The Role of Splanchnic and Lumbar Sympathetic Nerves in the Physiologic Response to Fever and Hypoxia in Dogs either Anesthetized or Unanesthetized

摘要

Fever up to 42° C. rectal temperature in the dog produced an increase in oxygen con¬sumption rate, plasma creatinine, blood lactic acid, hematocrit, blood oxygen content, blood pH, pulse rate, cardiac output, and arterial-venous oxygen difference.nThe main effects of anesthesia were appar¬ently the reduced sensitivity of the respiratory centers to increasing CO2 blood level and decreasing blood 02 level. The anesthetic also reduced muscle tone and general muscular activity probably by reduction of cerebral cor¬tical activity.nThe most important function of the splanch¬nic and lumbar sympathetic nerves was appar¬ently the control of the circulatory system and secondly the partial regulation of blood glucose through liberation of epinephrine from the adrenal medulla.