首页> 中国专利> 用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物

用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物

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摘要

本发明提供了用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物，所述药物包括IL‑18抗体和/或IL‑18R受体siRNA外泌体。本发明的药物以IL‑18抗体和/或装载IL‑18R受体siRNA外泌体为功效成分，通过与牙周组织中IL‑18结合，抑制牙周膜细胞分泌促炎细胞因子，改善炎症状态下牙周膜细胞功能紊乱导致的牙周支持组织丧失及炎症细胞浸润的作用，从而阻止牙周疾病的发生发展，对牙周疾病的临床预防治疗有着潜在的巨大应用价值。

著录项

公开/公告号CN110433289A

专利类型发明专利
公开/公告日2019-11-12

原文格式PDF
申请/专利权人中山大学附属口腔医院;
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申请/专利号CN201910851817.2
发明设计人谭家莉;李丹枫;匡威;
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申请日2019-09-10
分类号A61K39/395(20060101);A61K31/7105(20060101);A61K48/00(20060101);A61P1/02(20060101);A01K67/027(20060101);A61K49/00(20060101);
代理机构11332 北京品源专利代理有限公司;
代理人巩克栋
地址 510055广东省广州市陵园西路56号
入库时间 2024-02-19 14:07:45

法律信息

法律状态公告日

法律状态信息

法律状态
2019-12-06

实质审查的生效 IPC(主分类):A61K39/395 申请日:20190910

实质审查的生效
2019-11-12

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1. 用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物 [P] . 中国专利： CN110433289A . 2019-11-12
2. S1PR1拮抗剂在制备用于治疗流感病毒感染引起的细胞因子风暴的药物中的应用 [P] . 中国专利： CN111265504A . 2020-06-12
3. composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion [P] . BRPI0617987A2 . 2011-08-16

机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病
4. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法
5. "use of polyols, appropriate device for the treatment or prophylaxis of mucosal infection caused by yeast in mammals, process for therapeutic or prophylactic treatment of mammals suffering from or being subjected to an increased risk of infection of the mucosa caused by yeast, composition for use in this treatment, and, pharmaceutical preparation for use in the prophylactic or therapeutic systemic or topical treatment of mucosal infections caused by yeast. " [P] . BR9814721A . 2000-10-03

机译： “多元醇的用途，用于治疗或预防哺乳动物中酵母引起的粘膜感染的适当装置，用于治疗或预防由酵母引起的粘膜感染或增加感染风险的哺乳动物的方法，使用的组合物在这种治疗中，以及用于预防性或治疗性全身或局部治疗由酵母引起的粘膜感染的药物制剂。”