Scientific Literature Review: Discussion of Factors which Might Affect Malaria Sporozoite Vaccine Efficacy. Part 1. Malaria, Nutrition, Epidemiology, Age, Pregnancy, Anti-Malarial Drugs, Vaccine Immunogens

摘要

An experimental vaccine whose success will have profound effects on health and well-being in developing and tropical countries is a vaccine for malaria. The most promising vaccine candidate is composed of antigens associated with the sporozoite stage of the parasite. Of concern with respect to assessment of vaccine efficacy are field conditions which might adversely affect the response of test subjects. These conditions might include the immunosuppressive effects of malaria as well as nutritional, environmental, socioeconomic and technical factors. Host responses to the vaccine may be affected also by pregnancy, age for vaccination, anti-malarial drug treatment and other factors. The purpose of this report was to identify factors described in the published literature which might affect host responses adversely. The results of this survey will be issued in two separate reports, one of which is presented here in five chapters, each with extensive bibliographies. Identification of these factors should facilitate the planning of field trials and the interpretation of data derived from those trials.