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一种抑制Hippo信号通路和胃癌的基因抑制剂

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摘要

本发明提供了一种Hippo信号通路基因抑制剂，属于肿瘤细胞生物学技术领域。本发明所提供的Hippo通路基因抑制剂为LINC02083的siRNA，所述siRNA的正义链如SEQ ID NO.6所示，所示siRNA的反义链如SEQ ID NO.7所示。通过本发明所提供的siRNA能够有效的抑制Hippo通路核心分子YAP和下游分子CTGF和CYR61的蛋白表达。

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公开/公告号CN112301030A

专利类型发明专利
公开/公告日2021-02-02

原文格式PDF
申请/专利权人济南帕斯维德生物科技有限公司;
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申请/专利号CN202011220586.4
发明设计人不公告发明人;
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申请日2020-11-05
分类号C12N15/113(20100101);A61K31/713(20060101);A61P35/00(20060101);
代理机构37231 济南智圆行方专利代理事务所(普通合伙企业);
代理人梁轶聪
地址 250014 山东省济南市历下区二环东路5812号三单元602
入库时间 2023-06-19 09:46:20

法律信息

法律状态公告日

法律状态信息

法律状态
2022-04-22

专利申请权的转移 IPC(主分类):C12N15/113 专利申请号:2020112205864 登记生效日:20220412 变更事项:申请人变更前权利人:济南帕斯维德生物科技有限公司变更后权利人:南京科佰生物科技有限公司变更事项:地址变更前权利人:250014 山东省济南市历下区二环东路5812号三单元602 变更后权利人:210028 江苏省南京市栖霞区迈皋桥创业园科技研发基地寅春路18号-A895

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