Initial Submission: Letter from Hoechst Celanese Corp Submitting Information on an Oral Study of the Embryotoxic Effect with a Formulation of Glufosinate Nh4 in Wistar Rats

摘要

Glufosinate ammonium (77182-82-2) was evaluated for developmental toxicity. Twenty pregnant Wistar rats per group were administered the test material by oral gavage at 0, 10, 50, or 250 mg/kg/day on days 7- 16 of gestation. Dose-dependent maternal toxicity was observed at all treatment levels including motorial unrest, hyperactivity (50-150 mg/kg/day), drowsiness, vaginal hemorrhages, weight loss, and at 250 mg/kg/day only, intrauterine death and one mortality. Ureter and kidney dilation were observed in fetuses of all treatment groups. A slight retardation of skeletal ossification was observed at 250 mg/kg/day. This study was briefly summarized. No further information was reported.