Hemolytic Disease in Newborn Dogs Following Isoimmunization of the Dam by Transfusions.

摘要

Four different isohemagglutinins have been demonstrated in sera of dogs following transfusions with dog erythrocytes containing antigenic factors lacking in their own cells. The factors thus far identified serologically may conveniently be designated as 'canine A, B, C, and and the corresponding antibodies as 'canine anti-A, -B, -C, and -D.' In our experience to date, A antibodies have been most easily produced bi high titer, and in many respects their behavior in vitro is similar to that of Rh antibodies. Possible relationships between antigenic factors bi dog red blood cells and factors present in erythrocytes of other species are under investigation. Pending completion of these studies, it is convenient to refer to dog cells containing the canine A factor as 'Do-positive' and to cells lacking the canine A factor as 'Do-negative.' Observations on hemolytic reactions following transfusion of Do-positive cells into immunized Do-negative recipient dogs and of anti-Do plasma into Do-positive recipients are described in separate reports (2, 4, 5). The object of this paper is to record the production of hemolytic disease in four Do-positive puppies born to a Do-negative bitch (mostly pointer) that had been immunized by transfusions of Do-positive cells and then mated with a Do-positive male (mostly German shepherd). Four Do-negative puppies in the same litter showed no evidence of hemolytic disease.