PCB77 Promotes Obesity-Associated Atherosclerosis.

摘要

Polychlorinated biphenyls (PCBs) are industrial chemicals that bioaccumulate in the ecosystem. PCBs are highly lipophilic and accumulate markedly in fatty tissues, so obesity could increase the body burden of PCBs. Although adipocytes (fat cells) are likely to be frequently exposed to PCBs, the specific effects of PCBs on adipocyte function have not been defined. Moreover, the relationship between increased PCB body burden with obesity and the development of obesityassociated diseases is unknown.