt caaaacaagt 24300

tgcagaacgt aacgaagtcg caagaacaag ttaacacgct tacgaacgaa cttttcgaac 24360

tgtcgaaccg cacgcgcgcg ggtattgaag aaacggcgac agcgtttaca cgcttcgacc 24420

gtgccttggc gtttatgggt aagtcgcaag aagattcgtt gcgaatgacc gaaaccatta 24480

acaaggcttt gattgtttcc ggtgcaacag cgcaagaagc gtcgtcggct ttgttgcagc 24540

tttcgcaggg cttcaacgcc ggtaagctgc aaggcgacga attccgcgcc gtttcggaaa 24600

atatgccaat cgttttggac gcagtagcga aggcgcttaa cgttccgatt aaccgcgtta 24660

aagaactttc gaccgaaggt aagattactt ccgaagttct gtttgaagct ttcaagctta 24720

tacaagacca agtagacgca acgtttaaca agacgacgcc cacaatcggc caaagcttga 24780

cggttcttcg caacaatgca attcagttct tcggcgaatt gaacaaagcg accggcttta 24840

ctgccgggct ttcgcgcgcg attatttggc ttggcgaaaa cttgaagacg gttgccgtaa 24900

ttgtcgccgg gcttggcgtc gcattgcttg tcgccttcgg tgccccgttg gttggtgcgc 24960

tggccggtgc gacggctgcg gtaaaagcct ttacgctggc gcttgcttcg aacccgattg 25020

gccttatcgt cgtcgcgctt tcgaccgcga ttgcgtatct aacgcttttc cgcgacgaaa 25080

ttaacttggg aatcgacgac gttacgacgt tgggcgattt cttccgcgcg acctttgaag 25140

gcatcggcca agcaatcgac gacgttaaaa ccatcgcgtc gcaattgtgg gcagaactta 25200

gcgacttcgc aagcgcagcc cttggcgaaa ttacttcgaa cgttgacgat tcgacttctt 25260

cttggtcgga cagttacgcc gaatttttcc aaaccaaccg tacaggttgg gccggtgcgt 25320

tggaaaacgc cgcaaaagtt cttgacgcaa tcgccgggct tttgaccggg gccgcaacgt 25380

tcgcaggccg tgcaatggcc gaagttgtta tttcggttca aaacggaatc gcaaacgctt 25440

acaacgttgt cgcgggttgg attgaaaacg taacgaataa agccattgaa gccgcgaaca 25500

ggcttcgcgc gatggttggt aagtcggctt acgaacttgt ccaattcgaa cgcatgggca 25560

gcgcaggcca aaccgaattc gaatcttggg gcaagctttg ggcgcaatcg ctggaagacg 25620

gatttaacag ccaaggcggc gcaatgcaaa acctgttgaa cggccttttc gaccgttcgc 25680

agcaaatcgg cgcgcagcgc agggccgcag gaagcgcgca gcttcgcggg gccggtacgt 25740

cgcagcttgc cggggctacc gacgcaaacg cggcgaaggc tgcggaacgt cgcgcgctgg 25800

cgttggaaaa aatcaatacg cagcttgata acgaattggc gcgcatgttc cagcttcaac 25860

cgcagcgcga agcgcaagcg aagttcgacc aaatcgaaga aagcttgatt cagaaaaaga 25920

ttaagcttac gtcggaagaa gccgaagcaa tcaaggcgaa gattaaggcc gttcaagacg 25980

cgaccgaagt tcaacgccag ttcgacgcaa tttacgccga agctgttaac cctttgaagg 26040

agtacaacgc ggcgcaggaa gcggcgaaca agcttcttca aatgggcgcg attacgcagg 26100

aacagcacgc ccgcgcagta acgaaggcgt cggaagctta cgcgaattcg caagacccgt 26160

tgcggcagta taaccgcgac cttgaacagc aattgcagct tttgcaaatg ctgccgaagc 26220

aacgcgaaat cgaacagcag gttatgcaag ttcagaacga tttgcttgca aagggcatcg 26280

ttctaaacga aaccgaattg gcgcagcttc gcgaaaagct gttgcttatt cagcaagtaa 26340

acgccgtttc gcagcaagaa gcgtcgttgt tggacgccag cgtaaacaag cgccaacagt 26400

ttatcgacca acttaaagca attcagaact tgcgcaacaa cagcggaagc ggtttcaacg 26460

caggcgacca agccgaagca actaacagca tgttgcaagg catgggcatt gatacgacga 26520

actttcaaac gcagcttaac gcgcaattgg cgcaatatca aacttacgtc gaacagctta 26580

aaatgctgaa cgaacagcgt ttgattagcg accaagaata cgccgccgca agtatgcaac 26640

ttgaattgca gcggcaaaac ctgtacttga attcggcaag tagtttcttc ggaaacttgg 26700

ccgcgcttca acagtcggga aataagaaaa tggcggcggt cgggaaggcc gcagcaatcg 26760

cgcaagcgat gattaatacg tatcaatcgg caacgtcggc ttatgctgcg atggcgtcga 26820

ttccttacgt cggcccggcg ttgggcgcgg ctgcggctgc ggctgcaatt gccgcaggct 26880

tggcgaacgt tcagcaaatc cggtcgcaga ataccgggtt taagtcgggc ggttttaccg 26940

ggtcaatggg cgtaaacgaa gtcgcgggcg tcgtacacgg ccaagaattc gttatgaacg 27000

cagcggcgac caaccgtatt ggcgttgcag accttcaagc cctgcaaacg ggcgcggcca 27060

gtgttcagcg caacgacgaa caggcaatgg cggctagtgt gggcaggggc ggcaattccg 27120

aacccgcgcc cgcgccggtt gtcaatgtac cttttagcgc cgttgtcgta caatcgaaag 27180

aagcggcctt ggccgggctt aaatctgcgg aaggtcgggc tttcattctg gaaactatcg 27240

aacaaaacgg cggcaccgtc gcaaaaatcg tcggagttaa ataaatgggt tacgcaattg 27300

gaacagttac aaaaggcggc ggcgacgatt gccattatca agttttggca attatcaaaa 27360

cgctggccga agcgaacgga tggacgacgc ttcgttacgt atcaaccgga cttgaccgcg 27420

aattgatttt gaaaggcgtt ggtttgtccg gtcttgaaga aatctttgta gggtttaagt 27480

gttatcaaag cgtcggcggc gattattaca atattaattg cggaactttc gtcggttacg 27540

taagcggaaa cactttcgaa acgcaacccg gcgcgcagtt tagcgcaacg cctgcccaca 27600

ataacgcgat tacgtatttc ataacggcca acgcccaacg aatcgtcgga tgcttcaaag 27660

tcggtacgcc ggtttacgaa catttttacg tcggcaagtt ctttccgtat gcgcggcccg 27720

gtgaatatcc gtcgccgctt gtttgcggtg cgatgctttc caacgcgcag gcaatgcgat 27780

tcgacaacaa cgcgcagtcg ttcccgtatc cgggctatta ttacgacacg acgaacaacc 27840

gcctttatat tcgcgaccaa gcgggcaact ggattcgccc ttggtgttgg ccatttacca 27900

atggaaacgg cgcaaacacc gcgcttgcag ggccgcaagg aacttcgacg cttgttcctg 27960

ccgacgtgta ttaccaactt gaaccaatta ttttggcgca gcaaagcaac aataacaacc 28020

cttcgaacgt atggggcgaa ttcgacggcg tttatttctg ttccggcttt aacaacggcg 28080

tcgaaaacgt agttcaggaa ggcggaagtt ctgtcgttga ccaaaccggg cttaccgtac 28140

ttcaagccgt agacgctatt aaggcggtcg gcgggcgggc gtttgtaatg ttgcaaaacg 28200

tctatcgtac ttcttggcgc gattttatcg ctttggaaat gaaataatgg catacattac 28260

aggaaccgcc gcaaactttg cggatttgaa aacagccatt gaaaacgcct gtacttctaa 28320

cggttgggcg cttgccgacg gcatattgtc gaagaacggt tgtttctttc aactaatcgc 28380

cgatagtttg ggcggttatc cgcaacttcg cttgcatggc ggaacaggca aaagcggttc 28440

gacgcttaca ggccagccgc ctagcaatta cggggcaaag gtcgcaagcc ctgtcggaaa 28500

tcaaatcgta ttcccgatta attacgaaat acatttgttt accgaccccg acgaagttta 28560

ttgtatcatt aattacaatt cggactttta ccaacaactt tcgttcggca agtctgatat 28620

tccgggcatt ggtggaactg gcgcatggtt taccggggca tatcggcacg actacggatt 28680

gaccgacgca acttacgccc atagggtttt tacggcgatt tcttggcccg aaataactgg 28740

cgtcgcaact tatgccggaa tgtgcgtcgg tttgtttttt gaaggcaacg cttcgcaaac 28800

tggcggaagt tatttcgcaa gcttcgtaca taccgggctt gattcgacgc cttggcgaag 28860

cggccacggc ggcgacacgc tgttaagcgg ctatcgcggg gccggtcttt ccgtcggttc 28920

gcttttaatg tcactgccga atatttcgaa ccaagcaacg attttgcttc ctattaagcc 28980

ggttgcgcgt cgttcaagcg gcggcgcaac tattatcgca aacccgaaaa acgcgcgtta 29040

tttgcgaatc gacaacgttg taccgggcga aattattaca ttcggtgccg accaatggaa 29100

ggtttacccg ttttaccgca aagacgcaac cgttcgaaac ggcgtcggtt ggtcaagcgg 29160

cgcgacgcat agcggaacgt tcggatacgc cattaaatac actggaactt aaaaagaatg 29220

gccggaagaa ttggaacatt tttagcggcg gaaagtttta tttacggcga ttataacccg 29280

aacctttccg ccgaacttaa cgaacttacc gccgcagaat acgcgccgac gatttacgac 29340

ccgcgcgata tgttcttgcg cggcggatat tcggcgtaca aaatcgcgcc ttcgaatcgc 29400

tggcctattg tgggcaaaga acaaggcaac ttcgggcgcg actattatta tcgcgttcac 29460

gtttcgccat tggtcttgga cttgcaaacg gtcgcgtcgt cgcaaacgcg cgaattcaac 29520

gtttggaacg catggcccga ccgtgcggct aatcttgacg acattttggt aagtaatccg 29580

gtcggtattg aaattacagg ccaagcgacg ccgtatgcaa tgccgccgct tcaagaactt 29640

acttacgaaa taaccgtagg cgtttcgggg ccgccgaata ttaacgttga agttcaattt 29700

gacttttcca acgttcccga cccgctgccg attctgatta caggaacgcg cgcggttaag 29760

ttcgacattg tgcccgaagt tccattgaac gaaacttggg aatggttaag cgacaacatt 29820

gtagcggttg acggaacaga acagcgcata gcacttcgcg gcgaaatgcc gcgtattgaa 29880

gaacgcttga aagtaatttt tgattctgtc gaagccgtgc gccgttttta cggcgacgtt 29940

atgtcggcag ttggtcggct ttggattccc gaatttcagt acgcgacccg aattactgcc 30000

gcaagcaata gcggcgcgct tcaaatttat tttgaccgaa cgaagaccga cgttcgcgat 30060

accgaatacg tcttgattca aacgccgctt gttgcggcac ttgtcgaaat cgacgtattg 30120

acagccgacg gggctacgct tggttcgccg ctgttgttcg acattccggc agggtcgtta 30180

atcatgccgg gttcgcccgc gcttattgac gacaatacag cacttgcgcg gtattccgtc 30240

gataccgtcg gcgaagtaga aattaacgcg aagatgattc gccagcgttc gcaacttacc 30300

cgacccggcg caaccgtcgt acttgaacag ttcggcggcg tgccgatttt gacgaagcgt 30360

ccgcttgcga acgaccttgt acgcgacgaa gtttcaaccg gccaaatttc aatcgacaat 30420

caaaccggac ttgccgacat tattagccgt tgggactata gccgcatcgg cgggccgcga 30480

agcttcaaag taaaccgtat ttcgaatccc gaagaattgg attattggaa agcgattctt 30540

gcgtatgcac gcggacaggc gcgcaagttt tggatgccca catatcgaac cgatttggct 30600

ttggccgtgc aaccgtccga cgcgacttca agctataccg tcgaagggtc ggagtatgcc 30660

gaaaagattt ggccgattat cacgcatcgt tatatcgaaa tcgaaacagc gtccggcatt 30720

catcgaaccg aaatattggg cgcaactttg cttgaaactg gcaatacaat tcttcttctt 30780

ggtacgccgc ttccgaccgg ggccggatgg atggaagtta agcgaatttc gtacttgttg 30840

cctgtacgcc ttggcgacga taaagtagaa tggaagcatt acggccttga atcaatcttg 30900

aatctttcaa ttcgaacggc ggaaccctaa tgtctgatta cgacgacaaa gaagaaagcg 30960

taggcgatag cgcgccattt gaactttacg aattcgtcgg ttcatatcgc aattattaca 31020

tgacttccga cgttctggcg cacgtcttca acagtgcgac atataacccc gttccgggtt 31080

tgaagcgcag tacgttaaaa gtcggaacgc acgaagacga caacgtagat atgacggtta 31140

cgcttccgat tacggaacaa atcgttaaag actatgcgtt tcaaactacg ccgccgtctt 31200

tggttttgac gatttaccgt cgccagcgcg acgccgcaac ttgggttgca tactggaaag 31260

ggccgattgc ttcaatttcg gttgacgacg aatttgtaac gtttagaacg ccaagcaagt 31320

tcggttcgat gctgtcgggc aatataccga acgtttacgt acagccgcct tgcaataacg 31380

ttttgttcga cgaacgttgt aaggtaagtc gcgtaagcaa ttcgctagat acgcaggttt 31440

cggcggtcga aggtcgtaac atttcgattc cgtcgcttgg cggttttccc gacggttggt 31500

ttatcggcgg cgaaatcgca atacctgcgc gcaacgaacg tcgaatgatt gtcgcgcaag 31560

ccggggcaat tctaacggta aattacgaat tcgcgcgtat ttctgtcggc acttcggttc 31620

aggttacggc aggttgcgac cattcttaca acggggccaa cggttgcccc aagttcaaca 31680

atcaaccgaa cttcggcggt tgcccgtttg ttccgggcga atcgaataac gtatttcaaa 31740

gcggggttca ttaacaaatg tggattgcaa ttgtcttcgt cgtcgccttc ttacttatgg 31800

cggcgcttat gccgaaaccg aacgtcgaaa acgcacgcgc ggcgaaactt ggcgacttcc 31860

aatttccgcg ttctaagtac ggcgacccaa tgccgctagt gtggggaaca gtgcgccaga 31920

aatcgccgat aacggcttgg tttggcgact tccgcccggt gccaattcgt aagaaaatga 31980

agaccgggct ttttagttcg aagaaagtta cggtcggtta taaaaattat cttggcattg 32040

attgcatttt gtgccttggc cccggcgttc ggcttcgtaa gttttgggcc ggtacttacc 32100

ttgtttggga aggcaactta acttcgtccg gcgatattta cattaacaag ccgaacttgt 32160

ttggcggcga agatgaacgc ggcggcctgc aaggtacaat ttcgttttac gacggtcgtt 32220

ttgacccgcc gcaagattct tacttggttt cgaagattgg cccgaatgtt ccggcttaca 32280

acggctttgc gcgtgcgttg ttcaaagcct tttatatcgg aacaggtacg acgccggaac 32340

cgttcagctt cgaaattcag cgcattacgt ccggcttgca cgcgacttat tcaatcatgc 32400

caaacgggtt ggacgttaac ccgatggaaa ttgtttacga cgcaatgacg caaaaatggg 32460

gccgattcgg caaccttgaa agcgaaattg atatgccttc gttcacggcc tgcgcgcaaa 32520

cgctgtataa cgaaggcttg ggtatgtcgc ttattgttca atctgcgatt accggaaaag 32580

acttgttgga agaagtaatg cgcgtcgccg acggcgtgtt gtatcaagac ccggcaacgg 32640

cgaagattgt tgcgaaactt gttcgccaag attacacaat ttccgaactt cttgttcttg 32700

acgaatcttc cgttaaggaa cttcgcaatt tccagaaaac aacatgggaa aacaccttta 32760

accaatgccg ggttacgttc aaaaaccgcg ccagtagtta cgacgacagc gtagcaatta 32820

cccaagactt cgcaaatatc aactttcaaa accgcgttaa gtctacggaa gtttcgacgc 32880

ccggcgttac cgacgcaacg gtagcaagca agattgcggc gcgtcaactt tcaattttga 32940

acgttccgct ttacaagtgc gacttgaccg ttaaccgcaa ggcgcagaac ttgcggcccg 33000

gaagcgtgtt cgttctgaat tggtcgccgt tcggcatttc gaatatggtt atgcgtgtta 33060

cgaaaattga tttcggcgaa cttacgtcta accaaatcaa gctttcttgc gttcaagacc 33120

gcttttcgtc ttcaacgctt acgttcgcac cgcccgaagg ttcaggatgg acgccaatta 33180

gtacggaacc gacgccggtt acaacgcggc ttctttttac gccgcctgcg ttccttacgt 33240

caaacagcga aaacgaaaca ctttccaatt ttgataacta cggtcggttg tatcttgccg 33300

cagttgcgcc gggttctacg tctatttctt acgacgcaat gacggccccg gacaatttca 33360

gttcgtcgcc tattctgtcg cttgaaagtg ccccgtacaa cggcggcggc gtgttgctga 33420

acgcctacgc ttcgacagtc gccagcgaaa cccgtaacga tacaagcgga agccttgtcg 33480

taaccggcgt gtcgcaagca agcattgaag gtttgcagca atacacgacg ctagaccaag 33540

cgcgcgacgg ttcggccttc ctgctgatta ataacgaact gttcgtttat gtgggcttcg 33600

