首页> 中国专利> 一种细胞外ABL1激酶活性检测试剂盒及其应用

一种细胞外ABL1激酶活性检测试剂盒及其应用

页面导航

摘要
著录项
法律信息
相似文献

摘要

本发明公开了一种细胞外ABL1激酶活性检测试剂盒，包括以下试剂：ATP、ABL1底物多肽、反应缓冲液，以及ABL1蛋白或ABL1激酶结构域(PTK)对应的多肽片段。本发明ABL1激酶活性检测试剂盒操作简便、有效，可以在细胞外高通量地检测ABL1激酶的活性，从而用于大规模地筛选ABL1激酶活性的抑制剂。

著录项

公开/公告号CN111321200A

专利类型发明专利
公开/公告日2020-06-23

原文格式PDF
申请/专利权人广州安镝声生物医药科技有限公司;
展开▼

申请/专利号CN202010133489.5
发明设计人费嘉;阴钊;
展开▼

申请日2020-02-28
分类号
代理机构广州三环专利商标代理有限公司;
代理人颜希文
地址 510000 广东省广州市天河区中山大道105号华景新城华景路35号2楼201号
入库时间 2023-12-17 09:16:50

法律信息

法律状态公告日

法律状态信息

法律状态
2020-07-17

实质审查的生效 IPC(主分类):C12Q1/48 申请日:20200228

实质审查的生效
2020-06-23

公开

公开

相似文献

专利
中文文献
外文文献

1. 一种细胞外ABL1激酶活性检测试剂盒及其应用 [P] . 中国专利： CN111321200A . 2020-06-23
2. 肿瘤ABL1基因位点分型检测试剂盒、使用方法及应用 [P] . 中国专利： CN104152542B . 2016.09.14
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

机译：修饰的多聚核苷酸绝缘带，宿主细胞，分离的转基因非人类动物多肽，经过修饰以表达对ALK具有抗性的多肽突变体，与对ALK具有抗性的多肽突变体特异性结合的抗体，试剂盒p用于检测生物样品中对ALK抑制剂具有抗性的突变，以及用于评估生物样品为对ALK抑制剂具有抗性的突变的方法，用于诊断对至少一种对ALK抑制剂具有抗性或可能发展出抗性的癌症激酶小分子ALK，以评估Anto对ALK抑制剂具有抗性的突变的生物样品。用于诊断对至少一种激酶小分子ALK抑制剂具有抗药性或可能产生抗性的癌症，以评估该生物样品作为对ALK抑制剂有抗性的突变，即对狄诺司他抗性或可能对PF产生抗药性的癌症-02341066
5. Extracellular signal-regulated kinase, array, manufacturing methods and applications [P] . 日本专利： JPH08510897A . 1996-11-19

机译：细胞外信号调节激酶，阵列，制造方法和应用