METHOD OF TREATING PAIN BY ADMINISTERING 24-HOUR ORAL OPIOID FORMULATION EXHIBITING RAPID RATE OF INITIAL RISE OF PLASMA DRUG LEVEL

摘要

PPROBLEM TO BE SOLVED: To provide an oral, sustained-release opioid preparation. PSOLUTION: A patient is treated using the 24-hour oral sustained-release opioid formulation which, upon administration, provides an initially rapid opioid absorption such that the minimum effective analgesic concentration of the opioid is more quickly achieved. Such the sustained-release opioid formulation contains an effective amount of at least one retardant material to cause the opioid analgesic to be released at a such a rate as to provide an analgesic effect after oral administration to a human patient for at least about 24 hours, and is characterized by an absorption half-life of from 1 to about 8 hours. A method of titrating a human patient utilizing the sustained-release opioid formulation is also disclosed. PCOPYRIGHT: (C)2009,JPO&INPIT