ttgacaatgg cggcggtcaa gttactttcc cgaacgtgta tcgcggcgtt ctggataccg 33660

tgccgggcaa tcatgcggcg aacgaccgcg tttggttcat tagcggaacc gacggactgt 33720

tgccggaact tgtttcggtc ggaacgacgc gatacgttaa gcttttggat acgacttcgg 33780

gcggcaagct tgatatttcg ttggccccgt cgtttagcgg gtcgcttacc aaccgggccg 33840

ggttgccgct gccgccgcag tacctaacgc ttgcaggaag ccgcacgcca agcccacaag 33900

taggcgcaac gtcgattgtt gcggaatggc gcaaccgcag ccgggccgat accttgttgc 33960

gcgtgtatca cgacacggcg aacacgcggg aagctggcac cgaaacccgc gttcgctggc 34020

gtgtaggcgg cggcgcttac acgaccgtta cgactgccgg aagttcaaca acccttgacg 34080

taacgggcaa gtacggcacg ctagaagtta ttgtagattc gttcattacg tcgaattcga 34140

aatattcgac gtacagcgat tcgcttacaa tgaccctaac ggcaccgccg ccgccgtaat 34200

caaaagaacg acagcgcggc ggttttggcc ttcttcaacc gcccgcagtc gtacaacatt 34260

tcgaccgctt cgttaatgta ccaatcgtaa tttatatcgt cgggaaattc cgtcggcaag 34320

tccattacag ggcgcgcgcc gtcggttttc ccgactttgt ttccgctgga tacgtaagca 34380

atatatccgg cttcgttctt cgggtaatac caacgaacga ccttgccaag ataacgaccg 34440

ttcttttcgc cgccgccgcg cacgttcttt actgcaacga agcgccggaa gtcgcggcat 34500

tccttaattg tcttttcgac cggcgttccg tcaacaagga accgaacaac ggcgtcggaa 34560

caaatcaggg tttcggggtt cttcgaaaga atcgaattca aagccgaccc gcgttcgcaa 34620

taagcgccct tcgtttttgc gcccaactgt tcgtcaataa agcgcgcttc ggggtcgccg 34680

ccgtcttcct tgattgcgac ataactatta acgtcgcggc tgaatacggc tttatatcgc 34740

gtttcttcgg tcttgtatcc tgtccattct tcccaagacg caataagcgc ccttacttcg 34800

tcgtgtcgcg atttgtgata cttggaaata atgccgtcgg tattgccgga aataacttcg 34860

atgccgattt gttccaaagc ttcgataagc ataagcaaca caagttgccc ggtaatcgtt 34920

acttgcaaca taagttgcgg cgcgtaaagc gtcgaatact tgttgccaag cttgccgaag 34980

cttccgttaa tggtaatttt caaactgtcg gcaattgtct tccatttctt cgcggctgcg 35040

cggtcgcccg ccttctttgc ctttgccgct tcggctttgg cgtgaattcg cgtatttacg 35100

attttttcgt aaacggtcaa gaaagcttcg cccaagtgcg gcgggcaaag tctttgatta 35160

aggattgttc gcgggtaaaa cgattctacg tcgttgtctg ccaaaattat ttcgtcggtc 35220

gcatagtgcg ccgttttctt ttcggtagaa tgcaaaccgc ccatgcctag tttgtacgtc 35280

gaaccgccaa tggttacttt cagcttttcc agttcgggcg gcatgattgg cgaccccaag 35340

ccgtcaagat agaagcgggc atttcgcacg acttccagca tttcgcgaag ctgcgtcgtt 35400

tgatagcaaa cgaagtcggg cacgtcgtaa accaagaccg tatcggcgga tagtgtgggc 35460

ttcttcggat aatagccaag gactttttga agttcggagt taataaccgc ttcggctact 35520

tgtgcgtctg atttcgaccg aaggtctacg ccgtattctt ccgacatttc ggcccgcaac 35580

ttcaattcgg gcgcaagttc gttaaaaaga agttcggtat tcgaaaggtc gttgcagcaa 35640

taaggccgca ctatttcggc gtcttcctgc gttaatacat ggtcttcggg aaacggcaag 35700

tcttgcatac gttcgcaatg caagcgcccc gcgtacagct tcaacgaacc ttgaagcggc 35760

gcaacttcta taaggtcgat atgattgtat cggccaattt gtacgccgta cttcttttcg 35820

aacgcgaacg gcgttacctt ttcggttcca tagttcggcc cgcttttaat gatgaaatcg 35880

gacgcttctt taagcttcgc gcagcttgcc ccgcgtgcgg ctagttcaat catcggcaag 35940

tcataattac gcgaattgaa gccgacgata cagaaccgcc aaagcatcca aagaagcttc 36000

gtcgggttaa aatcatggtc ggggctgcgt tcgaacgcga cgaactttcc gttatcaagc 36060

gacttaaacg ctacgtaaaa gaaatttacg taagtttcaa cgtcgaagac gaagacactt 36120

ccggcaggca ttgccgttag ttcttcgtcc gacataaatt cgacaggccg caaagcctgt 36180

cgaatgcttg cggccagctt atcgacgacg cggcttttct ttgcgacgat aaagccttgt 36240

tcgttaatca tgcgaaagcc ccttaaaacg gtatgtcgtc ttcgtaattg tccgacggat 36300

tatgcgtcgc ttcgctgcca aggtcaagac ccataagaac gccgcgcaaa ttgtcgccga 36360

aaaatacgac cttgtttgct tccggtgcga aatgcgcttt cttaaacgca tgttcgacgg 36420

aaagaagcaa cttcgcagaa aagcccattc gttccggcaa gccttcgatt ttgtacgtcg 36480

aagcttcttc tttgtgcatc ttcgacaaaa ccgcgccgtc gtcgaagaat acgtttccgt 36540

tcgggctgaa tgactgaatc gcgcgaacgc cgttgtaaaa atcgtcggga accggccaag 36600

ggttcaaacc gtcaacttcg aaaacgactt ggtaattcgg gtaacgttcg ccgtaaagct 36660

gcgttttgat aaacgccccg ttttcgaaat agaacgttgc cgacgacgcc gaaaagccga 36720

agccggtaag ggccgggcca gccttggcga cagcgaccgc cgcgcacttc ggaagcatca 36780

tgccgggcgg aaggtcgata ccgtgccacg cttccagcaa ggccgccccg ttggtcgcga 36840

cggcgcttcc ggcttgcagc aagacggcgg cataggtcgc attcggtgcg ccgtctgtcg 36900

caagccctgc gaccgcagcg aaggccgttt taatccggtc gtcgattgtg gcgcattgcg 36960

ggtcgggcgc ggtaatcggc acgtcgtcga agcccacaca aggcaccaac gcccggaacg 37020

cgccagacga tacggcaagg gcgttcgcgg taagctgcgt aatcgacagt tcttcgccga 37080

ccttcgacag cgcgtcgata aactgcaacg tatgcgggca cgctaccaag tcttcttcga 37140

taggatgcgc gacggtcaaa accccgtcgg aagccgccgc ccaattgtgg gcaatatgcc 37200

cgaactgaac gttcgtcggc ccggcttttt tctgcgcgat ggcaacgaac ttcaacgccg 37260

ccaaaagcga cgccgcaggg cttggcccct tcgccttttt ctttccggct gcggcttgcc 37320

tgcgcgccct tggctttttc ttcggctgtt cggcggctgg cgcttcgtct tcgggcggaa 37380

gcggaatatt actgtcgatt ttcattttcg gccccttctt cgtcaagttt cgaaattgcc 37440

gcttgaagat agttcgctaa gtctagcgtt tcttctagcg cgtgttgcaa ccaatcgcga 37500

agcgataacg ggttattatc cgtcgttacg ccgtactttg caagtccaac gattgaacgt 37560

tgcaacagta attcgcggtt cttttctacg tttttatcgg gcgatgtttc ggccatttgt 37620

tcaccattca gcggaaagaa cttcgggata ctttttgttc acccatacgc gaacacggcg 37680

cggcgtgcga agttctgaaa cacgctgcaa agcttgataa gtcgtcggcg gcggttcttc 37740

ggcgtgccgc tgccgccacc aatcgcgcga acgtttcgca gcaagccccg gatgttcaag 37800

cattataaat tcgttgaaca tttggaagcc gcaaaagtaa ctaaccttaa tcatcggcgg 37860

tttcgttaga tttccgtttg cgtcgcgctt ttcgtgcaaa ttgtaaagta ccttttgaac 37920

gtcgaaatat tcgactatcg gcgcgtcgct tcgcagcggt tccagcgttc cggcagttgc 37980

aaacaacttc gtttcaaaag taaattcggt gccgcagttg atacactgcc gggccgcagc 38040

gtgattatat acgccgcata cgtcgcaaat acgaacgggc gcgtcgccgc cgcctttgcc 38100

cggtctgttc ggaattcgcg ggtcgttgat tgggccaagc cttcgaacgt ttccggcaaa 38160

gtccgcgtac aggcaatttt gtttgccagt atccggcgac ggtcgggttc cgcgtcccaa 38220

cttttgaacg tgtttgcccg gcgatagcgt cgggttcaaa tcgccgataa agtcgattgg 38280

cggatggtcg aaacccgttg taagtttctg ccctgatacc aagccgcgaa gttcgccagc 38340

tttgaaagcg cgcaagcgtt cggtattggt cttcgaaggc aacttggaat gaaccggcaa 38400

aacttccaag ccgtaagact gaattacgtt cgcgacgtgt tcggtattat caatgccagt 38460

tgcgaagata agccaagtcg aacggtcgta agctatttcg gtcatttccc gaacagcgtt 38520

aaaaacaact tcgtcggtat ctacggcggc ttctagttgc ttgctgttga attcgccagc 38580

cgttacgcct actttcgaca agtcgatttc ggttcgcgtc ggccttgcga taagcggcga 38640

caagtagcct tcggcgataa gtcggttaaa cgattcgacg ccggttatat cgtaacaaat 38700

gtcggtaaaa attccgttgt cggtaataag ccccattttc attcgatagg gcgttgccgt 38760

aaatccaata actttaagat gcgggttaat cttgcgaagt tcggcgataa tgtattggta 38820

atgcgaatct tccttgtcgc ttaacaaatg gcattcgtcg attaacagca agtcgcgcca 38880

accgaaatgg cgaagatgcg ccgggcgtcc gtcgtcttct tcaagcccgc gtttaatcgc 38940

aggcgctacg gactgaacgc cgccgaatac gattggcata atcatatcgc gggaattcaa 39000

gcccgccgaa taaatgccca ttggcgcggt cggccaaatc gacataagct tttcggcgtt 39060

ctgttcgatt agttctttaa cgtgcgtaag catcattatt cgttgattcg gccagtaacc 39120

gaaaattcga cgaataaagt ttgcaattac gaccgacttt ccggttcctg tcggcatggc 39180

gacgacgggg tttccgaccc cgccgcgctg gaaataatcg aatattgaat attccgcttc 39240

gtcttgatac caacgcggaa cataaatatt agacattctt tgcaaccgct gtaattggcg 39300

aataagaatc gcaacccgta gcgatgaaat cgcccggaat tacgccgttg tgaacttcgc 39360

aaaaccattc gccgttttcg acaggatttg cggccttgca gcttcggcag ttcttttcag 39420

gaatcgcgcc cttgtggcaa atatccttcg ccgcgcaata tccgcacttg tgaaacgtcg 39480

gattatccga caagcgcggc ggcgcttcct gcgacagaat gatttgttcg gccttctcct 39540

tcatttgctg gcctagccga tggtctagct ttacaacttc gcaatgcaag tcgtcgtcgt 39600

tcttgttaat gttcaggtaa agaacataac gaaaacgata ttcgttgcca tacgtcgaag 39660

tttgggcgaa atgctgcggc ttgcttactg ccattccttg cgacattaag tccgaaaagc 39720

ctttgccggt tccgttggtc ttgaattcca gcaaaacggg ttcgtcgata ccgtagcgtt 39780

cgggaagccg ggcgatgccg tcaagcgacc cgccgaagtg ccccataacg ccggaaatgc 39840

ggtattgtgg gaattccaag ccgtcggctt tcgcgcgtgc gacgtgttgg gcgtaatacg 39900

gattttcgtt cgtaataagg tcgcagccca acggcagttc ttcgccttcc ttcaatatgc 39960

cgtaactgtc gctttcggct tggtaaaaga aaccgtcgcg gttttcgtac caacattgaa 40020

cgccgatgcc ttccagccat tcgataaagc gggcttcttc acggtgccca cgattaaaca 40080

agcgttgctt gcgcccgtcg gtttgttcgc ggaaacacca acggaagata taccaaagct 40140

tccgcttgca ttcgtcgcca atcaaagacg cgccaaggtg ccgacggtgc ccgccgtcat 40200

acgtgcgaac gcaatattcg tctatatctt ctttaatgcg cttcgcaagg gcggttgcaa 40260

cgccgggcgc gtcaaggtct acgctttgtt ttcctgcgtc ggatttcgtc ggctgcgcgt 40320

cgttcagcgt taattgtgcg ttcttcgcgt ctttgctgtt ttgcatcgtt cttcaccttg 40380

cgccgcataa gggcttcgta attgttcgct agataatccg ccgaaagtgt cgcaacgtct 40440

ttaagttggt ctttcgacag ccaagatata tggcattccg acgggtcgat tcctaattgg 40500

ttcgcaagcc aattgtacgc cttcgcgcgc gacattaagc cggtttgcca aaggcggtcg 40560

aattcgttat gggctttcgt tcgaagctgg cgcgttgttc tgtcggccat acgacccaac 40620

ggaataaacg tgcccggatg gcaaccaacg gcggcgcgac aatcattgca ataataaatg 40680

tgcggccaat tgccataagt tcgcccgtaa atcttgtcgt tcgttgttag ttcaatgttg 40740

aacgaacaac aagtatcgca ttgttcgggc gtcggcaatg cgtcttttat tttcgacata 40800

agttcgcata ctccttaaaa agaaacgccg gggccggtta agaccccggc gaatctacgc 40860

cgcgacggcg ttacgcctta acgctggccc caaggtgccg cgcctgccgg tgcgccgccc 40920

tgcgcgggct ggccgccgcc ctgttgccag ccgccgccct gcggttgctg ctgcgcgggc 40980

tgttgggcag gctggccgcc ccatgccggt tggccgccct gcggggccgg gttctgcgcc 41040

ggttggccgc cccaagctgc gccgccctgc ggctgttggg ccggttgctg cgcgggctgc 41100

tgctgtccgc cccaagcggc accgcctgcg ggctgctgcg gctggccctg cggggcaccg 41160

ccccaagcgc cgttcggctg gccctgcggc tgctgttgct gcggctgcgc tgccgctgcg 41220

cctgcgccag ccttgcccgg ttcgttcccg ttcatatcga agaccttttt aacttcggta 41280

tactgcgggt cgtttttctg cgggccgact tcgataagaa acggcaggtt gtgaagctgc 41340

gacgaatcgg taacttggaa cacgccgatt acgtggcaga ttgccgaaag ctggcgatgc 41400

gcgatttcga cggtctgttg gttggaatgg tacaggttca ggcgataagc gccggtcgtg 41460

ccctgctgcg ggccgtcgat aatccgcaag ttcagttgca gataaccgcc gtcgttcgcc 41520

ttgttggcct tgacttcgga agattcgacg ataaccggat gcttgccaat cggcaggctt 41580

ccgacgcctt gggtcgggtc gtactgttgg gcgttgaacg cttggataag ttgcatgatg 41640

tttcaccttt tcgaaaagtc ttcgccattg gttacggcgg cgaagtaaac cgttttattg 41700

catcgctttc gcgaacaatg cggtaaggtc gggctgttca agttcgttaa gattgcccaa 41760

acggtcgcgc gcgaaaactt cgggaatttc cttcgttcgc agcgcccgaa ccggcttcgg 41820

cattccgggt acgcttgctt cgcccaagtg cataacgtta tcgaacaaat gcggaacttt 41880

aacgttaagg tctttgcccg gaaagaacgg gcgtttttgc ataatcggtt cgtaagtaac 41940

ttcgccgttc tgcaaaatcg tttgccgtcc gttttcgaca agggcttgct ttgcaatcat 42000

tacgatatgc ttttgcggca tgtaatacaa gtcgttcgcg attttcatta cacgttcgga 42060

catattgccg taagccttca taccgtgttt aaccttgccc aattcgtcgg ccaagataat 42120

ttcggcgatg ttcgaaatac tgtcaatacc caacgtatcg aaattcgcag cttcgcgcga 42180

tttcataaac cattcgaaga attcgacgat aagcgcgggc gaatacgctt cccatgcggg 42240

aacgttcgaa ccgcgcatgg acagcatacc gggttcggtc acaagcaaaa ccggacgcgg 42300

cgcagtattg ataagcggcg ttttgccgga accgggcgca ccgaatacga cggactttac 42360

gccgtagcgg cgggccagtt gcgacgccgg ttttaattgc gacatttgca taacttgcac 42420

cttcgggaat ggccccggcg cttgtgggca accggggcgg ggttgttact tcgacttcgg 42480

cgcgacaagt tcaagcgcgg gcgttgcttc cttcgacgtt acaacttcgt cgataagctt 42540

acggaacttg tcgggaaggt tcttgtattc ggtaacggaa agttcgggct tccattttac 42600

caaacgttcg gcgataaatt cgccttcggg gccggtcttt tcgattttct gcaaagcctt 42660

ttcgacggct tcttggccgc ctgcgaagct gcggttaatc ttaaaaacgg ctttcagctt 42720

gtaacctgcg ccaagttcga cgttttcggt tccttcgcgc aaagcttcgg ggtcgaaagc 42780

gaaagcgttt ttcagaactt cggcgcgcaa tgcggattcg gcttctttcg ctgcggcaag 42840

cgccttcgtt gcttcctgcc attgcagaat caaagcgtcg cggttagcgt tttcgttgaa 42900

agacattgtt gttactcctt cggttgggcc gc 42932

