Ocular Hypertension Treatment Study (OHTS) Manual of Procedures. Version 2.0

摘要

Elevated intraocular pressure (IOP) is a common condition and is though to be theleading risk factor for the development of open-angle glaucoma. There is conflicting evidence as to whether early medical treatment is effective in preventing or delaying the onset of glaucomatous damage in individuals with elevated intraocular pressure (referred to as ocular hypertensive individuals or glaucoma suspects). The proposed study is a long-term randomized, multicenter, clinical trial to determine whether medical reduction of intraocular pressure prevents or delays the onset of glaucomatous optic nerve and/or visual field defects in ocular hypertensive subjects. The subjects will be followed for a minimum of five years with follow-up continuing until study termination. The document outlines the specific rationale for admission into the study and the method for following these subjects.