ATM Heterozygosity and the Development of Radiation-Induced Erectile Dysfunction and Urinary Morbidity Following Radiotherapy for Prostate Cancer

摘要

The goal of this training grant project is to determine whether the prevalence of ATM carriers among prostate cancer patients treated with radiotherapy that develop erectile dysfunction and urinary morbidity is greater than the prevalence of ATM heterozygosity among patients that do not develop this complication. Regardless of the scientific outcome of the proposal the PI will be left with a vast experience in translational research from which to form new hypotheses and research strategies as he begins his career as an independent physician scientist. To assure a well-rounded experience, the school of medicine will insure that the PI will participate for the first two years of the funded period in Mount Sinai's rigorous clinical research training program. The NIH sponsored program will give the PI formal instruction in Clinical Research and Policy Evaluation, Epidemiology and Biostatistics, Basic Science for the Clinical Investigator, Cultural, Illness, and Community Health Outcomes, Behavioral Medicine, and Ethical Issues in Clinical Research. Also the PI, while at Mount Sinai, will make significant progress in establishing collaborative relationships with well-established prostate cancer researchers and will continue this approach in order to expand the scope of the outlined proposal throughout the funding period of this grant.