<210> 16

<211> 42932

<212> DNA

<213> Artificial Sequence

<220>

<223> s4 phage变体

<400> 16

ttgcggtaaa ctcaaagggc cgggtaatac cggccctttc ttcattcaat cggagtaaat 60

caaatgtctg gactgtttaa gcaattcaaa acgaattcga ccaaggaagt cgaaggcgtc 120

gaaatcgaat ttcccgaagc gcagaacgac gacggcagcg ttccgacttt cgttatttcc 180

cgcatgggca aatcgaacaa ggcgtattca aaggcgcttg acgcggcgac ccgtccttat 240

cgccgtcaag tcgaacttgg cacgctgaaa aacgaagtcg ccgaatcgct gtttatgggc 300

gtgttcgtcg ataccgtgtt gcgcggctgg aaaaacgttc agggcgaaga cggcaaggaa 360

attgcgtatt cgaaagacgc cgcaatttcg cttctttccg aactgccgga cgtttacgaa 420

cgtttgcagg aagaagccaa gttggcttcg aacttccgcg ataacgcttt ggaagccgaa 480

gcaaaaaact aaccgaagtt ttggcgcacc tgttggaact tggcccacac gaacaggcga 540

tagcaaaaca agcgatgcgc gcggggcagc cgttacccga acgcatcgcg aacgcgccag 600

aacttgaagt aggcttgcag ttgtatttgc aagccttctt cgacctagat agcgaacggt 660

cgcacggcaa cggtttaacg ccgatacctt ggacaagtat ggcggcttac gcaagggctt 720

tcgagtttga cgaagaacaa accgaagact tgttttactt tatgcgaaag cttgattcgg 780

aacacttgaa gaaactagcg gataaacaga aagcggcggc atcgaatggc aaaaagcctg 840

ctagacctag ccgataggct ggaaaagaaa gcgaaggcaa tagacgaagc ggcgtcacaa 900

aacgccgtcg ataccgcttt ggctattgtg ggcgacttgg cgtacaaaac gcccgtagat 960

acttcgcaag ctttgtcgaa ctggattgta acgctagaaa gtccgtcggg tcaacaaatc 1020

aagccgcatt ttccgggttc gcagggttca acgcaacgcg cttcggcggc tgaaacgttg 1080

aattctgcga agcttgtttt acgaaacaag aagcccggcc aagcgatatt tattacgaac 1140

aaccttccgt atatccgcag gctgaacgac ggttattcgg cacaagcccc ggcggggttc 1200

gtcgaacgcg ccgttttgat tggtcgcaaa atgcgtaaga agttcaagat taaggattaa 1260

aagaaatggc cgacgaaaac atagaaatta aggttcaaga caaagtttcg ccgtccattt 1320

cgacgaagct tcgcacaatt gcaagcgaag cccgcaacgc cgacgccgca gttaagaacc 1380

ttcaaacgca gctttcggca attaacgtcg gcggcttgtc gcagcttatc aacgcatcgg 1440

ccagcgcaac gcgccagctt caacaaggcg cgcttgccgc gcaacggctg gcaaccgaac 1500

agcagcgcac cgcaacagcc gcagcgcagg ccgccgcagc ccaacagcgc gtcgcgacgg 1560

ctgcgaccca aggggcaacc gcgcaagcca accttgccag cgccacgcag cgcacgcaga 1620

cggcccaaca gcagacggcg acagccgcgc agcgcctagc gacagaacag cagcggacag 1680

ccgttcagac ggccaacgcg gcggcagcga acgaccgggc cgcccttgcc gccctgcggc 1740

tgcaacaggc gcaagaccgg gccgccaatt cgacccgcaa tgcgacttcg gcccttggcg 1800

gatacattcg aaccgctgcc ggaattcttg gcgtaacgat ttcggcgaac gcaattcttg 1860

caagcgccga cgcatacgtt acgcttcaaa acaagttgca gaacgtaacg aagtcgcaag 1920

aacaagttaa cacgcttacg aacgaacttt tcgaactgtc gaaccgcacg cgcgcgggta 1980

ttgaagaaac ggcgacagcg tttacacgct tcgaccgtgc cttggcgttt atgggtaagt 2040

cgcaagaaga ttcgttgcga atgaccgaaa ccattaacaa ggctttgatt gtttccggtg 2100

caacagcgca agaagcgtcg tcggctttgt tgcagctttc gcagggcttc aacgccggta 2160

agctgcaagg cgacgaattc cgcgccgttt cggaaaatat gccaatcgtt ttggacgcag 2220

tagcgaaggc gcttaacgtt ccgattaacc gcgttaaaga actttcgacc gaaggtaaga 2280

ttacttccga agttctgttt gaagctttca agcttataca agaccaagta gacgcaacgt 2340

ttaacaagac gacgcccaca atcggccaaa gcttgacggt tcttcgcaac aatgcaattc 2400

agttcttcgg cgaattgaac aaagcgaccg gctttactgc cgggctttcg cgcgcgatta 2460

tttggcttgg cgaaaacttg aagacggttg ccgtaattgt cgccgggctt ggcgtcgcat 2520

tgcttgtcgc cttcggtgcc ccgttggttg gtgcgctggc cggtgcgacg gctgcggtaa 2580

aagcctttac gctggcgctt gcttcgaacc cgattggcct tatcgtcgtc gcgctttcga 2640

ccgcgattgc gtatctaacg cttttccgcg acgaaattaa cttgggaatc gacgacgtta 2700

cgacgttggg cgatttcttc cgcgcgacct ttgaaggcat cggccaagca atcgacgacg 2760

ttaaaaccat cgcgtcgcaa ttgtgggcag aacttagcga cttcgcaagc gcagcccttg 2820

gcgaaattac ttcgaacgtt gacgattcga cttcttcttg gtcggacagt tacgccgaat 2880

ttttccaaac caaccgtaca ggttgggccg gtgcgttgga aaacgccgca aaagttcttg 2940

acgcaatcgc cgggcttttg accggggccg caacgttcgc aggccgtgca atggccgaag 3000

ttgttatttc ggttcaaaac ggaatcgcaa acgcttacaa cgttgtcgcg ggttggattg 3060

aaaacgtaac gaataaagcc attgaagccg cgaacaggct tcgcgcgatg gttggtaagt 3120

cggcttacga acttgtccaa ttcgaacgca tgggcagcgc aggccaaacc gaattcgaat 3180

cttggggcaa gctttgggcg caatcgctgg aagacggatt taacagccaa ggcggcgcaa 3240

tgcaaaacct gttgaacggc cttttcgacc gttcgcagca aatcggcgcg cagcgcaggg 3300

ccgcaggaag cgcgcagctt cgcggggccg gtacgtcgca gcttgccggg gctaccgacg 3360

caaacgcggc gaaggctgcg gaacgtcgcg cgctggcgtt ggaaaaaatc aatacgcagc 3420

ttgataacga attggcgcgc atgttccagc ttcaaccgca gcgcgaagcg caagcgaagt 3480

tcgaccaaat cgaagaaagc ttgattcaga aaaagattaa gcttacgtcg gaagaagccg 3540

aagcaatcaa ggcgaagatt aaggccgttc aagacgcgac cgaagttcaa cgccagttcg 3600

acgcaattta cgccgaagct gttaaccctt tgaaggagta caacgcggcg caggaagcgg 3660

cgaacaagct tcttcaaatg ggcgcgatta cgcaggaaca gcacgcccgc gcagtaacga 3720

aggcgtcgga agcttacgcg aattcgcaag acccgttgcg gcagtataac cgcgaccttg 3780

aacagcaatt gcagcttttg caaatgctgc cgaagcaacg cgaaatcgaa cagcaggtta 3840

tgcaagttca gaacgatttg cttgcaaagg gcatcgttct aaacgaaacc gaattggcgc 3900

agcttcgcga aaagctgttg cttattcagc aagtaaacgc cgtttcgcag caagaagcgt 3960

cgttgttgga cgccagcgta aacaagcgcc aacagtttat cgaccaactt aaagcaattc 4020

agaacttgcg caacaacagc ggaagcggtt tcaacgcagg cgaccaagcc gaagcaacta 4080

acagcatgtt gcaaggcatg ggcattgata cgacgaactt tcaaacgcag cttaacgcgc 4140

aattggcgca atatcaaact tacgtcgaac agcttaaaat gctgaacgaa cagcgtttga 4200

ttagcgacca agaatacgcc gccgcaagta tgcaacttga attgcagcgg caaaacctgt 4260

acttgaattc ggcaagtagt ttcttcggaa acttggccgc gcttcaacag tcgggaaata 4320

agaaaatggc ggcggtcggg aaggccgcag caatcgcgca agcgatgatt aatacgtatc 4380

aatcggcaac gtcggcttat gctgcgatgg cgtcgattcc ttacgtcggc ccggcgttgg 4440

gcgcggctgc ggctgcggct gcaattgccg caggcttggc gaacgttcag caaatccggt 4500

cgcagaatac cgggtttaag tcgggcggtt ttaccgggtc aatgggcgta aacgaagtcg 4560

cgggcgtcgt acacggccaa gaattcgtta tgaacgcagc ggcgaccaac cgtattggcg 4620

ttgcagacct tcaagccctg caaacgggcg cggccagtgt tcagcgcaac gacgaacagg 4680

caatggcggc tagtgtgggc aggggcggca attccgaacc cgcgcccgcg ccggttgtca 4740

atgtaccttt tagcgccgtt gtcgtacaat cgaaagaagc ggccttggcc gggcttaaat 4800

ctgcggaagg tcgggctttc attctggaaa ctatcgaaca aaacggcggc accgtcgcaa 4860

aaatcgtcgg agttaaataa atgggttacg caattggaac agttacaaaa ggcggcggcg 4920

acgattgcca ttatcaagtt ttggcaatta tcaaaacgct ggccgaagcg aacggatgga 4980

cgacgcttcg ttacgtatca accggacttg accgcgaatt gattttgaaa ggcgttggtt 5040

tgtccggtct tgaagaaatc tttgtagggt ttaagtgtta tcaaagcgtc ggcggcgatt 5100

attacaatat taattgcgga actttcgtcg gttacgtaag cggaaacact ttcgaaacgc 5160

aacccggcgc gcagtttagc gcaacgcctg cccacaataa cgcgattacg tatttcataa 5220

cggccaacgc ccaacgaatc gtcggatgct tcaaagtcgg tacgccggtt tacgaacatt 5280

tttacgtcgg caagttcttt ccgtatgcgc ggcccggtga atatccgtcg ccgcttgttt 5340

gcggtgcgat gctttccaac gcgcaggcaa tgcgattcga caacaacgcg cagtcgttcc 5400

cgtatccggg ctattattac gacacgacga acaaccgcct ttatattcgc gaccaagcgg 5460

gcaactggat tcgcccttgg tgttggccat ttaccaatgg aaacggcgca aacaccgcgc 5520

ttgcagggcc gcaaggaact tcgacgcttg ttcctgccga cgtgtattac caacttgaac 5580

caattatttt ggcgcagcaa agcaacaata acaacccttc gaacgtatgg ggcgaattcg 5640

acggcgttta tttctgttcc ggctttaaca acggcgtcga aaacgtagtt caggaaggcg 5700

gaagttctgt cgttgaccaa accgggctta ccgtacttca agccgtagac gctattaagg 5760

cggtcggcgg gcgggcgttt gtaatgttgc aaaacgtcta tcgtacttct tggcgcgatt 5820

ttatcgcttt ggaaatgaaa taatggcata cattacagga accgccgcaa actttgcgga 5880

tttgaaaaca gccattgaaa acgcctgtac ttctaacggt tgggcgcttg ccgacggcat 5940

attgtcgaag aacggttgtt tctttcaact aatcgccgat agtttgggcg gttatccgca 6000

acttcgcttg catggcggaa caggcaaaag cggttcgacg cttacaggcc agccgcctag 6060

caattacggg gcaaaggtcg caagccctgt cggaaatcaa atcgtattcc cgattaatta 6120

cgaaatacat ttgtttaccg accccgacga agtttattgt atcattaatt acaattcgga 6180

cttttaccaa caactttcgt tcggcaagtc tgatattccg ggcattggtg gaactggcgc 6240

atggtttacc ggggcatatc ggcacgacta cggattgacc gacgcaactt acgcccatag 6300

ggtttttacg gcgatttctt ggcccgaaat aactggcgtc gcaacttatg ccggaatgtg 6360

cgtcggtttg ttttttgaag gcaacgcttc gcaaactggc ggaagttatt tcgcaagctt 6420

cgtacatacc gggcttgatt cgacgccttg gcgaagcggc cacggcggcg acacgctgtt 6480

aagcggctat cgcggggccg gtctttccgt cggttcgctt ttaatgtcac tgccgaatat 6540

ttcgaaccaa gcaacgattt tgcttcctat taagccggtt gcgcgtcgtt caagcggcgg 6600

cgcaactatt atcgcaaacc cgaaaaacgc gcgttatttg cgaatcgaca acgttgtacc 6660

gggcgaaatt attacattcg gtgccgacca atggaaggtt tacccgtttt accgcaaaga 6720

cgcaaccgtt cgaaacggcg tcggttggtc aagcggcgcg acgcatagcg gaacgttcgg 6780

atacgccatt aaatacactg gaacttaaaa agaatggccg gaagaattgg aacattttta 6840

gcggcggaaa gttttattta cggcgattat aacccgaacc tttccgccga acttaacgaa 6900

cttaccgccg cagaatacgc gccgacgatt tacgacccgc gcgatatgtt cttgcgcggc 6960

ggatattcgg cgtacaaaat cgcgccttcg aatcgctggc ctattgtggg caaagaacaa 7020

ggcaacttcg ggcgcgacta ttattatcgc gttcacgttt cgccattggt cttggacttg 7080

caaacggtcg cgtcgtcgca aacgcgcgaa ttcaacgttt ggaacgcatg gcccgaccgt 7140

gcggctaatc ttgacgacat tttggtaagt aatccggtcg gtattgaaat tacaggccaa 7200

gcgacgccgt atgcaatgcc gccgcttcaa gaacttactt acgaaataac cgtaggcgtt 7260

tcggggccgc cgaatattaa cgttgaagtt caatttgact tttccaacgt tcccgacccg 7320

ctgccgattc tgattacagg aacgcgcgcg gttaagttcg acattgtgcc cgaagttcca 7380

ttgaacgaaa cttgggaatg gttaagcgac aacattgtag cggttgacgg aacagaacag 7440

cgcatagcac ttcgcggcga aatgccgcgt attgaagaac gcttgaaagt aatttttgat 7500

tctgtcgaag ccgtgcgccg tttttacggc gacgttatgt cggcagttgg tcggctttgg 7560

attcccgaat ttcagtacgc gacccgaatt actgccgcaa gcaatagcgg cgcgcttcaa 7620

atttattttg accgaacgaa gaccgacgtt cgcgataccg aatacgtctt gattcaaacg 7680

ccgcttgttg cggcacttgt cgaaatcgac gtattgacag ccgacggggc tacgcttggt 7740

tcgccgctgt tgttcgacat tccggcaggg tcgttaatca tgccgggttc gcccgcgctt 7800

attgacgaca atacagcact tgcgcggtat tccgtcgata ccgtcggcga agtagaaatt 7860

aacgcgaaga tgattcgcca gcgttcgcaa cttacccgac ccggcgcaac cgtcgtactt 7920

gaacagttcg gcggcgtgcc gattttgacg aagcgtccgc ttgcgaacga ccttgtacgc 7980

gacgaagttt caaccggcca aatttcaatc gacaatcaaa ccggacttgc cgacattatt 8040

agccgttggg actatagccg catcggcggg ccgcgaagct tcaaagtaaa ccgtatttcg 8100

aatcccgaag aattggatta ttggaaagcg attcttgcgt atgcacgcgg acaggcgcgc 8160

aagttttgga tgcccacata tcgaaccgat ttggctttgg ccgtgcaacc gtccgacgcg 8220

acttcaagct ataccgtcga agggtcggag tatgccgaaa agatttggcc gattatcacg 8280

catcgttata tcgaaatcga aacagcgtcc ggcattcatc gaaccgaaat attgggcgca 8340

actttgcttg aaactggcaa tacaattctt cttcttggta cgccgcttcc gaccggggcc 8400

ggatggatgg aagttaagcg aatttcgtac ttgttgcctg tacgccttgg cgacgataaa 8460

gtagaatgga agcattacgg ccttgaatca atcttgaatc tttcaattcg aacggcggaa 8520

ccctaatgtc tgattacgac gacaaagaag aaagcgtagg cgatagcgcg ccatttgaac 8580

tttacgaatt cgtcggttca tatcgcaatt attacatgac ttccgacgtt ctggcgcacg 8640

tcttcaacag tgcgacatat aaccccgttc cgggtttgaa gcgcagtacg ttaaaagtcg 8700

gaacgcacga agacgacaac gtagatatga cggttacgct tccgattacg gaacaaatcg 8760

ttaaagacta tgcgtttcaa actacgccgc cgtctttggt tttgacgatt taccgtcgcc 8820

agcgcgacgc cgcaacttgg gttgcatact ggaaagggcc gattgcttca atttcggttg 8880

acgacgaatt tgtaacgttt agaacgccaa gcaagttcgg ttcgatgctg tcgggcaata 8940

taccgaacgt ttacgtacag ccgccttgca ataacgtttt gttcgacgaa cgttgtaagg 9000

taagtcgcgt aagcaattcg ctagatacgc aggtttcggc ggtcgaaggt cgtaacattt 9060

cgattccgtc gcttggcggt tttcccgacg gttggtttat cggcggcgaa atcgcaatac 9120

ctgcgcgcaa cgaacgtcga atgattgtcg cgcaagccgg ggcaattcta acggtaaatt 9180

acgaattcgc gcgtatttct gtcggcactt cggttcaggt tacggcaggt tgcgaccatt 9240

cttacaacgg ggccaacggt tgccccaagt tcaacaatca accgaacttc ggcggttgcc 9300

cgtttgttcc gggcgaatcg aataacgtat ttcaaagcgg ggttcattaa caaatgtgga 9360

