Toxicology and Carcinogenesis Studies of 1,2,3-Trichloropropane (CAS No. 96-18-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

摘要

1,2,3-Trichloropropane is a colorless liquid used as a paint and varnish remover, solvent, and degreasing agent, and as a crosslinking agent in the synthesis of polysulfides and hexafluoropropylene. Toxicology and carcinogenicity studies were conducted by administering 1,2,3-trichloropropane (greater than 99% pure) in corn oil by gavage to groups of F344/N rats and B6C3F1, mice for 17 weeks and 2 years. Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of 1,2,3-trichloropropane in male and female F344/N rats based on increased incidences of squamous cell papillomas and carcinomas of the oral mucosa and forestomach. There was clear evidence of carcinogenic activity of 1,2,3-trichloropropane in male and female B6C3F1 mice based on increased incidences of squamous cell papillomas and carcinomass of the forestomach, hepatocellular adenomas or carcinomas of the liver, and harderian gland adenomas.