Analytical and Characterization Studies of Organic Chemicals, Drugs, and Drug Formulation

摘要

During the period October 22, 2010 to October 21, 2011, the project personnel continued to perform chemical/physical analyses on bulk pharmaceutical substances and formulated drug products, and to develop dosage formulations of interest to the USAMRMC Drug Development Program for parasitic and infectious diseases, chemical and biological defense, etc. Specific objectives were to design, develop, validate, and apply methods to determine chemical and physical characteristics of the bulk drugs, drug products, to determine their stability under defined conditions, to prepare formulations of bulk drugs for biological testing, and to coordinate ongoing stability studies on an artesunate dosage form with a subcontractor.