ttgcaattgt cttcgtcgtc gccttcttac ttatggcggc gcttatgccg aaaccgaacg 9420

tcgaaaacgc acgcgcggcg aaacttggcg acttccaatt tccgcgttct aagtacggcg 9480

acccaatgcc gctagtgtgg ggaacagtgc gccagaaatc gccgataacg gcttggtttg 9540

gcgacttccg cccggtgcca attcgtaaga aaatgaagac cgggcttttt agttcgaaga 9600

aagttacggt cggttataaa aattatcttg gcattgattg cattttgtgc cttggccccg 9660

gcgttcggct tcgtaagttt tgggccggta cttaccttgt ttgggaaggc aacttaactt 9720

cgtccggcga tatttacatt aacaagccga acttgtttgg cggcgaagat gaacgcggcg 9780

gcctgcaagg tacaatttcg ttttacgacg gtcgttttga cccgccgcaa gattcttact 9840

tggtttcgaa gattggcccg aatgttccgg cttacaacgg ctttgcgcgt gcgttgttca 9900

aagcctttta tatcggaaca ggtacgacgc cggaaccgtt cagcttcgaa attcagcgca 9960

ttacgtccgg cttgcacgcg acttattcaa tcatgccaaa cgggttggac gttaacccga 10020

tggaaattgt ttacgacgca atgacgcaaa aatggggccg attcggcaac cttgaaagcg 10080

aaattgatat gccttcgttc acggcctgcg cgcaaacgct gtataacgaa ggcttgggta 10140

tgtcgcttat tgttcaatct gcgattaccg gaaaagactt gttggaagaa gtaatgcgcg 10200

tcgccgacgg cgtgttgtat caagacccgg caacggcgaa gattgttgcg aaacttgttc 10260

gccaagatta cacaatttcc gaacttcttg ttcttgacga atcttccgtt aaggaacttc 10320

gcaatttcca gaaaacaaca tgggaaaaca cctttaacca atgccgggtt acgttcaaaa 10380

accgcgccag tagttacgac gacagcgtag caattaccca agacttcgca aatatcaact 10440

ttcaaaaccg cgttaagtct acggaagttt cgacgcccgg cgttaccgac gcaacggtag 10500

caagcaagat tgcggcgcgt caactttcaa ttttgaacgt tccgctttac aagtgcgact 10560

tgaccgttaa ccgcaaggcg cagaacttgc ggcccggaag cgtgttcgtt ctgaattggt 10620

cgccgttcgg catttcgaat atggttatgc gtgttacgaa aattgatttc ggcgaactta 10680

cgtctaacca aatcaagctt tcttgcgttc aagaccgctt ttcgtcttca acgcttacgt 10740

tcgcaccgcc cgaaggttca ggatggacgc caattagtac ggaaccgacg ccggttacaa 10800

cgcggcttct ttttacgccg cctgcgttcc ttacgtcaaa cagcgaaaac gaaacacttt 10860

ccaattttga taactacggt cggttgtatc ttgccgcagt tgcgccgggt tctacgtcta 10920

tttcttacga cgcaatgacg gccccggaca atttcagttc gtcgcctatt ctgtcgcttg 10980

aaagtgcccc gtacaacggc ggcggcgtgt tgctgaacgc ctacgcttcg acagtcgcca 11040

gcgaaacccg taacgataca agcggaagcc ttgtcgtaac cggcgtgtcg caagcaagca 11100

ttgaaggttt gcagcaatac acgacgctag accaagcgcg cgacggttcg gccttcctgc 11160

tgattaataa cgaactgttc gtttatgtgg gcttcgttga caatggcggc ggtcaagtta 11220

ctttcccgaa cgtgtatcgc ggcgttctgg ataccgtgcc gggcaatcat gcggcgaacg 11280

accgcgtttg gttcattagc ggaaccgacg gactgttgcc ggaacttgtt tcggtcggaa 11340

cgacgcgata cgttaagctt ttggatacga cttcgggcgg caagcttgat atttcgttgg 11400

ccccgtcgtt tagcgggtcg cttaccaacc gggccgggtt gccgctgccg ccgcagtacc 11460

taacgcttgc aggaagccgc acgccaagcc cacaagtagg cgcaacgtcg attgttgcgg 11520

aatggcgcaa ccgcagccgg gccgatacct tgttgcgcgt gtatcacgac acggcgaaca 11580

cgcgggaagc tggcaccgaa acccgcgttc gctggcgtgt aggcggcggc gcttacacga 11640

ccgttacgac tgccggaagt tcaacaaccc ttgacgtaac gggcaagtac ggcacgctag 11700

aagttattgt agattcgttc attacgtcga attcgaaata ttcgacgtac agcgattcgc 11760

ttacaatgac cctaacggca ccgccgccgc cgtaatcaaa agaacgacag cgcggcggtt 11820

ttggccttct tcaaccgccc gcagtcgtac aacatttcga ccgcttcgtt aatgtaccaa 11880

tcgtaattta tatcgtcggg aaattccgtc ggcaagtcca ttacagggcg cgcgccgtcg 11940

gttttcccga ctttgtttcc gctggatacg taagcaatat atccggcttc gttcttcggg 12000

taataccaac gaacgacctt gccaagataa cgaccgttct tttcgccgcc gccgcgcacg 12060

ttctttactg caacgaagcg ccggaagtcg cggcattcct taattgtctt ttcgaccggc 12120

gttccgtcaa caaggaaccg aacaacggcg tcggaacaaa tcagggtttc ggggttcttc 12180

gaaagaatcg aattcaaagc cgacccgcgt tcgcaataag cgcccttcgt ttttgcgccc 12240

aactgttcgt caataaagcg cgcttcgggg tcgccgccgt cttccttgat tgcgacataa 12300

ctattaacgt cgcggctgaa tacggcttta tatcgcgttt cttcggtctt gtatcctgtc 12360

cattcttccc aagacgcaat aagcgccctt acttcgtcgt gtcgcgattt gtgatacttg 12420

gaaataatgc cgtcggtatt gccggaaata acttcgatgc cgatttgttc caaagcttcg 12480

ataagcataa gcaacacaag ttgcccggta atcgttactt gcaacataag ttgcggcgcg 12540

taaagcgtcg aatacttgtt gccaagcttg ccgaagcttc cgttaatggt aattttcaaa 12600

ctgtcggcaa ttgtcttcca tttcttcgcg gctgcgcggt cgcccgcctt ctttgccttt 12660

gccgcttcgg ctttggcgtg aattcgcgta tttacgattt tttcgtaaac ggtcaagaaa 12720

gcttcgccca agtgcggcgg gcaaagtctt tgattaagga ttgttcgcgg gtaaaacgat 12780

tctacgtcgt tgtctgccaa aattatttcg tcggtcgcat agtgcgccgt tttcttttcg 12840

gtagaatgca aaccgcccat gcctagtttg tacgtcgaac cgccaatggt tactttcagc 12900

ttttccagtt cgggcggcat gattggcgac cccaagccgt caagatagaa gcgggcattt 12960

cgcacgactt ccagcatttc gcgaagctgc gtcgtttgat agcaaacgaa gtcgggcacg 13020

tcgtaaacca agaccgtatc ggcggatagt gtgggcttct tcggataata gccaaggact 13080

ttttgaagtt cggagttaat aaccgcttcg gctacttgtg cgtctgattt cgaccgaagg 13140

tctacgccgt attcttccga catttcggcc cgcaacttca attcgggcgc aagttcgtta 13200

aaaagaagtt cggtattcga aaggtcgttg cagcaataag gccgcactat ttcggcgtct 13260

tcctgcgtta atacatggtc ttcgggaaac ggcaagtctt gcatacgttc gcaatgcaag 13320

cgccccgcgt acagcttcaa cgaaccttga agcggcgcaa cttctataag gtcgatatga 13380

ttgtatcggc caatttgtac gccgtacttc ttttcgaacg cgaacggcgt taccttttcg 13440

gttccatagt tcggcccgct tttaatgatg aaatcggacg cttctttaag cttcgcgcag 13500

cttgccccgc gtgcggctag ttcaatcatc ggcaagtcat aattacgcga attgaagccg 13560

acgatacaga accgccaaag catccaaaga agcttcgtcg ggttaaaatc atggtcgggg 13620

ctgcgttcga acgcgacgaa ctttccgtta tcaagcgact taaacgctac gtaaaagaaa 13680

tttacgtaag tttcaacgtc gaagacgaag acacttccgg caggcattgc cgttagttct 13740

tcgtccgaca taaattcgac aggccgcaaa gcctgtcgaa tgcttgcggc cagcttatcg 13800

acgacgcggc ttttctttgc gacgataaag ccttgttcgt taatcatgcg aaagcccctt 13860

aaaacggtat gtcgtcttcg taattgtccg acggattatg cgtcgcttcg ctgccaaggt 13920

caagacccat aagaacgccg cgcaaattgt cgccgaaaaa tacgaccttg tttgcttccg 13980

gtgcgaaatg cgctttctta aacgcatgtt cgacggaaag aagcaacttc gcagaaaagc 14040

ccattcgttc cggcaagcct tcgattttgt acgtcgaagc ttcttctttg tgcatcttcg 14100

acaaaaccgc gccgtcgtcg aagaatacgt ttccgttcgg gctgaatgac tgaatcgcgc 14160

gaacgccgtt gtaaaaatcg tcgggaaccg gccaagggtt caaaccgtca acttcgaaaa 14220

cgacttggta attcgggtaa cgttcgccgt aaagctgcgt tttgataaac gccccgtttt 14280

cgaaatagaa cgttgccgac gacgccgaaa agccgaagcc ggtaagggcc gggccagcct 14340

tggcgacagc gaccgccgcg cacttcggaa gcatcatgcc gggcggaagg tcgataccgt 14400

gccacgcttc cagcaaggcc gccccgttgg tcgcgacggc gcttccggct tgcagcaaga 14460

cggcggcata ggtcgcattc ggtgcgccgt ctgtcgcaag ccctgcgacc gcagcgaagg 14520

ccgttttaat ccggtcgtcg attgtggcgc attgcgggtc gggcgcggta atcggcacgt 14580

cgtcgaagcc cacacaaggc accaacgccc ggaacgcgcc agacgatacg gcaagggcgt 14640

tcgcggtaag ctgcgtaatc gacagttctt cgccgacctt cgacagcgcg tcgataaact 14700

gcaacgtatg cgggcacgct accaagtctt cttcgatagg atgcgcgacg gtcaaaaccc 14760

cgtcggaagc cgccgcccaa ttgtgggcaa tatgcccgaa ctgaacgttc gtcggcccgg 14820

cttttttctg cgcgatggca acgaacttca acgccgccaa aagcgacgcc gcagggcttg 14880

gccccttcgc ctttttcttt ccggctgcgg cttgcctgcg cgcccttggc tttttcttcg 14940

gctgttcggc ggctggcgct tcgtcttcgg gcggaagcgg aatattactg tcgattttca 15000

ttttcggccc cttcttcgtc aagtttcgaa attgccgctt gaagatagtt cgctaagtct 15060

agcgtttctt ctagcgcgtg ttgcaaccaa tcgcgaagcg ataacgggtt attatccgtc 15120

gttacgccgt actttgcaag tccaacgatt gaacgttgca acagtaattc gcggttcttt 15180

tctacgtttt tatcgggcga tgtttcggcc atttgttcac cattcagcgg aaagaacttc 15240

gggatacttt ttgttcaccc atacgcgaac acggcgcggc gtgcgaagtt ctgaaacacg 15300

ctgcaaagct tgataagtcg tcggcggcgg ttcttcggcg tgccgctgcc gccaccaatc 15360

gcgcgaacgt ttcgcagcaa gccccggatg ttcaagcatt ataaattcgt tgaacatttg 15420

gaagccgcaa aagtaactaa ccttaatcat cggcggtttc gttagatttc cgtttgcgtc 15480

gcgcttttcg tgcaaattgt aaagtacctt ttgaacgtcg aaatattcga ctatcggcgc 15540

gtcgcttcgc agcggttcca gcgttccggc agttgcaaac aacttcgttt caaaagtaaa 15600

ttcggtgccg cagttgatac actgccgggc cgcagcgtga ttatatacgc cgcatacgtc 15660

gcaaatacga acgggcgcgt cgccgccgcc tttgcccggt ctgttcggaa ttcgcgggtc 15720

gttgattggg ccaagccttc gaacgtttcc ggcaaagtcc gcgtacaggc aattttgttt 15780

gccagtatcc ggcgacggtc gggttccgcg tcccaacttt tgaacgtgtt tgcccggcga 15840

tagcgtcggg ttcaaatcgc cgataaagtc gattggcgga tggtcgaaac ccgttgtaag 15900

tttctgccct gataccaagc cgcgaagttc gccagctttg aaagcgcgca agcgttcggt 15960

attggtcttc gaaggcaact tggaatgaac cggcaaaact tccaagccgt aagactgaat 16020

tacgttcgcg acgtgttcgg tattatcaat gccagttgcg aagataagcc aagtcgaacg 16080

gtcgtaagct atttcggtca tttcccgaac agcgttaaaa acaacttcgt cggtatctac 16140

ggcggcttct agttgcttgc tgttgaattc gccagccgtt acgcctactt tcgacaagtc 16200

gatttcggtt cgcgtcggcc ttgcgataag cggcgacaag tagccttcgg cgataagtcg 16260

gttaaacgat tcgacgccgg ttatatcgta acaaatgtcg gtaaaaattc cgttgtcggt 16320

aataagcccc attttcattc gatagggcgt tgccgtaaat ccaataactt taagatgcgg 16380

gttaatcttg cgaagttcgg cgataatgta ttggtaatgc gaatcttcct tgtcgcttaa 16440

caaatggcat tcgtcgatta acagcaagtc gcgccaaccg aaatggcgaa gatgcgccgg 16500

gcgtccgtcg tcttcttcaa gcccgcgttt aatcgcaggc gctacggact gaacgccgcc 16560

gaatacgatt ggcataatca tatcgcggga attcaagccc gccgaataaa tgcccattgg 16620

cgcggtcggc caaatcgaca taagcttttc ggcgttctgt tcgattagtt ctttaacgtg 16680

cgtaagcatc attattcgtt gattcggcca gtaaccgaaa attcgacgaa taaagtttgc 16740

aattacgacc gactttccgg ttcctgtcgg catggcgacg acggggtttc cgaccccgcc 16800

gcgctggaaa taatcgaata ttgaatattc cgcttcgtct tgataccaac gcggaacata 16860

aatattagac attctttgca accgctgtaa ttggcgaata agaatcgcaa cccgtagcga 16920

tgaaatcgcc cggaattacg ccgttgtgaa cttcgcaaaa ccattcgccg ttttcgacag 16980

gatttgcggc cttgcagctt cggcagttct tttcaggaat cgcgcccttg tggcaaatat 17040

ccttcgccgc gcaatatccg cacttgtgaa acgtcggatt atccgacaag cgcggcggcg 17100

cttcctgcga cagaatgatt tgttcggcct tctccttcat ttgctggcct agccgatggt 17160

ctagctttac aacttcgcaa tgcaagtcgt cgtcgttctt gttaatgttc aggtaaagaa 17220

cataacgaaa acgatattcg ttgccatacg tcgaagtttg ggcgaaatgc tgcggcttgc 17280

ttactgccat tccttgcgac attaagtccg aaaagccttt gccggttccg ttggtcttga 17340

attccagcaa aacgggttcg tcgataccgt agcgttcggg aagccgggcg atgccgtcaa 17400

gcgacccgcc gaagtgcccc ataacgccgg aaatgcggta ttgtgggaat tccaagccgt 17460

cggctttcgc gcgtgcgacg tgttgggcgt aatacggatt ttcgttcgta ataaggtcgc 17520

agcccaacgg cagttcttcg ccttccttca atatgccgta actgtcgctt tcggcttggt 17580

aaaagaaacc gtcgcggttt tcgtaccaac attgaacgcc gatgccttcc agccattcga 17640

taaagcgggc ttcttcacgg tgcccacgat taaacaagcg ttgcttgcgc ccgtcggttt 17700

gttcgcggaa acaccaacgg aagatatacc aaagcttccg cttgcattcg tcgccaatca 17760

aagacgcgcc aaggtgccga cggtgcccgc cgtcatacgt gcgaacgcaa tattcgtcta 17820

tatcttcttt aatgcgcttc gcaagggcgg ttgcaacgcc gggcgcgtca aggtctacgc 17880

tttgttttcc tgcgtcggat ttcgtcggct gcgcgtcgtt cagcgttaat tgtgcgttct 17940

tcgcgtcttt gctgttttgc atcgttcttc accttgcgcc gcataagggc ttcgtaattg 18000

ttcgctagat aatccgccga aagtgtcgca acgtctttaa gttggtcttt cgacagccaa 18060

gatatatggc attccgacgg gtcgattcct aattggttcg caagccaatt gtacgccttc 18120

gcgcgcgaca ttaagccggt ttgccaaagg cggtcgaatt cgttatgggc tttcgttcga 18180

agctggcgcg ttgttctgtc ggccatacga cccaacggaa taaacgtgcc cggatggcaa 18240

ccaacggcgg cgcgacaatc attgcaataa taaatgtgcg gccaattgcc ataagttcgc 18300

ccgtaaatct tgtcgttcgt tgttagttca atgttgaacg aacaacaagt atcgcattgt 18360

tcgggcgtcg gcaatgcgtc ttttattttc gacataagtt cgcatactcc ttaaaaagaa 18420

acgccggggc cggttaagac cccggcgaat ctacgccgcg acggcgttac gccttaacgc 18480

tggccccaag gtgccgcgcc tgccggtgcg ccgccctgcg cgggctggcc gccgccctgt 18540

tgccagccgc cgccctgcgg ttgctgctgc gcgggctgtt gggcaggctg gccgccccat 18600

gccggttggc cgccctgcgg ggccgggttc tgcgccggtt ggccgcccca agctgcgccg 18660

ccctgcggct gttgggccgg ttgctgcgcg ggctgctgct gtccgcccca agcggcaccg 18720

