Preliminary results of the project A.I.D.A.ud(Auto Immunity: Diagnosis Assisted by computer)

摘要

In this paper, are presented the preliminary results of the A.I.D.A. (Auto Immunity: DiagnosisudAssisted by computer) project which is developed in the frame of the cross-border cooperation Italy-Tunisia.udAccording to the main objectives of this project, a database of interpreted Indirect ImmunoFluorescence (IIF)udimages on HEp 2 cells is being collected thanks to the contribution of Italian and Tunisian experts involved inudroutine diagnosis of autoimmune diseases. Through exchanging images and double reporting; a Gold Standarduddatabase, containing around 1000 double reported IIF images with different patterns including negative tests,udhas been settled. This Gold Standard database has been used for optimization of a computing solution (CADComputerudAided Detection) and for assessment of its added value in order to be used along with anudimmunologist as a second reader in detection of auto antibodies for autoimmune disease diagnosis. From theudpreliminary results obtained, the CAD appeared more powerful than junior immunologists used as secondudreaders and may significantly improve their efficacy.