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一种降低新霉素发酵过程中新霉素C含量的方法

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摘要

本发明涉及一种降低新霉素发酵过程中新霉素C含量的方法，包括发酵培养，以及在发酵培养过程中通过分阶段控制溶氧降低新霉素C含量的方法，得到效价高、新霉素C含量低的发酵液。本发明方法操作简单，在原有的发酵工艺基础上，不额外增加生产成本，减少后期提取工艺处理难度，提高产品收率，简化工艺。

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公开/公告号CN111394412A

专利类型发明专利
公开/公告日2020-07-10

原文格式PDF
申请/专利权人河北圣雪大成制药有限责任公司;
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申请/专利号CN202010116690.2
发明设计人李猛;袁昉;王绘砖;徐珍;曹建全;
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申请日2020-02-25
分类号C12P19/52(20060101);C12N1/38(20060101);
代理机构13125 石家庄君联专利代理事务所(特殊普通合伙);
代理人高宝新
地址 051430 河北省石家庄市栾城区圣雪路50号
入库时间 2023-12-17 10:12:19

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法律状态
2020-07-10

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1. 一种降低新霉素发酵过程中新霉素C含量的方法 [P] . 中国专利： CN111394412A . 2020-07-10
2. 一种从新霉素发酵液中提取新霉素的方法 [P] . 中国专利： CN105418701B . 2018.04.10
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机译：一般配方的多聚新霉素衍生物（I）;组合产品;药物成分;革兰氏阴性菌引起的患者感染的治疗，缓解或改善的方法;将革兰氏阴性细菌敏化为抗菌剂的方法;开发未发表的抗生素的方法;在个体感染治疗中降低多粘菌素，天然八肽及其衍生物毒性的方法;改善多聚体，天然螯合剂及其衍生物的药动学性质的方法;认识临床上重要的革兰氏阴性细菌对血清中防御机制的补充;使用衍生词;的多聚新霉素衍生物的制备和方法（I）
4. POLYMIXIN DERIVATIVE OF GENERAL FORMULA (I); COMBINATION PRODUCT; PHARMACEUTICAL COMPOSITION; Method for Sensitizing Gram-Negative Bacteria to an Antibacterial Agent; METHOD FOR DEVELOPING ANTIBIOTICS; METHOD FOR REDUCING THE TOXICITY OF POLYMIXINES, NATURAL OCTAPEPTINS AND THEIR DERIVATIVES DURING APPLICATION OF THE SAME IN THE TREATMENT OF INFECTIONS IN AN INDIVIDUAL; METHOD FOR IMPROVING PHARMACOKINETIC PROPERTIES OF POLYMIXINS, NATURAL OCTAPEPTINS AND THEIR DERIVATIVES; METHOD FOR SENSITIZING GRAM-NEGATIVE BACTERIA CLINICALLY IMPORTANT TO A DEFENSE MECHANISM COMPLEMENT IN SERUM; USE OF A DERIVATIVE; AND PROCESS FOR THE PREPARATION OF A FORMULA POLYMIXIN DERIVATIVE (I). [P] . BRPI0715095B1 . 2018-08-07

机译：一般配方的多聚新霉素衍生物（I）;组合产品;药物成分;使革兰氏阴性细菌对抗菌剂敏感的方法;开发抗生素的方法;在个体感染治疗中降低多聚毒素，天然八肽及其衍生物毒性的方法;改善多聚体，天然螯合剂及其衍生物的药动学性质的方法;敏化临床上对血清防御机制的补充重要的革兰氏阴性细菌的方法;使用衍生词;式多聚新霉素衍生物的制备和方法（I）。
5. POLYMIXIN DERIVATIVE OF THE GENERAL FORMULA (I); COMBINATION PRODUCT; PHARMACEUTICAL COMPOSITION; METHOD FOR THE TREATMENT, RELIEF OR IMPROVEMENT OF AN INFECTION, IN A PATIENT, CAUSED BY A GRAM-NEGATIVE BACTERIA; METHOD FOR SENSITIZING GRAM-NEGATIVE BACTERIA TO AN ANTIBACTERIAL AGENT; METHOD FOR THE DEVELOPMENT OF UNPUBLISHED ANTIBIOTICS; METHODS FOR REDUCING THE TOXICITY OF POLYMIXINS, NATURAL OCTAPEPTINS AND THEIR DERIVATIVES DURING THE APPLICATION OF THE SAME IN THE TREATMENT OF INFECTIONS IN AN INDIVIDUAL; METHOD TO IMPROVE PHARMACOKINETIC PROPERTIES, OF POLYMIXINS, NATURAL OCTAPEPTINS AND THEIR DERIVATIVES; METHOD FOR THE AWARENESS OF CLINICALLY IMPORTANT GRAM-NEGATIVE BACTERIA TO A DEFENSE MECHANISM COMPLEMENT IN THE SERUM; USE OF A DERIVATIVE; AND PROCESS FOR THE PREPARATION OF A POLYMIXIN DERIVATIVE OF FORMULA (I) [P] . BRPI0715095A2 . 2013-10-15

机译：一般配方的多聚新霉素衍生物（I）;组合产品;药物成分;革兰氏阴性菌引起的患者感染的治疗，缓解或改善的方法;将革兰氏阴性细菌敏化为抗菌剂的方法;开发未发表的抗生素的方法;在个体感染治疗中降低多粘菌素，天然八肽及其衍生物毒性的方法;改善多聚体，天然螯合剂及其衍生物的药动学性质的方法;认识临床上重要的革兰氏阴性细菌对血清中防御机制的补充;使用衍生词;的多聚新霉素衍生物的制备和方法（I）