cctgcgggct gctgcggctg gccctgcggg gcaccgcccc aagcgccgtt cggctggccc 18780

tgcggctgct gttgctgcgg ctgcgctgcc gctgcgcctg cgccagcctt gcccggttcg 18840

ttcccgttca tatcgaagac ctttttaact tcggtatact gcgggtcgtt tttctgcggg 18900

ccgacttcga taagaaacgg caggttgtga agctgcgacg aatcggtaac ttggaacacg 18960

ccgattacgt ggcagattgc cgaaagctgg cgatgcgcga tttcgacggt ctgttggttg 19020

gaatggtaca ggttcaggcg ataagcgccg gtcgtgccct gctgcgggcc gtcgataatc 19080

cgcaagttca gttgcagata accgccgtcg ttcgccttgt tggccttgac ttcggaagat 19140

tcgacgataa ccggatgctt gccaatcggc aggcttccga cgccttgggt cgggtcgtac 19200

tgttgggcgt tgaacgcttg gataagttgc atgatgtttc accttttcga aaagtcttcg 19260

ccattggtta cggcggcgaa gtaaaccgtt ttattgcatc gctttcgcga acaatgcggt 19320

aaggtcgggc tgttcaagtt cgttaagatt gcccaaacgg tcgcgcgcga aaacttcggg 19380

aatttccttc gttcgcagcg cccgaaccgg cttcggcatt ccgggtacgc ttgcttcgcc 19440

caagtgcata acgttatcga acaaatgcgg aactttaacg ttaaggtctt tgcccggaaa 19500

gaacgggcgt ttttgcataa tcggttcgta agtaacttcg ccgttctgca aaatcgtttg 19560

ccgtccgttt tcgacaaggg cttgctttgc aatcattacg atatgctttt gcggcatgta 19620

atacaagtcg ttcgcgattt tcattacacg ttcggacata ttgccgtaag ccttcatacc 19680

gtgtttaacc ttgcccaatt cgtcggccaa gataatttcg gcgatgttcg aaatactgtc 19740

aatacccaac gtatcgaaat tcgcagcttc gcgcgatttc ataaaccatt cgaagaattc 19800

gacgataagc gcgggcgaat acgcttccca tgcgggaacg ttcgaaccgc gcatggacag 19860

cataccgggt tcggtcacaa gcaaaaccgg acgcggcgca gtattgataa gcggcgtttt 19920

gccggaaccg ggcgcaccga atacgacgga ctttacgccg tagcggcggg ccagttgcga 19980

cgccggtttt aattgcgaca tttgcataac ttgcaccttc gggaatggcc ccggcgcttg 20040

tgggcaaccg gggcggggtt gttacttcga cttcggcgcg acaagttcaa gcgcgggcgt 20100

tgcttccttc gacgttacaa cttcgtcgat aagcttacgg aacttgtcgg gaaggttctt 20160

gtattcggta acggaaagtt cgggcttcca ttttaccaaa cgttcggcga taaattcgcc 20220

ttcggggccg gtcttttcga ttttctgcaa agccttttcg acggcttctt ggccgcctgc 20280

gaagctgcgg ttaatcttaa aaacggcttt cagcttgtaa cctgcgccaa gttcgacgtt 20340

ttcggttcct tcgcgcaaag cttcggggtc gaaagcgaaa gcgtttttca gaacttcggc 20400

gcgcaatgcg gattcggctt ctttcgctgc ggcaagcgcc ttcgttgctt cctgccattg 20460

cagaatcaaa gcgtcgcggt tagcgttttc gttgaaagac attgttgtta ctccttcggt 20520

tgggccgccg cacaattgcg ccggtatgta cgaactatac gacggccctt cgttactgtc 20580

aagccccttt ttcaagaatt tttcgttctt cgaacaagtc gcgattgttg gcgtcgaatt 20640

cggtaaaggc gttcgggaag cgacgacgaa gcttcgcgat gttgaccgac tgcgcttcgc 20700

cgaagttcga accaatggcg cgcagcaaaa gcgcatcgta ccaaaagccg tcgccgactt 20760

cttcaagcgc gttaacagcg tcgaaagctt cgccttcggc tgcggcgctt agggcttcca 20820

acagttcgcc cgcttcggtc gccttgccga taattgcatg aatgacgttc acggctgcgg 20880

cgtcgtcttc ggggcggtcg gaaatccatt cgggaagctt cgccagcgtt gccgcgttgg 20940

cttccggggc cggaacgcca gcgtcgcgac cgtagaacat ggttttctcg attgcgtcaa 21000

gcttgttaag ggcttcgacg gcttcggcga tggtttcgcg gaagtaggcc agcgacacgc 21060

ggtcgccgta atacttatcc gacgcggtta cgtgcgcttc ttcgatatag tcgaaggtct 21120

ttgcgggttc gttcatacgt tcacctttta gaagggccgg gcaccatgcg ccagcgttcc 21180

agcactgtaa ccgaccgcgc ctttcctgtc aacaacaatt gacagcaagc aagaagccgg 21240

gtaagctgcc cacaattgct agaaggtggc gttatggaca ttgaagaact tacgaagcgg 21300

gtaaagaaag caagcgtcgg gcggtcgctg cgggcgctgg ccgcgcaatg caacgtttcg 21360

cacgaactta taagaaagct tttgcttgcc aattctgcgc cgaacataac ggcgacgact 21420

tataacaaga ttgataaagg attggcgaag aatggacttt aacaatattc cgcacgaaat 21480

gcggatttac ccgcaatggg tcgtttggcg atacgaagac acggattcaa agaaaccgac 21540

gaaggttccg tattcagcaa aaaccgggca ccttgccagc gtaaccgacc cgaacacttg 21600

ggccgggttc gacgaatgcg ttaacgctat gtcgtccggt tggtatgccg gaatcggttt 21660

cgtattgact gaaaacgacc cgtattcgtt tatcgacctt gacgacacaa aaggcgacca 21720

aacggcgctt gaccgccaaa taaagatttt taacgaattc aacagctacg ccgaacggtc 21780

gccttccggt tcggggttgc atatcatcgt taagggcgcg attccgtcgg gccgccgtcg 21840

ttcgtttatc gaagtttatt cttcgcttcg ttatatgaca atgaccggcg acgtttaccg 21900

caacgcaccg attaacgatt gtaacgaact gttaaacgtt ctttggggcc aaatggggca 21960

aggttcggtc gccgtcgcgc attatgccgg acttgccgaa gccaaggaaa ccgacgaaca 22020

ggtttataac cgcgcagtcg ccgcagccaa tggcgacaag ttcgccgaac tgtacgcggg 22080

caaatgggaa ggcatgtacg cttcgcagtc cgaagccgac tttgccttgg tcgatattat 22140

cgcgttttat acgcagaacc gggcgcagat ttcgcgaatg tttcgcgcgt cgggcttggg 22200

gcagcgtgac aaagcaaaac gcgacgatta cgtttcgtac atgctgaaca agtgtttcga 22260

ccgcatgttg ccgcccgttg acgttgacgg attgcgcaac aagctagacg aagccatagc 22320

gaagaaagaa gccgccgaca gggccgccgc gttgtcgcag aacagcgaag cgacgccgca 22380

tccgaaagcc ccggccccga accttagcga agtttcgaag gtatacagcg tgccgcccgg 22440

attagtcgga gaaattgcgc aatacattta cgcacaagcg ccgcgcccgg tgcccgaaat 22500

cgcgttggcc ggtgcccttg gcttggtcgc cggtattgtg ggcagggcgt acaacatttc 22560

cggcactggc cttaatcaat acgttctgtt gttggcaccg accggaacag gtaaagaagc 22620

catcgcaagc ggcattgata agctaatggc gcaggttatc cgaaccgttc ccgctgcgtc 22680

ggactttatc ggccccggtg aaattgcgtc ggcccaagcg attattaagt atatgtcgcg 22740

cggcccaacg tcgttcgttt cgttggtcgg cgaattcggc atttaccttc aacaaatggc 22800

aagcgtaaac gcaccgccgc accttaccgg gcttcgtcgc ttcctgttgg atgcttacaa 22860

caagtcgggc gaaggcaagg tacttcggcc ttcgatttat tcagacaagg acaagaacac 22920

gaccgccgtt ctttcgccgt cctttacctt gcttggcgaa tcgacgcccg aaaagtttta 22980

cgaaggtttg cacgaaggtt tgatttccga aggtctgttg ccgcgtttta cgatgattga 23040

atatcacggc gaacgcccgg cgttgaatcc ggggcacctg tcggcccaac cttcgttcga 23100

acttatcgac aggctttcga ccttgtgcgc ccatgcgcta atgctgaaca gccagcataa 23160

ggcgattcac gttcaaaccg acgcaaccgc ccgcgaactg ttccagcaat tcgacgcgca 23220

ttgcgacgcg aacattaaca caagcgaccg cgaagttcgg cggcaccttt ggaaccgggc 23280

gcacgtaaag gcgttgaagc tggccggaat tatcgccgtc ggctgcaacc cttacgaccc 23340

gaccattacc gccgacgttg cgtcttgggc gattaacctt gtcgtcgccg acgttcgaaa 23400

cttgcttgcc cggttcgatg ctggcgaaat tggcatagac aacgacgaaa cgaaacagct 23460

tgcgaaggtt attgcaaccg ttaaagattt cgtcgtttca ccttggccgg acgttgcgaa 23520

gtacgcaggc gaaggaatgt ccaaccttca ttcgaaccga attgttccgt acagctacgt 23580

tcaacgcagg cttgccgctg ttgccgtctt tcgtaaagac cgcatcggcg caagcggggc 23640

aatcaagcgc gccttgaaga ccctttgcga acgcggcgat ttgcaggaag taagccgggc 23700

cacactggcg aaggattacg gaacaagcgc cgttgcatac atggtcgcgc atccgggcgt 23760

tttcggcctg taacgcgcgc ccgccagtgt gggcagaacg ggccgccttc gggcggcttt 23820

ttcgtgcctg taaaaaaaag ttcgtcgtac ctgttgacgt agcttcgaac tgtacgtaga 23880

atacaaacca tcgaagcaac gaaacaaacc aaggaaccga agccatgaac gtaaccaacc 23940

ttaaaaccgc cgtcgaaatc aaaattgaaa ttgaattggc cgcttgggcc aacggcgaaa 24000

agaaagttaa cgtttccaac caattcgacg aaagcgtttt ggaatcggcc aaagaagcaa 24060

ttagcgtcga agcaatcgcc gcaatcgttg ccaagtatcc gggcgcgaac ttcgaaggct 24120

tttcggttat gacttgggcg cacgaacttt cggcgttcaa agccccggaa atcgaccggg 24180

cttggttcga ctaagcaagc gcccttcggg gcgttttttt tgttcgtacc tattgacgaa 24240

gcttcgaagt tgccgtatat ttaaaccatc gaagcaaaca acgaaggact aacgaacatg 24300

aacgcactta acaacattca acgggtcgta agctggaaca gcaagaagaa cgccgacggc 24360

acctttaccg ctaccgcgta cagcttcgac cataacgcgc cgaccgtcgt acatgccagc 24420

tacacgcgcg ccagccgcgc ccaagccgtc gcagacgcca agaaggccgt tcgttacctg 24480

aaagcccaac agcgcaccgc gtaaggagtc gccgccatgt ttgcccatta cttcgccagc 24540

aagaaaacga agttcgttgt aatcagcgaa acgaaccgcc cggaaggcca gcgaatcgcc 24600

gtaagcggca aagccgaagc ccgcagggtc gccaaggaac gcaacgcgca gccttggaac 24660

ttctaacccc ggccacggcc cttggcacgc gctaggggcc gcgcagcctg cccacattaa 24720

gcgaaggacg accgaccatg cgtacaaccc ttgcagccgt aaacaaagcc cttgccgccg 24780

ctggaatcga cgcggaattg gtcaagggtc gcgggtactt ttacttcgtt ggttccgccg 24840

tagattgcgc caaagaacaa ggcgtttacg gcgtgtatcg gctttccgaa ttgaccgttt 24900

cccaatgggt cgaagaagcc cgccaacgta tcgaaaagga gtaagaacaa atgaccgcat 24960

attttatcgc atttggcgtc gcgcttgggt tggcccttgc gcgcttggcc gcttcccaat 25020

tcgaagccgc ttgttacctg ttctgcaacg gcgaatttcg aaaggcattc cgggcaacga 25080

tgcacgccct tacctgcgtt gcgttgcttg cgttggttgt ttcgcccgtt gcttcgttct 25140

tcgatagctt cgaagttata agcattgaac aaccttcgcc caatccttcg aagggtcttc 25200

gcgtataata gccgacgggt cgtataatgg gcacgtataa gccttaaacc cttgatacat 25260

aaggctttca gcggattcat aacaagtata acgtataacg cccttgaccc tgaaaccccg 25320

gcccaatgtt ataaattaag ctttctttat atagattgat ttttagttat tatacttatt 25380

aaatttatta tatttcctta tttatcaagg acttagcagc tatacagccc cttcaattcg 25440

tataacgggc tttttgtgtt ataacgttgt tgacatacaa actttataag gctatgattc 25500

cggcacgcac taacgaaagg ggcttgcaat gtcttacgaa ataatcgaat gttcgccgaa 25560

ggcgcgaagc aaaattaagt cgttcgaaga tgcgctaggc gttgacgccg aattgacgca 25620

ccaacgttcg aagtatcctt ggccgctgtt gaaaatcggc cagtcgttcg ccgtgccgtt 25680

ggccgaaggt aacgaagcat cgttgcgaaa cggcgcgtcg cagttcagca agaagaccgg 25740

caagaagttt gcggttattc ggcattctga atacggctgt ttcgaatgcg cgcgcatcgc 25800

ttagcgccgg gccaatgtgg gcaacaaccg aaggggcaac caatgtacga aatcgaaacc 25860

ggccataaag tgccgaagca acgtcgcaag gctggaagcg tgccgaaggc cgttcaacag 25920

gcgttcaacg actacgccga agcgtataag gccgtttacg gcgttcgccc gctgtcgttc 25980

acgtatgacc gcgaaagcgg ctttattcgt gtcgaaagta gcggcggcgt aagcgtcgca 26040

aggctgcgcg aaatgacgaa acagcttcgt taccgaaaag gataaaaaaa ttcgttcgaa 26100

gggttgacgt actgtcgaag ccgtcgtact atatacccat accaacgaac acaaggaacc 26160

gccgaaatgc aaaacgtcca aatcaaacgc cccgcagcga ttaccgaagg ccaagcaatg 26220

aacgcagttt tcgacgcctt ccgccaagtg tggcgcaacg tcgaagcccg cgccgaaatg 26280

cttaaaggcg tttcgcagtc ggtcaaggtc ggcggcttcg aagtgtcggt tttcgcatgg 26340

cgcgacggtc gcattcaagc caacgtttac gcaggcggct ttaaccccgt cgcaaccgcc 26400

gaagttgacg aattcgacgc ctaatcaacc aagcgcgccg ggcgcaaccc ggcatttttg 26460

aaggagttat aacaatgtgc atcgtatgcg atattaaaca ggccgtcgaa gcttccggcc 26520

cgaacaaaga agaccgcgcc aaaatccttg gcttggtcga aaagctggcc gaagccttgg 26580

gcgatgttct ggaagtcgcg caggaagtac acgaagccaa gcccgaagcg ttccagccgg 26640

aacacgtcga acgcttgcag aacgccgccg acttgctgaa cgaccggggc gaactgcccg 26700

acgccctgtt ggccctgctg ttggccgccc ttgggcgcgg cgtcaaggtc gaaacaatcc 26760

gcgtcgaact gcgcgaaggc gaaacgccag aacaggccgt agcgcgtgta atggccgaac 26820

gcgaaggcgg ggccgcgacg aaacactaac caaagcgccc cggctgttgt atagtcgggg 26880

cttctttcta tcatggggaa cgaaagaaca tggcggacga agtagaccaa acagccgacc 26940

gaatagaaaa cgaagtaagc tttacggtcg gcgaactttg ccgaaaggcc gcagcgatac 27000

ccgcaggccg tccgggcgaa tgtgattttt gcggcgaaca cttcgcgcgc gttgtcgaag 27060

tgaccgaccc gcgaacgggc gaagtcgtcg aaagctgcgg tcgctgtcgt gaccgaaggg 27120

gcatcgcatg acgcccgcaa cccttgccaa gtctggcacc gaacacgcgc accaaacggc 27180

gctttttgcc tatgctgccg tcgcatactt acacggcttc gacgttgccg acgaatggtc 27240

aaagaccggc aagctaccga agcgcgaccc ggacgcaccg ccgaaggtgc ccgcccttga 27300

atggttccac gccataccga acggcggcag tcgcggcgac gacgacaagt cgcgaaagat 27360

acgcggcgcg cagttgaagg ccgaaggcgt gcggcagggc gtagccgata cgttcttgcc 27420

ttggcctgtt tacgaaccgt gcccaagcga cccgcaaata atgatgatga aatgggccgg 27480

tctttatatc gaaatgaaga agccgaccga acgtccgaag tcggaaaccg caaagggcgg 27540

cgtatcggac gaacaacgca gcttcggcga atacgcaaag cgcgtcggct atggttgggc 27600

cgtctgctat gattgggaac aagcggcgtc gtaccttcgt tcctatatcg aatggggttc 27660

gtaatggggc tttcgtgcct tgcctgcgaa cttacccgcg cccggttgaa agcggcggcg 27720

ctggcccttg tgggctggcc ccttgaccgc atcgccgggc atttgtcgtc atgctatggc 27780

gaacggtatt acgtcgaagg cggcaagctg tatcgcgcgt cgaagttgcc gccgtatcaa 27840

ccgcacttga taaggggcga agaatgaaaa agaccgacga agaattgata gacgaagccc 27900

gcagcattgc gcgttcgaaa cgctgtttcg tcgtaacgaa gccgggttat tggctgttat 27960

accgcgaatg cacgccgcgt aacgtatgcg tcggcaaacg gtcgtcggct gcggcgttgc 28020

