COMPARATIVE STUDY OF SOLUBILITY AND STABILITY OF FOUR SOLUBLE ORAL AMOXICILLIN FORMULATIONS IN WATER AT HIGH CONCENTRATION

摘要

The administration of amoxicillin in drinking water is widely used to control bacterial diseases in pigs. This route is especially useful in pig production because of the efficiency and ease of application, particularly in large populations exhibitingreduced feed consumption due to disease. However, there are differences between formulations with regard to their solubility and stability (1). With amoxicillin formulations, it is well known that, once dissolved, the active ingredient is degraded, sometimes to levels which affect its efficacy. Solubility is another factor which needs to be considered, particularly when dosing pumps are used that require very high concentrations in the pre-dilution tank.