Interim Procedures for Estimating Risks Associated with Exposures of Mixtures of Chlorinated Dibenzo-p-Dioxins and -Dibenzofurans (CDDs and CDFs)

摘要

As part of its effort to address risks posed by chlorinated dibenzo-p-dioxins and chlorinated dibenzofurans (CDDs and CDFs) in the environment, the U.S. Environmental Protection Agency (EPA) has adopted an interim procedure, based on dioxin toxicity equivalence factors (TEFs), for estimating the hazard and dose-response of complex mixtures containing CDDs and CDFs in addition to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The TEF procedure, and the scientific data upon which it is based, are the subject of the report. The document describes the recommended interim procedure for generating the TCDD equivalence of complex mixtures of CDDs and CDFs, based on congener or homologue-specific data, and for using such information in assessing risk.