ttcaacttgc gaaaaaggct tgacgtagct tcgaagctgt cgtacacttc ttcgtaagtt 28080

gaacgaacaa aggagtaacg accatgcccg catataacgt aacaaccgaa ttcgaaatga 28140

ccgacggtcg cgttctgtcg tgcgaatacg tcttgtcggt tacgcccggt cgctattccg 28200

gcccttggga agattgttac ccggacgaat ccgacgcagg cgaaccgacg tattttatcg 28260

acggcgaaga agtcgattac aaagaacttc caaaaggatt ggacgcaatc gccgacaagc 28320

tttacgaagc tggcgacggc gaatacaatt acaaggaaga acgcgacgaa ccggattacg 28380

aaccggatta cgattacgat tattaacgaa ggagtaacga aaatgtcttg gcttattggt 28440

tgggccgtac tttccgtcgg cgttgttgtc ggcttcttgc ttgcggcctt gctgcgggcc 28500

aacgggcgcg acgtgccggt tccttcggct accgttaccg ccctgtcgcc gcaggaacgc 28560

gcccgcatgg gctacgcgct ggcaagggct ggcgacttgc tggacagcgg cgaccttgaa 28620

tacgtgtcgg gcggctttat ggtgcaagac gtaggacacg gcgtcgtaat tatcaaaggc 28680

gatttgtcgt tgcgggttgc cgaagatgaa taaggacgaa gcgcgcgaaa tgttcgaagc 28740

cgtcaaggcc aaccgggcga agattgacgg ttgcgcccgc catcgcttcg aaatcggcga 28800

cccgccgtac acgttcgggc aaaagttcac ttgttcgaac tgcggcggaa caatggacgc 28860

cgtacaggcg ttccgatact gtcaaggctt caaggccgca ggcggcgacc cgaacgaagt 28920

tataccgggt tacgaataac gcttgacaag cggcgaaggt tcggcgaaac ttagacgtaa 28980

cgaagaaacc ccgttaagga gttgccgaaa tgaccgttct aattttgctt ctttgcaccg 29040

ttgccgcttt gttcattcat cgcatgtttg ttcgtccgat tctggattgg ttcgaacaac 29100

gcgaatacgc cgaacgtatg cgcgaagctg aacagcgcgc ggcgttggaa gaagcaaggc 29160

gggccaagtg tcgataatct acgcaccgcg cgacgccctg tcgaaatggg acgcgcgatt 29220

tattgaactg gccgaacacg tcgccggatg gtcgaaaggg ccgcgtaagc gcatcggcgc 29280

ggctatcgtg cgcccgaatc ggtcgattgc gtcgcttggg tacaacggcc cgccgcgcgg 29340

cttcgacgac gccgtttttc tgaacatgac gcgcgacgaa caacacgcgg tcgtaattca 29400

tgccgaagac aacgcaattc gacaggctgc gccgggcgaa gacttgtccg cgtgtacgct 29460

gtacgtttcg ccgctgtttc cgtgcgccat ttgtgccgac cgcattgttc gggccggtat 29520

ccgtcgcgtt gtcgcttatt gtgggcatat atcgccagac tggcgcgcgt ctgccgacga 29580

agccgaacgc atctttaacc aagcgggcgt cgaatgcctg tttacaatgg attaacgaac 29640

atgaaaccgc tagaccattc gcaaatcgaa ggcttgttgt tctatcaaga cccgacaacg 29700

caaaactata tcggcgcacc gaaggccgac ccgttcaacc aagccggaag cttcgtcgca 29760

ttcgggccgc gtgttaccgt tgacccggcg ttgtataact tgcttgccgc agcgccgaca 29820

atgtaccaag ccctttcgat gcaatacgct taccttcaag cgcaaatcga agttatcgaa 29880

cgcttgccaa aggcgggcga acttgataag ctgttgtcgt cgctaatcga agcgcagaac 29940

gcttgcctaa tggcccaacg tatcgcgcaa gtcggttacg aaaatgtcgc aaattcactt 30000

gacaaaggtt cgaagcggtc gtaagcttga accatcgaaa cgaacaaagg tgcccacaat 30060

gaaccgtaag cttcttgtta tcgctggaat cgtcgccttc gtcgcgttgc ttggcatggt 30120

cgggcaaatg gacttcgaag acgaagcccg cgcgcacctg ttgtattgtg acaacgtagc 30180

gaacggcgtt tggccggatt acgacaaaat ttacgattct gaatgcacgc ccgaacgcat 30240

cgcagaaatc gaagaaattt tgcgttgacc gcttgacacg aagaacggtc ggcgtaaaat 30300

caacccgtcg caacaacgcg acataacctt aacgttaagg agttacacaa aatggctacc 30360

aagaaatcga ccgcgaagaa gaacaccgcc gccccggtta tcggccttgc cgaaattgtt 30420

gcagccgggc cgaatggtct gtatacttcg cctgccgtac atggcccgct tgtcgaagcc 30480

ggtatggtgg aaatcaaccc ggcaatgacc aacgaagcgg gcgaaatcgc aacccgcgca 30540

acccaaaaag gaatcgacga aatgaaccag aacaccgaaa ccggcaccgc cgcagcttcc 30600

gccccggtcg ctacttcctt cgccatcgaa gacaacgtac ccatgccgac cggcagcggt 30660

cgcggtcgcg gcggcaacgt ctacccgttc gacgcgctgg aagtcggcca aagcttcttc 30720

gttccgaaca gcgaagaaaa gccgaacgcc gcgaagtcgc ttgcttcgac cgtttccagc 30780

gcaaccgccc gtttcgccgt gccttccgaa gacggcgcga ccaagaccaa caagaagggc 30840

gaaaccgtgc ccgtcatggt cgaaacccgc aagttcgttg ttcgttcggt cgaaggcggc 30900

gcgcgcgtct ggcgcaccaa gtaagcgacg gcgcgggcta cggcccgccc tacgcctacg 30960

cttcaacgga aaccccggcc attgcgccgg ggttttcttt tgcttttctt gtcaatttgt 31020

gctaatccgt gctaatcttc ggccaaatac atttcggggc cggggcttgt gatgaatgaa 31080

cgaacaacaa ttttttaacg tagccgtcgc aattatcggc gcgttgggcg gttggtggat 31140

gcgcgttatg tggcagtcac ttaaagaact tcaagcgcaa gattcgaagt tggccgataa 31200

agtcggcaat atcgaagttc ttgtagccgg gcagtatgtc aagcgcgacg atatgaaccg 31260

cgacataatg gcgattttcg ccaaacttga ccgcatcgaa gacaagatag acaaaaaggc 31320

cgacaaatga agaagcccga acttatcgaa gattggcgcg aatgctggcg cttttggtcg 31380

gttcgactgg ccgcagtcgg caccgcaatt actggccttc ttgttgcgtt tcccgacgca 31440

gcgttggccg cttgggcaat ccttccgcac gaattgaagt cgtcgattcc gccgcagtat 31500

atgccgctta tcggcgttgt tgttttcgcg ctttccatcg ttgcccgcct tgtcaagcaa 31560

aagaacttga acaaggggcc gaaggatgaa taacgaactt ccttgggtag ccgaagcccg 31620

aaagtatatc ggccttcgcg aagacacttc gaagacttcg cataacccga agcttcttgc 31680

catgcttgac cgcatgggcg aattttccaa cgaatcccgc gcttggtggc atgacgacga 31740

aacgccttgg tgcggtctgt tcgtcggcta ttgcttgggc gtagccgggc gctacgtcgt 31800

ccgcgaatgg tacagggcgc gggcatggga agccccgcag cttaccaagc ttgaccggcc 31860

cgcatacggc gcgcttgtga ccttcacgcg aagcggcggc ggccacgtcg gttttattgt 31920

gggcaaggat gcgcgcggta atcttatggt tcttggcggt aatcagtcga acgccgtaag 31980

tatcgcaccg ttcgcagtat cccgcgtaac cggctatttc tggccgtcgt tctggcgaaa 32040

caagaccgca gttaaaagcg ttccgttcga agaacgttat tcgctgccgc tgttgaagtc 32100

gaacggcgaa ctttcgacga atgaagctta aaggggcatc gcatgttttc cgtaatttgg 32160

gccaagtttg gcaaatggct tgccgcaatc ggcgcgggtc ttgtcatgct ggcaagtatt 32220

ttttatgccg gtcgcaagtc cggcgcaacc aaggccgaag ccaacgcagc aaacgaacgg 32280

gcaaacgacc gcgaagcaat cgcagttcgc caagttaacg aagcccgcga agcttccgaa 32340

caacaggtaa aggcggtaca aaatgcgaaa gacgttgctt ccgataattc tacttttgac 32400

gacgacgaag ttactaagcg gctgcgcgac gaatggtcgc gcgactgaac cgcaaagcat 32460

cgccgacgca gtgcaaacga agcccgttgt aatcgacacg gcttgcaaat gggttgcgcc 32520

tatttggatt tcgaaggccg acggcttgac cgctggcacg gcccggcaaa ttctgaacca 32580

taacgaagcc gtcgaacgca attgcgggcc gcagtcgccg cctaaatctg cggacaagcc 32640

ttaacagaac gcggggcttg cggtatagtg aagccaacga cgtataaact aggccgacac 32700

tatgtccgac gaactgaaag aaagcgaaga aaaggccgca tacgcggccc ttcttttgaa 32760

agaacgcgac ccgttcaagg ctgcgctttc gctgtttccg aacaacacga atcgcgcgct 32820

atgggttgcg aaccattggc cgaacgacgc cgaagttaag gccgaacaaa agcgccttac 32880

cgacgaaggc ggcgatatgg catttcttcc gggcaaaggc gaccttgccc gcgacatttg 32940

gcagcgtatg caaggtacga cgcttccgaa cggcgtaacc attccgccga cgcccgaaga 33000

atacgcgaag cttgccaagc tttacgccga cgttcgcggg ttcatcgaaa aaccgcaaac 33060

gaacgttaac gtaacgacga acgtaaaccg cgtcgtcgaa atgcccgtat tcgctaacga 33120

aagcgaatgg gaagcggaag ccgcacggca acagcgcgaa ttgttagaaa atgcacgcac 33180

tcgccattga tacgaacggg gcgaaacctg ttccgtatga agtcgtattt aagccccttc 33240

cggggtcgca gactatcgcc ctttgttcga tggcagcgca tacgctgtac gaaggcgcac 33300

gcggccccgg taagacgctt acgcagctta tgcgctttta tcgtaacgtc ggcaaaggct 33360

acggcaagtt ctggcgcggc gttatcttcg atttggaatt tgaccatttg ggcggccttg 33420

ttgccgaatc gaaaaaatgg ttcggcgata acggaaagct aaaagacggc ggcaagtttt 33480

acgaatcaac gtcggcttat aaatgggttt ggccgacagg cgaagaactg ttgtttcggc 33540

acgttaagaa gctgtcggat tacgaaggct tccacggtca cgaatacccg tttatcggtt 33600

ggaacgaact tacgaagcat ccaagcggcg acctttacga caaatttatg tcggtcaacc 33660

gctgtacgtt cgacccgata aaagacacgc cgaaagaccc gaaaaccggg cgctatttga 33720

cgccgaacgg cgaaccgctg ccgcctgtaa agtgcgaagt attcagcaca acgaacccaa 33780

gcggccccgg tcacaattgg gtaaaacgtc gctttattac gattgccccg cgcggcaccg 33840

tagttcgtcg cgaaattcag atttacaacc cggcgaccga aaaagaagaa acgcacgtaa 33900

ttagccaaat cgctatcttc ggttcgtata aggaaaaccc gtaccttccg gcttcgtata 33960

tcgccgaact ggaaagtatc aaagaaccga acttgcggaa ggcttggctt tacggcgatt 34020

gggacgttac cgcaggcggc gcaatcgacg acctttggca atcgcatata cacgttgtac 34080

cgcgcttcgt cattccgcca agctggcgaa tcgacagaac atacgacgac gggtcttcgc 34140

atccgtttag tgtgggctgg tgggcggaag cggacggcac cgaagcgacc atagttcttt 34200

cggatggcac cgaatttacg ttttgcccgc aaccgggttc gcttgttcag ttgttcgaat 34260

ggtacggatg cgcgaaagac gaaaaaggcg aatacatacc gaataaaggt ttgaagcttt 34320

cggcgtcgaa tatcgcacaa ggtataatcg accgcgaaat ttcgctaatg gcgaacggtt 34380

ggatttattc gcagccttgg cccggccctg ccgacaaccg cattcgccaa gtaatcgaca 34440

gcgaactaga cacgaccgaa aagcttatgt cgaagaaggg cgttcgttgg acggaatcgg 34500

acaaatcgcc gggttcgcgc gtaatcgggt tgcagctttt ccgcgaccgg ctagaagcgt 34560

ctgttaatcg cgaagggccg ggtatatact ttatgtcgaa ttgcgttgca agtattgatt 34620

tgctgcccac actgccgcgc gacgaaaaga agattgacga cgtagacacg accgccgaag 34680

accattgtta cgatatggtg cgttatcgcg tattgaaagg cgcgaacaaa gcggcagcga 34740

aattcaaact tgttatgcca acttaaagga acccaaatca tgccgaacgt ttcatttatt 34800

cgccccgaac ttggtaagct gctgccgctg tattacctga ttcgcgacgc aatcgcgggc 34860

gaaccaacgg taaaaggcgc gcggacgact tatcttccga tgccgaacgc cgaagaccaa 34920

tcgaaagaaa ataaggcgcg atacgaagcg tacttgaagc gggccgtttt ctataacgta 34980

gcccgtcgaa ccttgttcgg cttggtcggt caagtgttca tgcgcgaccc ggttgtaaag 35040

gttcccgcgc tgttgaaccc gcttgtcgca aacgcgacgg gttcgggtat caaccttacg 35100

cagcttgcga aaaaggccgt atcgctgaac cttgcgtatt cccgcgccgg gctgttggtc 35160

gattacccga cgaccgaagc cgaaggcggc gcgtcgattg ccgaccttga agccgggcgc 35220

attcgtccga ccctgtacgt atattcgccg accgaaatta tcaattggcg aacgaccgac 35280

cggggcgcgg aagaagtttt atcgttggtc gtactgttcg aaacttggtg cgctgccgat 35340

gatggttttg aaatgaaaac gtcggggcaa ttccgcgttt tgcgtttgga cgaagaaggt 35400

tattacgtcc acgaaatttg gcgcgaaccg cagccgacca aagccgacgg tacgaagatt 35460

ccgaaaggca attaccaaca atacacggtt tacaagccga cggacgcaaa cggcaatcgt 35520

cttaccgaaa ttccgtttat gttcatcggt tcggaaaaca acgattcgaa cccggacaac 35580

ccgaactttt acgaccttgc gtcgctgaat atggcgcatt atcgcaattc ggcggattac 35640

gaagaaagtt gttatatcgt cggacagccg acgccggttc ttatcggact taccgaagaa 35700

tgggttacga acgttcttaa aggttccgtt aacttcggtt cgcgcggcgg tattccgctt 35760

cctgccgggg ccgacgcgaa gttgcttcaa gcatccgaaa acaccatgct taaagaagca 35820

atggatacca aagaacgcca aatggtcgca cttggcgcaa agcttgtcga acaaaaggaa 35880

gtgcaacgca cggcaaccga agccgaattg gaagccgctt cggaaggttc gacgctttcc 35940

agtgcaacca agaacgtttc ggcggccttt gaatgggcgt tgaaatgggc ggcccgttgg 36000

gtcggtcaag ccgacagcgg cgttaagttc gaactgaata cagatttcga cattgcccgc 36060

atgacgccgg aagaacgccg ttcgcttgtt gaagaatggc agaaaggcgc aattaccttc 36120

gaagaaatgc gaaccggctt gcgtaaagct ggcgtcgcaa ccgaagacga cgccaaggct 36180

aaagaaaaaa tcgccaagga taccgccgaa gcaatggccc ttgctgcccc ggctaacgtg 36240

ccgggcgatg gcagcggcgg cgataatgtg ggcaacaacg gataaggggc gcaatcatgg 36300

cactatcgga caataagcga ctgtacgata ttgcgacgcg ccttgctgtt tacgtcgaag 36360

acgtgaaagt ttggcagtcc cgacaattcg ggttcgtact tcgcgaagta aacttggaat 36420

taacgcgcct tcttggtcgt gttcgttata agacccttga cggtctttcg aaggcgcagt 36480

taaacaagct tgtttcggaa ttacgggaat cgcaatcgaa gatttacagc gcatacacgc 36540

aaacgctgct tgaacagtta aaggaattca tgcgggccga cttggaagta aaccggcgcg 36600

cttgggttac gggttatatc gaacttgacg gcgaagaaag cgacgacatt atttcggacg 36660

aagaagcgat acagtttctt ttagaagtac caaacgccga ttcgaaccct ttgttcggtt 36720

tggccgctgt tacaggaagc gacgaacgca tttggtcgca agttacgaat acgccaattc 36780

cggcaaatgg tttgtacttg ctgccgttta tcaagacgtt tacgaattcg gcacaagctg 36840

gcgtcgaaag catgattcgc aaagcttggg cgaaccgttg gacggttgaa gaaaccttaa 36900

cggcgcttgt cggcgatgga accgcagcgc agggcacgcc gtcgcagttg caccgggtca 36960

acgcgcaagc cgcgtcggta atccatacgg caaccgcgca cgttgcggcg gtcgttgcgg 37020

ctggcgttat gtctgcggtt ttcggtcgtt acgtttggta ttcggtaatc gacggaagaa 37080

cgacggacat ttgcataagt cgaaatcgcc gaatctatcg cttcggcgaa gggccgttgc 37140

cgcccgcgca tatccgttgc cggtcgcacg ttgccccggc aaataccgct agtgacttgg 37200

ccgaagaaac gttttatact tgggttgccc gtcaacctgc ccaagtgcaa gacgacatat 37260

taggcgacga aggcggcgaa gctttgcgcg atggtcgctt aaaggcgaag gatattccga 37320

