Final Report on the Reproductive Toxicity of Thiophenol (CAS No. 108-98-5)Administered by Gavage to Sprague-Dawley Rats

摘要

The potential reproductive toxicity of thiphenol in Sprague-Dawley rats wasevaluated using the Reproductive Assessment by Continuous Breeding (RACB) protocol. Based on acute oral LD50 of 46.2 mg/kg and the increased mortality in the 40 mg/kg/day females and the increased liver weights at 30 mg/kg/day noted during a previous RACB study with thiophenol, dose levels for the continuous breeding phase for this study were set at 9, 19, and 35 mg/kg. Male and female Sprague-Dawley rats were exposed to thiophenol in corn oil by oral gavage. During 15 weeks of cohabitation, live pup weight adjusted for litter size was decreased by 4 and 6% in the 9 and 35 mg/kg dose groups, respectively. The number of live pups was slightly but not significantly decreased (7%) at 35 mg/kg. No differences were observed in the pregnancy index, cumulative days to litter, mean average litters per pair, proportion of pups born alive, or sex ratio of pups. A crossover mating trial (Task 3) revealed the females as the affected sex. When naive males were mated with control or 35 mg/kg females, the mean live pup weight and adjusted live pup weight were reduced in the 35 mg/kg group by 8-9%. No other treatment-related effects were seen. When naive females were mated with control or 35 mg/kg males, reproductive parameters were comparable between dose groups.