Evaluation of Research on Cadmium Inhalation Exposure Estimate and Their Significance for Kidney and Liver Cadmium Burden

摘要

The time weighted exposure matrix for cadmium suggested in an earlier study was evaluated to identify factors in the association between occupational cadmium exposure and accumulation of tissue cadmium burden that requires additional consideration. The external dose of cadmium was undoubtedly underestimated because the ingestion route was not evaluated. Another potential complication was that age may be a factor in producing increased urinary excretion of proteins. A solution would be to calculate these data with age as a covariable. Another major consideration was the high person to person variability in the half time of cadmium in liver and kidney. Whether this reflected biological variation, time exposure, or anomalies in the exposure matrix could not be judged from the available data. Even so, assuming a biological basis, person to person variability was an important consideration in evaluating the relation between external exposure and renal damage. The author concludes that the approach taken in the earlier report appears to be the best method for associating occupational cadmium exposures with renal dysfunction.