agtatgatgc ggacaggccg ctaacttacg aagaattccg acgcaagatt aaagaaattc 37380

tttcccgctg attcggtgaa tcggcataac cgcaaggagt ccttgaaatg gcactgaaaa 37440

agaaacttac caaagaagaa cacgcgaagc tttcggatgc actgaaagcc gaatatatcg 37500

aagacggcga cggcttccgc cttgacgttg acggcgacga agatacgggc gctttgaagc 37560

gcgccaaaga ccgcgaagcg cagttgcgca aagacgccga aaaggaagcg aaggaacttc 37620

gcgaacggct ggaatccatc gaaggcgacg acgcgcgcaa gaaaggcgac attgcgacgc 37680

ttgaaaagtc ttggcaatcg aagcttgaaa aacagcgcga agaatacgaa gccaaggttt 37740

ccaagcttac cgcgcatacg acgaaaacgc ttgtcgataa cgtcgcgtcg cagcttgccc 37800

acaagatttc gaacgccccg gcaatcatca tgccgcatat caagtcgcgg cttatcgcag 37860

acttcgaagg cgacacgccg gttacgcgcg ttctggacaa ggacggcaag ccgtcggccc 37920

ttactatcga cgaactggca aacgaattcg ttgcaaacaa ggatttttct gctattatca 37980

cagctagtaa ggcgtccggc ggtgccggta agccttcgca gaacggcggc ggtgccccga 38040

aatttaacgg tcaatccgac aaacccgccg acctttcgaa gatgaatccc gcagaacttg 38100

cggcgcatct taaagaagcg aaggcaaacg aaactaagga cgcttaatca tggcactttc 38160

cgaccttgct gtttactccg aatacgctta ttcggctttc tccgaaaccc tgcgccaaca 38220

ggttgatttg ttcaacgctg cgacgggcgg ggctatcatg ctgcaatccg cagcgcacca 38280

aggcgacttt tccgacgttg cctttttcgc caaggtaacg ggcggccttg ttcgccgtcg 38340

taacgcctac ggttccggca ccgtcgccga aaaggtcttg aaacaccttg tcgatacgtc 38400

ggttaaggtc gcagccggta cgccgcctgt tcgccttgac cccggccaat tccgttggat 38460

tcagcagaac ccggaagtcg caggcgcggc aatggggcag caactcgccg tcgatacgat 38520

ggcggatatg ctgaacgttg gtcttggttc ggtctattcg gcactttcgc aggttgcggc 38580

ggttgtttac gacgcgaccg gcaatactgc gcccgacgac ggcccgactt ggaacaacct 38640

taacaacggc caagccaagt tcggcgacca atccgcgcag attgcggcat ggattatgca 38700

cagtacgccc atgcacaagc tgtacggtaa caacctgaac aactccgaac gcctgtttac 38760

ttacggcacc gtgaacgttg ttcgcgaccc gttcggcaag cttcttgtta tgaccgattc 38820

gccaaacctg ttcgaagccg gtacgccgaa cgtttatcgc atccttggcc ttgtgccggg 38880

cgcggttatg attggtcaaa acaacgactt cgacgcgaac gaagaaacca agaacggcga 38940

cgaaaacatt attcggactt accaagccga atggtcgtac aacgtcggcg ttaagggctt 39000

cgcttgggac aaggcgaacg gcggcaagtc gccgaccgac gcggcgttgt tcacttcgac 39060

caattgggac aagtacgcaa cttccgaaaa ggatttggcg ggcgttgtcg tcgaagttca 39120

ctaacggacg gcagacggac ggggcttcgg ccccgttctt ctagtccttc acaaattcaa 39180

aggagtttcg aagatgaaac cggcaaaaat cctgtatttc gtcgatggca acgcaccgac 39240

cccggaagac ttcgcagccg ccgccgaact gaacgcgcaa gttatgttca ggaacgcccg 39300

cgctgttccg tccgaaccgc attcgctgga aatctgcgac ggcgtagcgg gcaaggttcc 39360

gaagctgtac gccgacgctt acccggaagc gggcgaagca atcaagaaga aggccgccga 39420

actgaaagcc cttgcttcga aggtcggcga cgccccggca ccgaaggcca gcggcaaggc 39480

cgccgacaag cccgcagccg ctacgcaggg ccagaaagcc ccggcagcgg ccccgcaggg 39540

cggcagcgcc ccggcttgga accctaaccc ggcgcagtaa ccaacggacg gcctgtcgct 39600

tattgtgggc aggccgtttc aacaacgaac taaggagtct tcgcaatggc aacgaaaaag 39660

gttgtttatt ttacggcagg cattaccgca accgctggcg aacttgccgc aattgcgaag 39720

cttaacgcag ccgccgaacc gcaatatgaa gttttggtag ccaatggcgc ggcaaatgcc 39780

gaatacggcg aaaccgaccg aatcattccg tcggattatg tcgccggtac tgttccttcg 39840

gaatattcgg cggttgacgt aatcgacccc gacgcaatcc cgaatcaggc gcttacgcca 39900

acgcaagcaa tcgttaacga cgccgaagcc ttgaccgttc cggttactgg cacttacacg 39960

acgaccgcaa ccgttagcgt tgcgaacggc gttgtaaccg gcatcgttct ttcgtaagga 40020

cgttgacgca tggcaattac aatcgttgtt gaagacggaa gcggcgtaac aaacgcgaac 40080

agttacgtaa gcgtcgcaga cgcgcgcatt tacgcttcga atcgcggcgt cgaacttccg 40140

ttggacgacg acgaattggc ggccatgctg attcgttcga cggattacct agaagcgcag 40200

gcttgccggt tccaaggcaa gccaacttcg acgacgcagg ctttgcaatg gccgcgaact 40260

ggcgtctttc ttaacgaaga cgaagtaccg tcgaacgtta ttccgaagtc gcttattgcc 40320

gcgcaagttc agcttgcaat ggcgattaac gcaggcttcg accttcaacc gaacgtttcg 40380

ccgcaagact acgttacgcg cgaaaaggtc gggccgattg aaacggaata cgccgacccg 40440

ctgtcggttg gcatcatgcc cacatttacc gcagcgaacg cacttcttgc gccgctgttt 40500

ggcgaatgcg cttcgaacaa gtttgcgctt cgtacaataa gggtttgacg aatggcacgt 40560

ttcgacgcag caattaaaac ggcgcaacgc cttatcgcaa agaacggcga aaaggtgaaa 40620

tggcgcgtta tcgaagacgc gacgccgaca gacccgaaca agccttggga acccggcccg 40680

gcattgccgg acgacaaaga cgttaccatt tgctttttgc cggttgaccg gcagacgcaa 40740

gaaactttca acttcattaa aggcaccgaa gttccgaaag gttcggtaat ggggcttatg 40800

ggcaatgttc cgtttgaacc gaatttgaaa gacgttgtaa ttcgtaacgg ggtcgaactt 40860

cgcttggctt atatcgacgt actttcgccg aacgggcaaa aggtacttta tacgatggta 40920

tttcaagcat gattgaattc gaccaagtta acgacgaagt aaacgcgctt tttcttgcaa 40980

cttggaacgc aggaagcgcg gcaattgcgg gttatgttcc cgaaattcgt tggcagggcg 41040

tgcaatatcg cgacttgccg gacggttcga agttttgggt tcggctgtcg aagcaaaccg 41100

tttttgaaga acaagcgacc ctttcaacct gcgaaggagt accggggcaa agaaaatata 41160

cggcgtcggg tcttgtcttc gtacaaatct tttgcccgaa atcgaatacg caagcgttcg 41220

aacttgggca gaaattggcg aaactttccc gtaatgcttt tcgcgggaaa tcgacgccgg 41280

gtaaggtttg gtttcgcaat acgcgaatta acgaacttcc gcccgaagaa ctttacgaac 41340

ggtttaacgt cgttaccgaa tttgaatacg acgaaatagg ttaaggagtt cttaacatgg 41400

tatgcgaaat tgccaaaatc gacagcaaca ttaccggact tgccttcgcc gaagaagaat 41460

gcttgaagca acttccgacg acgcccgttt ggtacggact ggaacccaac agctattcgg 41520

acttcggcgg cgaactttcg accgttgccc gcgcgcctat cgacccgtcg cgccagaaca 41580

agaaaggcac gattaccgac cttgacgcat cgggcggctt caacgccgac tttacgaaga 41640

ccaaccttac gcgaattctg caaggcttct tcttcgcaga cgcgcgcgaa cttccttcga 41700

cgcagccgct taacggcgca tcggtcgcac ttaccggcgt taccgcagtt gacagcactt 41760

acgccgcagc ttccgggctt ggcgtgttcg gtgccgatat gctggtatat gcgaccggct 41820

ttaccaacgc ggcgaacaac ggccttaaaa ccgtcgtttc ggctaccgct gcgggcgtcg 41880

ttgttgctga aaccttgatt gacgaaaccc cgcccgcagg cgcgaagctg gaatgcgtcg 41940

gtcgccagct tgccgccgca gacgcgaaca ttgccgtaac tggcaacgtc gtttcgctta 42000

tcgttaccgc tggcgacttt acgaccatgc ccgaactgtt ccccggtcgt tgggtcttcg 42060

tcggcggcga tgcgacggca aaccgcttcg ctaataatgt gggctatgcc cgcattaagt 42120

cggttgcagc gaaggcgctt gttttcgacg acgtgacttg gcaggcggcc aacgaaaccg 42180

gaaccggcaa gtcgattcgt cttttcgtcg gaactgttat caagaacgaa aagaccccgg 42240

cacttatcaa gcgtcgttcg tatcaaatcg aacgcacctt gggcgaaggt ttgaacggta 42300

cgcagtgcga atatctggaa ggcgcagtac cgaacgaatt tacgttgaac gttccgcagg 42360

ccgacaagct gaacgccgac ctttcgtttg ttgcgtgcga caacacttac cgcagcggcg 42420

accccggcga cgaacagaaa accggaaccc gcgtgcctgc gcccggcgaa gacgcttaca 42480

acacttcttc ggacgtttac cgaatcaaga tggccgttca cgacgccgcg tcgtcgaacc 42540

ccgccgccct gttcggctac gtttccgaag cgaacgtttc gattaacaac aacgttacgc 42600

cgaacaaggc ggtcggcgtg ttgggcgcgt tcgatacttc ggcgggtaac ttcgaagtcg 42660

gcggttcgat taccgcttac tttacgaccg tcgcagcggt taaggctgtt cgcgcgaacg 42720

ccgacgttgg tttgtcggta atcagtgcgg ccaagaacgc cggtttcgtg ttcgatattc 42780

cgttgcttgg tttgggcggc ggtcgtctga acgtcgaaaa agacgcgccg attaccgttc 42840

cgctggaacc cgcaggcgca gaaaacgcga acggctatac gatgctgtac gaagtgtttt 42900

cttatctgcc gaatctggca atgccggact aa 42932

<210> 17

<211> 783

<212> DNA

<213> Artificial Sequence

<220>

<223> RFP

<400> 17

ttgacaatta atcatcggct cgtataatgt gtggaattgt gagcggataa caatttcaca 60

caggaaacac atatggtttc taaaggtgaa gaagacaaca tggctatcat caaagaattt 120

atgcgtttca aagttcacat ggaaggttct gtgaacggtc acgaatttga aatcgaaggt 180

gaaggtgaag gtcgtccgta tgaaggcacc cagaccgcta aactgaaagt taccaaaggt 240

ggtccgctgc cgttcgcttg ggacatcctg tctccgcagt tcatgtacgg ttctaaagcg 300

tatgttaaac acccggctga catcccggac tacctgaaac tgtctttccc ggaaggtttc 360

aaatgggaac gtgttatgaa ctttgaagac ggtggtgttg ttaccgttac ccaggactct 420

tctctgcaag acggtgaatt tatctacaaa gttaaactgc gtggcaccaa cttcccgtct 480

gacggtccgg ttatgcagaa gaaaacgatg ggttgggaag cgtcttctga acgtatgtac 540

ccggaagacg gtgctctgaa aggtgaaatc aaacagcgtc tgaaactgaa agacggtggt 600

cactacgacg ctgaagttaa aaccacctac aaagctaaaa agccggttca actgccgggt 660

gcttacaacg tgaacatcaa actggacatc acctctcaca acgaagacta caccatcgtt 720

gaacagtacg aacgtgctga aggtcgtcac tctaccggcg gtatggacga actgtataaa 780

taa 783

<210> 18

<211> 21

<212> DNA

<213> Artificial Sequence

<220>

<223> 引物

<400> 18

cgcctgttta cttacggcac c 21

<210> 19

<211> 20

<212> DNA

<213> Artificial Sequence

<220>

<223> 引物

<400> 19

cgcagatttc cagcgaatgc 20

<210> 20

<211> 21

<212> DNA

<213> Artificial Sequence

<220>

<223> 引物

<400> 20

gacgaccgac catgcgtaca a 21

<210> 21

<211> 21

<212> DNA

<213> Artificial Sequence

<220>

<223> 引物

<400> 21

tgggcgaagg ttgttcaatg c 21

<210> 22

<211> 11963

<212> DNA

<213> Artificial Sequence

<220>

<223> pYF-II

<400> 22

gcggccgcaa ggggttcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 60

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 120

gcgtaaggag aaaataccgc atcaggcgcc attcgccatt caggctgcgc aactgttggg 180

aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 240

caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 300

ccagtgaatt gtaatacgac tcactatagg gcgaattcga gctcggtacc cggggatcct 360

ctagagtcga cctgcaggca tgcaagcttg agtattctat agtgtcacct aaatagcttg 420

gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 480

aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc 540

acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg 600

cattaatgaa tcggccaacg cgaacccctt gcggccgccc gggccgtcga ccaattctca 660

tgtttgacag cttatcatcg aatttctgcc attcatccgc ttattatcac ttattcaggc 720

gtagcaacca ggcgtttaag ggcaccaata actgccttaa aaaaattacg ccccgccctg 780

ccactcatcg cagtactgtt gtaattcatt aagcattctg ccgacatgga agccatcaca 840

aacggcatga tgaacctgaa tcgccagcgg catcagcacc ttgtcgcctt gcgtataata 900

tttgcccatg gtgaaaacgg gggcgaagaa gttgtccata ttggccacgt ttaaatcaaa 960

actggtgaaa ctcacccagg gattggctga gacgaaaaac atattctcaa taaacccttt 1020

agggaaatag gccaggtttt caccgtaaca cgccacatct tgcgaatata tgtgtagaaa 1080

ctgccggaaa tcgtcgtggt attcactcca gagcgatgaa aacgtttcag tttgctcatg 1140

gaaaacggtg taacaagggt gaacactatc ccatatcacc agctcaccgt ctttcattgc 1200

catacggaat tccggatgag cattcatcag gcgggcaaga atgtgaataa aggccggata 1260

aaacttgtgc ttatttttct ttacggtctt taaaaaggcc gtaatatcca gctgaacggt 1320

ctggttatag gtacattgag caactgactg aaatgcctca aaatgttctt tacgatgcca 1380

ttgggatata tcaacggtgg tatatccagt gatttttttc tccattttag cttccttagc 1440

tcctgaaaat ctcgataact caaaaaatac gcccggtagt gatcttattt cattatggtg 1500

aaagttggaa cctcttacgt gccgatcaac gtctcatttt cgccaaaagt tggcccaggg 1560

cttcccggta tcaacaggga caccaggatt tatttattct gcgaagtgat cttccgtcac 1620

aggtatttat tcgcgataag ctcatggagc ggcgtaaccg tcgcacagga aggacagaga 1680

aagcgcggat ctgggaagtg acggacagaa cggtcaggac ctggattggg gaggcggttg 1740

ccgccgctgc tgctgacggt gtgacgttct ctgttccggt cacaccacat acgttccgcc 1800

attcctatgc gatgcacatg ctgtatgccg gtataccgct gaaagttctg caaagcctga 1860

tgggacataa gtccatcagt tcaacggaag tctacacgaa ggtttttgcg ctggatgtgg 1920

ctgcccggca ccgggtgcag tttgcgatgc cggagtctga tgcggttgcg atgctgaaac 1980

aattatcctg agaataaatg ccttggcctt tatatggaaa tgtggaactg agtggatatg 2040

ctgtttttgt ctgttaaaca gagaagctgg ctgttatcca ctgagaagcg aacgaaacag 2100

tcgggaaaat ctcccattat cgtagagatc cgcattatta atctcaggag cctgtgtagc 2160

gtttatagga agtagtgttc tgtcatgatg cctgcaagcg gtaacgaaaa cgatttgaat 2220

atgccttcag gaacaataga aatcttcgtg cggtgttacg ttgaagtgga gcggattatg 2280

tcagcaatgg acagaacaac ctaatgaaca cagaaccatg atgtggtctg tccttttaca 2340

gccagtagtg ctcgccgcag tcgagcgaca gggcgaagcc aagagtttgt agaaacgcaa 2400

aaaggccatc cgtcaggatg gccttctgct taatttgatg cctggcagtt tatggcgggc 2460

gtcctgcccg ccaccctccg ggccgttgct tcgcaacgtt caaatccgct cccggcggat 2520

