T3P® (propylphosphonic anhydride) Mediated Conversion of Carboxylic Acids into Acid Azides and one-pot Synthesis of Ureidopeptides

摘要

A general, mild, efficient, and environmentally benign protocol, which makes use of T3P® as an acid activating agent for the direct synthesis of acid azides from carboxylic acids is described. Further, the protocol is employed for the one-pot synthesis of α-ureidopeptides starting from N-protected α-amino acids.