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一种用于癌症检测的生长抑素类似物及其制备方法和应用

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摘要

本发明提供了一种生长抑素类似物，所述生长抑素类似物多肽序列为：HYNIC‑D‑Phe‑cyclo[Cys‑Tyr‑D‑Trp‑Lys‑Thr‑Cys]‑L‑threoninol。本发明的上述生长抑素类似物或其类似物采用9‑芴甲氧羰基固相合成(FMOC‑SPPS)方法合成。本发明所述的99mTc标记的生长抑素类似物，产物的标记率较高、稳定高，可直接标记，通过细胞实验及大鼠实验证明，本发明所述的标记可直观反映出各个器官的肿瘤位置，结果准确。

著录项

公开/公告号CN108440664A

专利类型发明专利
公开/公告日2018-08-24

原文格式PDF
申请/专利权人上海欣科医药有限公司;
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申请/专利号CN201810258502.2
发明设计人徐鹏程;吴松年;夏伟;张莉君;
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申请日2018-03-27
分类号C07K14/475(20060101);C07K1/20(20060101);C07K1/04(20060101);A61K51/08(20060101);A61K103/10(20060101);
代理机构11569 北京高沃律师事务所;
代理人刘奇
地址 201100 上海市闵行区莘庄工业区春东路528号
入库时间 2023-06-19 06:13:14

法律信息

法律状态公告日

法律状态信息

法律状态
2018-09-18

实质审查的生效 IPC(主分类):C07K14/475 申请日:20180327

实质审查的生效
2018-08-24

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1. 一种用于癌症检测的生长抑素类似物及其制备方法和应用 [P] . 中国专利： CN108440664A . 2018-08-24
2. 一种用于胞内癌症标志物双重检测的卫星状纳米组装体的制备方法及应用 [P] . 中国专利： CN106367510A . 2017-02-01
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

机译：修饰的多聚核苷酸绝缘带，宿主细胞，分离的转基因非人类动物多肽，经过修饰以表达对ALK具有抗性的多肽突变体，与对ALK具有抗性的多肽突变体特异性结合的抗体，试剂盒p用于检测生物样品中对ALK抑制剂具有抗性的突变，以及用于评估生物样品为对ALK抑制剂具有抗性的突变的方法，用于诊断对至少一种对ALK抑制剂具有抗性或可能发展出抗性的癌症激酶小分子ALK，以评估Anto对ALK抑制剂具有抗性的突变的生物样品。用于诊断对至少一种激酶小分子ALK抑制剂具有抗药性或可能产生抗性的癌症，以评估该生物样品作为对ALK抑制剂有抗性的突变，即对狄诺司他抗性或可能对PF产生抗药性的癌症-02341066
5. COMPOUND, PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL SOLUTION CONTAINING THE COMPOUND, A METHOD OF DETERMINING THE PRESENCE OF CANCER, A KIT FOR CANCER DETECTION, AND THE USE OF HYDROLYSIS OF THE COMPOUND FOR THE DETECTION OF CANCER [P] . 美国专利： US2019248835A1 . 2019-08-15

机译：化合物，其制备过程，包含该化合物的药物解决方案，一种确定癌症存在的方法，一种用于癌症检测的工具包以及使用该化合物的水解物进行癌症检测的方法