ttgtcctact caggagagcg ttcaccgaca aacaacagat aaaacgaaag gcccagtctt 2580

tcgactgagc ctttcgtttt atttgatgcc tggttaggtg gcggtacttg ggtcgatatc 2640

aaagtgcatc acttcttccc gtatgcccaa ctttgtatag agagccactg cgggatcgtc 2700

accgtaatct gcttgcacgt agatcacata agcaccaagc gcgttggcct catgcttgag 2760

gagattgatg agcgcggtgg caatgccctg cctccggtgc tcgccggaga ctgcgagatc 2820

atagatatag atctcactac gcggctgctc aaacctgggc agaacgtaag ccgcgagagc 2880

gccaacaacc gcttcttggt cgaaggcagc aagcgcgatg aatgtcttac tacggagcaa 2940

gttcccgagg taatcggagt ccggctgatg ttgggagtag gtggctacgt ctccgaactc 3000

acgaccgaaa agatcaagag cagcccgcat ggatttgact tggtcagggc cgagcctaca 3060

tgtgcgaatg atgcccatac ttgagccacc taactttgtt ttagggcgac tgccctgctg 3120

cgtaacatcg ttgctgctgc gtaacatcgt tgctgctcca taacatcaaa catcgaccca 3180

cggcgtaacg cgcttgctgc ttggatgccc gaggcataga ctgtacaaaa aaacagtcat 3240

aacaagccat gaaaaccgcc actgcgccgt taccaccgct gcgttcggtc aaggttctgg 3300

accagttgcg tgagcgcata cgctacttgc attacagttt acgaaccgaa caggcttatg 3360

tcaattcgct agagtcgatc ttcgccagca gggcgaggat cgtggcatca ccgaaccgcg 3420

ccgtgcgcgg gtcgtcggtg agccagagtt tcagcaggcc gcccaggcgg cccaggtcgc 3480

cattgatgcg ggccagctcg cggacgtgct catagtccac gacgcccgtg attttgtagc 3540

cctggccgac ggccagcagg taggccgaca ggctcatgcc ggctgccgcc gccttttcct 3600

caatcgctct tcgttcgtct ggaaggcagt acaccttgat aggtgggctg cccttcctgg 3660

ttggcttggt ttcatcagcc atccgcttgc cctcatctgt tacgccggcg gtagccggcc 3720

agcctcgcag agcaggattc ccgttgagca ccgccaggtg cgaataaggg acagtgaaga 3780

aggaacaccc gctcgcgggt gggcctactt cacctatcct gcccggctga cgccgttgga 3840

tacaccaagg aaagtctaca cgaacccttt ggcaaaatcc tgtatatcgt gcgaaaaagg 3900

atggatatac cgaaaaaatc gctataatga ccccgaagca gggttatgca gcggaaaagc 3960

gctgcttccc tgctgttttg tggaatatct accgactgga aacaggcaaa tgcaggaaat 4020

tactgaactg aggggacagg cgagagacga tgccaaagag ctacaccgac gagctggccg 4080

agtgggttga atcccgcgcg gccaagaagc gccggcgtga tgaggctgcg gttgcgttcc 4140

tggcggtgag ggcggatgtc gaccgggagg gttcgagaag ggggggcacc ccccttcggc 4200

gtgcgcggtc acgcgcacag ggcgcagccc tggttaaaaa caaggtttat aaatattggt 4260

ttaaaagcag gttaaaagac aggttagcgg tggccgaaaa acgggcggaa acccttgcaa 4320

atgctggatt ttctgcctgt ggacagcccc tcaaatgtca ataggtgcgc ccctcatctg 4380

tcagcactct gcccctcaag tgtcaaggat cgcgcccctc atctgtcagt agtcgcgccc 4440

ctcaagtgtc aataccgcag ggcacttatc cccaggcttg tccacatcat ctgtgggaaa 4500

ctcgcgtaaa atcaggcgtt ttcgccgatt tgcgaggctg gccagctcca cgtcgccggc 4560

cgaaatcgag cctgcccctc atctgtcaac gccgcgccgg gtgagtcggc ccctcaagtg 4620

tcaacgtccg cccctcatct gtcagtgagg gccaagtttt ccgcgaggta tccacaacgc 4680

cggcggccgg ccgcggtgtc tcgcacacgg cttcgacggc gtttctggcg cgtttgcagg 4740

gccatagacg gccgccagcc cagcggcgag ggcaaccagc ccggctcgag tgagcgagga 4800

agcaccaggg aacagcactt atatattctg cttacacacg atgcctgaaa aaacttccct 4860

tggggttatc cacttatcca cggggatatt tttataatta ttttttttat agtttttaga 4920

tcttcttttt tagagcgcct tgtaggcctt tatccatgct ggttctagag aaggtgttgt 4980

gacaaattgc cctttcagtg tgacaaatca ccctcaaatg acagtcctgt ctgtgacaaa 5040

ttgcccttaa ccctgtgaca aattgccctc agaagaagct gttttttcac aaagttatcc 5100

ctgcttattg actctttttt atttagtgtg acaatctaaa aacttgtcac acttcacatg 5160

gatctgtcat ggcggaaaca gcggttatca atcacaagaa acgtaaaaat agcccgcgaa 5220

tcgtccagtc aaacgacctc actgaggcgg catatagtct ctcccgggat caaaaacgta 5280

tgctgtatct gttcgttgac cagatcagaa aatctgatgg caccctacag gaacatgacg 5340

gtatctgcga gatccatgtt gctaaatatg ctgaaatatt cggattgacc tctgcggaag 5400

ccagtaagga tatacggcag gcattgaaga gtttcgcggg gaaggaagtg gttttttatc 5460

gccctgaaga ggatgccggc gatgaaaaag gctatgaatc ttttccttgg tttatcaaac 5520

gtgcgcacag tccatccaga gggctttaca gtgtacatat caacccatat ctcattccct 5580

tctttatcgg gttacagaac cggtttacgc agtttcggct tagtgaaaca aaagaaatca 5640

ccaatccgta tgccatgcgt ttatacgaat ccctgtgtca gtatcgtaag ccggatggct 5700

caggcatcgt ctctctgaaa atcgactgga tcatagagcg ttaccagctg cctcaaagtt 5760

accagcgtat gcctgacttc cgccgccgct tcctgcaggt ctgtgttaat gagatcaaca 5820

gcagaactcc aatgcgcctc tcatacattg agaaaaagaa aggccgccag acgactcata 5880

tcgtattttc cttccgcgat atcacttcca tgacgacagg atagtctgag ggttatctgt 5940

cacagatttg agggtggttc gtcacatttg ttctgaccta ctgagggtaa tttgtcacag 6000

ttttgctgtt tccttcagcc tgcatggatt ttctcatact ttttgaactg taatttttaa 6060

ggaagccaaa tttgagggca gtttgtcaca gttgatttcc ttctctttcc cttcgtcatg 6120

tgacctgata tcgggggtta gttcgtcatc attgatgagg gttgattatc acagtttatt 6180

actctgaatt ggctatccgc gtgtgtacct ctacctggag tttttcccac ggtggatatt 6240

tcttcttgcg ctgagcgtaa gagctatctg acagaacagt tcttctttgc ttcctcgcca 6300

gttcgctatc acgtgctata aaaataatta taatttaaat tttttaatat aaatatataa 6360

attaaaaata gaaagtaaaa aaagaaatta aagaaaaaat agtttttgtt ttccgaagat 6420

gtaaaagact ctagggggat cgccaacaaa tactaccttt tatcttgctc ttcctgctct 6480

caggtattaa tgccgaattg tttcatcttg tctgtgtaga agaccacaca cgaaaatcct 6540

gtgattttac attttactta tcgttaatcg aatgtatatc tatttaatct gcttttcttg 6600

tctaataaat atatatgtaa agtacgcttt ttgttgaaat tttttaaacc tttgtttatt 6660

tttttttctt cattccgtaa ctcttctacc ttctttattt actttctaaa atccaaatac 6720

aaaacataaa aataaataaa cacagagtaa attcccaaat tattccatca ttaaaagata 6780

cgaggcgcgt gtaagttaca ggcaagcgat ccgtctaaga aaccattatt atcatgacat 6840

taacctataa aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg 6900

gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg 6960

ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc 7020

ttaactatgc ggcatcagag cagattgtac tgagagtgca ccataaattc ccgttttaag 7080

agcttggtga gcgctaggag tcactgccag gtatcgtttg aacacggcat tagtcaggga 7140

agtcataaca cagtcctttc ccgcaatttt ctttttctat tactcttggc ctcctctagt 7200

acactctata tttttttatg cctcggtaat gattttcatt tttttttttc cacctagcgg 7260

atgactcttt ttttttctta gcgattggca ttatcacata atgaattata cattatataa 7320

agtaatgtga tttcttcgaa gaatatacta aaaaatgagc aggcaagata aacgaaggca 7380

aagatgacag agcagaaagc cctagtaaag cgtattacaa atgaaaccaa gattcagatt 7440

gcgatctctt taaagggtgg tcccctagcg atagagcact cgatcttccc agaaaaagag 7500

gcagaagcag tagcagaaca ggccacacaa tcgcaagtga ttaacgtcca cacaggtata 7560

gggtttctgg accatatgat acatgctctg gccaagcatt ccggctggtc gctaatcgtt 7620

gagtgcattg gtgacttaca catagacgac catcacacca ctgaagactg cgggattgct 7680

ctcggtcaag catttaaaga ggccctaggg gccgtgcgtg gagtaaaaag gtttggatca 7740

ggatttgcgc ctttggatga ggcactttcc agagcggtgg tagatctttc gaacaggccg 7800

tacgcagttg tcgaacttgg tttgcaaagg gagaaagtag gagatctctc ttgcgagatg 7860

atcccgcatt ttcttgaaag ttttgcagag gctagcagaa ttaccctcca cgttgattgt 7920

ctgcgaggca agaatgatca tcaccgtagt gagagtgcgt tcaaggctct tgcggttgcc 7980

ataagagaag ccacctcgcc caatggtaca aacgatgttc cctccaccaa aggtgttctt 8040

atgtagcgct atgctcggtt acacggctgc ggcgagcgct agtgataata agtgactgag 8100

gtatgtgctc ttcttatctc cttttgtagt gttgctctta ttttaaacaa ctttgcggtt 8160

ttttgatgac tttgcgattt tgttgttgct ttgcagtaaa ttgcaagatt taataaaaaa 8220

acgcaaagca atgattaaag gatgttcaga atgaaactca tggaaacact taaccagtgc 8280

ataaacgctg gtcatgaaat gacgaaggct atcgccattg cacagtttaa tgatgacagc 8340

ccggaagcga ggaaaataac ccggcgctgg agaataggtg aagcagcgga tttagttggg 8400

gtttcttctc aggctatcag agatgccgag aaagcagggc gactaccgca cccggatatg 8460

gaaattcgag gacgggttga gcaacgtgtt ggttatacaa ttgaacaaat taatcatatg 8520

cgtgatgtgt ttggtacgcg attgcgacgt gctgaagacg tatttccacc ggtgatcggg 8580

gttgctgccc ataaaggtgg cgtttacaaa acctcagttt ctgttcatct tgctcaggat 8640

ctggctctga aggggctacg tgttttgctc gtggaaggta acgaccccca gggaacagcc 8700

tcaatgtatc acggatgggt accagatctt catattcatg cagaagacac tctcctgcct 8760

ttctatcttg gggaaaagga cgatgtcact tatgcaataa agcccacttg ctggccgggg 8820

cttgacatta ttccttcctg tctggctctg caccgtattg aaactgagtt aatgggcaaa 8880

tttgatgaag gtaaactgcc caccgatcca cacctgatgc tccgactggc cattgaaact 8940

gttgctcatg actatgatgt catagttatt gacagcgcgc ctaacctggg tatcggcacg 9000

attaatgtcg tatgtgctgc tgatgtgctg attgttccca cgcctgctga gttgtttgac 9060

tacacctccg cactgcagtt tttcgatatg cttcgtgatc tgctcaagaa cgttgatctt 9120

aaagggttcg agcctgatgt acgtattttg cttaccaaat acagcaatag taatggctct 9180

cagtccccgt ggatggagga gcaaattcgg gatgcctggg gaagcatggt tctaaaaaat 9240

gttgtacgtg aaacggatga agttggtaaa ggtcagatcc ggatgagaac tgtttttgaa 9300

caggccattg atcaacgctc ttcaactggt gcctggagaa atgctctttc tatttgggaa 9360

cctgtctgca atgaaatttt cgatcgtctg attaaaccac gctgggagat tagataatga 9420

agcgtgcgcc tgttattcca aaacatacgc tcaatactca accggttgaa gatacttcgt 9480

tatcgacacc agctgccccg atggtggatt cgttaattgc gcgcgtagga gtaatggctc 9540

gcggtaatgc cattactttg cctgtatgtg gtcgggatgt gaagtttact cttgaagtgc 9600

tccggggtga tagtgttgag aagacctctc gggtatggtc aggtaatgaa cgtgaccagg 9660

agctgcttac tgaggacgca ctggatgatc tcatcccttc ttttctactg actggtcaac 9720

agacaccggc gttcggtcga agagtatctg gtgtcataga aattgccgat gggagtcgcc 9780

gtcgtaaagc tgctgcactt accgaaagtg attatcgtgt tctggttggc gagctggatg 9840

atgagcagat ggctgcatta tccagattgg gtaacgatta tcgcccaaca agtgcttatg 9900

aacgtggtca gcgttatgca agccgattgc agaatgaatt tgctggaaat atttctgcgc 9960

tggctgatgc ggaaaatatt tcacgtaaga ttattacccg ctgtatcaac accgccaaat 10020

tgcctaaatc agttgttgct cttttttctc accccggtga actatctgcc cggtcaggtg 10080

atgcacttca aaaagccttt acagataaag aggaattact taagcagcag gcatctaacc 10140

ttcatgagca gaaaaaagct ggggtgatat ttgaagctga agaagttatc actcttttaa 10200

cttctgtgct taaaacgtca tctgcatcaa gaactagttt aagctcacga catcagtttg 10260

ctcctggagc gacagtattg tataagggcg ataaaatggt gcttaacctg gacagatctc 10320

gtgttccaac tgagtgtata gagaaaattg aggccattct taaggaactt gaaaagccag 10380

caccctgatg cgaccacgtt ttagtctacg tttatctgtc tttacttaat gtcctttgtt 10440

acaggccaga aagcataact ggcctgaata ttctctctgg gcccactgtt ccacttgtat 10500

cgtcggtctg ataatcagac tgggaccacg gtcccactcg tatcgtcggt ctgattatta 10560

gtctgggacc acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accacggtcc 10620

cactcgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt atcgtcggtc 10680

tgattattag tctgggacca tggtcccact cgtatcgtcg gtctgattat tagtctggga 10740

ccacggtccc actcgtatcg tcggtctgat tattagtctg gaaccacggt cccactcgta 10800

tcgtcggtct gattattagt ctgggaccac ggtcccactc gtatcgtcgg tctgattatt 10860

agtctgggac cacgatccca ctcgtgttgt cggtctgatt atcggtctgg gaccacggtc 10920

ccacttgtat tgtcgatcag actatcagcg tgagactacg attccatcaa tgcctgtcaa 10980

gggcaagtat tgacatgtcg tcgtaacctg tagaacggag taacctcggt gtgcggttgt 11040

atgcctgctg tggattgctg ctgtgtcctg cttatccaca acattttgcg cacggttatg 11100

tggacaaaat acctggttac ccaggccgtg ccggcacgtt aacttggtaa cgaatcagac 11160

aattgacggc ttgacggagt agcatagggt ttgcagaatc cctgcttcgt ccatttgaca 11220

ggcccaggca tcaaataaaa cgaaaggctc agtcgaaaga ctgggccttt cgttttatct 11280

gttgtttgtc ggtgaacgct ctcctgagta ggacaaatcc gccgggagcg gatttgaacg 11340

ttgcgaagca acggcccgga gggtggcggg caggacgccc gccataaact gccaggcatc 11400

aaattaagca gaaggccatc ctgacggatg gcctttttgc gtttctacaa actcttcggg 11460

ctgcatccga tgcaagtgtg tcgctgtcga cgagctcgcg agctcggaca tgaggttgcc 11520

ccgtattcag tgtcgctgat ttgtattgtc tgaagttgtt tttacgttaa gttgatgcag 11580

atcaattaat acgatacctg cgtcataatt gattatttga cgtggtttga tggcctccac 11640

gcacgttgtg atatgtagat gataatcatt atcactttac gggtcctttc cggtgatccg 11700

acaggttacg gggcggcgac ctcgcgggtt ttcgctattt atgaaaattt tccggtttaa 11760

ggcgtttccg ttcttcttcg tcataactta atgtttttat ttaaaatacc ctctgaaaag 11820

aaaggaaacg acaggtgctg aaagcgagct ttttggcctc tgtcgtttcc tttctctgtt 11880

tttgtccgtg gaatgaacaa tggaagtccg agctcatcgc taataacttc gtatagcata 11940

cattatacga agttatattc gat 11963