The Renal Excretion of Sodium and Potassium in the Dog

摘要

Studies were carried out on unanesthetized dogs to determine some of the factors controlling the fraction of filtered sodium and potassium reabsorbed by the renal tubules. The interference with the reabsorption of each of these ions by the other and the phenomenon of tubular secretion of potassium were investigated. Filtration rate (as measured by inulin and creatinine clearance) and effective renal plasma flow (as measured by sodium para-aminohippurate clearance) were determined before and during the intravenous infusion of 0.9% NaCl, 10% NaCl and 1.2% KCl solutions. The percentage of filtered electrolyte reabsorbed for both sodium and potassium was measured. The presence of the chloride salt of each ion in the glomerular filtrate depresses the reabsorption of the other ion. The ingestion of potassium chloride prior to the infusion of this salt augments the depression of potassium reabsorption which normally follows an increased filtration of potassium. (Author)