Evaluation of the Potential Carcinogenicity of 2-Naphthylamine (91-59-8)

摘要

2-Naphthylamine is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Sufficient'. The potency factor (F) for 2-naphthylamine is estimated to be 4.77 (mg/kg/day)-1, placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, 2-naphthylamine is assigned a 'HIGH' hazard ranking.