Alkylation of Substituted Malonic and Cyanoacetic Esters with 2-Dimethylaminomethylpyrrole. A Proposed Synthesis of Beta-2-Pyrrolealanine.

摘要

B-2-Thienylalanine and B-2-furylalanine have been shown to inhibit microbial growth presumably due to their structural similarity to phenylalanine. The corresponding nitrogen analog, b-2-pyrrolealanine, is not described in the literature. As part of a program to correlate the structure of amino acids with their biological activity, it seemed desirable to prepare this substance so that it might be available for microbiological studies. jg p.2.